Any feedback?
Literature summary for 2.8.2.4 extracted from
- Variable sulfation of dietary polyphenols by recombinant human sulfotransferase (SULT) 1A1 genetic variants and SULT1E1 (2007), Drug Metab. Dispos., 35, 740-746.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| stable expression of SULT1E1 in MCF-7 cells, expression of His-tagged SULT1E1 using a baculoviral-Spodoptera frugiperda Sf9 cell system | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | proliferative response of MCF-7 cells stably expressing SULT1E1 to polyphenols, overview | Homo sapiens |
| additional information | MCF-7 cells stably expressing SULT1E1 show altered cellular proliferation upon treatment with chrysin, quercetin, or resveratrol, thus suggesting inactivation of these compounds by SULT1E1 | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetics | Homo sapiens | |
| additional information | - |
additional information | kinetics of SULT1E1, overview | Homo sapiens | |
| 0.002 | - |
quercetin | pH 6.5, 37°C, recombinant SULT1E1 | Homo sapiens |  |
| 0.002 | - |
quercetin | pH 6.5, 37°C, SULT1E1 | Homo sapiens | |
| 0.0045 | - |
chrysin | pH 6.5, 37°C, recombinant SULT1E1 | Homo sapiens | |
| 0.0045 | - |
chrysin | pH 6.5, 37°C, SULT1E1 | Homo sapiens | |
| 0.0053 | - |
apigenin | pH 6.5, 37°C, recombinant SULT1E1 | Homo sapiens | |
| 0.0053 | - |
apigenin | pH 6.5, 37°C, SULT1E1 | Homo sapiens | |
| 0.0069 | - |
resveratrol | pH 6.5, 37°C, recombinant SULT1E1 | Homo sapiens | |
| 0.0069 | - |
resveratrol | pH 6.5, 37°C, SULT1E1 | Homo sapiens | |
| 0.962 | - |
epicatechin | pH 6.5, 37°C, recombinant SULT1E1 | Homo sapiens | |
| 0.962 | - |
epicatechin | pH 6.5, 37°C, SULT1E1 | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | SULT1E1 has a major role in estrogen conjugation. Important role for SULT isozymes and their pharmacogenetics in polyphenol disposition | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Homo sapiens | P49888 | SULT1E1 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylyl sulfate + apigenin | - |
Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
| 3'-phosphoadenylyl sulfate + chrysin | - |
Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
| 3'-phosphoadenylyl sulfate + epicatechin | - |
Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
| 3'-phosphoadenylyl sulfate + quercetin | - |
Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
| 3'-phosphoadenylyl sulfate + resveratrol | - |
Homo sapiens | adenosine 3',5'-bisphosphate + ? | - |
? | |
| additional information | SULT1E1 has a major role in estrogen conjugation. Important role for SULT isozymes and their pharmacogenetics in polyphenol disposition | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SULT1E1 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
assay at | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
