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Literature summary for 2.8.2.4 extracted from

  • Gong, H.; Jarzynka, M.J.; Cole, T.J.; Lee, J.H.; Wada, T.; Zhang, B.; Gao, J.; Song, W.C.; DeFranco, D.B.; Cheng, S.Y.; Xie, W.
    Glucocorticoids antagonize estrogens by glucocorticoid receptor-mediated activation of estrogen sulfotransferase (2008), Cancer Res., 68, 7386-7393.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.8.2.4

Activating Compound

Activating Compound Comment Organism Structure
additional information activation of the glucocorticoid receptor by dexamethasone induces the expression and activity of estrogen sulfotransferase SULT1E1 Homo sapiens
additional information activation of the glucocorticoid receptor by dexamethasone induces the expression and activity of estrogen sulfotransferase SULT1E1, which is suppressed by the coadministration of RU486, a glucocorticoid receptor antagonist. The pregnane X receptor PXR agonist PCN fails to increase Sult1E1 mRNA level in wild-type mice Mus musculus

Application

Application Comment Organism
pharmacology reactivation of endogenous SULT1E1 gene expression may represent a novel therapeutic strategy to inhibit estrogen-dependent growth of breast cancer cells Mus musculus
pharmacology reactivation of endogenous SULT1E1 gene expression may represent a novel therapeutic strategy to inhibit estrogen-dependent growth of breast cancer cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information ectopic expression of SULT1E1 in MCF-7 cells suppresses the estrogen response Mus musculus
additional information ectopic expression of SULT1E1 in MCF-7 cells suppresses the estrogen response Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mus musculus 5829
-
cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus SULT1E1 or EST is an enzyme important for the metabolic deactivation of estrogens, because sulfonated estrogens fail to activate the estrogen receptor. Ectopic expression of SULT1E1 in MCF-7 cells suppresses the estrogen response. Dexamethasone inhibits mouse uterine estrogen responses in a Sult1E1/EST-dependent manner. SULT1E1 is a transcriptional target of the glucocorticoid receptor, molecular mechanism, overview ?
-
 ?
additional information Homo sapiens SULT1E1 or EST is an enzyme important for the metabolic deactivation of estrogens, because sulfonated estrogens fail to activate the estrogen receptor. ectopic expression of SULT1E1 in MCF-7 cells suppresses the estrogen response. SULT1E1 is a transcriptional target of the glucocorticoid receptor, molecular mechanism, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
 three-week-old virgin female mice
-

Source Tissue

Source Tissue Comment Organism Textmining
breast
-
 Mus musculus
-
breast
-
 Homo sapiens
-
breast cancer cell
-
 Mus musculus
-
breast cancer cell
-
 Homo sapiens
-
hepatocyte primary culture Mus musculus
-
hepatocyte primary culture Homo sapiens
-
liver
-
 Mus musculus
-
liver
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information SULT1E1 or EST is an enzyme important for the metabolic deactivation of estrogens, because sulfonated estrogens fail to activate the estrogen receptor. Ectopic expression of SULT1E1 in MCF-7 cells suppresses the estrogen response. Dexamethasone inhibits mouse uterine estrogen responses in a Sult1E1/EST-dependent manner. SULT1E1 is a transcriptional target of the glucocorticoid receptor, molecular mechanism, overview Mus musculus ?
-
 ?
additional information SULT1E1 or EST is an enzyme important for the metabolic deactivation of estrogens, because sulfonated estrogens fail to activate the estrogen receptor. ectopic expression of SULT1E1 in MCF-7 cells suppresses the estrogen response. SULT1E1 is a transcriptional target of the glucocorticoid receptor, molecular mechanism, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
EST
-
 Mus musculus
EST
-
 Homo sapiens
estrogen sulfotransferase
-
 Mus musculus
estrogen sulfotransferase
-
 Homo sapiens
SULT1E1
-
 Mus musculus
SULT1E1
-
 Homo sapiens