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Literature summary for 2.8.2.4 extracted from

  • Horwitz, J.P.; Misra, R.S.; Rozhin, J.; Neenan, J.P.; Huo, A.; Godefroi, V.E.; Philips, K.D.; Chung, H.L.; Butke, G.; Brooks, S.C.
    IV. Synthesis and assay of analogs of adenosine 3,5-diphosphate as inhibitors of bovine adrenal estrogen sulfotranferase (1978), Biochim. Biophys. Acta, 525, 364-372.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
(7-amino-3(beta-D-ribofuranosyl)-pyrazolo-[4,3-d]pyrimidine) 3',5'-diphosphate
-
 Bos taurus
3'-AMP
-
 Bos taurus
7-deazadenosine tubercidin Bos taurus
8-bromoadenosine 3',5'-diphosphate
-
 Bos taurus
adenosine 3',5'-diphosphate
-
 Bos taurus
adenosine 3'-diphosphate 5'-phosphate
-
 Bos taurus
adenosine 3'-phosphate 5'-diphosphate
-
 Bos taurus
adenosine 5'-phosphosulfate
-
 Bos taurus
adenosine 5'-sulfate
-
 Bos taurus
adenosine N1-oxide 3,5'-diphosphate
-
 Bos taurus
AMP
-
 Bos taurus
guanosine 2',3'-cyclic phosphate 5'-phosphate
-
 Bos taurus
inosine 3',5'-diphosphate
-
 Bos taurus
N6-dimethylaminoadenosine 3',5'-diphosphate
-
 Bos taurus
nebularine(9-beta-D-ribofuranosylpurine)adenosine 3',5'-diphosphate
-
 Bos taurus
tubercidin 2',5'-diphosphate
-
 Bos taurus
tubercidin 3',5'-bisphosphate
-
 Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.044
-
 adenosine 3'-phosphate 5'-phosphosulfate pH 7.5, 37°C Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylylsulfate + estrone Bos taurus
-
 adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
 r

Organism

Organism UniProt Comment Textmining
Bos taurus
-
 bovine
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylylsulfate + estrone
-
 Bos taurus adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
 r
additional information simple phenols or steroid alcohols are no substrates Bos taurus ?
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0006
-
 tubercidin 3',5'-bisphosphate pH 7.5, 37°C Bos taurus
0.0017
-
 8-bromoadenosine 3',5'-diphosphate pH 7.5, 37°C Bos taurus
0.0053
-
 tubercidin 2',5'-diphosphate pH 7.5, 37°C Bos taurus
0.007
-
 adenosine 3',5'-diphosphate pH 7.5, 37°C Bos taurus
0.043
-
 (7-amino-3(beta-D-ribofuranosyl)-pyrazolo-[4,3-d]pyrimidine) 3,5''-diphosphate pH 7.5, 37°C Bos taurus
0.046
-
 adenosine 3'-diphosphate 5'-phosphate pH 7.5, 37°C Bos taurus
0.068
-
 nebularine(9-beta-D-ribofuranosylpurine)adenosine 3',5'-diphosphate pH 7.5, 37°C Bos taurus
0.084
-
 guanosine 2',3'-cyclic phosphate 5'-phosphate pH 7.5, 37°C Bos taurus
0.116
-
 adenosine 3'-phosphate 5'-diphosphate pH 7.5, 37°C Bos taurus
0.125
-
 N6-dimethylaminoadenosine 3',5'-diphosphate pH 7.5, 37°C Bos taurus
0.35
-
 adenosine N1-oxide 3,5'-diphosphate pH 7.5, 37°C Bos taurus
0.8
-
 inosine 3',5'-diphosphate pH 7.5, 37°C Bos taurus