Activating Compound | Comment | Organism | Structure |
---|---|---|---|
3beta-hydroxytibolone | 102% stimulation of activity at 0.0005 mM | Homo sapiens | |
celecoxib | - |
Homo sapiens | |
medrogestone | 85% stimulation of activity at 0.0005 mM | Homo sapiens | |
nomegestrol acetate | 42% stimulation of activity at 0.0005 mM | Homo sapiens | |
Promegestone | 31% stimulation of activity at 0.0005 mM | Homo sapiens | |
quercetin | - |
Homo sapiens | |
resveratrol | - |
Homo sapiens | |
tibolone | 41% stimulation of activity at 0.0005 mM | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
resveratrol | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
35000 | - |
SULT1E1 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | - |
Homo sapiens | - |
Human-7 cell | - |
Homo sapiens | - |
mammary gland | estrogen sulfotransferase is significantly more active in the normal breast cell than in the cancer cell | Homo sapiens | - |
MCF-7 cell | estrogen sulfotransferase is significantly more active in the normal breast cell than in the cancer cell | Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
T-47D cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylyl sulfate + estradiol | SULT1E1 acts at nanomolar concentration of estradiol. SULT1A1 is active at micromolar concentration of estradiol and has an affinity 300fold lower than SULT1E1 | Homo sapiens | adenosine 3',5'-bisphosphate + estradiol 3-sulfate | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | - |
Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
EST | - |
Homo sapiens |
estrogen sulfotransferase | - |
Homo sapiens |
SULT1A1 | active in breast cancer cells | Homo sapiens |
SULT1E1 | active in normal breast cells | Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | SULT expression in breast cancer cells can be stimulated by promegestone, SULT1E1 expression can be controlled by progesterone during the menstrual cycle and during early pregnancy | up |