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Literature summary for 2.8.2.4 extracted from

  • Horwitz, J.P.; Misra, R.S.; Rozhin, J.; Helmer, S.; Bhuta, A.; Brooks, S.C.
    Studies on bovine adrenal estrogen sulfotransferase. V. Synthesis and assay of analogs of 3-phosphoadenosine 5-phosphosulfate as cosubstrates for estrogen sulfurylation (1980), Biochim. Biophys. Acta, 613, 85-94.
    View publication on PubMed
Search for more literature for 2.8.2.4

Inhibitors

Inhibitors Comment Organism Structure
(7-amino-3(beta-D-ribofuranosyl)-pyrazolo-[4,3-d]pyrimidine) 3',5'-diphosphate
-
 Bos taurus
8-bromoadenosine 3'-phosphate 5'-phosphosulfate
-
 Bos taurus
adenosine 2',5'-diphosphate noncompetitive inhibition Bos taurus
adenosine 3',5'-diphosphate
-
 Bos taurus
formycin 3'-phosphate 5'-phosphosulfate
-
 Bos taurus
inosine 3',5'-diphosphate
-
 Bos taurus
nebularine 3',5'-diphosphate
-
 Bos taurus
tubercidin 2',5'-diphosphate noncompetitive inhibition Bos taurus
tubercidin 3'-phosphate 5'-phosphosulfate
-
 Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.018
-
 8-bromoadenosine 3'-phosphate 5'-phosphosulfate pH 7.5, 37°C Bos taurus
0.021
-
 tubercidin 3'-phosphate 5'-phosphosulfate pH 7.5, 37°C Bos taurus
0.13
-
 formycin 3'-phosphate 5'-phosphosulfate pH 7.5, 37°C Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylylsulfate + estrone Bos taurus
-
 adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
 r

Organism

Organism UniProt Comment Textmining
Bos taurus
-
 bovine
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylylsulfate + estrone
-
 Bos taurus adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
 r
8-bromoadenosine 3'-phosphate 5'-phosphosulfate + estrone
-
 Bos taurus 8-bromoadenosine 3',5'-bisphosphate + estrone sulfate
-
 r
adenosine 3'-phosphate 5'-phosphosulfate + estrone
-
 Bos taurus adenosine 3',5'-bisphosphate + estrone sulfate
-
 r
formycin 3'-phosphate 5'-phosphosulfate + estrone
-
 Bos taurus formycin 3',5'-bisphosphate + estrone sulfate
-
 r
additional information dehydroepiandrosterone is no substrate Bos taurus ?
-
 ?
tubercidin 3'-phosphate 5'-phosphosulfate + estrone
-
 Bos taurus tubercidin 3',5'-bisphosphate + estrone sulfate
-
 r

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0006
-
 tubercidin 3'-phosphate 5'-phosphosulfate pH 7.5, 37°C, competitive inhibition Bos taurus
0.0017
-
 8-bromoadenosine 3'-phosphate 5'-phosphosulfate pH 7.5, 37°C, competitive inhibition Bos taurus
0.005
-
 tubercidin 2',5'-diphosphate pH 7.5, 37°C, noncompetitive inhibition Bos taurus
0.007
-
 adenosine 3',5'-diphosphate pH 7.5, 37°C Bos taurus
0.043
-
 formycin 3'-phosphate 5'-phosphosulfate pH 7.5, 37°C, noncompetitive inhibition Bos taurus
0.068
-
 nebularine 3',5'-diphosphate pH 7.5, 37°C Bos taurus
0.8
-
 inosine 3',5'-diphosphate pH 7.5, 37°C Bos taurus
12.9
-
 adenosine 2',5'-diphosphate pH 7.5, 37°C, noncompetitive inhibition Bos taurus