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Literature summary for 2.8.2.4 extracted from

  • Jackson, E.N.; Rowland-Faux, L.; James, M.O.; Wood, C.E.
    Administration of low dose triclosan to pregnant ewes results in placental uptake and reduced estradiol sulfotransferase activity in fetal liver and placenta (2018), Toxicol. Lett., 294, 116-121 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.8.2.4

Inhibitors

Inhibitors Comment Organism Structure
triclosan triclosan directly inhibits and indirectly induces certain phase II UDP-glucuronosyltransferase (UGT) and PAPS-sulfotransferase (SULT) enzymes. It is an especially potent competitive inhibitor of ovine placental estrogen sulfotransferase Ovis aries

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Ovis aries 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + 17beta-estradiol Ovis aries
-
 adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
 ?
3'-phosphoadenylyl sulfate + estrone Ovis aries
-
 adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
 ?

Organism

Organism UniProt Comment Textmining
Ovis aries
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver fetal Ovis aries
-
placenta
-
 Ovis aries
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + 17beta-estradiol
-
 Ovis aries adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
 ?
3'-phosphoadenylyl sulfate + estrone
-
 Ovis aries adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
 ?

Synonyms

Synonyms Comment Organism
estradiol sulfotransferase
-
 Ovis aries
SULT1E1
-
 Ovis aries

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Ovis aries

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Ovis aries

General Information

General Information Comment Organism
malfunction administration of low dose triclosan to pregnant ewes results in placental uptake and reduced estradiol sulfotransferase activity in fetal liver and placenta, effects of triclosan exposure (administered to late gestation fetal sheep for two days either by direct infusion into the fetal circulation or infusion into the maternal blood) of pregnant ewes on placental and hepatic sulfotransferase activity, overview. Placenta contained higher concentrations of triclosan than liver in each individual sheep in both treatment groups Ovis aries