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Literature summary for 2.8.2.4 extracted from

  • Pasqualini, J.R.; Chetrite, G.S.
    Correlation of estrogen sulfotransferase activity and proliferation in normal and carcinomatous human breast. A hypothesis (2007), Anticancer Res., 27, 3219-3225.
    View publication on PubMed
Search for more literature for 2.8.2.4

Activating Compound

Activating Compound Comment Organism Structure
3alpha-hydroxy-tibolone biphasic effect, inhibits at high concentrations, but stimulates at low concentrations, in MCF-7 and T4-7D cells, overview Homo sapiens
3alpha-tibolone activates SULT1E1 in MCF-7 cells by 50% and 37% at low concentrations of 50 nM and 500 nM, respectively, inhibits at 0.05 mM by 63% Homo sapiens
3beta-hydroxy-tibolone biphasic effect, inhibits at high concentrations, but stimulates at low concentrations, in MCF-7 and T4-7D cells, overview Homo sapiens
3beta-tibolone activates SULT1E1 in MCF-7 cells by 101% and 74% at low concentrations of 50 nM and 500 nM, respectively, inhibits at 0.05 mM by 54% Homo sapiens
4-ene-tibolone
-
 Homo sapiens
medrogestone
-
 Homo sapiens
medrogestone biphasic effect, inhibits at high concentrations, but stimulates at low concentrations, overview Homo sapiens
nomegestrol acetate activates SULT1E1 maximally at 500 nM by 83% in MCF-7 cells and by 69% in T-47D cells Homo sapiens
nomegestrol acetate stimulates at low concentrations, but has no effect at high concentrations, overview Homo sapiens
Promegestone activates SULT1E1 by 26% at low concentrations of 500 nM, inhibits at 0.05 mM by 41%, leads to increased and decreased expression levels, respetively Homo sapiens
Promegestone biphasic effect, inhibits at high concentrations, but stimulates at low concentrations, overview Homo sapiens
tibolone activates SULT1E1 in MCF-7 cells by 63% and 44% at low concentrations of 50 nM and 500 nM, respectively, inhibits at 0.05 mM by 64% Homo sapiens
tibolone biphasic effect, inhibits at high concentrations, but stimulates at low concentrations, in MCF-7 and T4-7D cells, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
3alpha-tibolone activates SULT1E1 in MCF-7 cells by 50% and 37% at low concentrations of 50 nM and 500 nM, respectively, inhibits at 0.05 mM by 63% Homo sapiens
3beta-tibolone activates SULT1E1 in MCF-7 cells by 101% and 74% at low concentrations of 50 nM and 500 nM, respectively, inhibits at 0.05 mM by 54% Homo sapiens
4-ene tibolone inhibits at high concentrations of 0.05 mM by 59% Homo sapiens
medrogestone biphasic effect, inhibits at high concentrations, but stimulates at low concentrations, overview Homo sapiens
Promegestone activates SULT1E1 by 26% at low concentrations of 500 nM, inhibits at 0.05 mM by 41%, leads to increased and decreased expression levels, respetively; biphasic effect, inhibits at high concentrations, but stimulates at low concentrations, overview Homo sapiens
tibolone activates SULT1E1 in MCF-7 cells by 63% and 44% at low concentrations of 50 nM and 500 nM, respectively, inhibits at 0.05 mM by 64% Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + 17beta-estradiol Homo sapiens
-
 adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
 ?
3'-phosphoadenylyl sulfate + estradiol Homo sapiens SULT1E1 is involved in estrogen inactivation adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
 ?
3'-phosphoadenylyl sulfate + estrone Homo sapiens
-
 adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
 ?
3'-phosphoadenylyl sulfate + estrone Homo sapiens SULT1E1 is involved in estrogen inactivation adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
 ?
additional information Homo sapiens progestins, which activate the enzyme decrease cell proliferation of breast cancer cell lines, overview ?
-
 ?
additional information Homo sapiens SULT1E1 is involved in breast cancer cell proloferation, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast
-
 Homo sapiens
-
breast cancer cell
-
 Homo sapiens
-
epithelial cell
-
 Homo sapiens
-
epithelial cell mammary Homo sapiens
-
Huma-7 cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
T-47D cell
-
 Homo sapiens
-
ZR-75-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + 17beta-estradiol
-
 Homo sapiens adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
 ?
3'-phosphoadenylyl sulfate + estradiol SULT1E1 is involved in estrogen inactivation Homo sapiens adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
 ?
3'-phosphoadenylyl sulfate + estradiol high activity by SULT1E1, low activity by SULT1A1, EC 2.8.2.1 Homo sapiens adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
 ?
3'-phosphoadenylyl sulfate + estrone
-
 Homo sapiens adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
 ?
3'-phosphoadenylyl sulfate + estrone SULT1E1 is involved in estrogen inactivation Homo sapiens adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
 ?
3'-phosphoadenylyl sulfate + estrone high activity by SULT1E1, low activity by phenol sulfotransferase SULT1A1, EC 2.8.2.1 Homo sapiens adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
 ?
additional information progestins, which activate the enzyme decrease cell proliferation of breast cancer cell lines, overview Homo sapiens ?
-
 ?
additional information SULT1E1 is involved in breast cancer cell proloferation, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
EST
-
 Homo sapiens
estrogen sulfotransferase
-
 Homo sapiens
estrone sulfotransferase
-
 Homo sapiens
steroid sulfotransferase
-
 Homo sapiens
SULT1E1
-
 Homo sapiens