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Literature summary for 2.8.2.4 extracted from
- Biochemistry and reproductive endocrinology of estrogen sulfotransferase (2001), Ann. N. Y. Acad. Sci., 948, 43-50.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4,4'-(hydroxy)2-3,5,'3',5'-tetrachlorobiphenyl | - |
Homo sapiens |  |
| 4-hydroxy-2,3,5,2',3',4',5'-heptachlorobiphenyl | - |
Homo sapiens | |
| 4-hydroxy-2,3,5,3',4'-pentachlorobiphenyl | - |
Homo sapiens | |
| 4-hydroxy-3,5,2',3',4'-pentachlorobiphenyl | - |
Homo sapiens | |
| 4-hydroxy-3,5,3',4',5'-pentachlorobiphenyl | - |
Homo sapiens | |
| 4-hydroxy-3,5,3',4'-tetrachlorobiphenyl | - |
Homo sapiens | |
| 4-hydroxy-3,5,3',5'-tetrachlorobiphenyl | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.000025 | - |
estradiol | - |
Mus musculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Cavia porcellus | 5829 | - |
| cytosol | - |
Mus musculus | 5829 | - |
| cytosol | - |
Homo sapiens | 5829 | - |
| cytosol | - |
Rattus norvegicus | 5829 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylylsulfate + estradiol | Cavia porcellus | - |
adenosine 3',5'-bisphosphate + estradiol 3-sulfate | - |
r | |
| 3'-phosphoadenylylsulfate + estradiol | Homo sapiens | - |
adenosine 3',5'-bisphosphate + estradiol 3-sulfate | - |
r | |
| 3'-phosphoadenylylsulfate + estradiol | Mus musculus | enzyme does not distinguish between estradiol and estrone, both appear to be natural substrates | adenosine 3',5'-bisphosphate + estradiol 3-sulfate | - |
r | |
| 3'-phosphoadenylylsulfate + estrone | Cavia porcellus | - |
adenosine 3',5'-bisphosphate + estrone 3-sulfate | - |
r | |
| 3'-phosphoadenylylsulfate + estrone | Homo sapiens | - |
adenosine 3',5'-bisphosphate + estrone 3-sulfate | - |
r | |
| 3'-phosphoadenylylsulfate + estrone | Bos taurus | - |
adenosine 3',5'-bisphosphate + estrone 3-sulfate | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Cavia porcellus | - |
guinea pig | - |
| Homo sapiens | - |
human | - |
| Mus musculus | - |
mouse | - |
| Rattus norvegicus | - |
rat | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | - |
Cavia porcellus | - |
| adrenal gland | - |
Bos taurus | - |
| epithelium | mammary epithelial cells | Homo sapiens | - |
| epithelium | not expressed in a host of breast cancer cell lines such as MCF-7 cells | Homo sapiens | - |
| placenta | - |
Mus musculus | - |
| placenta | - |
Homo sapiens | - |
| placenta | - |
Bos taurus | - |
| testis | - |
Cavia porcellus | - |
| testis | - |
Homo sapiens | - |
| testis | - |
Rattus norvegicus | - |
| testis | localized exclusively to Leydig cells | Mus musculus | - |
| uterus | - |
Cavia porcellus | - |
| uterus | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylylsulfate + dehydroepiandrosterone | - |
Mus musculus | adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate | - |
r | |
| 3'-phosphoadenylylsulfate + dehydroepiandrosterone | - |
Homo sapiens | adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate | - |
r | |
| 3'-phosphoadenylylsulfate + estradiol | - |
Cavia porcellus | adenosine 3',5'-bisphosphate + estradiol 3-sulfate | - |
r | |
| 3'-phosphoadenylylsulfate + estradiol | - |
Mus musculus | adenosine 3',5'-bisphosphate + estradiol 3-sulfate | - |
r | |
| 3'-phosphoadenylylsulfate + estradiol | - |
Homo sapiens | adenosine 3',5'-bisphosphate + estradiol 3-sulfate | - |
r | |
| 3'-phosphoadenylylsulfate + estradiol | enzyme does not distinguish between estradiol and estrone, both appear to be natural substrates | Mus musculus | adenosine 3',5'-bisphosphate + estradiol 3-sulfate | - |
r | |
| 3'-phosphoadenylylsulfate + estrone | - |
Cavia porcellus | adenosine 3',5'-bisphosphate + estrone 3-sulfate | - |
r | |
| 3'-phosphoadenylylsulfate + estrone | - |
Homo sapiens | adenosine 3',5'-bisphosphate + estrone 3-sulfate | - |
r | |
| 3'-phosphoadenylylsulfate + estrone | - |
Rattus norvegicus | adenosine 3',5'-bisphosphate + estrone 3-sulfate | - |
r | |
| 3'-phosphoadenylylsulfate + estrone | - |
Bos taurus | adenosine 3',5'-bisphosphate + estrone 3-sulfate | - |
r | |
| additional information | very little reactivity toward hydroxysteroids such as dehydroepiandrosterone | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| EST | - |
Cavia porcellus |
| EST | - |
Mus musculus |
| EST | - |
Homo sapiens |
| EST | - |
Rattus norvegicus |
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