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Literature summary for 2.8.2.4 extracted from

  • Harris, R.M.; Wood, D.M.; Bottomley, L.; Blagg, S.; Owen, K.; Hughes, P.J.; Waring, R.H.; Kirk, C.J.
    Phytoestrogens are potent inhibitors of estrogen sulfation: implications for breast cancer risk and treatment (2004), J. Clin. Endocrinol. Metab., 89, 1779-1787.
    View publication on PubMed
Search for more literature for 2.8.2.4

Inhibitors

Inhibitors Comment Organism Structure
3',4',7-trihydroxyisoflavone
-
 Homo sapiens
daidzein
-
 Homo sapiens
daidzein 4,7-bissulfate IC50: 0.01 mM Homo sapiens
equol potent mixed type inhibitor Homo sapiens
formononetin
-
 Homo sapiens
genistein potent mixed type inhibitor Homo sapiens
additional information low SULT1E1 and/or high steroid sulfatase expression in breast tumor tissue correlates with a poor prognosis for disease progression. Concentrations of isoflavonoids that may be achieved in individuals consuming a high-soy diet may inhibit SULT1E1 activity while exerting no effect on steroid sulfatase Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylylsulfate + estradiol
-
 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?

Synonyms

Synonyms Comment Organism
estrogen sulfotransferase
-
 Homo sapiens
SULT1E1
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0004
-
 equol
-
 Homo sapiens
0.0005
-
 genistein
-
 Homo sapiens
0.002
-
 daidzein
-
 Homo sapiens
0.002
-
 3',4',7-trihydroxyisoflavone
-
 Homo sapiens
0.006
-
 formononetin
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.01
-
 IC50: 0.01 mM Homo sapiens daidzein 4,7-bissulfate