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Literature summary for 2.8.2.4 extracted from

  • Nazmeen, A.; Chen, G.; Maiti, S.
    Dependence between estrogen sulfotransferase (SULT1E1) and nuclear transcription factor Nrf-2 regulations via oxidative stress in breast cancer (2020), Mol. Biol. Rep., 47, 4691-4698 .
    View publication on PubMed
Search for more literature for 2.8.2.4

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
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 Homo sapiens 5829
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + 17beta-estradiol Homo sapiens
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 adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
 ?
3'-phosphoadenylyl sulfate + estrone Homo sapiens
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 adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P49888
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-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell reduced SULT1E1 expression in MCF-7 cells, but elevated SULT1E1 expression in breast tumour tissue, which also exhibits elevated E2 concentrations and increased Nrf2 expression as compared to the surrounding. Nrf2 is an oxidative stress responsive transcription protein, in situ expression analysis, overview Homo sapiens
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MCF-7 cell reduced SULT1E1 expression in MCF-7 cells, but elevated SULT1E1 expression in breast tumour tissue, which also exhibits elevated E2 concentrations and increased Nrf2 expression as compared to the surrounding. Nrf2 is an oxidative stress responsive transcription protein Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + 17beta-estradiol
-
 Homo sapiens adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
 ?
3'-phosphoadenylyl sulfate + estrone
-
 Homo sapiens adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
 ?

Synonyms

Synonyms Comment Organism
estrogen sulfotransferase
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 Homo sapiens
SULT1E1
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 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens factors HNF4alpha and Nrf2 induce the expression of enzyme SULT1E1. Factor HNF4alpha is induced by oxidative stress, and factor Nrf2 is induced by estradiol via the P13K/GSK3B pathway up

General Information

General Information Comment Organism
malfunction reduced SULT1E1 expression is observed in MCF-7 cells, breast tumour tissue also exhibits elevated E2 concentrations as compared to the surrounding Homo sapiens
metabolism interdependence between estrogen sulfotransferase (SULT1E1) and nuclear transcription factor Nrf-2, Nrf2 an oxidative stress responsive transcription protein, regulations via oxidative stress in breast cancer. Human estrogen sulfotransferase (SULT1E1) and nuclear factor erythroid 2-related factor 2 (Nrf-2) expressions influence each other in advanced human breast carcinogenesis. The difference in the metabolism of estradiol (E2) in pre- and postmenopausal women is connected with post-menopausal breast cancer. A synergism between reactive oxygen species (ROS) production and E2 generation is demonstrated. ROS dependent regulation of Nrf-2 is one of the most important determinants of E2 regulation by altering SULT1E1 expression. Oxidative stress is the link between SULT1E1 and Nrf2 expression Homo sapiens
additional information estradiol (E2) may be responsible for carcinogenesis in the breasts Homo sapiens
physiological function SULT1E1 deactivates estradiol and estrone by adding a sulfate group and forming estrogen sulfate which has least addiction towards the estrogen receptor Homo sapiens