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Literature summary for 2.8.2.4 extracted from

  • Sun, Y.; Machalz, D.; Wolber, G.; Parr, M.; Bureik, M.
    Functional expression of all human sulfotransferases in fission yeast, assay development, and structural models for isoforms SULT4A1 and SULT6B1 (2020), Biomolecules, 10, 1-17 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
analysis a modified variant of sulfotransferase assay employs permeabilized fission yeast cells (enzyme bags). A new and convenient SULT activity assay is based on the sulfation of a proluciferin compound, which is catalyzed by SULT1E1, SULT2A1, SULT4A1, and SULT6B1 Homo sapiens
synthesis generation of a complete set of recombinant fission yeast strains each expressing one of the 14 human SULT enzymes. The intracellular production of the cofactor 3'-phosphoadenosine 5'-phosphosulfate (PAPS) necessary for SULT activity is sufficiently high to support metabolite production Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P49888 isoform SULT1E1
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + 6-hydroxy-4-methylbenzo[d]thiazole-2-carbonitrile i.e. proluciferin substrate UGT-Glo substrate A, GSA Homo sapiens adenosine 3',5'-bisphosphate + ?
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 ?

Synonyms

Synonyms Comment Organism
SULT1E1
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 Homo sapiens