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Literature summary for 2.8.2.4 extracted from

  • Hoff, R.H.; Czyryca, P.G.; Sun, M.; Leyh, T.S.; Hengge, A.C.
    Transition state of the sulfuryl transfer reaction of estrogen sulfotransferase (2006), J. Biol. Chem., 281, 30645-30649.
    View publication on PubMed
Search for more literature for 2.8.2.4

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information transition state and kinetic isotope effects, detailed overview Homo sapiens
0.15
-
 4-nitrophenol pH 6.1, 25°C Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ activates Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
3'-phosphoadenylyl sulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate a reaction transition state with substantial S-O bond fission and partial charge neutralization of the leaving group Homo sapiens
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + 4-nitrophenol reaction of phenol sulfonyltransferase, EC 2.8.2.1, determination of reaction equilibrium in the forward direction at 70% of conversion of 4-nitrophenol Homo sapiens adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
 r
3'-phosphoadenylyl sulfate + estrone
-
 Homo sapiens adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
 r

Synonyms

Synonyms Comment Organism
EST
-
 Homo sapiens
estrogen sulfotransferase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.52
-
 4-nitrophenol pH 6.1, 25°C Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.1
-
-
 Homo sapiens