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Literature summary for 2.8.2.4 extracted from
- Oxidant stress induction and signalling in xenografted (human breast cancer-tissues) plus estradiol treated or N-ethyl-N-nitrosourea treated female rats via altered estrogen sulfotransferase (rSULT1E1) expressions and SOD1/catalase regulations (2018), Mol. Biol. Rep., 45, 2571-2584 .
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
| cytosol | - |
Rattus norvegicus | 5829 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylyl sulfate + 17beta-estradiol | Homo sapiens | - |
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate | - |
? |  |
| 3'-phosphoadenylyl sulfate + 17beta-estradiol | Rattus norvegicus | - |
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate | - |
? | |
| 3'-phosphoadenylyl sulfate + 17beta-estradiol | Rattus norvegicus Wistar | - |
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate | - |
? | |
| 3'-phosphoadenylyl sulfate + estrone | Homo sapiens | - |
adenosine 3',5'-bisphosphate + estrone 3-sulfate | - |
? | |
| 3'-phosphoadenylyl sulfate + estrone | Rattus norvegicus | - |
adenosine 3',5'-bisphosphate + estrone 3-sulfate | - |
? | |
| 3'-phosphoadenylyl sulfate + estrone | Rattus norvegicus Wistar | - |
adenosine 3',5'-bisphosphate + estrone 3-sulfate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P49888 | - |
- |
| Rattus norvegicus | P52844 | - |
- |
| Rattus norvegicus Wistar | P52844 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| breast cancer cell | - |
Homo sapiens | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylyl sulfate + 17beta-estradiol | - |
Homo sapiens | adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate | - |
? | |
| 3'-phosphoadenylyl sulfate + 17beta-estradiol | - |
Rattus norvegicus | adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate | - |
? | |
| 3'-phosphoadenylyl sulfate + 17beta-estradiol | - |
Rattus norvegicus Wistar | adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate | - |
? | |
| 3'-phosphoadenylyl sulfate + estrone | - |
Homo sapiens | adenosine 3',5'-bisphosphate + estrone 3-sulfate | - |
? | |
| 3'-phosphoadenylyl sulfate + estrone | - |
Rattus norvegicus | adenosine 3',5'-bisphosphate + estrone 3-sulfate | - |
? | |
| 3'-phosphoadenylyl sulfate + estrone | - |
Rattus norvegicus Wistar | adenosine 3',5'-bisphosphate + estrone 3-sulfate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| estrogen sulfotransferase | - |
Homo sapiens |
| estrogen sulfotransferase | - |
Rattus norvegicus |
| hSULT1E1 | - |
Homo sapiens |
| rSULT1E1 | - |
Rattus norvegicus |
| SULT1E | - |
Homo sapiens |
| SULT1E | - |
Rattus norvegicus |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Rattus norvegicus | rSULT1E1 expression is reduced in the liver tissues of the N-ethyl-N-nitrosourea-administered group and in the estradiol-treated group compared to the control group | down |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | impairment in the hepatic estrogen sulfotransferase (SULT1E1) protein expression are noticed with interfered hepatic free-thiols only in a N-ethyl-N-nitrosourea (ENU) and a xenograft-estradiol (E2) group compared to the arsenic group. Impairment of SULT1E1 expression and E2 regulations through oxidant-stress signalling. Oxidative stress has a vital role in E2 regulation and can structurally modify or alter the expression level of E2 metabolizing proteins. As such, estrogen receptors lose their DNA binding ability and thus impairing transcription. The estradiol binding site gets blocked in estrogen sulfotransferase under oxidative stress | Rattus norvegicus |
| malfunction | oxidative stress has a vital role in E2 regulation and can structurally modify or alter the expression level of E2 metabolizing proteins. As such, estrogen receptors lose their DNA binding ability and thus impairing transcription. The estradiol binding site gets blocked in estrogen sulfotransferase under oxidative stress | Homo sapiens |
| physiological function | estrogen sulfotransferase (SULT1E1) is a phase-2 drug metabolizing enzyme, it sulfonates estrogen and produces estradiol sulfate (E2S) or estrone sulfate (E1S), which are biologically inactive and unable to bind to estrogen receptor (ER)alpha or ERbeta, important role of rSULT1E1 in the regulation of estradiol (E2) metabolism, overview | Homo sapiens |
| physiological function | estrogen sulfotransferase (SULT1E1) is a phase-2 drug metabolizing enzyme, it sulfonates estrogen and produces estradiol sulfate (E2S) or estrone sulfate (E1S), which are biologically inactive and unable to bind to estrogen receptor (ER)alpha or ERbeta, important role of rSULT1E1 in the regulation of estradiol (E2) metabolism, overview | Rattus norvegicus |
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