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Information on EC 3.5.2.6 - beta-lactamase
for references in articles please use BRENDA:EC3.5.2.6
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EC Tree 3 Hydrolases
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.5.2 In cyclic amides
3.5.2.6 beta-lactamase
IUBMB Comments
A group of enzymes of varying specificity hydrolysing β-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. The latter were formerly listed as EC 3.5.2.8, cephalosporinase.
The enzyme appears in viruses and cellular organisms
- 3.5.2.6
- pneumonia
- klebsiella
- enterobacteriaceae
-
esbls
- carbapenems
- aeruginosa
-
carbapenem-resistant
- ampicillin
-
esbl-producing
-
multidrug-resistant
- enterobacter
- cefotaxime
- ceftazidime
- aureus
- acinetobacter
-
surveillance
- meropenem
-
nosocomial
-
clavulanic
-
microbiological
- haemophilus
- aminoglycosides
- ciprofloxacin
- baumannii
- cloacae
- tetracycline
-
pulsed-field
-
outbreak
-
disk
- gentamicin
- integrons
-
plasmid-mediated
- colistin
- amikacin
- ceftriaxone
- fluoroquinolones
-
microdilution
-
quinolone
- citrobacter
- proteus
-
multilocus
-
carriage
- mirabilis
- gonorrhoeae
-
staphylococci
-
community-acquired
-
third-generation
- methicillin
-
penicillin-binding
-
enterococci
- drug development
- synthesis
- diagnostics
- medicine
- pharmacology
showSynonyms
beta-lactamase, carbapenemase, extended-spectrum beta-lactamase, ndm-1, penicillinase, tem-1, blandm-1, ges-1, blactx-m-15, kpc-2, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
AmpC
AmpC beta-lactamase
AmpC beta-lactamases M19
AmpC beta-lactamases M29
AmpC beta-lactamases M37
AmpC M19
AmpC M29
AmpC M37
apo Bacillus cereus 569/H/9 enzyme
BcII
BCL-1
Beta lactamase OXA-10
-
-
-
-
beta-lactamase
beta-lactamase A-C
-
different in substrate specificity, amino acid sequence, mechanistic properties, metal ion requirement
beta-lactamase AME I
-
-
-
-
beta-lactamase I-III
beta-lactamase II
-
-
-
-
beta-lactamase OXA-10
beta-lactamase P99
beta-lactamase, class C
beta-lactamse A-D
BLA
Bla-A
Bla-B
BlaA
BlaB
BlaC
blaCMY-2
blaCTX-M-14
blaCTX-M-15
BLAIMP
-
-
-
-
blaKPC-2
BlaMab
blaNDM-7
blaSHV-14
blaTEM-1
carbapenem-hydrolyzing class A beta-lactamase
carbapenemase
Carbenicillinase
cefotaximase
-
-
-
-
ceftazidimase
-
-
-
-
cefurooximase
-
-
-
-
Cefuroximase
-
-
-
-
Cephalosporinase
CIA-1
CKO
class A beta-lactamase
class C beta-lactamase
class C P99 beta-lactamase
class D beta-lactamase
CMY-37
CTX-M-14
CTX-M-64
CTX-M-64 beta-lactamase
EC 3.5.2.8
-
-
formerly
-
ESBL
extended spectrum beta-lactamase
extended-spectrum beta-lactamase
GC1 beta-lactamase
GES-5
GIM-1
Imipenem-cefoxitin hydrolyzing enzyme
-
-
-
-
imipenemase
-
-
-
-
ImiS
IMP-1
IMP-13
IMP-18
KLUA-9
KPC-2
L1 beta-lactamase
L2 beta-lactamase
M19
M29
M37
MbetaL
MBL
metallo-beta-lactamase
metallo-beta-lactamase IMP-1
metallo-beta-lactamase L1
MIR-4 beta-lactamase
Mox-1
Mox-1 beta-lactamase
MSMEG_4455
NDM
NDM-1
neutrapen
-
-
-
-
New Delhi MBL
New Delhi metallo-beta-lactamase
New Delhi metallo-beta-lactamase-1
OXA-1
oxa-1 beta-lactamase
OXA-10
OXA-40
OXA-63
Oxacillinase
P99 beta-lactamase
penicillinase
penicillinase I, II
PSE-1
serine beta-lactamase
SFC-1
Sfh-I
SHV-1
SHV-14 beta-lactamase
SHV-2A
TEM
TEM-1
TEM-1 beta-lactamase
TEM-149
VIM-1
VIM-11
VIM-12
VIM-13
VIM-2
VIM-7
VIM-type MBL
zinc beta-lactamase
additional information
beta-lactamase
-
-
-
-
beta-lactamase I-III
-
different in molecular weight, localization, metal ion requirement
beta-lactamase I-III
-
different in molecular weight, localization, metal ion requirement
-
beta-lactamase I-III
-
different in molecular weight, localization, metal ion requirement
beta-lactamse A-D
-
A,C and D enzymes utilize a nucleophilic serine at the active center which becomes acylated by substrate, B enzymes are metalloenzymes requiring Zn2+ for activity
beta-lactamse A-D
-
A,C and D enzymes utilize a nucleophilic serine at the active center which becomes acylated by substrate, B enzymes are metalloenzymes requiring Zn2+ for activity
-
beta-lactamse A-D
-
A,C and D enzymes utilize a nucleophilic serine at the active center which becomes acylated by substrate, B enzymes are metalloenzymes requiring Zn2+ for activity
beta-lactamse A-D
-
A,C and D enzymes utilize a nucleophilic serine at the active center which becomes acylated by substrate, B enzymes are metalloenzymes requiring Zn2+ for activity
-
BlaA