Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.5.2.6 extracted from

  • Grace, M.E.; Gregory, F.M.; Hung, P.P.; Fu, K.P.
    Purification and properties of a beta-lactamase from Proteus penneri (1986), J. Antibiot., 7, 938-942.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
clavulanic acid
-
Proteus penneri
Sulbactam
-
Proteus penneri

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.017
-
benzylpenicillin
-
Proteus penneri
0.071
-
cephalothin
-
Proteus penneri
0.079
-
ampicillin
-
Proteus penneri
0.114
-
cefttriaxone
-
Proteus penneri
0.328
-
cefotaxime
-
Proteus penneri
0.343
-
cefuroxime
-
Proteus penneri
0.368
-
cephaloridine
-
Proteus penneri

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
30000
-
SDS-PAGE Proteus penneri

Organism

Organism UniProt Comment Textmining
Proteus penneri
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Proteus penneri

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ampicillin + H2O 9% relative activity to cephaloridine Proteus penneri (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
benzylpenicillin + H2O 3% relative activity to cephaloridine Proteus penneri (2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
cefoperazone + H2O 11% relative activity to cephaloridine Proteus penneri (2R)-2-[(R)-carboxy{[(2S)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-(4-hydroxyphenyl)acetyl]amino}methyl]-5-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
cefotaxime + H2O 48% relative activity to cephaloridine Proteus penneri (2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
ceftriaxone + H2O 23% relative activity to cephaloridine Proteus penneri (2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-5-[[(6-hydroxy-2-methyl-5-oxo-2,5-dihydro-1,2,4-triazin-3-yl)sulfanyl]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
cefuroxime + H2O 93% relative activity to cephaloridine Proteus penneri (2R)-5-[(carbamoyloxy)methyl]-2-[(R)-carboxy{[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
cephaloridine + H2O 100% relative activity to other substrates tested Proteus penneri (2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
?
cephalothin + H2O 50% relative activity to cephaloridine Proteus penneri (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?

Subunits

Subunits Comment Organism
monomer 1* 30000 Proteus penneri

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
45
-
-
Proteus penneri

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
-
Proteus penneri