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Literature summary for 3.5.2.6 extracted from

  • Huang, W.; Beharry, Z.; Zhang, Z.; Palzkill, T.
    A broad-spectrum peptide inhibitor of beta-lactamase identified using phage display and peptide arrays (2003), Protein Eng., 16, 853-860.
    View publication on PubMed
Search for more literature for 3.5.2.6

Application

Application Comment Organism
pharmacology enzyme is a target for design of non-beta-lactam, broad-spectrum peptidomimetic enzyme inhibitors Escherichia coli
pharmacology enzyme is a target for design of non-beta-lactam, broad-spectrum peptidomimetic enzyme inhibitors Enterobacter cloacae
pharmacology enzyme is a target for design of non-beta-lactam, broad-spectrum peptidomimetic enzyme inhibitors Bacillus anthracis

Inhibitors

Inhibitors Comment Organism Structure
AAGHYY synthetic peptide, derived from screenings using phage display and peptide arrays Enterobacter cloacae
clavulanic acid mechanism-based inhibitor, specific for class A beta-lactamases Bacillus anthracis
clavulanic acid mechanism-based inhibitor, specific for class A beta-lactamases Escherichia coli
HSAYSDTRRGDYG synthetic peptide, derived from screens using phage display and peptide arrays Bacillus anthracis
HSAYSDTRRGDYG synthetic peptide, derived from screenings using phage display and peptide arrays Enterobacter cloacae
HSAYSDTRRGDYG synthetic peptide, derived from screens using phage display and peptide arrays Escherichia coli
additional information no inhibition by Arg-Arg Bacillus anthracis
additional information no inhibition by Arg-Arg Enterobacter cloacae
additional information no inhibition by Arg-Arg Escherichia coli
RRGHYY synthetic peptide, derived from screens using phage display and peptide arrays; synthetic peptide, derived from screens using phage display and peptide arrays, inhibition mechanism Bacillus anthracis
RRGHYY synthetic peptide, derived from screenings using phage display and peptide arrays, inhibition mechanism Enterobacter cloacae
RRGHYY synthetic peptide, derived from screens using phage display and peptide arrays; synthetic peptide, derived from screens using phage display and peptide arrays, inhibition mechanism Escherichia coli

Organism

Organism UniProt Comment Textmining
Bacillus anthracis
-
 class A enzyme Bla1
-
Enterobacter cloacae
-
 class C enzyme P99
-
Escherichia coli
-
 class A enzyme TEM-1
-

Synonyms

Synonyms Comment Organism
Bla1
-
 Bacillus anthracis
P99
-
 Enterobacter cloacae
TEM-1
-
 Escherichia coli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.042
-
 RRGHYY pH 7.0 Bacillus anthracis
0.07
-
 HSAYSDTRRGDYG pH 7.0 Bacillus anthracis
0.072
-
 AAGHYY pH 7.0 Bacillus anthracis
0.136
-
 RRGHYY pH 7.0 Escherichia coli
0.14
-
 RRGHYY pH 7.0 Enterobacter cloacae
0.254
-
 HSAYSDTRRGDYG pH 7.0 Enterobacter cloacae
0.298
-
 HSAYSDTRRGDYG pH 7.0 Escherichia coli
0.438
-
 AAGHYY pH 7.0 Escherichia coli
0.468
-
 AAGHYY pH 7.0 Enterobacter cloacae

pI Value

Organism Comment pI Value Maximum pI Value
Enterobacter cloacae
-
 4.7 4.6
Bacillus anthracis
-
 4.7 4.6
Escherichia coli
-
-
 4.9