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Literature summary for 3.5.2.6 extracted from

  • Adediran, S.; Cabaret, D.; Lohier, J.; Wakselman, M.; Pratt, R.
    Substituted aryl malonamates as new serine beta-lactamase substrates: structure-activity studies (2010), Bioorg. Med. Chem., 18, 282-291.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0026
-
3-([[2-benzyl-3-oxo-3-(benzylamino)propanoyl]oxy]methyl)benzoic acid pH 7.5, 25°C Enterobacter cloacae
0.032
-
3-([3-dibenzylamino-3-oxopropanoyl]oxy)benzoic acid pH 7.5, 25°C Enterobacter cloacae
0.06
-
3-([[(2R)-3-(benzylamino)-2-methyl-3-oxopropanoyl]oxy]methyl)benzoic acid pH 7.5, 25°C Enterobacter cloacae
0.7
-
3-([3-[benzyl(methyl)amino]-3-oxopropanoyl]oxy)benzoic acid pH 7.5, 25°C Enterobacter cloacae
2.8
-
3-([[(2S)-3-(benzylamino)-2-methyl-3-oxopropanoyl]oxy]methyl)benzoic acid pH 7.5, 25°C Enterobacter cloacae

Organism

Organism UniProt Comment Textmining
Enterobacter cloacae P05364
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-([3-dibenzylamino-3-oxopropanoyl]oxy)benzoic acid + H2O
-
Enterobacter cloacae ?
-
?
3-([3-[benzyl(methyl)amino]-3-oxopropanoyl]oxy)benzoic acid + H2O
-
Enterobacter cloacae ?
-
?
3-([[(2R)-3-(benzylamino)-2-methoxy-3-oxopropanoyl]oxy]methyl)benzoic acid + H2O
-
Enterobacter cloacae ?
-
?
3-([[(2R)-3-(benzylamino)-2-methyl-3-oxopropanoyl]oxy]methyl)benzoic acid + H2O
-
Enterobacter cloacae ?
-
?
3-([[(2S)-3-(benzylamino)-2-methoxy-3-oxopropanoyl]oxy]methyl)benzoic acid + H2O
-
Enterobacter cloacae ?
-
?
3-([[(2S)-3-(benzylamino)-2-methyl-3-oxopropanoyl]oxy]methyl)benzoic acid + H2O
-
Enterobacter cloacae ?
-
?
3-([[2-benzyl-3-oxo-3-(benzylamino)propanoyl]oxy]methyl)benzoic acid + H2O
-
Enterobacter cloacae ?
-
?
additional information substituted aryl malonamates are substrates of class A and class C beta-lactamases, and of soluble DD-peptidases Enterobacter cloacae ?
-
?

Synonyms

Synonyms Comment Organism
TEM
-
Enterobacter cloacae

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.05
-
3-([[2-benzyl-3-oxo-3-(benzylamino)propanoyl]oxy]methyl)benzoic acid pH 7.5, 25°C Enterobacter cloacae
0.25
-
3-([3-dibenzylamino-3-oxopropanoyl]oxy)benzoic acid pH 7.5, 25°C Enterobacter cloacae
0.33
-
3-([3-[benzyl(methyl)amino]-3-oxopropanoyl]oxy)benzoic acid pH 7.5, 25°C Enterobacter cloacae
1.17
-
3-([[(2R)-3-(benzylamino)-2-methyl-3-oxopropanoyl]oxy]methyl)benzoic acid pH 7.5, 25°C Enterobacter cloacae
2.9
-
3-([[(2R)-3-(benzylamino)-2-methoxy-3-oxopropanoyl]oxy]methyl)benzoic acid pH 7.5, 25°C Enterobacter cloacae
6.6
-
3-([[(2S)-3-(benzylamino)-2-methyl-3-oxopropanoyl]oxy]methyl)benzoic acid pH 7.5, 25°C Enterobacter cloacae
7.4
-
3-([[(2S)-3-(benzylamino)-2-methoxy-3-oxopropanoyl]oxy]methyl)benzoic acid pH 7.5, 25°C Enterobacter cloacae

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.47
-
3-([3-[benzyl(methyl)amino]-3-oxopropanoyl]oxy)benzoic acid pH 7.5, 25°C Enterobacter cloacae
2.36
-
3-([[2-benzyl-3-oxo-3-(benzylamino)propanoyl]oxy]methyl)benzoic acid pH 7.5, 25°C Enterobacter cloacae
7.9
-
3-([3-dibenzylamino-3-oxopropanoyl]oxy)benzoic acid pH 7.5, 25°C Enterobacter cloacae
21.3
-
3-([[(2S)-3-(benzylamino)-2-methyl-3-oxopropanoyl]oxy]methyl)benzoic acid pH 7.5, 25°C Enterobacter cloacae
245
-
3-([[(2R)-3-(benzylamino)-2-methyl-3-oxopropanoyl]oxy]methyl)benzoic acid pH 7.5, 25°C Enterobacter cloacae