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Literature summary for 3.5.2.6 extracted from

  • Munday, C.J.; Boyd, D.A.; Brenwald, N.; Miller, M.; Andrews, J.M.; Wise, R.; Mulvey, M.R.; Hawkey, P.M.
    Molecular and kinetic comparison of the novel extended-spectrum beta-lactamases CTX-M-25 and CTX-M-26 (2004), Antimicrob. Agents Chemother., 48, 4829-4834.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
beta-lactamases CTX-M-25 Escherichia coli
beta-lactamases CTX-M-26 Klebsiella pneumoniae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0023
-
(2S,5R,6R)-6-[[(2R)-2-carboxy-2-thiophen-3-ylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid beta-lactamases CTX-M-25 Escherichia coli
0.0077
-
ampicillin beta-lactamases CTX-M-25 Escherichia coli
0.013
-
ceftazidime beta-lactamases CTX-M-25 Escherichia coli
0.024
-
ampicillin beta-lactamases CTX-M-26 Klebsiella pneumoniae
0.027
-
(2S,5R,6R)-6-[[(2R)-2-carboxy-2-thiophen-3-ylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid beta-lactamases CTX-M-26 Klebsiella pneumoniae
0.028
-
cefotaxime beta-lactamases CTX-M-25 Escherichia coli
0.044
-
cefuroxime beta-lactamases CTX-M-25 Escherichia coli
0.06
-
benzylpenicillin beta-lactamases CTX-M-26 Klebsiella pneumoniae
0.074
-
benzylpenicillin beta-lactamases CTX-M-25 Escherichia coli
0.11
-
cephalothin beta-lactamases CTX-M-26 Klebsiella pneumoniae
0.12
-
aztreonam beta-lactamases CTX-M-25 Escherichia coli
0.13
-
aztreonam beta-lactamases CTX-M-26 Klebsiella pneumoniae
0.15
-
cefotaxime beta-lactamases CTX-M-26 Klebsiella pneumoniae
0.19
-
cephalothin beta-lactamases CTX-M-25 Escherichia coli
0.3
-
cefuroxime beta-lactamases CTX-M-26 Klebsiella pneumoniae
3.3
-
ceftazidime beta-lactamases CTX-M-26 Klebsiella pneumoniae

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
29000
-
x * 29000, beta-lactamases CTX-M-25, SDS-PAGE Escherichia coli
29000
-
x * 29000, beta-lactamases CTX-M-26, SDS-PAGE Klebsiella pneumoniae

Organism

Organism UniProt Comment Textmining
Escherichia coli Q8KSA6
-
-
Klebsiella pneumoniae Q8GD10
-
-

Purification (Commentary)

Purification (Comment) Organism
beta-lactamases CTX-M-25 Escherichia coli
beta-lactamases CTX-M-26 Klebsiella pneumoniae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ampicillin + H2O beta-lactamases CTX-M-25 Escherichia coli (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
ampicillin + H2O beta-lactamases CTX-M-26 Klebsiella pneumoniae (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
aztreonam + H2O beta-lactamases CTX-M-25 Escherichia coli [(1S,2S)-1-[[(2Z)-2-(2-ammonio-1,3-thiazol-4-yl)-2-[[(2-carboxypropan-2-yl)oxy]imino]acetyl]amino]-1-carboxypropan-2-yl]sulfamate
-
?
aztreonam + H2O beta-lactamases CTX-M-26 Klebsiella pneumoniae [(1S,2S)-1-[[(2Z)-2-(2-ammonio-1,3-thiazol-4-yl)-2-[[(2-carboxypropan-2-yl)oxy]imino]acetyl]amino]-1-carboxypropan-2-yl]sulfamate
-
?
benzylpenicillin + H2O beta-lactamases CTX-M-25 Escherichia coli (2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
benzylpenicillin + H2O beta-lactamases CTX-M-26 Klebsiella pneumoniae (2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
cefotaxime + H2O beta-lactamases CTX-M-25 Escherichia coli (2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
cefotaxime + H2O beta-lactamases CTX-M-26 Klebsiella pneumoniae (2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
ceftazidime + H2O beta-lactamases CTX-M-25 Escherichia coli (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}(carboxy)methyl]-5-[(pyridin-1-ium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
?
ceftazidime + H2O beta-lactamases CTX-M-26 Klebsiella pneumoniae (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}(carboxy)methyl]-5-[(pyridin-1-ium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
?
cefuroxime + H2O beta-lactamases CTX-M-25 Escherichia coli (2R)-5-[(carbamoyloxy)methyl]-2-[(R)-carboxy{[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
cefuroxime + H2O beta-lactamases CTX-M-26 Klebsiella pneumoniae (2R)-5-[(carbamoyloxy)methyl]-2-[(R)-carboxy{[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
cephalothin + H2O beta-lactamases CTX-M-25 Escherichia coli (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
cephalothin + H2O beta-lactamases CTX-M-26 Klebsiella pneumoniae (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
ticarcillin + H2O beta-lactamases CTX-M-25 Escherichia coli (2R,4S)-2-[(R)-carboxy[[(2R)-2-carboxy-2-(thiophen-3-yl)acetyl]amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
ticarcillin + H2O beta-lactamases CTX-M-26 Klebsiella pneumoniae (2R,4S)-2-[(R)-carboxy[[(2R)-2-carboxy-2-(thiophen-3-yl)acetyl]amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?

Subunits

Subunits Comment Organism
? x * 29000, beta-lactamases CTX-M-25, SDS-PAGE Escherichia coli
? x * 29000, beta-lactamases CTX-M-26, SDS-PAGE Klebsiella pneumoniae

Synonyms

Synonyms Comment Organism
beta-lactamases CTX-M-25
-
Escherichia coli
beta-lactamases CTX-M-26
-
Klebsiella pneumoniae

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.015
-
ceftazidime beta-lactamases CTX-M-26 Klebsiella pneumoniae
5.9
-
ampicillin beta-lactamases CTX-M-25 Escherichia coli
8.2
-
ticarcillin beta-lactamases CTX-M-25 Escherichia coli
8.2
-
(2S,5R,6R)-6-[[(2R)-2-carboxy-2-thiophen-3-ylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid beta-lactamases CTX-M-25 Escherichia coli
12
-
ampicillin beta-lactamases CTX-M-26 Klebsiella pneumoniae
21
-
cefuroxime beta-lactamases CTX-M-26 Klebsiella pneumoniae
33
-
benzylpenicillin beta-lactamases CTX-M-25 Escherichia coli
33
-
ceftazidime beta-lactamases CTX-M-25 Escherichia coli
84
-
aztreonam beta-lactamases CTX-M-25 Escherichia coli
84
-
ticarcillin beta-lactamases CTX-M-26 Klebsiella pneumoniae
84
-
(2S,5R,6R)-6-[[(2R)-2-carboxy-2-thiophen-3-ylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid beta-lactamases CTX-M-26 Klebsiella pneumoniae
100
-
aztreonam beta-lactamases CTX-M-26 Klebsiella pneumoniae
101
-
cefotaxime beta-lactamases CTX-M-25 Escherichia coli
120
-
cefotaxime beta-lactamases CTX-M-26 Klebsiella pneumoniae
190
-
cefuroxime beta-lactamases CTX-M-25 Escherichia coli
230
-
cephalothin beta-lactamases CTX-M-25 Escherichia coli
420
-
benzylpenicillin beta-lactamases CTX-M-26 Klebsiella pneumoniae
530
-
cephalothin beta-lactamases CTX-M-26 Klebsiella pneumoniae

pI Value

Organism Comment pI Value Maximum pI Value
Escherichia coli isoelectric focusing, beta-lactamases CTX-M-25, pH-range 3.5-9.5
-
7.5
Klebsiella pneumoniae isoelectric focusing, beta-lactamases CTX-M-26, pH-range 3.5-9.5
-
8