Cloned (Comment) | Organism |
---|---|
beta-lactamases CTX-M-25 | Escherichia coli |
beta-lactamases CTX-M-26 | Klebsiella pneumoniae |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0023 | - |
(2S,5R,6R)-6-[[(2R)-2-carboxy-2-thiophen-3-ylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid | beta-lactamases CTX-M-25 | Escherichia coli | |
0.0077 | - |
ampicillin | beta-lactamases CTX-M-25 | Escherichia coli | |
0.013 | - |
ceftazidime | beta-lactamases CTX-M-25 | Escherichia coli | |
0.024 | - |
ampicillin | beta-lactamases CTX-M-26 | Klebsiella pneumoniae | |
0.027 | - |
(2S,5R,6R)-6-[[(2R)-2-carboxy-2-thiophen-3-ylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid | beta-lactamases CTX-M-26 | Klebsiella pneumoniae | |
0.028 | - |
cefotaxime | beta-lactamases CTX-M-25 | Escherichia coli | |
0.044 | - |
cefuroxime | beta-lactamases CTX-M-25 | Escherichia coli | |
0.06 | - |
benzylpenicillin | beta-lactamases CTX-M-26 | Klebsiella pneumoniae | |
0.074 | - |
benzylpenicillin | beta-lactamases CTX-M-25 | Escherichia coli | |
0.11 | - |
cephalothin | beta-lactamases CTX-M-26 | Klebsiella pneumoniae | |
0.12 | - |
aztreonam | beta-lactamases CTX-M-25 | Escherichia coli | |
0.13 | - |
aztreonam | beta-lactamases CTX-M-26 | Klebsiella pneumoniae | |
0.15 | - |
cefotaxime | beta-lactamases CTX-M-26 | Klebsiella pneumoniae | |
0.19 | - |
cephalothin | beta-lactamases CTX-M-25 | Escherichia coli | |
0.3 | - |
cefuroxime | beta-lactamases CTX-M-26 | Klebsiella pneumoniae | |
3.3 | - |
ceftazidime | beta-lactamases CTX-M-26 | Klebsiella pneumoniae |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
29000 | - |
x * 29000, beta-lactamases CTX-M-25, SDS-PAGE | Escherichia coli |
29000 | - |
x * 29000, beta-lactamases CTX-M-26, SDS-PAGE | Klebsiella pneumoniae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | Q8KSA6 | - |
- |
Klebsiella pneumoniae | Q8GD10 | - |
- |
Purification (Comment) | Organism |
---|---|
beta-lactamases CTX-M-25 | Escherichia coli |
beta-lactamases CTX-M-26 | Klebsiella pneumoniae |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ampicillin + H2O | beta-lactamases CTX-M-25 | Escherichia coli | (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? | |
ampicillin + H2O | beta-lactamases CTX-M-26 | Klebsiella pneumoniae | (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? | |
aztreonam + H2O | beta-lactamases CTX-M-25 | Escherichia coli | [(1S,2S)-1-[[(2Z)-2-(2-ammonio-1,3-thiazol-4-yl)-2-[[(2-carboxypropan-2-yl)oxy]imino]acetyl]amino]-1-carboxypropan-2-yl]sulfamate | - |
? | |
aztreonam + H2O | beta-lactamases CTX-M-26 | Klebsiella pneumoniae | [(1S,2S)-1-[[(2Z)-2-(2-ammonio-1,3-thiazol-4-yl)-2-[[(2-carboxypropan-2-yl)oxy]imino]acetyl]amino]-1-carboxypropan-2-yl]sulfamate | - |
? | |
benzylpenicillin + H2O | beta-lactamases CTX-M-25 | Escherichia coli | (2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? | |
benzylpenicillin + H2O | beta-lactamases CTX-M-26 | Klebsiella pneumoniae | (2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? | |
cefotaxime + H2O | beta-lactamases CTX-M-25 | Escherichia coli | (2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
cefotaxime + H2O | beta-lactamases CTX-M-26 | Klebsiella pneumoniae | (2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
ceftazidime + H2O | beta-lactamases CTX-M-25 | Escherichia coli | (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}(carboxy)methyl]-5-[(pyridin-1-ium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate | - |
? | |
ceftazidime + H2O | beta-lactamases CTX-M-26 | Klebsiella pneumoniae | (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}(carboxy)methyl]-5-[(pyridin-1-ium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate | - |
? | |
cefuroxime + H2O | beta-lactamases CTX-M-25 | Escherichia coli | (2R)-5-[(carbamoyloxy)methyl]-2-[(R)-carboxy{[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
cefuroxime + H2O | beta-lactamases CTX-M-26 | Klebsiella pneumoniae | (2R)-5-[(carbamoyloxy)methyl]-2-[(R)-carboxy{[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
cephalothin + H2O | beta-lactamases CTX-M-25 | Escherichia coli | (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
cephalothin + H2O | beta-lactamases CTX-M-26 | Klebsiella pneumoniae | (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
ticarcillin + H2O | beta-lactamases CTX-M-25 | Escherichia coli | (2R,4S)-2-[(R)-carboxy[[(2R)-2-carboxy-2-(thiophen-3-yl)acetyl]amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? | |
ticarcillin + H2O | beta-lactamases CTX-M-26 | Klebsiella pneumoniae | (2R,4S)-2-[(R)-carboxy[[(2R)-2-carboxy-2-(thiophen-3-yl)acetyl]amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 29000, beta-lactamases CTX-M-25, SDS-PAGE | Escherichia coli |
? | x * 29000, beta-lactamases CTX-M-26, SDS-PAGE | Klebsiella pneumoniae |
Synonyms | Comment | Organism |
---|---|---|
beta-lactamases CTX-M-25 | - |
Escherichia coli |
beta-lactamases CTX-M-26 | - |
Klebsiella pneumoniae |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.015 | - |
ceftazidime | beta-lactamases CTX-M-26 | Klebsiella pneumoniae | |
5.9 | - |
ampicillin | beta-lactamases CTX-M-25 | Escherichia coli | |
8.2 | - |
ticarcillin | beta-lactamases CTX-M-25 | Escherichia coli | |
8.2 | - |
(2S,5R,6R)-6-[[(2R)-2-carboxy-2-thiophen-3-ylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid | beta-lactamases CTX-M-25 | Escherichia coli | |
12 | - |
ampicillin | beta-lactamases CTX-M-26 | Klebsiella pneumoniae | |
21 | - |
cefuroxime | beta-lactamases CTX-M-26 | Klebsiella pneumoniae | |
33 | - |
benzylpenicillin | beta-lactamases CTX-M-25 | Escherichia coli | |
33 | - |
ceftazidime | beta-lactamases CTX-M-25 | Escherichia coli | |
84 | - |
aztreonam | beta-lactamases CTX-M-25 | Escherichia coli | |
84 | - |
ticarcillin | beta-lactamases CTX-M-26 | Klebsiella pneumoniae | |
84 | - |
(2S,5R,6R)-6-[[(2R)-2-carboxy-2-thiophen-3-ylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid | beta-lactamases CTX-M-26 | Klebsiella pneumoniae | |
100 | - |
aztreonam | beta-lactamases CTX-M-26 | Klebsiella pneumoniae | |
101 | - |
cefotaxime | beta-lactamases CTX-M-25 | Escherichia coli | |
120 | - |
cefotaxime | beta-lactamases CTX-M-26 | Klebsiella pneumoniae | |
190 | - |
cefuroxime | beta-lactamases CTX-M-25 | Escherichia coli | |
230 | - |
cephalothin | beta-lactamases CTX-M-25 | Escherichia coli | |
420 | - |
benzylpenicillin | beta-lactamases CTX-M-26 | Klebsiella pneumoniae | |
530 | - |
cephalothin | beta-lactamases CTX-M-26 | Klebsiella pneumoniae |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Escherichia coli | isoelectric focusing, beta-lactamases CTX-M-25, pH-range 3.5-9.5 | - |
7.5 |
Klebsiella pneumoniae | isoelectric focusing, beta-lactamases CTX-M-26, pH-range 3.5-9.5 | - |
8 |