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Literature summary for 3.5.2.6 extracted from

  • Power, P.; Galleni, M.; Ayala, J.A.; Gutkind, G.
    Biochemical and molecular characterization of three new variants of AmpC beta-lactamases from Morganella morganii (2006), Antimicrob. Agents Chemother., 50, 962-967.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
-
Morganella morganii subsp. morganii
expressed in Escherichia coli Morganella morganii subsp. morganii
pMB19-2 plasmid, expression in Escherichia coli Morganella morganii subsp. morganii

Inhibitors

Inhibitors Comment Organism Structure
aztreonam effective inhibitor; effective inhibitor; effective inhibitor Morganella morganii subsp. morganii
carbenicillin effective inhibitor; effective inhibitor; effective inhibitor Morganella morganii subsp. morganii
tazobactam effective inhibitor; effective inhibitor; effective inhibitor Morganella morganii subsp. morganii

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.000003
-
Oxacillin 30°C, pH 7.0 Morganella morganii subsp. morganii
0.000018
-
cefoxitin 30°C, pH 7.0 Morganella morganii subsp. morganii
0.00002
-
cefotaxime 30°C, pH 7.0 Morganella morganii subsp. morganii
0.00002
-
cefotaxime in 20 mM phosphate buffer, (pH 7.0) at 30°C Morganella morganii subsp. morganii
0.00006
-
ampicillin in 20 mM phosphate buffer, (pH 7.0) at 30°C Morganella morganii subsp. morganii
0.00008
-
ampicillin 30°C, pH 7.0 Morganella morganii subsp. morganii
0.00008
-
ampicillin in 20 mM phosphate buffer, (pH 7.0) at 30°C Morganella morganii subsp. morganii
0.00009
-
cefotaxime in 20 mM phosphate buffer, (pH 7.0) at 30°C Morganella morganii subsp. morganii
0.00013
-
ampicillin 30°C, pH 7.0 Morganella morganii subsp. morganii
0.00013
-
ampicillin in 20 mM phosphate buffer, (pH 7.0) at 30°C Morganella morganii subsp. morganii
0.00017
-
piperacillin 30°C, pH 7.0 Morganella morganii subsp. morganii
0.00025
-
benzylpenicillin 30°C, pH 7.0 Morganella morganii subsp. morganii
0.0005
-
cefotaxime 30°C, pH 7.0 Morganella morganii subsp. morganii
0.0005
-
cefotaxime in 20 mM phosphate buffer, (pH 7.0) at 30°C Morganella morganii subsp. morganii
0.0009
-
ceftazidime 30°C, pH 7.0 Morganella morganii subsp. morganii
0.001
-
Imipenem in 20 mM phosphate buffer, (pH 7.0) at 30°C Morganella morganii subsp. morganii
0.002
-
Imipenem 30°C, pH 7.0 Morganella morganii subsp. morganii
0.002
-
Imipenem in 20 mM phosphate buffer, (pH 7.0) at 30°C Morganella morganii subsp. morganii
0.004
-
Imipenem 30°C, pH 7.0 Morganella morganii subsp. morganii
0.004
-
Imipenem in 20 mM phosphate buffer, (pH 7.0) at 30°C Morganella morganii subsp. morganii
0.025
-
nitrocefin 30°C, pH 7.0 Morganella morganii subsp. morganii
0.046
-
cephalothin 30°C, pH 7.0 Morganella morganii subsp. morganii
0.046
-
cephalothin in 20 mM phosphate buffer, (pH 7.0) at 30°C Morganella morganii subsp. morganii
0.06
-
ampicillin 30°C, pH 7.0 Morganella morganii subsp. morganii
0.09
-
cefotaxime 30°C, pH 7.0 Morganella morganii subsp. morganii
0.095
-
cefepime 30°C, pH 7.0 Morganella morganii subsp. morganii
0.106
-
cephalothin in 20 mM phosphate buffer, (pH 7.0) at 30°C Morganella morganii subsp. morganii
0.148
-
cephalothin 30°C, pH 7.0 Morganella morganii subsp. morganii
0.148
-
cephalothin in 20 mM phosphate buffer, (pH 7.0) at 30°C Morganella morganii subsp. morganii
1
-
Imipenem 30°C, pH 7.0 Morganella morganii subsp. morganii
106
-
cephalothin 30°C, pH 7.0 Morganella morganii subsp. morganii

Organism

Organism UniProt Comment Textmining
Morganella morganii subsp. morganii Q704Y9
-
-
Morganella morganii subsp. morganii Q704Z0
-
-
Morganella morganii subsp. morganii Q705J0
-
-
Morganella morganii subsp. morganii PP19 Q705J0
-
-
Morganella morganii subsp. morganii PP29 Q704Z0
-
-
Morganella morganii subsp. morganii PP37 Q704Y9
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Morganella morganii subsp. morganii
Sephadex G-100 column chromatography, CM-Sepharose column chromatography Morganella morganii subsp. morganii

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ampicillin + H2O
-
Morganella morganii subsp. morganii (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
ampicillin + H2O
-
Morganella morganii subsp. morganii PP37 (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
ampicillin + H2O
-
Morganella morganii subsp. morganii PP19 (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
ampicillin + H2O
-
Morganella morganii subsp. morganii PP29 (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
benzylpenicillin + H2O
-
Morganella morganii subsp. morganii (2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
benzylpenicillin + H2O
-
Morganella morganii subsp. morganii PP37 (2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
benzylpenicillin + H2O
-
Morganella morganii subsp. morganii PP19 (2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
benzylpenicillin + H2O
-
Morganella morganii subsp. morganii PP29 (2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
cefepime + H2O
-
Morganella morganii subsp. morganii (2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-5-[(1-methylpyrrolidinium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
?
cefotaxime + H2O
-
Morganella morganii subsp. morganii (2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
cefotaxime + H2O
-
Morganella morganii subsp. morganii PP37 (2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
cefotaxime + H2O
-
Morganella morganii subsp. morganii PP19 (2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
cefotaxime + H2O
-
Morganella morganii subsp. morganii PP29 (2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
cefoxitin + H2O
-
Morganella morganii subsp. morganii (2R)-5-[(carbamoyloxy)methyl]-2-[(S)-carboxy(methoxy)[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
cefoxitin + H2O
-
Morganella morganii subsp. morganii PP37 (2R)-5-[(carbamoyloxy)methyl]-2-[(S)-carboxy(methoxy)[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
cefoxitin + H2O
-
Morganella morganii subsp. morganii PP19 (2R)-5-[(carbamoyloxy)methyl]-2-[(S)-carboxy(methoxy)[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
cefoxitin + H2O
-
Morganella morganii subsp. morganii PP29 (2R)-5-[(carbamoyloxy)methyl]-2-[(S)-carboxy(methoxy)[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
ceftazidime + H2O
-
Morganella morganii subsp. morganii (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}(carboxy)methyl]-5-[(pyridin-1-ium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
?
cephalothin + H2O
-
Morganella morganii subsp. morganii (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
cephalothin + H2O
-
Morganella morganii subsp. morganii PP37 (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
cephalothin + H2O
-
Morganella morganii subsp. morganii PP19 (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
cephalothin + H2O
-
Morganella morganii subsp. morganii PP29 (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
imipenem + H2O
-
Morganella morganii subsp. morganii (5R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
?
nitrocefin + H2O
-
Morganella morganii subsp. morganii (2R)-2-{(R)-carboxy[2-(thiophen-2-yl)acetamido]methyl}-5-[(E)-2-(2,4-dinitrophenyl)ethenyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
oxacillin + H2O
-
Morganella morganii subsp. morganii (2R,4S)-2-{(R)-carboxy[(5-methyl-3-phenyl-1,2-oxazole-4-carbonyl)amino]methyl}-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
piperacillin + H2O
-
Morganella morganii subsp. morganii (2R,4S)-2-[(R)-carboxy[[(2R)-2-[[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino]-2-phenylacetyl]amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?

Synonyms

Synonyms Comment Organism
AmpC beta-lactamase
-
Morganella morganii subsp. morganii
AmpC beta-lactamases M19
-
Morganella morganii subsp. morganii
AmpC beta-lactamases M29
-
Morganella morganii subsp. morganii
AmpC beta-lactamases M37
-
Morganella morganii subsp. morganii
AmpC M19
-
Morganella morganii subsp. morganii
AmpC M29
-
Morganella morganii subsp. morganii
AmpC M37
-
Morganella morganii subsp. morganii
beta-lactamase, class C
-
Morganella morganii subsp. morganii
M19
-
Morganella morganii subsp. morganii
M29
-
Morganella morganii subsp. morganii
M37
-
Morganella morganii subsp. morganii

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.0074
-
benzylpenicillin 30°C, pH 7.0 Morganella morganii subsp. morganii
0.008
-
cefepime 30°C, pH 7.0 Morganella morganii subsp. morganii
0.022
-
Oxacillin 30°C, pH 7.0 Morganella morganii subsp. morganii
0.032
-
cefotaxime 30°C, pH 7.0 Morganella morganii subsp. morganii
0.032
-
cefotaxime in 20 mM phosphate buffer, (pH 7.0) at 30°C Morganella morganii subsp. morganii
0.038
-
cefoxitin 30°C, pH 7.0 Morganella morganii subsp. morganii
0.04
-
ceftazidime 30°C, pH 7.0 Morganella morganii subsp. morganii
0.06
-
ampicillin 30°C, pH 7.0 Morganella morganii subsp. morganii
0.06
-
ampicillin in 20 mM phosphate buffer, (pH 7.0) at 30°C Morganella morganii subsp. morganii
0.065
-
ampicillin 30°C, pH 7.0 Morganella morganii subsp. morganii
0.07
-
Imipenem 30°C, pH 7.0 Morganella morganii subsp. morganii
0.07
-
Imipenem in 20 mM phosphate buffer, (pH 7.0) at 30°C Morganella morganii subsp. morganii
0.07
-
cefotaxime in 20 mM phosphate buffer, (pH 7.0) at 30°C Morganella morganii subsp. morganii
0.09
-
cefotaxime in 20 mM phosphate buffer, (pH 7.0) at 30°C Morganella morganii subsp. morganii
0.11
-
Imipenem 30°C, pH 7.0 Morganella morganii subsp. morganii
0.11
-
Imipenem in 20 mM phosphate buffer, (pH 7.0) at 30°C Morganella morganii subsp. morganii
1.5
-
piperacillin 30°C, pH 7.0 Morganella morganii subsp. morganii
6
-
cephalothin 30°C, pH 7.0 Morganella morganii subsp. morganii
6
-
cephalothin in 20 mM phosphate buffer, (pH 7.0) at 30°C Morganella morganii subsp. morganii
14
-
cephalothin 30°C, pH 7.0 Morganella morganii subsp. morganii
14
-
cephalothin in 20 mM phosphate buffer, (pH 7.0) at 30°C Morganella morganii subsp. morganii
93
-
nitrocefin 30°C, pH 7.0 Morganella morganii subsp. morganii
140
-
cephalothin 30°C, pH 7.0 Morganella morganii subsp. morganii
140
-
cephalothin in 20 mM phosphate buffer, (pH 7.0) at 30°C Morganella morganii subsp. morganii

pI Value

Organism Comment pI Value Maximum pI Value
Morganella morganii subsp. morganii isoelectric focusing
-
6.6
Morganella morganii subsp. morganii isoelectric focusing, pH-range 3-10
-
6.6
Morganella morganii subsp. morganii isoelectric focusing
-
7.4
Morganella morganii subsp. morganii isoelectric focusing, pH-range 3-10
-
7.4
Morganella morganii subsp. morganii isoelectric focusing
-
7.8
Morganella morganii subsp. morganii isoelectric focusing, pH-range 3-10
-
7.8