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Literature summary for 3.5.2.6 extracted from

  • Brown, S.; Young, H.K.; Amyes, S.G.
    Characterisation of OXA-51, a novel class D carbapenemase found in genetically unrelated clinical strains of Acinetobacter baumannii from Argentina (2005), Clin. Microbiol. Infect., 11, 15-23.
    View publication on PubMed
Search for more literature for 3.5.2.6

Inhibitors

Inhibitors Comment Organism Structure
clavulanate 0.1 mM, 50% inhibition Acinetobacter baumannii
Cloxacillin 0.398 mM, 50% inhibition Acinetobacter baumannii
Imipenem 2.5 mM, 50% inhibition Acinetobacter baumannii
meropenem 0.000004 mM, 50% inhibition Acinetobacter baumannii
NaCl 3.2 mM, 50% inhibition Acinetobacter baumannii
Sulbactam 0.05 mM, 50% inhibition Acinetobacter baumannii

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.011
-
 Imipenem 37°C, pH 7.0 Acinetobacter baumannii
0.024
-
 ampicillin 37°C, pH 7.0 Acinetobacter baumannii
0.077
-
 cephaloridine 37°C, pH 7.0 Acinetobacter baumannii
0.129
-
 Cloxacillin 37°C, pH 7.0 Acinetobacter baumannii
0.531
-
 Oxacillin 37°C, pH 7.0 Acinetobacter baumannii

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35500
-
 x * 35500, SDS-PAGE Acinetobacter baumannii

Organism

Organism UniProt Comment Textmining
Acinetobacter baumannii Q5QT35 from genetically distinct carbapenem-resistant strains from Argentina
-

Purification (Commentary)

Purification (Comment) Organism
-
 Acinetobacter baumannii

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ampicillin + H2O
-
 Acinetobacter baumannii (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
cephaloridine + H2O
-
 Acinetobacter baumannii (2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
cloxacillin + H2O
-
 Acinetobacter baumannii (2R,4S)-2-[(R)-carboxy{[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino}methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
imipenem + H2O
-
 Acinetobacter baumannii (5R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
 ?
oxacillin + H2O
-
 Acinetobacter baumannii (2R,4S)-2-{(R)-carboxy[(5-methyl-3-phenyl-1,2-oxazole-4-carbonyl)amino]methyl}-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?

Subunits

Subunits Comment Organism
? x * 35500, SDS-PAGE Acinetobacter baumannii

pI Value

Organism Comment pI Value Maximum pI Value
Acinetobacter baumannii
-
-
 7