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Literature summary for 3.5.2.6 extracted from

  • Alba, J.; Ishii, Y.; Thomson, K.; Moland, E.S.; Yamaguchi, K.
    Kinetics study of KPC-3, a plasmid-encoded class A carbapenem-hydrolyzing beta-lactamase (2005), Antimicrob. Agents Chemother., 49, 4760-4762.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
moxalactam
-
Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.004
-
meropenem
-
Escherichia coli
0.023
-
Imipenem
-
Escherichia coli
0.03
-
Sulbactam
-
Escherichia coli
0.042
-
nitrocefin
-
Escherichia coli
0.044
-
cephalotin
-
Escherichia coli
0.065
-
ampicillin
-
Escherichia coli
0.088
-
ceftazidime
-
Escherichia coli
0.095
-
cefotaxime
-
Escherichia coli
0.261
-
cephaloridine
-
Escherichia coli
0.97
-
cefoxitin
-
Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
plasmid encoded enzyme
-

Purification (Commentary)

Purification (Comment) Organism
-
Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ampicillin + H2O
-
Escherichia coli (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
cefotaxime + H2O
-
Escherichia coli (2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
cefoxitin + H2O
-
Escherichia coli (2R)-5-[(carbamoyloxy)methyl]-2-[(S)-carboxy(methoxy)[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
ceftazidime + H2O
-
Escherichia coli (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}(carboxy)methyl]-5-[(pyridin-1-ium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
?
cephaloridine + H2O
-
Escherichia coli (2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
?
cephalotin + H2O
-
Escherichia coli (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
imipenem + H2O
-
Escherichia coli (5R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
?
meropenem + H2O
-
Escherichia coli (4R,5S)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
?
moxalactam + H2O
-
Escherichia coli (2R)-2-{(R)-carboxy[2-carboxy(4-hydroxyphenyl)acetamido]methoxymethyl}-5-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-3,6-dihydro-2H-1,3-oxazine-4-carboxylic acid
-
?
nitrocefin + H2O
-
Escherichia coli (2R)-2-{(R)-carboxy[2-(thiophen-2-yl)acetamido]methyl}-5-[(E)-2-(2,4-dinitrophenyl)ethenyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
sulbactam + H2O
-
Escherichia coli (2R,4S)-2-(carboxymethyl)-5,5-dimethyl-1,1-dioxo-1lambda~6~,3-thiazolidine-4-carboxylic acid
-
?

Synonyms

Synonyms Comment Organism
KPC-3
-
Escherichia coli

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3
-
ceftazidime
-
Escherichia coli
4
-
Sulbactam
-
Escherichia coli
6
-
meropenem
-
Escherichia coli
45
-
Imipenem
-
Escherichia coli
52
-
cefotaxime
-
Escherichia coli
77
-
ampicillin
-
Escherichia coli
107
-
nitrocefin
-
Escherichia coli
153
-
cephalotin
-
Escherichia coli
364
-
cephaloridine
-
Escherichia coli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.014
-
moxalactam
-
Escherichia coli