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Literature summary for 3.5.2.6 extracted from

  • Drawz, S.M.; Bethel, C.R.; Doppalapudi, V.R.; Sheri, A.; Pagadala, S.R.; Hujer, A.M.; Skalweit, M.J.; Anderson, V.E.; Chen, S.G.; Buynak, J.D.; Bonomo, R.A.
    Penicillin sulfone inhibitors of class D beta-lactamases (2010), Antimicrob. Agents Chemother., 54, 1414-1424.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
clavulanic acid
-
Acinetobacter sp.
clavulanic acid
-
plasmid RGN238
clavulanic acid
-
Pseudomonas aeruginosa
JDB/ASR-II-292
-
Acinetobacter sp.
JDB/ASR-II-292
-
plasmid RGN238
JDB/ASR-II-292
-
Pseudomonas aeruginosa
JDB/LN-1-255
-
Acinetobacter sp.
JDB/LN-1-255
-
plasmid RGN238
JDB/LN-1-255
-
Pseudomonas aeruginosa
tazobactam
-
Acinetobacter sp.
tazobactam
-
plasmid RGN238
tazobactam
-
Pseudomonas aeruginosa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.009
-
nitrocefin pH and temperature not specified in the publication Acinetobacter sp.
0.009
-
nitrocefin pH and temperature not specified in the publication, OXA-1 beta-lactamase plasmid RGN238
0.031
-
Oxacillin pH and temperature not specified in the publication Acinetobacter sp.
0.031
-
Oxacillin pH and temperature not specified in the publication, OXA-1 beta-lactamase plasmid RGN238
0.064
-
ampicillin pH and temperature not specified in the publication Acinetobacter sp.
0.064
-
ampicillin pH and temperature not specified in the publication, OXA-1 beta-lactamase plasmid RGN238
0.08
-
cephaloridine pH and temperature not specified in the publication Acinetobacter sp.
0.08
-
cephaloridine pH and temperature not specified in the publication, OXA-1 beta-lactamase plasmid RGN238

Organism

Organism UniProt Comment Textmining
Acinetobacter sp.
-
-
-
plasmid RGN238
-
-
-
Pseudomonas aeruginosa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Pseudomonas aeruginosa
-
Acinetobacter sp.
-
plasmid RGN238

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ampicillin + H2O
-
Pseudomonas aeruginosa (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
ampicillin + H2O
-
Acinetobacter sp. (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
ampicillin + H2O
-
plasmid RGN238 (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
cephaloridine + H2O
-
Pseudomonas aeruginosa (2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
?
cephaloridine + H2O
-
Acinetobacter sp. (2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
?
cephaloridine + H2O
-
plasmid RGN238 (2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
?
nitrocefin + H2O
-
Pseudomonas aeruginosa (2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-[(E)-2-(2,4-dinitrophenyl)ethenyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
nitrocefin + H2O
-
Acinetobacter sp. (2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-[(E)-2-(2,4-dinitrophenyl)ethenyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
nitrocefin + H2O
-
plasmid RGN238 (2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-[(E)-2-(2,4-dinitrophenyl)ethenyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
oxacillin + H2O
-
Pseudomonas aeruginosa (2R,4S)-2-[(R)-carboxy[[(5-methyl-3-phenyl-1,2-oxazol-4-yl)carbonyl]amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
oxacillin + H2O
-
Acinetobacter sp. (2R,4S)-2-[(R)-carboxy[[(5-methyl-3-phenyl-1,2-oxazol-4-yl)carbonyl]amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
oxacillin + H2O
-
plasmid RGN238 (2R,4S)-2-[(R)-carboxy[[(5-methyl-3-phenyl-1,2-oxazol-4-yl)carbonyl]amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?

Synonyms

Synonyms Comment Organism
oxa-1 beta-lactamase
-
Acinetobacter sp.
oxa-1 beta-lactamase
-
plasmid RGN238
OXA-10 beta-lactamase
-
Pseudomonas aeruginosa

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
16
-
cephaloridine pH and temperature not specified in the publication Acinetobacter sp.
16
-
cephaloridine pH and temperature not specified in the publication, OXA-1 beta-lactamase plasmid RGN238
96
-
nitrocefin pH and temperature not specified in the publication Acinetobacter sp.
96
-
nitrocefin pH and temperature not specified in the publication, OXA-1 beta-lactamase plasmid RGN238
357
-
ampicillin pH and temperature not specified in the publication Acinetobacter sp.
357
-
ampicillin pH and temperature not specified in the publication, OXA-1 beta-lactamase plasmid RGN238
577
-
Oxacillin pH and temperature not specified in the publication Acinetobacter sp.
577
-
Oxacillin pH and temperature not specified in the publication, OXA-1 beta-lactamase plasmid RGN238

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0007
-
JDB/LN-1-255 pH and temperature not specified in the publication Acinetobacter sp.
0.0007
-
JDB/LN-1-255 pH and temperature not specified in the publication, OXA-1 beta-lactamase plasmid RGN238
0.0014
-
JDB/ASR-II-292 pH and temperature not specified in the publication Acinetobacter sp.
0.0014
-
JDB/ASR-II-292 pH and temperature not specified in the publication, OXA-1 beta-lactamase plasmid RGN238
0.0014
-
JDB/LN-1-255 pH and temperature not specified in the publication, OXA-10 beta-lactamase Pseudomonas aeruginosa
0.004
-
JDB/ASR-II-292 pH and temperature not specified in the publication, OXA-10 beta-lactamase Pseudomonas aeruginosa
0.008
-
JDB/LN-1-255 pH and temperature not specified in the publication, OXA-10 beta-lactamase Pseudomonas aeruginosa
0.017
-
JDB/ASR-II-292 pH and temperature not specified in the publication, OXA-10 beta-lactamase Pseudomonas aeruginosa
0.019
-
clavulanic acid pH and temperature not specified in the publication, OXA-10 beta-lactamase Pseudomonas aeruginosa
0.03
-
tazobactam pH and temperature not specified in the publication, OXA-10 beta-lactamase Pseudomonas aeruginosa
0.104
-
clavulanic acid pH and temperature not specified in the publication, OXA-10 beta-lactamase Pseudomonas aeruginosa
0.17
-
tazobactam pH and temperature not specified in the publication, OXA-10 beta-lactamase Pseudomonas aeruginosa
0.195
-
clavulanic acid pH and temperature not specified in the publication Acinetobacter sp.
0.195
-
clavulanic acid pH and temperature not specified in the publication, OXA-1 beta-lactamase plasmid RGN238
0.585
-
tazobactam pH and temperature not specified in the publication Acinetobacter sp.
0.585
-
tazobactam pH and temperature not specified in the publication, OXA-1 beta-lactamase plasmid RGN238

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
200
-
cephaloridine pH and temperature not specified in the publication Acinetobacter sp.
200
-
cephaloridine pH and temperature not specified in the publication, OXA-1 beta-lactamase plasmid RGN238
5578
-
ampicillin pH and temperature not specified in the publication Acinetobacter sp.
5578
-
ampicillin pH and temperature not specified in the publication, OXA-1 beta-lactamase plasmid RGN238
10450
-
nitrocefin pH and temperature not specified in the publication Acinetobacter sp.
10450
-
nitrocefin pH and temperature not specified in the publication, OXA-1 beta-lactamase plasmid RGN238
18610
-
Oxacillin pH and temperature not specified in the publication Acinetobacter sp.
18610
-
Oxacillin pH and temperature not specified in the publication, OXA-1 beta-lactamase plasmid RGN238