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Literature summary for 3.5.2.6 extracted from

  • Lee, K.; Yum, J.H.; Yong, D.; Jeong, S.H.; Rossolini, G.M.; Docquier, J.D.; Chong, Y.
    Biochemical characterization of the TEM-107 extended-spectrum beta-lactamase in a Klebsiella pneumoniae isolate from South Korea (2011), Antimicrob. Agents Chemother., 55, 5930-5932.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Klebsiella pneumoniae

Protein Variants

Protein Variants Comment Organism
additional information TEM-107 extended-spectrum beta-lactamase detected in a Klebsiella pneumoniae clinical isolate has a Gly238Ser substitution compared to the TEM-43 beta-lactamase Klebsiella pneumoniae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.001
-
ampicillin pH 7.0, 30°C Klebsiella pneumoniae
0.003
-
piperacillin pH 7.0, 30°C Klebsiella pneumoniae
0.005
-
nitrocefin pH 7.0, 30°C Klebsiella pneumoniae
0.01
-
cephalotin pH 7.0, 30°C Klebsiella pneumoniae
0.017
-
aztreonam pH 7.0, 30°C Klebsiella pneumoniae
0.022
-
cefotaxime pH 7.0, 30°C Klebsiella pneumoniae
0.026
-
cefepime pH 7.0, 30°C Klebsiella pneumoniae
0.034
-
cefuroxime pH 7.0, 30°C Klebsiella pneumoniae
0.086
-
ceftazidime pH 7.0, 30°C Klebsiella pneumoniae

Organism

Organism UniProt Comment Textmining
Klebsiella pneumoniae Q8KQ59
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ampicillin + H2O
-
Klebsiella pneumoniae (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
aztreonam + H2O
-
Klebsiella pneumoniae [(1S,2S)-1-[[(2Z)-2-(2-ammonio-1,3-thiazol-4-yl)-2-[[(2-carboxypropan-2-yl)oxy]imino]acetyl]amino]-1-carboxypropan-2-yl]sulfamate
-
?
cefepime + H2O
-
Klebsiella pneumoniae (2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-5-[(1-methylpyrrolidinium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
?
cefotaxime + H2O
-
Klebsiella pneumoniae (2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
ceftazidime + H2O
-
Klebsiella pneumoniae (2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[[(2-carboxypropan-2-yl)oxy]imino]acetyl]amino](carboxy)methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
?
cefuroxime + H2O
-
Klebsiella pneumoniae (2R)-5-[(carbamoyloxy)methyl]-2-[(R)-carboxy{[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
cephalotin + H2O
-
Klebsiella pneumoniae (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
nitrocefin + H2O
-
Klebsiella pneumoniae (2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-[(E)-2-(2,4-dinitrophenyl)ethenyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
piperacillin + H2O
-
Klebsiella pneumoniae (2R,4S)-2-[(R)-carboxy[[(2R)-2-[[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino]-2-phenylacetyl]amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?

Synonyms

Synonyms Comment Organism
class A beta-lactamase
-
Klebsiella pneumoniae
extended-spectrum beta-lactamase
-
Klebsiella pneumoniae
TEM-107
-
Klebsiella pneumoniae

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1
-
cephalotin pH 7.0, 30°C Klebsiella pneumoniae
2
-
cefuroxime pH 7.0, 30°C Klebsiella pneumoniae
2
-
aztreonam pH 7.0, 30°C Klebsiella pneumoniae
3
-
cefotaxime pH 7.0, 30°C Klebsiella pneumoniae
3
-
cefepime pH 7.0, 30°C Klebsiella pneumoniae
5
-
ampicillin pH 7.0, 30°C Klebsiella pneumoniae
11
-
piperacillin pH 7.0, 30°C Klebsiella pneumoniae
15
-
ceftazidime pH 7.0, 30°C Klebsiella pneumoniae
72
-
nitrocefin pH 7.0, 30°C Klebsiella pneumoniae

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
1200
-
cefotaxime pH 7.0, 30°C Klebsiella pneumoniae
1200
-
aztreonam pH 7.0, 30°C Klebsiella pneumoniae
1300
-
cefepime pH 7.0, 30°C Klebsiella pneumoniae
1400
-
nitrocefin pH 7.0, 30°C Klebsiella pneumoniae
1800
-
ceftazidime pH 7.0, 30°C Klebsiella pneumoniae
3300
-
piperacillin pH 7.0, 30°C Klebsiella pneumoniae
4200
-
ampicillin pH 7.0, 30°C Klebsiella pneumoniae
6700
-
cefuroxime pH 7.0, 30°C Klebsiella pneumoniae
7900
-
cephalotin pH 7.0, 30°C Klebsiella pneumoniae