Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Klebsiella pneumoniae |
Protein Variants | Comment | Organism |
---|---|---|
additional information | TEM-107 extended-spectrum beta-lactamase detected in a Klebsiella pneumoniae clinical isolate has a Gly238Ser substitution compared to the TEM-43 beta-lactamase | Klebsiella pneumoniae |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.001 | - |
ampicillin | pH 7.0, 30°C | Klebsiella pneumoniae | |
0.003 | - |
piperacillin | pH 7.0, 30°C | Klebsiella pneumoniae | |
0.005 | - |
nitrocefin | pH 7.0, 30°C | Klebsiella pneumoniae | |
0.01 | - |
cephalotin | pH 7.0, 30°C | Klebsiella pneumoniae | |
0.017 | - |
aztreonam | pH 7.0, 30°C | Klebsiella pneumoniae | |
0.022 | - |
cefotaxime | pH 7.0, 30°C | Klebsiella pneumoniae | |
0.026 | - |
cefepime | pH 7.0, 30°C | Klebsiella pneumoniae | |
0.034 | - |
cefuroxime | pH 7.0, 30°C | Klebsiella pneumoniae | |
0.086 | - |
ceftazidime | pH 7.0, 30°C | Klebsiella pneumoniae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Klebsiella pneumoniae | Q8KQ59 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ampicillin + H2O | - |
Klebsiella pneumoniae | (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? | |
aztreonam + H2O | - |
Klebsiella pneumoniae | [(1S,2S)-1-[[(2Z)-2-(2-ammonio-1,3-thiazol-4-yl)-2-[[(2-carboxypropan-2-yl)oxy]imino]acetyl]amino]-1-carboxypropan-2-yl]sulfamate | - |
? | |
cefepime + H2O | - |
Klebsiella pneumoniae | (2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-5-[(1-methylpyrrolidinium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate | - |
? | |
cefotaxime + H2O | - |
Klebsiella pneumoniae | (2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
ceftazidime + H2O | - |
Klebsiella pneumoniae | (2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[[(2-carboxypropan-2-yl)oxy]imino]acetyl]amino](carboxy)methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate | - |
? | |
cefuroxime + H2O | - |
Klebsiella pneumoniae | (2R)-5-[(carbamoyloxy)methyl]-2-[(R)-carboxy{[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
cephalotin + H2O | - |
Klebsiella pneumoniae | (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
nitrocefin + H2O | - |
Klebsiella pneumoniae | (2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-[(E)-2-(2,4-dinitrophenyl)ethenyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
piperacillin + H2O | - |
Klebsiella pneumoniae | (2R,4S)-2-[(R)-carboxy[[(2R)-2-[[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino]-2-phenylacetyl]amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? |
Synonyms | Comment | Organism |
---|---|---|
class A beta-lactamase | - |
Klebsiella pneumoniae |
extended-spectrum beta-lactamase | - |
Klebsiella pneumoniae |
TEM-107 | - |
Klebsiella pneumoniae |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1 | - |
cephalotin | pH 7.0, 30°C | Klebsiella pneumoniae | |
2 | - |
cefuroxime | pH 7.0, 30°C | Klebsiella pneumoniae | |
2 | - |
aztreonam | pH 7.0, 30°C | Klebsiella pneumoniae | |
3 | - |
cefotaxime | pH 7.0, 30°C | Klebsiella pneumoniae | |
3 | - |
cefepime | pH 7.0, 30°C | Klebsiella pneumoniae | |
5 | - |
ampicillin | pH 7.0, 30°C | Klebsiella pneumoniae | |
11 | - |
piperacillin | pH 7.0, 30°C | Klebsiella pneumoniae | |
15 | - |
ceftazidime | pH 7.0, 30°C | Klebsiella pneumoniae | |
72 | - |
nitrocefin | pH 7.0, 30°C | Klebsiella pneumoniae |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1200 | - |
cefotaxime | pH 7.0, 30°C | Klebsiella pneumoniae | |
1200 | - |
aztreonam | pH 7.0, 30°C | Klebsiella pneumoniae | |
1300 | - |
cefepime | pH 7.0, 30°C | Klebsiella pneumoniae | |
1400 | - |
nitrocefin | pH 7.0, 30°C | Klebsiella pneumoniae | |
1800 | - |
ceftazidime | pH 7.0, 30°C | Klebsiella pneumoniae | |
3300 | - |
piperacillin | pH 7.0, 30°C | Klebsiella pneumoniae | |
4200 | - |
ampicillin | pH 7.0, 30°C | Klebsiella pneumoniae | |
6700 | - |
cefuroxime | pH 7.0, 30°C | Klebsiella pneumoniae | |
7900 | - |
cephalotin | pH 7.0, 30°C | Klebsiella pneumoniae |