Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.5.2.6 extracted from

  • Lee, D.; Das, S.; Dawson, N.L.; Dobrijevic, D.; Ward, J.; Orengo, C.
    Novel computational protocols for functionally classifying and characterising serine beta-lactamases (2016), PLoS Comput. Biol., 12, e1004926 .
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
three-dimensional analysis using crystal structure PDB ID 1IYO, modeling Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli P62593
-
-
Escherichia coli Q47066
-
-

Subunits

Subunits Comment Organism
More three-dimensional analysis using crystal structures PDB IDs 1FQG and 1BTL, modeling Escherichia coli

Synonyms

Synonyms Comment Organism
BLA
-
Escherichia coli
blaTEM-1
-
Escherichia coli
blaToho-11
-
Escherichia coli
class A beta-lactamase
-
Escherichia coli
TEM-1
-
Escherichia coli
TEM1
-
Escherichia coli
Toho-1
-
Escherichia coli

General Information

General Information Comment Organism
evolution functionally classifying and characterising serine beta-lactamases: proposal of a grouping of serine beta-lactamases that more consistently captures and rationalizes the existing three classification schemes: classes (A, C and D, which vary in their implementation of the mechanism of action), types (that largely reflect evolutionary distance measured by sequence similarity), and variant groups (which largely correspond with the Bush-Jacoby clinical groups). Analysis of Class A enzymes, overview Escherichia coli
additional information structure-based classification of beta-lactamases, functional determinants between the Class A, C, D beta-lactamases and of sites in the active sites of class A serine beta-lactamases likely to be affecting phenotype Escherichia coli
additional information structure-based classification of beta-lactamases, identification functional determinants between the Class A, C, D beta-lactamases and of sites in the active sites of class A serine beta-lactamases likely to be affecting phenotype. Isozyme TEM-1 is a class A type 1 enzyme Escherichia coli