Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.5.2.6 extracted from

  • Edalucci, E.; Spinelli, R.; Dolzani, L.; Riccio, M.L.; Dubois, V.; Tonin, E.A.; Rossolini, G.M.; Lagatolla, C.
    Acquisition of different carbapenem resistance mechanisms by an epidemic clonal lineage of Pseudomonas aeruginosa (2008), Clin. Microbiol. Infect., 14, 88-90.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
carbapenemase activity of MBL results from acquisition of carbapenemase-encoding determinants via horizontal gene transfer, overview Pseudomonas aeruginosa
DNA and amino acid sequence determination and analysis Pseudomonas aeruginosa
macrorestriction profiling of chromosomal DNA from 30 isolates and identification of two different clonal lineages, named cluster A, serotype O11, and cluster B, serotype O12, that produce VIM-1 and VIM-2 MBLs, respectively. The VIM-2-producing isolates from Italy carried identical, or very similar, allelic forms of the oprD gene, harbour a common class 1 integron, belong to the same multilocus sequence type, and show macrorestriction profiles that are related to those of the MBL-negative French strains, overview Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
imipenem + H2O Pseudomonas aeruginosa the enzyme shows carbapenemase activity, e.g. against the carbapenem antibiotics meropenem and imipenem used in treatment of Pseudomonas aeruginosa infection, and contributes to resistance to anti-pseudomonal agents, overview (5R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
?
meropenem + H2O Pseudomonas aeruginosa the enzyme shows carbapenemase activity, e.g. against the carbapenem antibiotics meropenem and imipenem used in treatment of Pseudomonas aeruginosa infection, and contributes to resistance to anti-pseudomonal agents, overview (4R,5S)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
?

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
-
cluster B Italian isolates
-
Pseudomonas aeruginosa
-
genes blaVIM-1 and bla-VIM-2
-
Pseudomonas aeruginosa Q7BHJ5 beta-lactamase PSE-1; genes blaPSE-1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
imipenem + H2O
-
Pseudomonas aeruginosa (5R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
?
imipenem + H2O the enzyme shows carbapenemase activity, e.g. against the carbapenem antibiotics meropenem and imipenem used in treatment of Pseudomonas aeruginosa infection, and contributes to resistance to anti-pseudomonal agents, overview Pseudomonas aeruginosa (5R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
?
meropenem + H2O
-
Pseudomonas aeruginosa (4R,5S)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
?
meropenem + H2O the enzyme shows carbapenemase activity, e.g. against the carbapenem antibiotics meropenem and imipenem used in treatment of Pseudomonas aeruginosa infection, and contributes to resistance to anti-pseudomonal agents, overview Pseudomonas aeruginosa (4R,5S)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
?

Synonyms

Synonyms Comment Organism
beta-lactamase PSE-1
-
Pseudomonas aeruginosa
carbapenemase
-
Pseudomonas aeruginosa
MBL
-
Pseudomonas aeruginosa
metallo-beta-lactamase
-
Pseudomonas aeruginosa
VIM-1
-
Pseudomonas aeruginosa
VIM-2
-
Pseudomonas aeruginosa