Cloned (Comment) | Organism |
---|---|
carbapenemase activity of MBL results from acquisition of carbapenemase-encoding determinants via horizontal gene transfer, overview | Pseudomonas aeruginosa |
DNA and amino acid sequence determination and analysis | Pseudomonas aeruginosa |
macrorestriction profiling of chromosomal DNA from 30 isolates and identification of two different clonal lineages, named cluster A, serotype O11, and cluster B, serotype O12, that produce VIM-1 and VIM-2 MBLs, respectively. The VIM-2-producing isolates from Italy carried identical, or very similar, allelic forms of the oprD gene, harbour a common class 1 integron, belong to the same multilocus sequence type, and show macrorestriction profiles that are related to those of the MBL-negative French strains, overview | Pseudomonas aeruginosa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
imipenem + H2O | Pseudomonas aeruginosa | the enzyme shows carbapenemase activity, e.g. against the carbapenem antibiotics meropenem and imipenem used in treatment of Pseudomonas aeruginosa infection, and contributes to resistance to anti-pseudomonal agents, overview | (5R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid | - |
? | |
meropenem + H2O | Pseudomonas aeruginosa | the enzyme shows carbapenemase activity, e.g. against the carbapenem antibiotics meropenem and imipenem used in treatment of Pseudomonas aeruginosa infection, and contributes to resistance to anti-pseudomonal agents, overview | (4R,5S)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas aeruginosa | - |
cluster B Italian isolates | - |
Pseudomonas aeruginosa | - |
genes blaVIM-1 and bla-VIM-2 | - |
Pseudomonas aeruginosa | Q7BHJ5 | beta-lactamase PSE-1; genes blaPSE-1 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
imipenem + H2O | - |
Pseudomonas aeruginosa | (5R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid | - |
? | |
imipenem + H2O | the enzyme shows carbapenemase activity, e.g. against the carbapenem antibiotics meropenem and imipenem used in treatment of Pseudomonas aeruginosa infection, and contributes to resistance to anti-pseudomonal agents, overview | Pseudomonas aeruginosa | (5R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid | - |
? | |
meropenem + H2O | - |
Pseudomonas aeruginosa | (4R,5S)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid | - |
? | |
meropenem + H2O | the enzyme shows carbapenemase activity, e.g. against the carbapenem antibiotics meropenem and imipenem used in treatment of Pseudomonas aeruginosa infection, and contributes to resistance to anti-pseudomonal agents, overview | Pseudomonas aeruginosa | (4R,5S)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid | - |
? |
Synonyms | Comment | Organism |
---|---|---|
beta-lactamase PSE-1 | - |
Pseudomonas aeruginosa |
carbapenemase | - |
Pseudomonas aeruginosa |
MBL | - |
Pseudomonas aeruginosa |
metallo-beta-lactamase | - |
Pseudomonas aeruginosa |
VIM-1 | - |
Pseudomonas aeruginosa |
VIM-2 | - |
Pseudomonas aeruginosa |