Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) cells | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
aztreonam | competitive inhibitor | Escherichia coli | |
clavulanic acid | - |
Escherichia coli | |
additional information | imipenem, meropenem or doripenem do not behave as inactivators | Escherichia coli | |
tazobactam | - |
Escherichia coli |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00011 | - |
meropenem | in 50 mM phosphate buffer (pH 7.0), at 30°C | Escherichia coli | |
0.00047 | - |
Sulbactam | in 50 mM phosphate buffer (pH 7.0), at 30°C | Escherichia coli | |
0.0008 | - |
cefdinir | in 50 mM phosphate buffer (pH 7.0), at 30°C | Escherichia coli | |
0.0019 | - |
Imipenem | in 50 mM phosphate buffer (pH 7.0), at 30°C | Escherichia coli | |
0.011 | - |
benzylpenicillin | in 50 mM phosphate buffer (pH 7.0), at 30°C | Escherichia coli | |
0.02 | - |
piperacillin | in 50 mM phosphate buffer (pH 7.0), at 30°C | Escherichia coli | |
0.025 | - |
nitrocefin | in 50 mM phosphate buffer (pH 7.0), at 30°C | Escherichia coli | |
0.025 | - |
cefcapene | in 50 mM phosphate buffer (pH 7.0), at 30°C | Escherichia coli | |
0.027 | - |
cefalothin | in 50 mM phosphate buffer (pH 7.0), at 30°C | Escherichia coli | |
0.041 | - |
cefotaxime | in 50 mM phosphate buffer (pH 7.0), at 30°C | Escherichia coli | |
0.041 | - |
aztreonam | in 50 mM phosphate buffer (pH 7.0), at 30°C | Escherichia coli | |
0.125 | - |
cefaloridine | in 50 mM phosphate buffer (pH 7.0), at 30°C | Escherichia coli | |
0.15 | - |
doripenem | in 50 mM phosphate buffer (pH 7.0), at 30°C | Escherichia coli | |
13 | - |
ceftazidime | in 50 mM phosphate buffer (pH 7.0), at 30°C | Escherichia coli |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
27970 | - |
mass spectrum analysis | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Escherichia coli TUM1121 | - |
- |
- |
Purification (Comment) | Organism |
---|---|
CM-Sepharose column chromatography | Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
aztreonam + H2O | poorly active against ceftazidime and aztreonam | Escherichia coli | [(1S,2S)-1-[[(2Z)-2-(2-ammonio-1,3-thiazol-4-yl)-2-[[(2-carboxypropan-2-yl)oxy]imino]acetyl]amino]-1-carboxypropan-2-yl]sulfamate | - |
? | |
aztreonam + H2O | poorly active against ceftazidime and aztreonam | Escherichia coli TUM1121 | [(1S,2S)-1-[[(2Z)-2-(2-ammonio-1,3-thiazol-4-yl)-2-[[(2-carboxypropan-2-yl)oxy]imino]acetyl]amino]-1-carboxypropan-2-yl]sulfamate | - |
? | |
benzylpenicillin + H2O | - |
Escherichia coli | (2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? | |
benzylpenicillin + H2O | - |
Escherichia coli TUM1121 | (2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? | |
cefaloridine + H2O | - |
Escherichia coli | (2R)-2-{(R)-carboxy[2-(thiophen-2-yl)acetamido]methyl}-5-[(pyridin-1-ium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate | - |
? | |
cefalotin + H2O | - |
Escherichia coli | (2R)-5-[(acetyloxy)methyl]-2-{(R)-carboxy[2-(thiophen-2-yl)acetamido]methyl}-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
cefcapene + H2O | - |
Escherichia coli | (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)pent-2-enoyl]amino}(carboxy)methyl]-5-[(carbamoyloxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
cefdinir + H2O | - |
Escherichia coli | (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(hydroxyimino)acetyl]amino}(carboxy)methyl]-5-ethenyl-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
cefepime + H2O | - |
Escherichia coli | (2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-5-[(1-methylpyrrolidinium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate | - |
? | |
cefepime + H2O | - |
Escherichia coli TUM1121 | (2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-5-[(1-methylpyrrolidinium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate | - |
? | |
cefotaxime + H2O | - |
Escherichia coli | (2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
cefotaxime + H2O | - |
Escherichia coli TUM1121 | (2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
cefpodoxime + H2O | - |
Escherichia coli | (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}(carboxy)methyl]-5-(methoxymethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
ceftazidime + H2O | poorly active against ceftazidime and aztreonam | Escherichia coli | (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}(carboxy)methyl]-5-[(pyridin-1-ium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate | - |
? | |
ceftazidime + H2O | poorly active against ceftazidime and aztreonam | Escherichia coli TUM1121 | (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}(carboxy)methyl]-5-[(pyridin-1-ium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate | - |
? | |
ceftizoxime + H2O | - |
Escherichia coli | (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}(carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
doripenem + H2O | - |
Escherichia coli | (4R,5S)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4-methyl-3-({(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid | - |
? | |
imipenem + H2O | - |
Escherichia coli | (5R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid | - |
? | |
meropenem + H2O | - |
Escherichia coli | (4R,5S)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid | - |
? | |
nitrocefin + H2O | - |
Escherichia coli | (2R)-2-{(R)-carboxy[2-(thiophen-2-yl)acetamido]methyl}-5-[(E)-2-(2,4-dinitrophenyl)ethenyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
piperacillin + H2O | - |
Escherichia coli | (2R,4S)-2-[(R)-carboxy[[(2R)-2-[[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino]-2-phenylacetyl]amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? | |
sulbactam + H2O | - |
Escherichia coli | (2R,4S)-2-(carboxymethyl)-5,5-dimethyl-1,1-dioxo-1lambda~6~,3-thiazolidine-4-carboxylic acid | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CTX-M-14 | - |
Escherichia coli |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.003 | - |
Imipenem | in 50 mM phosphate buffer (pH 7.0), at 30°C | Escherichia coli | |
0.007 | - |
meropenem | in 50 mM phosphate buffer (pH 7.0), at 30°C | Escherichia coli | |
0.04 | - |
doripenem | in 50 mM phosphate buffer (pH 7.0), at 30°C | Escherichia coli | |
20 | - |
Sulbactam | in 50 mM phosphate buffer (pH 7.0), at 30°C | Escherichia coli | |
39 | - |
piperacillin | in 50 mM phosphate buffer (pH 7.0), at 30°C | Escherichia coli | |
48 | - |
benzylpenicillin | in 50 mM phosphate buffer (pH 7.0), at 30°C | Escherichia coli | |
83 | - |
cefdinir | in 50 mM phosphate buffer (pH 7.0), at 30°C | Escherichia coli | |
110 | - |
cefcapene | in 50 mM phosphate buffer (pH 7.0), at 30°C | Escherichia coli | |
360 | - |
nitrocefin | in 50 mM phosphate buffer (pH 7.0), at 30°C | Escherichia coli | |
510 | - |
cefalothin | in 50 mM phosphate buffer (pH 7.0), at 30°C | Escherichia coli | |
1300 | - |
cefaloridine | in 50 mM phosphate buffer (pH 7.0), at 30°C | Escherichia coli | |
1400 | - |
cefotaxime | in 50 mM phosphate buffer (pH 7.0), at 30°C | Escherichia coli |