EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.188 | prostaglandin-F synthase |
epimastigote |
- |
-, 761141 |
1.1.1.2 | alcohol dehydrogenase (NADP+) |
epimastigote |
- |
286193 |
1.1.1.40 | malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) |
epimastigote |
- |
-, 712042 |
1.1.1.42 | isocitrate dehydrogenase (NADP+) |
epimastigote |
- |
723129 |
1.1.1.44 | phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) |
epimastigote |
- |
656751 |
1.11.1.24 | thioredoxin-dependent peroxiredoxin |
epimastigote |
- |
684996 |
1.14.14.154 | sterol 14alpha-demethylase |
epimastigote |
- |
701584 |
1.14.19.22 | acyl-lipid omega-6 desaturase (cytochrome b5) |
epimastigote |
- |
675584 |
1.14.19.28 | sn-1 stearoyl-lipid 9-desaturase |
epimastigote |
- |
-, 745715 |
1.15.1.1 | superoxide dismutase |
epimastigote |
- |
705498 |
1.17.99.9 | heme a synthase |
epimastigote |
- |
759201 |
1.17.99.9 | heme a synthase |
epimastigote |
the replicative life stages (epimastigotes and amastigotes) show higher TcCox15 levels than the infective and non-replicative stage (trypomastigotes). Two times higher level in epimastigotes than in amastigotes and five times higher level than in trypomastigotes |
-, 758753 |
1.3.1.6 | fumarate reductase (NADH) |
epimastigote |
- |
655266, 699012 |
1.3.3.12 | L-galactonolactone oxidase |
epimastigote |
- |
684985 |
1.3.98.1 | dihydroorotate dehydrogenase (fumarate) |
epimastigote |
- |
656747 |
1.5.5.2 | proline dehydrogenase |
epimastigote |
TcPRODH mRNA and protein expression are strongly upregulated in the intracellular epimastigote, a stage which requires an external supply of proline |
-, 743635 |
1.6.2.4 | NADPH-hemoprotein reductase |
epimastigote |
- |
288556, 688895 |
1.6.2.4 | NADPH-hemoprotein reductase |
epimastigote |
overexpression of TcCPR-B in Trypanosoma cruzi epimastigotes increases its resistance to the typical chemotherapeutic agents Nifurtimox and Benznidazole |
688895 |
1.6.5.5 | NADPH:quinone reductase |
epimastigote |
the enzyme is expressed throughout the Trypanosoma cruzi life cycle |
671365 |
1.8.1.12 | trypanothione-disulfide reductase |
epimastigote |
- |
-, 724552, 725064 |
1.8.1.4 | dihydrolipoyl dehydrogenase |
epimastigote |
- |
393962 |
1.8.4.11 | peptide-methionine (S)-S-oxide reductase |
epimastigote |
- |
-, 712074 |
1.8.4.12 | peptide-methionine (R)-S-oxide reductase |
epimastigote |
- |
-, 764710 |
2.3.1.255 | N-terminal amino-acid Nalpha-acetyltransferase NatA |
epimastigote |
- |
-, 757472 |
2.3.1.256 | N-terminal methionine Nalpha-acetyltransferase NatC |
epimastigote |
- |
-, 757472 |
2.4.2.7 | adenine phosphoribosyltransferase |
epimastigote |
- |
-, 759538 |
2.4.99.18 | dolichyl-diphosphooligosaccharide-protein glycotransferase |
epimastigote |
- |
488498 |
2.5.1.58 | protein farnesyltransferase |
epimastigote |
- |
637511 |
2.5.1.59 | protein geranylgeranyltransferase type I |
epimastigote |
- |
688892 |
2.5.1.85 | all-trans-nonaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific] |
epimastigote |
- |
674727 |
2.6.1.43 | aminolevulinate transaminase |
epimastigote |
- |
640064 |
2.7.1.1 | hexokinase |
epimastigote |
- |
640216, 640217, 640265 |
2.7.1.11 | 6-phosphofructokinase |
epimastigote |
- |
640430 |
2.7.1.137 | phosphatidylinositol 3-kinase |
epimastigote |
- |
-, 708996 |
2.7.1.2 | glucokinase |
epimastigote |
- |
688890 |
2.7.1.21 | thymidine kinase |
epimastigote |
- |
641149 |
2.7.1.6 | galactokinase |
epimastigote |
expression of both isoforms GalK1 and GalK2 |
739235 |
2.7.1.67 | 1-phosphatidylinositol 4-kinase |
epimastigote |
- |
739027 |
2.7.11.11 | cAMP-dependent protein kinase |
epimastigote |
- |
692602 |
2.7.2.3 | phosphoglycerate kinase |
epimastigote |
- |
-, 738182, 761049 |
2.7.3.3 | arginine kinase |
epimastigote |
- |
642469, 662528, 673489 |
2.7.3.3 | arginine kinase |
epimastigote |
activity increases continuously during the exponential phase of growth |
642484 |
2.7.4.6 | nucleoside-diphosphate kinase |
epimastigote |
- |
-, 692239, 738181, 761808 |
2.7.7.7 | DNA-directed DNA polymerase |
epimastigote |
Trypanosoma cruzi DNA polymerase beta is restricted to the antipodal sites of kDNA in replicative epimastigote and amastigote developmental stages, being strictly localized to kDNA antipodal sites between G1/S and early G2 phase in replicative epimastigotes |
723132 |
2.7.9.1 | pyruvate, phosphate dikinase |
epimastigote |
- |
661517, 738186 |
2.7.9.1 | pyruvate, phosphate dikinase |
epimastigote |
during growth of epimastigotes in batch culture, an increase in the level of the 75 kDa enzyme form and a decrease of the 100 kDa enzyme form are observed. Expression of the 100 kDa PPDK slightly decreases, when the culture reaches the stationary phase, but its specific activity decreases about 3.25times to an almost undetectable level, and the phosphorylated 75 kDa PPDK signal increases significantly |
-, 739234 |
2.7.9.3 | selenide, water dikinase |
epimastigote |
cell culture |
694071 |
3.1.1.32 | phospholipase A1 |
epimastigote |
- |
730354 |
3.1.1.32 | phospholipase A1 |
epimastigote |
non-infective stage, low enzyme activity |
682242 |
3.1.3.48 | protein-tyrosine-phosphatase |
epimastigote |
- |
-, 714058 |
3.1.3.48 | protein-tyrosine-phosphatase |
epimastigote |
within the endocytic pathway |
664802 |
3.1.4.11 | phosphoinositide phospholipase C |
epimastigote |
TcPI-PLC expression at high levels in the epimastigote and amastigote stages |
652082 |
3.1.6.1 | arylsulfatase (type I) |
epimastigote |
- |
681811 |
3.2.1.143 | poly(ADP-ribose) glycohydrolase |
epimastigote |
the enzyme is expressed in a life stage-dependant manner |
732734 |
3.2.1.24 | alpha-mannosidase |
epimastigote |
- |
135960, 135970 |
3.2.1.51 | alpha-L-fucosidase |
epimastigote |
- |
655143 |
3.2.2.1 | purine nucleosidase |
epimastigote |
- |
326388 |
3.3.2.9 | microsomal epoxide hydrolase |
epimastigote |
- |
208891 |
3.4.11.1 | leucyl aminopeptidase |
epimastigote |
- |
717435 |
3.4.17.1 | carboxypeptidase A |
epimastigote |
- |
684959 |
3.4.17.19 | Carboxypeptidase Taq |
epimastigote |
- |
684959 |
3.4.21.104 | mannan-binding lectin-associated serine protease-2 |
epimastigote |
- |
709985 |
3.4.21.26 | prolyl oligopeptidase |
epimastigote |
low enzyme expression |
683369 |
3.4.22.51 | cruzipain |
epimastigote |
- |
-, 638878, 638881, 638885, 638890, 667653, 732673, 753924, 755082 |
3.4.24.35 | gelatinase B |
epimastigote |
- |
-, 708445 |
3.4.24.36 | leishmanolysin |
epimastigote |
- |
-, 710664 |
3.4.25.2 | HslU-HslV peptidase |
epimastigote |
HslV is localized in the kinetoplast of epimastigotes |
-, 719424 |
3.6.1.1 | inorganic diphosphatase |
epimastigote |
- |
734716 |
3.6.1.11 | exopolyphosphatase |
epimastigote |
- |
687628 |
3.6.5.2 | small monomeric GTPase |
epimastigote |
- |
667402, 667418 |
4.1.1.19 | arginine decarboxylase |
epimastigote |
enzyme activity is only present in the early stage of the parasite exponential growth, between 4 and 23 h of cultivation in presence of Arg, with a maximum at 14 h and disappears completely at the mid logarithmic phase. It is never detected during the stationary phase |
-, 655193 |
4.1.1.49 | phosphoenolpyruvate carboxykinase (ATP) |
epimastigote |
- |
-, 4626, 4631, 4636 |
4.2.99.18 | DNA-(apurinic or apyrimidinic site) lyase |
epimastigote |
enzyme is present and active in the two replicative parasite forms, epimastigotes and amastigotes, as well as in the nonreplicative, infective trypomastigotes |
-, 730104 |
4.4.1.5 | lactoylglutathione lyase |
epimastigote |
- |
678043, 692329 |
5.1.1.4 | proline racemase |
epimastigote |
- |
705499, 705500, 705596 |
5.2.1.8 | peptidylprolyl isomerase |
epimastigote |
- |
714320 |
5.2.1.8 | peptidylprolyl isomerase |
epimastigote |
neither cell growth kinetics nor cell morphology are affected by the overexpression of Pin1 |
681821 |
5.3.1.6 | ribose-5-phosphate isomerase |
epimastigote |
highest expression |
-, 678047 |
5.4.2.2 | phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) |
epimastigote |
- |
703892 |
5.6.2.2 | DNA topoisomerase (ATP-hydrolysing) |
epimastigote |
- |
-, 716381 |
6.3.1.2 | glutamine synthetase |
epimastigote |
- |
-, 743570 |
6.3.1.9 | trypanothione synthase |
epimastigote |
- |
-, 744910 |
7.2.2.3 | P-type Na+ transporter |
epimastigote |
- |
-, 654200, 695869 |
7.4.2.1 | ABC-type polar-amino-acid transporter |
epimastigote |
- |
718559 |
7.6.2.2 | ABC-type xenobiotic transporter |
epimastigote |
- |
-, 734833 |