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Literature summary for 2.7.1.2 extracted from

  • Caceres, A.J.; Quinones, W.; Gualdron, M.; Cordeiro, A.; Avilan, L.; Michels, P.A.; Concepcion, J.L.
    Molecular and biochemical characterization of novel glucokinases from Trypanosoma cruzi and Leishmania spp (2007), Mol. Biochem. Parasitol., 156, 235-245.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Trypanosoma cruzi
expression in Escherichia coli Leishmania major

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.35
-
ATP
-
Leishmania major
0.36
-
ATP
-
Trypanosoma cruzi
1
-
D-glucose
-
Trypanosoma cruzi
2.5 5 D-glucose recombinant enzyme without His6 Leishmania major
3.3
-
D-glucose recombinant (His)6-tagged enzyme Leishmania major

Localization

Localization Comment Organism GeneOntology No. Textmining
glycosome
-
Trypanosoma cruzi 20015
-
glycosome
-
Leishmania major 20015
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
43000
-
x * 43000, the enzyme may occur as a monomer or dimer, dependent on the protein concentration, SDS-PAGE Trypanosoma cruzi
46000
-
monomer, gel filtration Trypanosoma cruzi
46000
-
x * 46000, the enzyme may occur as a monomer or dimer, dependent on the protein concentration, SDS-PAGE Leishmania major
49000
-
monomer, gel filtration Leishmania major
86000
-
dimer, gel filtration Trypanosoma cruzi
86000
-
dimer, gel filtration Leishmania major

Organism

Organism UniProt Comment Textmining
Leishmania major Q4Q1I9
-
-
Trypanosoma cruzi Q4E4E1
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme Trypanosoma cruzi
recombinant enzyme Leishmania major

Source Tissue

Source Tissue Comment Organism Textmining
epimastigote
-
Trypanosoma cruzi
-
promastigote
-
Leishmania major
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + D-glucose enzyme is only able to phosphorylate glucose Trypanosoma cruzi ADP + D-glucose 6-phosphate
-
?
ATP + D-glucose enzyme is only able to phosphorylate glucose Leishmania major ADP + D-glucose 6-phosphate
-
?

Subunits

Subunits Comment Organism
? x * 43000, the enzyme may occur as a monomer or dimer, dependent on the protein concentration, SDS-PAGE Trypanosoma cruzi
? x * 46000, the enzyme may occur as a monomer or dimer, dependent on the protein concentration, SDS-PAGE Leishmania major

Synonyms

Synonyms Comment Organism
LmGlcK
-
Leishmania major
TcGlcK
-
Trypanosoma cruzi

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
317
-
ATP
-
Leishmania major
317
-
D-glucose
-
Leishmania major
1492
-
ATP
-
Trypanosoma cruzi
1492
-
D-glucose
-
Trypanosoma cruzi

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5 9
-
Trypanosoma cruzi
8.5 9
-
Leishmania major