Information on EC 2.7.4.6 - nucleoside-diphosphate kinase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.7.4.6
-
RECOMMENDED NAME
GeneOntology No.
nucleoside-diphosphate kinase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
adenosine deoxyribonucleotides de novo biosynthesis
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adenosine deoxyribonucleotides de novo biosynthesis II
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Biosynthesis of antibiotics
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Biosynthesis of secondary metabolites
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CMP phosphorylation
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guanosine deoxyribonucleotides de novo biosynthesis I
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guanosine deoxyribonucleotides de novo biosynthesis II
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guanosine ribonucleotides de novo biosynthesis
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Metabolic pathways
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non-pathway related
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ppGpp biosynthesis
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purine deoxyribonucleosides salvage
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purine metabolism
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Purine metabolism
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pyrimidine deoxyribonucleotide phosphorylation
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pyrimidine deoxyribonucleotides biosynthesis from CTP
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pyrimidine deoxyribonucleotides de novo biosynthesis I
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pyrimidine deoxyribonucleotides de novo biosynthesis II
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pyrimidine deoxyribonucleotides de novo biosynthesis III
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pyrimidine deoxyribonucleotides de novo biosynthesis IV
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pyrimidine metabolism
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Pyrimidine metabolism
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superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli)
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UTP and CTP de novo biosynthesis
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-
SYSTEMATIC NAME
IUBMB Comments
ATP:nucleoside-diphosphate phosphotransferase
Many nucleoside diphosphates can act as acceptors, while many ribo- and deoxyribonucleoside triphosphates can act as donors.
CAS REGISTRY NUMBER
COMMENTARY hide
9026-51-1
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
eel
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Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
gene Cf-ndpk
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
isozyme NDK B; isozyme NDK B
Uniprot
Manually annotated by BRENDA team
strain 4R
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-
Manually annotated by BRENDA team
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Uniprot
Manually annotated by BRENDA team
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Uniprot
Manually annotated by BRENDA team
strain 4593
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-
Manually annotated by BRENDA team
Jerusalem artichoke
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-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
Impatiens holstii
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Manually annotated by BRENDA team
strain LV78, clone 12-1, gene ndk
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Manually annotated by BRENDA team
strain LV78, clone 12-1, gene ndk
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-
Manually annotated by BRENDA team
magellanicus, isozyme NDK B; novezelandiae, isozyme NDK B
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-
Manually annotated by BRENDA team
isozyme NDK B
UniProt
Manually annotated by BRENDA team
isozyme NDK B
UniProt
Manually annotated by BRENDA team
isozyme NDK B
UniProt
Manually annotated by BRENDA team
isozyme NDK B
UniProt
Manually annotated by BRENDA team
isozyme NDK B
UniProt
Manually annotated by BRENDA team
isozyme NDK B
UniProt
Manually annotated by BRENDA team
isozyme NDK B
UniProt
Manually annotated by BRENDA team
isozyme NDK B
UniProt
Manually annotated by BRENDA team
isozyme NDK B
UniProt
Manually annotated by BRENDA team
isozyme NDK B
UniProt
Manually annotated by BRENDA team
isozyme NDK B
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-
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
hagfish
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Manually annotated by BRENDA team
cv. Bright Yellow 2; study on mitochondria during programmed cell death
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
seal
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Manually annotated by BRENDA team
strain FCR-3
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
strain 8822, kinase is associated in a complex with EC 6.2.1.5
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Manually annotated by BRENDA team
strain 8822, kinase is associated in a complex with EC 6.2.1.5
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Manually annotated by BRENDA team
strain ATCC 13525
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Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
Wistar strain
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Manually annotated by BRENDA team
isoform NDPK1, strongly regulated by the NTP/NDP ratio
SwissProt
Manually annotated by BRENDA team
potato
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Manually annotated by BRENDA team
dogfish
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Manually annotated by BRENDA team
strain HB8
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Manually annotated by BRENDA team
wheat
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Manually annotated by BRENDA team
procyclic and bloodstream forms
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Manually annotated by BRENDA team
multiple enzyme isoforms
UniProt
Manually annotated by BRENDA team
broad bean
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Manually annotated by BRENDA team
female mature frog
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
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loss of Nm23-H1 in diploid cells leads to cytokinetic furrow regression, followed by cytokinesis failure and generationof tetraploid cells. The loss of Nm23-H1, an event suspected to promote metastasis, additionally functions at an earlier stage of tumor development to drive the acquisition of chromosomal instability
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2',3'-dehydro-3'-deoxyTDP + ATP
2',3'-dehydro-3'-deoxyTTP + ADP
show the reaction diagram
-
-
-
?
3'-fluoro-2',3'-dideoxyUDP + ATP
3'-fluoro-2',3'-dideoxyUTP + ADP
show the reaction diagram
better than 2,3-dideoxyUDP, but much poorer than 2-deoxyUDP
-
-
?
3'-fluoro-3'-deoxyTDP + ATP
3'-fluoro-3'-deoxyTTP + ADP
show the reaction diagram
-
-
-
?
ADP + CTP
ATP + CDP
show the reaction diagram
ADP + dCTP
ATP + dCDP
show the reaction diagram
-
-
-
-
?
ADP + dGTP
ATP + dGDP
show the reaction diagram
-
-
-
?
ADP + dTTP
ATP + dTDP
show the reaction diagram
-
-
-
-
?
ADP + dUTP
ATP + dUDP
show the reaction diagram
-
-
-
-
?
ADP + GTP
ATP + GDP
show the reaction diagram
ADP + TTP
ATP + TDP
show the reaction diagram
-
-
-
-
?
ADP + UTP
ATP + UDP
show the reaction diagram
-
-
-
-
?
ATP + 8-bromo-IDP
ADP + ?
show the reaction diagram
ATP + 8-bromoinosine 5'-diphosphate
ADP + 8-bromoinosine 5'-triphosphate
show the reaction diagram
ATP + adenosine 5'-methylene diphosphonate
ADP + ?
show the reaction diagram
-
-
-
?
ATP + ADP
ADP + ATP
show the reaction diagram
ATP + CDP
ADP + CTP
show the reaction diagram
ATP + dADP
ADP + dATP
show the reaction diagram
ATP + dCDP
ADP + dCTP
show the reaction diagram
ATP + dGDP
ADP + dGTP
show the reaction diagram
ATP + dNDP
ADP + dNTP
show the reaction diagram
ATP + dTDP
ADP + dTTP
show the reaction diagram
ATP + dUDP
?
show the reaction diagram
ATP + dUDP
ADP + dUTP
show the reaction diagram
ATP + GDP
ADP + GTP
show the reaction diagram
ATP + NDP
ADP + NTP
show the reaction diagram
ATP + nucleoside diphosphate
ADP + nucleoside triphosphate
show the reaction diagram
-
-
-
?
ATP + TDP
ADP + TTP
show the reaction diagram
ATP + tubulin-GDP
ADP + tubulin-GTP
show the reaction diagram
-
-
-
?
ATP + UDP
ADP + UTP
show the reaction diagram
ATP + XDP
ADP + XTP
show the reaction diagram
-
reaction at 37% the rate of UDP
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-
?
CTP + ADP
CDP + ATP
show the reaction diagram
-
-
-
?
CTP + CDP
CDP + CTP
show the reaction diagram
dATP + ADP
dADP + ATP
show the reaction diagram
dATP + CDP
dADP + CTP
show the reaction diagram
-
-
-
r
dATP + GDP
dADP + GTP
show the reaction diagram
-
-
-
?
dATP + IDP
dADP + ITP
show the reaction diagram
-
-
-
?
dATP + UDP
dADP + UTP
show the reaction diagram
-
-
-
?
dCTP + ADP
dCDP + ATP
show the reaction diagram
dGDP + ATP
dGTP + ADP
show the reaction diagram
-
-
-
-
?
dGTP + ADP
dGDP + ATP
show the reaction diagram
dTTP + ADP
dTDP + ATP
show the reaction diagram
gamma-S-ATP + GDP
ADP + gamma-S-GTP
show the reaction diagram
gamma-S-GTP + GDP
GDP + gamma-S-GTP
show the reaction diagram
GDP + ATP
GTP + ADP
show the reaction diagram
-
-
-
?
GTP + ADP
GDP + ATP
show the reaction diagram
GTP + CDP
GDP + CTP
show the reaction diagram
GTP + dGDP
GDP + dGTP
show the reaction diagram
-
-
-
-
-
GTP + dTDP
GDP + dTTP
show the reaction diagram
-
-
-
-
?
GTP + GDP
GDP + GTP
show the reaction diagram
GTP + NDP
GDP + NTP
show the reaction diagram
GTP + nucleoside diphosphate
GDP + nucleoside triphosphate
show the reaction diagram
GTP + UDP
GDP + UTP
show the reaction diagram
GTP-bound Ras protein + NDP
GDP-bound Ras protein + NTP
show the reaction diagram
-
in vitro, inactivation of mutant oncogenic Ras proteins
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-
?
ITP + ADP
IDP + ATP
show the reaction diagram
ITP + UDP
IDP + UTP
show the reaction diagram
-
-
-
-
?
NDP + NTP
NTP + NDP
show the reaction diagram
NTP + ADP
NDP + ATP
show the reaction diagram
-
-
-
?
NTP + NDP
NDP + NTP
show the reaction diagram
NTP + nucleoside diphosphate
NDP + NTP
show the reaction diagram
TTP + ADP
TDP + ATP
show the reaction diagram
-
-
-
?
tubulin-GDP-complex + ATP
tubulin-GTP-complex + ADP
show the reaction diagram
-
-
-
-
?
UTP + ADP
UDP + ATP
show the reaction diagram
-
-
-
?
UTP + CDP
UDP + CTP
show the reaction diagram
UTP + dCDP
UDP + dCTP
show the reaction diagram
UTP + dTDP
UDP + dTDP
show the reaction diagram
UTP + UDP
UDP + UTP
show the reaction diagram
-
reaction at 31% the rate of ATP
-
?
additional information
?
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