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Literature summary for 2.7.4.6 extracted from

  • Hippe, H.J.; Luedde, M.; Lutz, S.; Koehler, H.; Eschenhagen, T.; Frey, N.; Katus, H.A.; Wieland, T.; Niroomand, F.
    Regulation of cardiac cAMP synthesis and contractility by nucleoside diphosphate kinase B/G protein beta gamma dimer complexes (2007), Circ. Res., 100, 1191-1199.
    View publication on PubMed
Search for more literature for 2.7.4.6

Protein Variants

Protein Variants Comment Organism
H266L generation of a Gbeta1gamma2-dimer carrying a single amino acid exchange at the intermediately phosphorylated His266 in the beta1 subunit, the mutant is termed Gbeta1H266Lgamma2, the mutant is integrated into heterotrimeric G proteins in rat cardiomyocytes but is deficient in intermediate Gbeta phosphorylation, mutant overexpression suppresses basal cAMP formation as well as the basal contractility up to 50-55% compared to the wild-type enzyme, overview Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane associated as complex of NDPK B and G proteinbetagamma-dimers Rattus norvegicus 5886
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus enzyme is involved in receptor-independent regulation of cAMP synthesis and contractility in intact cardiomyocytes and has histidine kinase activity for phosphorylation of G protein subunit beta phosphorylation at H266 ?
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 ?
additional information Rattus norvegicus In addition to the receptor-induced GDP/GTP exchange, G protein alpha subunits can be activated by a phosphate transfer via a plasma membrane-associated complex of NDPK B and G protein betagamma-dimers, Gbetagamma, requiring the intermediate phosphorylation of His266, the histidine kinase activity of NDPK B for Gbeta is important for the receptor-independent regulation of cAMP synthesis and contractility in intact cardiomyocytes, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
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Rattus norvegicus
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 isoform NDPK B
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Source Tissue

Source Tissue Comment Organism Textmining
cardiac myocyte
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 Rattus norvegicus
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cardiomyocyte
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 Rattus norvegicus
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H-10 cell
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 Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme is involved in receptor-independent regulation of cAMP synthesis and contractility in intact cardiomyocytes and has histidine kinase activity for phosphorylation of G protein subunit beta phosphorylation at H266 Rattus norvegicus ?
-
 ?
additional information In addition to the receptor-induced GDP/GTP exchange, G protein alpha subunits can be activated by a phosphate transfer via a plasma membrane-associated complex of NDPK B and G protein betagamma-dimers, Gbetagamma, requiring the intermediate phosphorylation of His266, the histidine kinase activity of NDPK B for Gbeta is important for the receptor-independent regulation of cAMP synthesis and contractility in intact cardiomyocytes, overview Rattus norvegicus ?
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 ?

Subunits

Subunits Comment Organism
More enzyme interacts with G protein betagamma complex. Receptor-independent activation of G proteins via enzyme isoform B/G protein betagamma complexes requires the intermediate phosphorylation of G protein subunit beta at H266 Rattus norvegicus

Synonyms

Synonyms Comment Organism
NDPK B
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 Rattus norvegicus
nucleoside diphosphate kinase B
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 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
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 Rattus norvegicus