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(S)-dihydroorotate + acceptor
orotate + reduced acceptor
(S)-dihydroorotate + ferricyanide
orotate + ferrocyanide
(S)-dihydroorotate + fumarate
orotate + succinate
(S)-dihydroorotate + O2
orotate + H2O2
dihydroorotate + 2,3-dimethoxy-5-methyl-6-(3-methyl-2-butenyl)-1,4-benzoquinone
orotate + reduced 2,3-dimethoxy-5-methyl-6-(3-methyl-2-butenyl)-1,4-benzoquinone
-
-
-
?
dihydroorotate + 2,6-dichloroindophenol
orotate + reduced 2,6-dichloroindophenol
-
-
-
?
dihydroorotate + 2,6-dichlorophenolindophenol
orotate + ?
-
-
-
-
?
dihydroorotate + 2,6-dichlorophenolindophenol
orotate + reduced 2,6-dichlorophenolindophenol
dihydroorotate + acceptor
orotate + reduced acceptor
dihydroorotate + ferricyanide
orotate + ferrocyanide
-
-
-
-
?
dihydroorotate + fumarate
orotate + ?
dihydroorotate + fumarate
orotate + reduced fumarate
dihydroorotate + fumarate
orotate + succinate
-
prefers fumarate over ubiquinone-1
-
-
?
dihydroorotate + O2
orotate + H2O2
dihydroorotate + ubiquinone-1
orotate + ubiquinol-1
-
-
-
-
?
dihydrooxonate + acceptor
oxonate + reduced acceptor
L-dihydroorotate + 2,6-dichloroindophenol
orotate + ?
-
-
-
-
?
L-dihydroorotate + 2,6-dichlorophenolindophenol
orotate + reduced 2,6-dichlorophenolindophenol
-
-
-
-
?
L-dihydroorotate + CoQ
orotate + ?
-
-
-
-
?
L-dihydroorotate + crotonate
orotate + butanoate
-
-
-
-
?
L-dihydroorotate + fumarate
orotate + succinate
L-dihydroorotate + mesaconate
orotate + 2-methylbutanedioate
-
-
-
-
?
L-dihydroorotate + O2
orotate + H2O2
-
-
-
-
?
orotate + ferricyanide
(S)-dihydroorotate + ferrocyanide
S-dihydroorotate + 2,6-dichlorophenolindophenol
orotate + reduced 2,6-dichlorophenolindophenol
-
-
-
-
?
S-dihydroorotate + fumarate
orotate + succinate
-
100% activity
-
-
?
S-dihydroorotate + menadione
orotate + menadiol
-
20% activity with menadione compared to fumarate
-
-
?
additional information
?
-
(S)-dihydroorotate + acceptor
orotate + reduced acceptor
-
fumarate and ferricyanide tested as electron acceptors
-
?
(S)-dihydroorotate + acceptor
orotate + reduced acceptor
-
fumarate and ferricyanide tested as electron acceptors
-
?
(S)-dihydroorotate + acceptor
orotate + reduced acceptor
-
2,6-dichlorophenolindophenol, potassium hexacyanoferrate(III) and molecular oxygen used as electron acceptors
-
?
(S)-dihydroorotate + acceptor
orotate + reduced acceptor
-
fourth step in synthesis of pyrimidine nucleotides
-
?
(S)-dihydroorotate + acceptor
orotate + reduced acceptor
-
fourth step in UMP-biosynthesis
-
?
(S)-dihydroorotate + acceptor
orotate + reduced acceptor
-
preferred electron acceptors in the decreasing order: ferricyanide, 2,6-dichlorophenolindophenol, ubiquinone-0, fumarate and O2
-
?
(S)-dihydroorotate + acceptor
orotate + reduced acceptor
-
fourth step in synthesis of pyrimidine nucleotides
-
?
(S)-dihydroorotate + ferricyanide
orotate + ferrocyanide
-
-
-
?
(S)-dihydroorotate + ferricyanide
orotate + ferrocyanide
-
ferricyanide usually used as electon acceptor in the assay
-
?
(S)-dihydroorotate + fumarate
orotate + succinate
-
-
-
-
?
(S)-dihydroorotate + fumarate
orotate + succinate
-
-
-
-
?
(S)-dihydroorotate + fumarate
orotate + succinate
-
-
-
-
?
(S)-dihydroorotate + fumarate
orotate + succinate
-
-
-
-
ir
(S)-dihydroorotate + fumarate
orotate + succinate
-
-
-
?
(S)-dihydroorotate + fumarate
orotate + succinate
-
enzyme is responsible for biosynthesis of succinate and orotate
-
-
?
(S)-dihydroorotate + fumarate
orotate + succinate
-
-
-
?
(S)-dihydroorotate + O2
orotate + H2O2
-
ferricyanide, 2,6-dichlorophenolindophenol, cytochrome c and quinones as alternate electron acceptor, with ferricyanide 12 times faster rate of catalysis than with air alone
-
?
(S)-dihydroorotate + O2
orotate + H2O2
-
different dihydroorotate isotopes tested for mechanistic and stereochemical analysis
-
?
(S)-dihydroorotate + O2
orotate + H2O2
-
ferricyanide, cytochrome c and 2,6-dichlorophenolindolphenol as alternate electron acceptor
-
?
(S)-dihydroorotate + O2
orotate + H2O2
-
redox dyes, 2,6-dichlorophenolindophenol, ferricyanide are most active electron acceptors, oxygen and cytochrome c are much slower
-
?
(S)-dihydroorotate + O2
orotate + H2O2
-
pathway of pyrimidine biosynthesis, constitutive biosynthetic enzyme
-
?
(S)-dihydroorotate + O2
orotate + H2O2
-
pathway of pyrimidine biosynthesis, constitutive biosynthetic enzyme
-
?
(S)-dihydroorotate + O2
orotate + H2O2
-
ferricyanide as alternate electron acceptor, enzyme produced regardless of the carbon source
-
?
(S)-dihydroorotate + O2
orotate + H2O2
-
ferricyanide, 2,6-dichlorophenolindophenol, cytochrome c and quinones as alternate electron acceptor, with ferricyanide 12 times faster rate of catalysis than with air alone
-
?
(S)-dihydroorotate + O2
orotate + H2O2
-
ferricyanide, 2,6-dichlorophenolindophenol, cytochrome c and quinones as alternate electron acceptor, with ferricyanide 12 times faster rate of catalysis than with air alone
-
?
(S)-dihydroorotate + O2
orotate + H2O2
-
-
-
-
?
dihydroorotate + 2,6-dichlorophenolindophenol
orotate + reduced 2,6-dichlorophenolindophenol
-
-
-
-
?
dihydroorotate + 2,6-dichlorophenolindophenol
orotate + reduced 2,6-dichlorophenolindophenol
-
-
-
-
?
dihydroorotate + acceptor
orotate + reduced acceptor
-
acceptor: 2,6-dichlorophenolindophenol
-
-
?
dihydroorotate + acceptor
orotate + reduced acceptor
-
not acceptors: NAD+, NADP+, coenzymes Q6, Q10, K2
-
-
?
dihydroorotate + acceptor
orotate + reduced acceptor
-
discussion of substrate binding and catalytic mechanism
-
-
?
dihydroorotate + acceptor
orotate + reduced acceptor
-
no substrate: dihydrouracil
-
-
?
dihydroorotate + acceptor
orotate + reduced acceptor
-
acceptors: potassium hexacyanoferrate(III), to a lower extent molecular oxygen
-
-
?
dihydroorotate + acceptor
orotate + reduced acceptor
-
-
-
-
?
dihydroorotate + acceptor
orotate + reduced acceptor
-
acceptor: 2,6-dichlorophenolindophenol
-
-
?
dihydroorotate + acceptor
orotate + reduced acceptor
-
kinetic isotope effects
-
-
?
dihydroorotate + acceptor
orotate + reduced acceptor
-
acceptor: ferricyanide, coenzyme Q0, fumarate, molecular oxygen
-
-
?
dihydroorotate + fumarate
orotate + ?
-
-
-
?
dihydroorotate + fumarate
orotate + ?
-
-
-
-
?
dihydroorotate + fumarate
orotate + ?
-
-
-
?
dihydroorotate + fumarate
orotate + ?
-
-
-
-
?
dihydroorotate + fumarate
orotate + ?
-
-
-
?
dihydroorotate + fumarate
orotate + reduced fumarate
-
-
-
-
?
dihydroorotate + fumarate
orotate + reduced fumarate
-
-
-
-
?
dihydroorotate + fumarate
orotate + reduced fumarate
-
-
-
?
dihydroorotate + O2
orotate + H2O2
-
-
-
-
?
dihydroorotate + O2
orotate + H2O2
-
-
-
-
?
dihydroorotate + O2
orotate + H2O2
-
-
-
-
?
dihydrooxonate + acceptor
oxonate + reduced acceptor
-
fumarate and ferricyanide tested as electron acceptors
-
?
dihydrooxonate + acceptor
oxonate + reduced acceptor
-
fumarate and ferricyanide tested as electron acceptors
-
?
dihydrooxonate + acceptor
oxonate + reduced acceptor
-
-
-
?
L-dihydroorotate + fumarate
orotate + succinate
-
-
-
-
?
L-dihydroorotate + fumarate
orotate + succinate
-
-
-
-
?
L-dihydroorotate + fumarate
orotate + succinate
-
fumarate is the most effective electron acceptor
-
-
?
L-dihydroorotate + fumarate
orotate + succinate
-
-
-
-
?
L-dihydroorotate + fumarate
orotate + succinate
-
DHODH catalyzes a coupled redox reaction in which dihydroorotate is oxidized to orotate and fumarate is reduced to succinate
-
-
?
L-dihydroorotate + fumarate
orotate + succinate
-
-
-
-
?
orotate + ferricyanide
(S)-dihydroorotate + ferrocyanide
-
-
-
-
r
orotate + ferricyanide
(S)-dihydroorotate + ferrocyanide
-
-
-
-
?
additional information
?
-
-
three-dimensional active site structure, profile of interactions for molecular recognition, interaction of DHODH with orotate via residues Asn212, Asn284, Ser215, Phe149, Lys100, Gly148, Asn217, Asn145, and Thr285, overview
-
-
?
additional information
?
-
-
no acceptor: fumarate, NAD+, coenzymes ubiquinone-6, ubiquinone-10
-
-
?
additional information
?
-
-
maleate, glutaconate, cis-aconitate, trans-aconitate, and cinnamate do not function as electron acceptor
-
-
?
additional information
?
-
-
does not perform electron transfer to menaquinone, Q0, Q1, Q2, QD, O2, or to NAD+
-
-
?
additional information
?
-
-
enzyme has methylviologen-fumarate reductase activity
-
-
?
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1,5-dihydrofuro[3,4-d]pyrimidine-2,4,7-trione
-
-
1-(1-naphthyl)-3-[2-(trifluoromethyl)phenyl]urea
-
50% inhibition at 0.0004 mM, wild type, 0.00034 mM, mutant R265A, above 0.2, mutant H185A
1-(2-methoxyphenyl)-3-(1-naphthyl)urea
-
50% inhibition at 0.00023 mM, wild type, 0.00024 mM, mutant R265A, 0.140, mutant H185A
1-(4-Chloro-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 3-(4-methyl-benzylamide) 5-phenylamide
-
minimum inhibitory concentration 0.032 mg/ml
1-(4-Chloro-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 3-benzylamide 5-(isobutyl-amide)
-
minimum inhibitory concentration above 0.064 mg/ml
1-(4-Chloro-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 3-benzylamide 5-[(4-carbamoyl-phenyl)-amide]
-
minimum inhibitory concentration 0.008 mg/ml
1-(4-Chloro-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 5-phenylamide 3-[(pyridin-3-ylmethyl)-amide]
-
minimum inhibitory concentration 0.00025 mg/ml
1-(4-Chloro-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 5-[(4-piperidin-1-yl-phenyl)-amide] 3-[(pyridin-3-ylmethyl)-amide]
-
minimum inhibitory concentration 0.002 mg/ml
1-(4-chlorophenyl)-3-quinolin-8-ylurea
-
50% inhibition at 0.00078 mM, wild type, 0.002 mM, mutant R265A, above 0.4, mutant H185A
1-(4-Methoxy-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 3-(isobutyl-amide) 5-[[4-(pyrrolidine-1-carbonyl)-phenyl]-amide]
-
minimum inhibitory concentration 0.064 mg/ml
1-(4-Methoxy-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 3-benzhydryl-amide 5-benzylamide
-
minimum inhibitory concentration above 0.032 mg/ml
1-(4-Methoxy-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 3-benzylamide 5-[[4-(pyrrolidine-1-carbonyl)-phenyl]-amide]
-
minimum inhibitory concentration 0.003 mg/ml
1-(4-Methoxy-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 5-benzylamide 3-[[4-(pyrrolidine-1-carbonyl)-phenyl]-amide]
-
minimum inhibitory concentration above 0.032 mg/ml
1-(4-Methoxy-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 5-phenylamide 3-[(pyridin-3-ylmethyl)-amide]
-
minimum inhibitory concentration 0.0005 mg/ml
1-(4-Methoxy-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 5-[[4-(pyrrolidine-1-carbonyl)-phenyl]-amide] 3-[(tetrahydro-furan-2-yl)-amide]
-
minimum inhibitory concentration above 0.032 mg/ml
2,3-dihydrotriazolo[4,5-d]pyrimidine-5,7-dione
-
-
2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid
-
-
2-methyl-3-nitro-N-[3-(trifluoromethyl)phenyl]benzamide
-
50% inhibition at 0.00008 mM, wild type, 0.00037 mM, mutant R265A, 0.120, mutant H185A
2-methyl-N-1-naphthyl-3-nitrobenzamide
-
50% inhibition at 0.00008 mM, wild type, 0.00048 mM, mutant R265A, 0.180, mutant H185A
2-thioorotate
-
orotate analogue, 50% inhibition at 0.018 mM
4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazine-2-carboxylic acid
-
-
5-amino-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid
-
-
5-aminoorotate
-
orotate analogue, 50% inhibition at 1.6 mM
5-bromoorotate
-
orotate analogue, 50% inhibition at 0.016 mM
5-fluoro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid
-
-
5-Fluoroorotate
-
orotate analogue, 50% inhibition at 0.055 mM
5-nitro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid
-
-
5-nitroorotate
-
orotate analogue, 50% inhibition at 0.076 mM
5-[(dimethylamino)methyl]-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid
-
-
7,9-dihydro-3H-purine-2,6,8-trione
-
-
Barbiturate
-
dead-end inhibitor, competitive with respect to (S)-dihydroorotate
butyl 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate
-
-
leflunomide
-
cell line A20R resistant to leflunomide shows enhanced expression of enzyme to bypass the inhibitory effect, following long-time exposure, enzyme gene amplification can be assumed
Mercuric chloride
-
40% inhibition after 15 min at 0.000045 mM
methanol extract of brown algae Fucus evanescens
-
59% inhibition, noncompetitive
-
methanol extract of brown algae Pelvetia babingtonii
-
58% inhibition, noncompetitive
-
N-(2,4-dichlorophenyl)-2-naphthamide
-
50% inhibition at 0.00005 mM, wild type, 0.00008 mM, mutant R265A, above 0.05, mutant H185A
N-(2-fluorophenyl)naphthalene-2-carboxamide
-
50% inhibition at 0.00047 mM, wild type, 0.00030 mM, mutant R265A, 0.21, mutant H185A
N-(3,4-dichlorophenyl)-2-methyl-3-nitrobenzamide
-
50% inhibition at 0.00008 mM, wild type, 0.0028 mM, mutant R265A, 0.06, mutant H185A
N-(3,4-difluorophenyl)-2-methyl-3-nitrobenzamide
-
50% inhibition at 0.00026 mM, wild type, 0.00082 mM, mutant R265A, 0.25, mutant H185A
N-(3,5-dichlorophenyl)-2-methyl-3-nitrobenzamide
-
50% inhibition at 0.00002 mM, wild type, 0.0004 mM, mutant R265A, 0.13, mutant H185A
N-(3-bromophenyl)-2-methyl-3-nitrobenzamide
-
50% inhibition at 0.00006 mM, wild type, 0.0012 mM, mutant R265A, 0.140, mutant H185A
N-(3-chloro-4-fluorophenyl)-2-methyl-3-nitrobenzamide
-
50% inhibition at 0.0001 mM, wild type, 0.0005 mM, mutant R265A, 0.13, mutant H185A
N-(4-bromo-2-methylphenyl)-2-naphthamide
-
50% inhibition at 0.00005 mM, wild type, 0.00005 mM, mutant R265A, 0.57, mutant H185A
N3-benzyl-1-(4-chlorophenyl)-N5-phenyl-1H-pyrazole-3,5-dicarboxamide
-
minimum inhibitory concentration 0.000125 mg/ml
orotate methyl ester
-
orotate analogue, 50% inhibition at 0.71 mM
oxonate
crystallization data
oxonic acid
-
orotate analogue, 50% inhibition at 0.0099 mM
p-hydroxymercuribenzoate
-
98% inhibition after 5 min at 0.00227 mM
Salicylhydroxamic acid
-
weak inhibition, pH 9.0, 37°C
suramin
-
weak inhibition, pH 9.0, 37°C
Tiron
-
inhibits cytochrome c reduction and sulfite autoxidation
Uracil
-
orotate analogue, 50% inhibition at 2.5 mM
3,4-dihydroxybenzoate
-
-
3,4-dihydroxybenzoate
-
competitive inhibition at 1 mM
3,5-Dihydroxybenzoate
-
-
3,5-Dihydroxybenzoate
-
non-competitive inhibition at 1 mM
Orotate
-
-
Orotate
-
competitive to dihydroorotate in ferricyanide reduction assay
Orotate
-
competitive product inhibition
Orotate
-
competitive, with ferricyanide as electron acceptor
Orotate
competitively inhibits all three DHOD enzymes to a comparable level
additional information
-
inhibitor virtual screening, overview
-
additional information
-
markable sensitivity to sulfhydryl inhibitors
-
additional information
-
visible light is inactivating
-
additional information
brequinar and DPC-AE661100 have no effect, even at a concentration of 1 mM
-
additional information
-
brequinar and DPC-AE661100 have no effect, even at a concentration of 1 mM
-
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0.000032 - 0.05
1-(4-Chloro-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 3-(4-methyl-benzylamide) 5-phenylamide
0.000091 - 0.05
1-(4-Chloro-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 3-benzylamide 5-(isobutyl-amide)
0.000006 - 0.05
1-(4-Chloro-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 3-benzylamide 5-[(4-carbamoyl-phenyl)-amide]
0.000004 - 0.05
1-(4-Chloro-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 5-phenylamide 3-[(pyridin-3-ylmethyl)-amide]
0.000008 - 0.05
1-(4-Chloro-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 5-[(4-piperidin-1-yl-phenyl)-amide] 3-[(pyridin-3-ylmethyl)-amide]
0.000138 - 0.05
1-(4-Methoxy-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 3-(isobutyl-amide) 5-[[4-(pyrrolidine-1-carbonyl)-phenyl]-amide]
0.0024 - 0.05
1-(4-Methoxy-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 3-benzhydryl-amide 5-benzylamide
0.000026 - 0.05
1-(4-Methoxy-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 3-benzylamide 5-[[4-(pyrrolidine-1-carbonyl)-phenyl]-amide]
0.0015 - 0.05
1-(4-Methoxy-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 5-benzylamide 3-[[4-(pyrrolidine-1-carbonyl)-phenyl]-amide]
0.000012 - 0.05
1-(4-Methoxy-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 5-phenylamide 3-[(pyridin-3-ylmethyl)-amide]
0.000331 - 0.05
1-(4-Methoxy-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 5-[[4-(pyrrolidine-1-carbonyl)-phenyl]-amide] 3-[(tetrahydro-furan-2-yl)-amide]
0.000004 - 0.05
N3-benzyl-1-(4-chlorophenyl)-N5-phenyl-1H-pyrazole-3,5-dicarboxamide
additional information
additional information
-
Ki-values are 0.0353 and 0.0103 mg per ml for methanol extract of Fucus evanescens and Pelvetia babingtonii, resp.
-
0.000032
1-(4-Chloro-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 3-(4-methyl-benzylamide) 5-phenylamide
-
-
0.05
1-(4-Chloro-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 3-(4-methyl-benzylamide) 5-phenylamide
-
above
0.000091
1-(4-Chloro-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 3-benzylamide 5-(isobutyl-amide)
-
-
0.05
1-(4-Chloro-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 3-benzylamide 5-(isobutyl-amide)
-
above
0.000006
1-(4-Chloro-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 3-benzylamide 5-[(4-carbamoyl-phenyl)-amide]
-
-
0.05
1-(4-Chloro-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 3-benzylamide 5-[(4-carbamoyl-phenyl)-amide]
-
above
0.000004
1-(4-Chloro-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 5-phenylamide 3-[(pyridin-3-ylmethyl)-amide]
-
-
0.05
1-(4-Chloro-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 5-phenylamide 3-[(pyridin-3-ylmethyl)-amide]
-
above
0.000008
1-(4-Chloro-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 5-[(4-piperidin-1-yl-phenyl)-amide] 3-[(pyridin-3-ylmethyl)-amide]
-
-
0.05
1-(4-Chloro-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 5-[(4-piperidin-1-yl-phenyl)-amide] 3-[(pyridin-3-ylmethyl)-amide]
-
above
0.000138
1-(4-Methoxy-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 3-(isobutyl-amide) 5-[[4-(pyrrolidine-1-carbonyl)-phenyl]-amide]
-
-
0.05
1-(4-Methoxy-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 3-(isobutyl-amide) 5-[[4-(pyrrolidine-1-carbonyl)-phenyl]-amide]
-
above
0.0024
1-(4-Methoxy-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 3-benzhydryl-amide 5-benzylamide
-
-
0.05
1-(4-Methoxy-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 3-benzhydryl-amide 5-benzylamide
-
above
0.000026
1-(4-Methoxy-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 3-benzylamide 5-[[4-(pyrrolidine-1-carbonyl)-phenyl]-amide]
-
-
0.05
1-(4-Methoxy-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 3-benzylamide 5-[[4-(pyrrolidine-1-carbonyl)-phenyl]-amide]
-
above
0.0015
1-(4-Methoxy-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 5-benzylamide 3-[[4-(pyrrolidine-1-carbonyl)-phenyl]-amide]
-
-
0.05
1-(4-Methoxy-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 5-benzylamide 3-[[4-(pyrrolidine-1-carbonyl)-phenyl]-amide]
-
above
0.000012
1-(4-Methoxy-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 5-phenylamide 3-[(pyridin-3-ylmethyl)-amide]
-
-
0.05
1-(4-Methoxy-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 5-phenylamide 3-[(pyridin-3-ylmethyl)-amide]
-
above
0.000331
1-(4-Methoxy-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 5-[[4-(pyrrolidine-1-carbonyl)-phenyl]-amide] 3-[(tetrahydro-furan-2-yl)-amide]
-
-
0.05
1-(4-Methoxy-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 5-[[4-(pyrrolidine-1-carbonyl)-phenyl]-amide] 3-[(tetrahydro-furan-2-yl)-amide]
-
above
0.000004
N3-benzyl-1-(4-chlorophenyl)-N5-phenyl-1H-pyrazole-3,5-dicarboxamide
-
-
0.05
N3-benzyl-1-(4-chlorophenyl)-N5-phenyl-1H-pyrazole-3,5-dicarboxamide
-
above
0.0045
Orotate
-
pH 9.0, 37°C
0.0156
Orotate
-
versus fumarate, pH 7.5, 25°C
0.0156
Orotate
inhibition of DHOD2 at 25°C, in the presence of 1 mM fumarate
0.0205
Orotate
-
versus (S)-dihydroorotate, pH 7.5, 25°C
0.0205
Orotate
inhibition of DHOD2 at 25°C, in the presence of 1 mM dihydroorotate
0.0237
Orotate
-
pH 8.5, 70°C
0.0424
Orotate
37°C, pH 7.0, versus dihydroorotate
0.0424
Orotate
inhibition of DHOD3 at 37°C, in the presence of 1 mM dihydroorotate
0.049
Orotate
37°C, pH 7.0, versus fumarate
0.049
Orotate
inhibition of DHOD3 at 37°C, in the presence of 1 mM fumarate
0.0573
Orotate
37°C, pH 7.0, versus dihydroorotate
0.0573
Orotate
inhibition of DHOD1 at 37°C, in the presence of 1 mM dihydroorotate
0.0622
Orotate
37°C, pH 7.0, versus fumarate
0.0622
Orotate
inhibition of DHOD1 at 37°C, in the presence of 1 mM fumarate
0.0714
Orotate
37°C, pH 7.0, versus dihydroorotate
0.0714
Orotate
inhibition of DHOD2 at 37°C, in the presence of 1 mM dihydroorotate
0.0773
Orotate
37°C, pH 7.0, versus fumarate
0.0773
Orotate
inhibition of DHOD2 at 37°C, in the presence of 1 mM fumarate
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0.0011
-
cytosolic fraction, native enzyme
0.06
-
using crotonate as electron acceptor
0.09
-
pH 8.0, 25°C, mutant N67A, substrate O2
0.11
-
pH 8.0, 25°C, mutant N67A, substrate dichlorophenolindophenol
0.14
-
pH 8.0, 25°C, mutant N193A, substrate fumarate
0.17
-
pH 8.0, 25°C, mutant N193A, substrate O2
0.3
-
pH 8.0, 25°C, mutant N67A, substrate fumarate
0.47
-
pH 8.0, 25°C, mutant P56A, substrate dichlorophenolindophenol
0.48
-
pH 8.0, 25°C, mutant P56A, substrate fumarate
0.75
-
pH 8.0, 25°C, mutant N127A, substrate dichlorophenolindophenol
0.94
-
using mesaconate as electron acceptor
0.987
-
using 0.02 mM ubiquinone-1 as acceptor, at 25°C
1
-
pH 8.0, 25°C, mutant N127A, substrate O2
1.2
-
pH 8.0, 25°C, mutant N127A, substrate fumarate
1.4
-
at 37°C, 5 mM sodium diphosphate buffer
1.6
-
pH 8.0, 25°C, mutant K136E, substrate O2
1.61
-
purified native enzyme, electron acceptor fumarate
1.8
-
pH 8.0, 25°C, mutant S129A, substrate O2
1.81
-
using O2 as electron acceptor
1.9
-
pH 8.0, 25°C, mutant K213E, substrate O2
11.7
-
pH 8.0, 25°C, mutant S129A, substrate dichlorophenolindophenol
117.5
-
with ferricyanide as acceptor
13
-
pH 8.0, 25°C, mutant K136E, substrate dichlorophenolindophenol
13.6
-
pH 8.0, 25°C, wild-type, substrate dichlorophenolindophenol
15.8
-
pH 8.0, 25°C, wild-type, substrate fumarate
151000
-
cosubstrate fumarate, pH 7.5
18.1
-
pH 8.0, 25°C, mutant K136E, substrate fumarate
19
-
pH 8.0, 25°C, mutant R50E, substrate fumarate
2
-
pH 8.0, 25°C, wild-type, substrate O2
2.3
-
pH 8.0, 25°C, mutant P131A, substrate O2
2.4
-
pH 8.0, 25°C, mutant K213E, substrate dichlorophenolindophenol
2.8
-
pH 8.0, 25°C, mutant S129A, substrate fumarate
2.95
-
purified recombinant enzyme, electron acceptor fumarate
27
-
pH 8.0, 25°C, mutant R57A, substrate fumarate
3.318
-
using 0.5 mM fumarate as acceptor, at 25°C
3.7
-
pH 8.0, 25°C, mutant P131A, substrate fumarate
4
-
pH 8.0, 25°C, mutant P131A, substrate dichlorophenolindophenol
5.1
-
using fumarate as electron acceptor
65.7
-
pH 8.0, 25°C, mutant R57A, substrate dichlorophenolindophenol
0.15
-
pH 8.0, 25°C, mutant N193A, substrate dichlorophenolindophenol
0.15
-
pH 8.0, 25°C, mutant P56A, substrate O2
3.3
-
pH 8.0, 25°C, mutant R50E, substrate O2
3.3
-
pH 8.0, 25°C, mutant R57A, substrate O2
7.2
-
pH 8.0, 25°C, mutant K213E, substrate fumarate
7.2
-
pH 8.0, 25°C, mutant R50E, substrate dichlorophenolindophenol
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Taylor, W.H.; Taylor, M.L.; Eames, D.F.
Two functionally different dihydroorotic dehydrogenases in bacteria
J. Bacteriol.
91
2251-2256
1966
Pseudomonas sp.
brenda
Taylor, W.H.; Taylor, C.D.; Taylor, M.L.
Biosynthetic dihydroorotate dehydrogenase from Lactobacillus bulgaricus: partial characterization of the enzyme
J. Bacteriol.
119
98-105
1974
Lactobacillus delbrueckii subsp. bulgaricus
brenda
Pascal, R.A.; Le Trang, N.; Cerami, A.; Walsh, C.
Purification and properties of dihydroorotate oxidase from Crithidia fasciculata and Trypanosoma brucei
Biochemistry
22
171-178
1983
Crithidia fasciculata, Trypanosoma brucei brucei, Trypanosoma brucei brucei EATRO 110
brenda
Taylor, M.L.; Taylor, D.F.; Eames, W.H.
Biosynthetic dihydroorotate dehydrogenase from Lactobacillus bulgaricus
J. Bacteriol.
105
1015-1027
1971
Lactobacillus delbrueckii subsp. bulgaricus
brenda
Pascal, R.A.; Walsh, C.T.
Mechanistic studies with deuterated dihydroorotates on the dihydroorotate oxidase from Crithidia fasciculata
Biochemistry
23
2745-2752
1984
Crithidia fasciculata
brenda
Bjornberg, O.; Jordan, D.B.; Palfey, B.A.; Jensen, K.F.
Dihydrooxonate is a substrate of dihydroorotate dehydrogenase (DHOD) providing evidence for involvement of cysteine and serine residues in base catalysis
Arch. Biochem. Biophys.
391
286-294
2001
Escherichia coli, Lactococcus lactis
brenda
Rowland, P.; Bjornberg, O.; Nielsen, F.S.; Jensen, K.F.; Larsen, S.
The crystal structure of Lactococcus lactis dihydroorotate dehydrogenase A complexed with the enzyme reaction product throws light on its enzymic function
Protein Sci.
7
1269-1279
1998
Lactococcus lactis
brenda
Nielsen, F.S.; Rowland, P.; Larsen, S.; Jensen, K.F.
Purification and characterization of dihydroorotate dehydrogenase A from Lactococcus lactis, crystallization and preliminary X-ray diffraction studies of the enzyme
Protein Sci.
5
852-856
1996
Lactococcus lactis
brenda
Jordan, D.B.; Bisaha, J.J.; Picollelli, M.A.
Catalytic properties of dihydroorotate dehydrogenase from Saccharomyces cerevisiae: studies on pH, alternate substrates, and inhibitors
Arch. Biochem. Biophys.
378
84-92
2000
Saccharomyces cerevisiae
brenda
Forman, H.J.; Kennedy, J.
Purification of the primary dihydroorotate dehydrogenase (oxidase) from rat liver mitochondria
Prep. Biochem.
7
345-355
1977
Rattus norvegicus
brenda
Sierra Pagan, M.L.; Zimmermann, B.H.
Cloning and expression of the dihydroorotate dehydrogenase from Toxoplasma gondii
Biochim. Biophys. Acta
1637
178-181
2003
Toxoplasma gondii (Q8MXD1)
brenda
Sorensen, G.; Dandanell, G.
A new type of dihydroorotate dehydrogenase, type 1S, from the thermoacidophilic archaeon Sulfolobus solfataricus
Extremophiles
6
245-251
2002
Saccharolobus solfataricus
brenda
Norager, S.; Arent, S.; Bjornberg, O.; Ottosen, M.; Lo Leggio, L.; Jensen, K.F.; Larsen, S.
Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function
J. Biol. Chem.
278
28812-28822
2003
Lactococcus lactis
brenda
Baldwin, J.; Michnoff, C.H.; Malmquist, N.A.; White, J.; Roth, M.G.; Rathod, P.K.; Phillips, M.A.
High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase
J. Biol. Chem.
280
21847-21853
2005
Plasmodium falciparum
brenda
Haque, T.S.; Tadesse, S.; Marcinkeviciene, J.; Rogers, M.J.; Sizemore, C.; Kopcho, L.M.; Amsler, K.; Ecret, L.D.; Zhan, D.L.; Hobbs, F.; Slee, A.; Trainor, G.L.; Stern, A.M.; Copeland, R.A.; Combs, A.P.
Parallel synthesis of potent, pyrazole-based inhibitors of Helicobacter pylori dihydroorotate dehydrogenase
J. Med. Chem.
45
4669-4678
2002
Helicobacter pylori
brenda
Takashima, E.; Inaoka, D.K.; Osanai, A.; Nara, T.; Odaka, M.; Aoki, T.; Inaka, K.; Harada, S.; Kita, K.
Characterization of the dihydroorotate dehydrogenase as a soluble fumarate reductase in Trypanosoma cruzi
Mol. Biochem. Parasitol.
122
189-200
2002
Trypanosoma cruzi
brenda
Loffler, M.; Klein, A.; Hayek-Ouassini, M.; Knecht, W.; Konrad, L.
Dihydroorotate dehydrogenase mRNA and protein expression analysis in normal and drug-resistant cells
Nucleosides Nucleotides Nucleic Acids
23
1281-1285
2004
Mus musculus
brenda
Nara, T.; Kamei, Y.; Tsubouchi, A.; Annoura, T.; Hirota, K.; Iizumi, K.; Dohmoto, Y.; Ono, T.; Aoki, T.
Inhibitory action of marine algae extracts on the Trypanosoma cruzi dihydroorotate dehydrogenase activity and on the protozoan growth in mammalian cells
Parasitol. Int.
54
59-64
2005
Trypanosoma cruzi
brenda
Ottosen, M.B.; Bjornberg, O.; Norager, S.; Larsen, S.; Palfey, B.A.; Jensen, K.F.
The dimeric dihydroorotate dehydrogenase A from Lactococcus lactis dissociates reversibly into inactive monomers
Protein Sci.
11
2575-2583
2002
Lactococcus lactis
brenda
Norager, S.; Jensen, K.F.; Bjornberg, O.; Larsen, S.
E. coli dihydroorotate dehydrogenase reveals structural and functional distinctions between different classes of dihydroorotate dehydrogenases
Structure
10
1211-1223
2002
Escherichia coli
brenda
Vorisek, J.; Technikova, Z.; Schwippel, J.; Benoist, P.
Enzymatic activities of Ura2 and Ura1 proteins (aspartate carbamoyltransferase and dihydro-orotate dehydrogenase) are present in both isolated membranes and cytoplasm of Saccharomyces cerevisiae
Yeast
19
449-457
2002
Saccharomyces cerevisiae
brenda
Hurt, D.E.; Widom, J.; Clardy, J.
Structure of Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor
Acta Crystallogr. Sect. D
62
312-323
2006
Plasmodium falciparum (Q08210), Plasmodium falciparum
brenda
Inaoka, D.K.; Takashima, E.; Osanai, A.; Shimizu, H.; Nara, T.; Aoki, T.; Harada, S.; Kita, K.
Expression, purification and crystallization of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with orotate
Acta Crystallogr. Sect. F
61
875-878
2005
Trypanosoma cruzi, Trypanosoma cruzi (Q4D3W2)
brenda
Cordeiro, A.T.; Feliciano, P.R.; Nonato, M.C.
Crystallization and preliminary X-ray diffraction analysis of Leishmania major dihydroorotate dehydrogenase
Acta Crystallogr. Sect. F
62
1049-1051
2006
Leishmania major
brenda
Annoura, T.; Nara, T.; Makiuchi, T.; Hashimoto, T.; Aoki, T.
The origin of dihydroorotate dehydrogenase genes of kinetoplastids, with special reference to their biological significance and adaptation to anaerobic, parasitic conditions
J. Mol. Evol.
60
113-127
2005
Euglena gracilis, Euglena gracilis (Q75XR0), Trypanosoma cruzi, Neobodo saliens, Neobodo saliens (Q6F4D1), Parabodo caudatus (Q6F4D0)
brenda
Sariego, I.; Annoura, T.; Nara, T.; Hashimoto, M.; Tsubouchi, A.; Iizumi, K.; Makiuchi, T.; Murata, E.; Kita, K.; Aoki, T.
Genetic diversity and kinetic properties of Trypanosoma cruzi dihydroorotate dehydrogenase isoforms
Parasitol. Int.
55
11-16
2006
Trypanosoma cruzi, Trypanosoma cruzi (Q4D3W2), Trypanosoma cruzi (Q4DEJ0), Trypanosoma cruzi (Q4DGV2)
brenda
Shi, J.; Dertouzos, J.; Gafni, A.; Steel, D.; Palfey, B.A.
Single-molecule kinetics reveals signatures of half-sites reactivity in dihydroorotate dehydrogenase A catalysis
Proc. Natl. Acad. Sci. USA
103
5775-5780
2006
Lactococcus lactis
brenda
Feliciano, P.R.; Cordeiro, A.T.; Costa-Filho, A.J.; Nonato, M.C.
Cloning, expression, purification, and characterization of Leishmania major dihydroorotate dehydrogenase
Protein Expr. Purif.
48
98-103
2006
Leishmania major
brenda
Annoura, T.; Sariego, I.; Nara, T.; Makiuchi, T.; Fujimura, T.; Taka, H.; Mineki, R.; Murayama, K.; Aoki, T.
Dihydroorotate dehydrogenase arises from novel fused gene product with aspartate carbamoyltransferase in Bodo saliens
Biochem. Biophys. Res. Commun.
358
253-258
2007
Neobodo saliens
brenda
Pinheiro, M.P.; Iulek, J.; Cristina Nonato, M.
Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase from Y strain
Biochem. Biophys. Res. Commun.
369
812-817
2008
Trypanosoma cruzi, Trypanosoma cruzi Y
brenda
Fagan, R.L.; Jensen, K.F.; Bjoernberg, O.; Palfey, B.A.
Mechanism of flavin reduction in the class 1A dihydroorotate dehydrogenase from Lactococcus lactis
Biochemistry
46
4028-4036
2007
Lactococcus lactis
brenda
Wolfe, A.E.; Thymark, M.; Gattis, S.G.; Fagan, R.L.; Hu, Y.C.; Johansson, E.; Arent, S.; Larsen, S.; Palfey, B.A.
Interaction of benzoate pyrimidine analogues with class 1A dihydroorotate dehydrogenase from Lactococcus lactis
Biochemistry
46
5741-5753
2007
Lactococcus lactis
brenda
Zameitat, E.; Pierik, A.J.; Zocher, K.; Loeffler, M.
Dihydroorotate dehydrogenase from Saccharomyces cerevisiae: spectroscopic investigations with the recombinant enzyme throw light on catalytic properties and metabolism of fumarate analogues
FEMS Yeast Res.
7
897-904
2007
Saccharomyces cerevisiae
brenda
Arakaki, T.L.; Buckner, F.S.; Gillespie, J.R.; Malmquist, N.A.; Phillips, M.A.; Kalyuzhniy, O.; Luft, J.R.; Detitta, G.T.; Verlinde, C.L.; Van Voorhis, W.C.; Hol, W.G.; Merritt, E.A.
Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies
Mol. Microbiol.
68
37-50
2008
Trypanosoma brucei
brenda
Inaoka, D.; Sakamoto, K.; Shimizu, H.; Shiba, T.; Kurisu, G.; Nara, T.; Aoki, T.; Kita, K.; Harada, S.
Structures of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with substrates and products: Atomic resolution insights into mechanisms of dihydroorotate oxidation and fumarate reduction
Biochemistry
47
10881-10891
2008
Trypanosoma cruzi (Q4D3W2), Trypanosoma cruzi
brenda
Pawlik, A.; Herczynska, M.; Kurzawski, M.; Safranow, K.; Dziedziejko, V.; Drozdzik, M.
The effect of exon (19C>A) dihydroorotate dehydrogenase gene polymorphism on rheumatoid arthritis treatment with leflunomide
Pharmacogenomics
10
303-309
2009
Homo sapiens
brenda
Cheleski, J.; Wiggers, H.J.; Citadini, A.P.; da Costa Filho, A.J.; Nonato, M.C.; Montanari, C.A.
Kinetic mechanism and catalysis of Trypanosoma cruzi dihydroorotate dehydrogenase enzyme evaluated by isothermal titration calorimetry
Anal. Biochem.
399
13-22
2010
Trypanosoma cruzi
brenda
Cheleski, J.; Rocha, J.R.; Pinheiro, M.P.; Wiggers, H.J.; da Silva, A.B.; Nonato, M.C.; Montanari, C.A.
Novel insights for dihydroorotate dehydrogenase class 1A inhibitors discovery
Eur. J. Med. Chem.
45
5899-5909
2010
Trypanosoma cruzi (Q4D3W2), Trypanosoma cruzi
brenda
Liu, Y.; Gao, Z.Q.; Liu, C.P.; Xu, J.H.; Li, L.F.; Ji, C.N.; Su, X.D.; Dong, Y.H.
Structure of the putative dihydroorotate dehydrogenase from Streptococcus mutans
Acta Crystallogr. Sect. F
67
182-187
2011
Streptococcus mutans (Q8DVA1), Streptococcus mutans
brenda
McDonald, C.A.; Palfey, B.A.
Substrate binding and reactivity are not linked: grafting a proton-transfer network into a Class 1A dihydroorotate dehydrogenase
Biochemistry
50
2714-2716
2011
Lactococcus lactis
brenda
Cordeiro, A.T.; Feliciano, P.R.; Pinheiro, M.P.; Nonato, M.C.
Crystal structure of dihydroorotate dehydrogenase from Leishmania major
Biochimie
94
1739-1748
2012
Leishmania major
brenda
Ke, H.; Morrisey, J.M.; Ganesan, S.M.; Painter, H.J.; Mather, M.W.; Vaidya, A.B.
Variation among Plasmodium falciparum strains in their reliance on mitochondrial electron transport chain function
Eukaryot. Cell
10
1053-1061
2011
Saccharomyces cerevisiae
brenda
Ganesan, S.M.; Morrisey, J.M.; Ke, H.; Painter, H.J.; Laroiya, K.; Phillips, M.A.; Rathod, P.K.; Mather, M.W.; Vaidya, A.B.
Yeast dihydroorotate dehydrogenase as a new selectable marker for Plasmodium falciparum transfection
Mol. Biochem. Parasitol.
177
29-34
2011
Saccharomyces cerevisiae
brenda
Reis, R.A.; Ferreira, P.; Medina, M.; Nonato, M.C.
The mechanistic study of Leishmania major dihydro-orotate dehydrogenase based on steady- and pre-steady-state kinetic analysis
Biochem. J.
473
651-660
2016
Leishmania major
brenda
Silva, N.d.e..F.; Lameira, J.; Alves, C.N.; Marti, S.
Computational study of the mechanism of half-reactions in class 1A dihydroorotate dehydrogenase from Trypanosoma cruzi
Phys. Chem. Chem. Phys.
15
18863-18871
2013
Trypanosoma cruzi (Q4D3W2), Trypanosoma cruzi, Trypanosoma cruzi CL Brener (Q4D3W2)
brenda