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Literature summary for 3.1.3.48 extracted from

  • Cuevas, I.C.; Rohloff, P.; Sanchez, D.O.; Docampo, R.
    Characterization of farnesylated protein tyrosine phosphatase TcPRL-1 from Trypanosoma cruzi (2005), Eukaryot. Cell, 4, 1550-1561.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information mutantv enzyme lacking C-terminal CAAX motif localizes to the cytoplasm Trypanosoma cruzi

Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibitory: pentamidine, okadaic acid, sodium fluoride up to 5 mM, EDTA up to 10 mM Trypanosoma cruzi
orthovanadate 50% inhibition at 0.075 mM Trypanosoma cruzi

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0008
-
4-nitrophenyl phosphate pH 7.5 Trypanosoma cruzi

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
21000
-
x * 21000, SDS-PAGE Trypanosoma cruzi

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi Q6JHV2 isoform PRL-1
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information enzyme is farnesylated Trypanosoma cruzi

Source Tissue

Source Tissue Comment Organism Textmining
amastigote within the endocytic pathway Trypanosoma cruzi
-
epimastigote within the endocytic pathway Trypanosoma cruzi
-
trypomastigote within the endocytic pathway Trypanosoma cruzi
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl phosphate + H2O
-
Trypanosoma cruzi 4-nitrophenol + phosphate
-
?

Subunits

Subunits Comment Organism
? x * 21000, SDS-PAGE Trypanosoma cruzi

Synonyms

Synonyms Comment Organism
PRL-1
-
Trypanosoma cruzi

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5 8
-
Trypanosoma cruzi