Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.5.1.59 extracted from

  • Yokoyama, K.; Gillespie, J.R.; Van Voorhis, W.C.; Buckner, F.S.; Gelb, M.H.
    Protein geranylgeranyltransferase-I of Trypanosoma cruzi (2008), Mol. Biochem. Parasitol., 157, 32-43.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Sf9 insect cells Trypanosoma cruzi

Inhibitors

Inhibitors Comment Organism Structure
GGTI-2151 16.3% inhibition at 50 nM Trypanosoma cruzi
GGTI-2154 14.7% inhibition at 50 nM Trypanosoma cruzi
GGTI-DU40 16.3% inhibition at 50 nM Trypanosoma cruzi
additional information the mammalian PGGT-I inhibitors GGTI-297 and FTI-276 have little effect on Trypanosoma cruzi PGGT-I activity Trypanosoma cruzi

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Trypanosoma cruzi 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
42000
-
beta subunit of PGGT-I, SDS-PAGE Trypanosoma cruzi

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi A7Y1U8
-
-

Purification (Commentary)

Purification (Comment) Organism
Q-Sepharose HP column chromatography and Superdex 200 gel filtration Trypanosoma cruzi

Source Tissue

Source Tissue Comment Organism Textmining
amastigote
-
Trypanosoma cruzi
-
epimastigote
-
Trypanosoma cruzi
-
trypomastigote
-
Trypanosoma cruzi
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
geranylgeranyl diphosphate + protein-cysteine
-
Trypanosoma cruzi S-geranylgeranyl-protein + diphosphate
-
?
additional information most of the CaaX-containing proteins with X= Leu and X= Met are good substrates of PGGT-I, whereas those with X= Phe are poor substrates for PGGT-I, Trypanosma cruzi j2 DNAJ protein, Trypanosoma cruzi PRL-1 protein tyrosine phosphatase, CHFM (a small GTPase like protein), and Trypanosoma cruzi Rho1 GTPase are no substrates for PGGT-I Trypanosoma cruzi ?
-
?

Subunits

Subunits Comment Organism
dimer
-
Trypanosoma cruzi

Synonyms

Synonyms Comment Organism
PGGT-I
-
Trypanosoma cruzi
protein geranylgeranyltransferase-I
-
Trypanosoma cruzi