Cloned (Comment) | Organism |
---|---|
expressed in Sf9 insect cells | Trypanosoma cruzi |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
GGTI-2151 | 16.3% inhibition at 50 nM | Trypanosoma cruzi | |
GGTI-2154 | 14.7% inhibition at 50 nM | Trypanosoma cruzi | |
GGTI-DU40 | 16.3% inhibition at 50 nM | Trypanosoma cruzi | |
additional information | the mammalian PGGT-I inhibitors GGTI-297 and FTI-276 have little effect on Trypanosoma cruzi PGGT-I activity | Trypanosoma cruzi |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Trypanosoma cruzi | 5829 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
42000 | - |
beta subunit of PGGT-I, SDS-PAGE | Trypanosoma cruzi |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma cruzi | A7Y1U8 | - |
- |
Purification (Comment) | Organism |
---|---|
Q-Sepharose HP column chromatography and Superdex 200 gel filtration | Trypanosoma cruzi |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
amastigote | - |
Trypanosoma cruzi | - |
epimastigote | - |
Trypanosoma cruzi | - |
trypomastigote | - |
Trypanosoma cruzi | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
geranylgeranyl diphosphate + protein-cysteine | - |
Trypanosoma cruzi | S-geranylgeranyl-protein + diphosphate | - |
? | |
additional information | most of the CaaX-containing proteins with X= Leu and X= Met are good substrates of PGGT-I, whereas those with X= Phe are poor substrates for PGGT-I, Trypanosma cruzi j2 DNAJ protein, Trypanosoma cruzi PRL-1 protein tyrosine phosphatase, CHFM (a small GTPase like protein), and Trypanosoma cruzi Rho1 GTPase are no substrates for PGGT-I | Trypanosoma cruzi | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | - |
Trypanosoma cruzi |
Synonyms | Comment | Organism |
---|---|---|
PGGT-I | - |
Trypanosoma cruzi |
protein geranylgeranyltransferase-I | - |
Trypanosoma cruzi |