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(+)-camphorquinone + NADPH
? + NADP+
(-)-camphorquinone + NADPH
? + NADP+
-
relative activity 2%
-
-
?
(2E)-4-hydroxynon-2-enal + NADPH
(2E)-non-2-ene-1,4-diol + NADP+
-
30% of activity with cinnamaldehyde
-
-
r
(2E)-hex-2-enal + NADPH + H+
(2E)-2-hexen-1-ol + NADP+
-
-
-
-
r
(2E,4E)-hexa-2,4-dienal + NAD(P)H + H+
(2E,4E)-6-hydroxyhexa-2,4-dienal + NAD(P)+
-
-
-
-
?
(2R,3R)-2,3-butanediol + NADP+
(R)-2-acetoin + NADPH + H+
the enzyme shows higher oxidation activities on the (2R,3R)-(-)-2,3-butanediol and meso-2,3-butanediol than on the (2S,3S)-(+)-2,3-butanediol, indicating that the enzyme predominantly oxidizes the R-hydroxyl group of 2,3-butanediol and minorly functions on the S-hydroxyl group. When meso-2,3-butanediol is oxidized, (S)-2-acetoin is the predominant product, with an enantiomeric excess (ee) of 88%, while oxidation of (2R,3R)-2,3-butanediol results in the production of (R)-2-acetoin with higher stereoselectivity (94% ee)
-
-
r
(2S)-methyl-1-butanol + NADP+
(2S)-methylbutanal + NADPH
-
39% activity compared to cinnamyl alcohol
-
-
r
(2S,3S)-2,3-butanediol + NADP+
(S)-2-acetoin + NADPH + H+
the enzyme shows higher oxidation activities on the (2R,3R)-(-)-2,3-butanediol and meso-2,3-butanediol than on the (2S,3S)-(+)-2,3-butanediol, indicating that the enzyme predominantly oxidizes the R-hydroxyl group of 2,3-butanediol and minorly functions on the S-hydroxyl group. When meso-2,3-butanediol is oxidized, (S)-2-acetoin is the predominant product, with an enantiomeric excess (ee) of 88%, while oxidation of meso-2,3-butanediol results in the production of (R)-2-acetoin with higher stereoselectivity (94% ee)
-
-
r
(4-hydroxy-3-[3-methyl-3-butene-1-ynyl]benzaldehyde) + NADPH + H+
(4-hydroxy-3-[3-methyl-3-butene-1-ynyl]benzyl alcohol) + NADP+
-
eutypine, a toxin produced by Eutypa lata, the causal agent of Eutypa dieback in the grapevine Vitis vinifera
eutypinol, non-toxic metabolite
ir
(R)-1-phenyl-2-propanol + NADP+
phenylacetone + NADPH + H+
-
-
-
-
?
(R)-2-butanol + NADP+
2-butanone + NADPH + H+
the enzyme shows a slight preference for the (S)-2-butanol over (R)-2-butanol
-
-
?
(S)-1-phenyl-2-propanol + NADP+
phenylacetone + NADPH + H+
-
-
-
-
r
(S)-2-butanol + NADP+
2-butanone + NADPH + H+
the enzyme shows a slight preference for the (S)-2-butanol over (R)-2-butanol
-
-
?
(S)-2-butanol + NADP+
butanone + NADPH + H+
196% of the activity with 2-propanol, 2fold preference for (S)-2-butanol over (RS)-2-butanol
-
-
?
1,2-butanediol + NADP+
? + NADPH + H+
25.6% of the activity compared to the substrate 2-butanol
-
-
?
1,2-cyclohexanedione + NADPH
? + NADP+
-
-
-
-
?
1,2-propanediol + NADP+
? + NADPH
-
-
-
-
?
1,3-butanediol + NADP+
? + NADPH
-
-
-
-
?
1,3-butanediol + NADP+
? + NADPH + H+
35.4% of the activity compared to the substrate 2-butanol
-
-
?
1,3-propanediol + 2 NADP+ + H2O
propanedial + 2 NADPH + 2 H+
-
-
-
r
1,3-propanediol + NADP+
?
-
-
-
-
?
1,3-propanediol + NADP+
? + NADPH
1,4-butanediol + NADP+
4-hydroxybutanal + NADPH + H+
1,4-butanediol + NADP+
?
-
-
-
-
?
1,5-pentanediol + NADP+
5-hydroxypentanal + NADPH + H+
-
-
-
-
r
1,5-pentanediol + NADP+
?
-
-
-
-
?
1,5-pentanediol + NADP+
? + NADPH + H+
-
-
-
?
1,6-hexanediol + NADP+
6-hydroxyhexanal + NADPH + H+
-
-
-
-
r
1-(3,4,5-trifluorophenyl)ethan-1-one + NADPH + H+
(1S)-1-(3,4,5-trifluorophenyl)ethan-1-ol + NADP+
-
-
90.8% conversion, 99% ee
-
r
1-(3-chlorophenyl)ethan-1-one + NADPH + H+
(1S)-1-(3-chlorophenyl)ethan-1-ol + NADP+
-
-
99.5% conversion, 99% ee
-
r
1-(4-fluorophenyl)ethan-1-one + NADPH + H+
(1S)-1-(4-fluorophenyl)ethan-1-ol + NADP+
-
-
99.5% conversion, 99% ee
-
r
1-(4-methylphenyl)ethan-1-one + NADPH + H+
(1S)-1-(4-methylphenyl)ethan-1-ol + NADP+
-
-
99.5% conversion, 99% ee
-
r
1-butanol + NADP+
butanal + NADPH
1-butanol + NADP+
butanal + NADPH + H+
1-butanol + NADP+
butyraldehyde + NADPH + H+
1-heptanol + NADP+
heptanal + NADPH + H+
1-hexanol + NADP+
hexanal + NADPH
1-hexanol + NADP+
hexanal + NADPH + H+
1-octanol + NADP+
octanal + NADPH
1-octanol + NADP+
octanal + NADPH + H+
1-pentanol + NADP+
n-pentanal + NADPH
1-pentanol + NADP+
n-pentanal + NADPH + H+
-
-
-
-
?
1-pentanol + NADP+
pentanal + NADPH
1-pentanol + NADP+
pentanal + NADPH + H+
1-phenyl-2-butanone + NADPH + H+
(S)-1-phenyl-2-butanol + NADP+
-
-
-
-
?
1-phenylethan-1-one + NADPH + H+
(1S)-1-phenylethan-1-ol + NADP+
-
-
99.5% conversion, 99% ee
-
r
1-propanol + NADP+
?
-
-
-
-
?
1-propanol + NADP+
propanal + NADPH
-
16% activity compared to cinnamyl alcohol
-
-
r
1-propanol + NADP+
propanal + NADPH + H+
13-cis-retinal + NADPH
13-cis-retinol + NADP+
-
-
-
-
?
2,2,2-trifluoro-1-phenylethanone + NADPH + H+
(1S)-2,2,2-trifluoro-1-phenylethanol + NADP+
-
-
99% conversion, 99% enantiomeric excess
-
?
2,2-difluoro-1-phenylethanone + NADPH + H+
(1S)-2,2-difluoro-1-phenylethanol + NADP+
-
-
99% conversion, 99% enantiomeric excess
-
?
2,3-butanediol + NADP+
acetoin + NADPH + H+
-
-
-
-
r
2,3-pentanedione + NADPH + H+
? + NADP+
2,4-hexadienal + NADPH
2,4-hexadien-1-ol + NADP+
-
-
-
-
?
2,4-pentanediol + NADP+
? + NADPH + H+
9.2% of the activity compared to the substrate 2-butanol
-
-
?
2,5-hexanedione + NADP+
(2S,5S)-hexanediol + NADPH + H+
-
-
-
-
r
2-(S)-methylbutanol + NADP+
(2S)-2-methylbutanal + NADPH
-
7% of activity with cinnamyl alcohol
-
-
r
2-butanol + NADP+
2-butanone + NADPH
-
2% of activity with cinnamyl alcohol
-
-
r
2-butanol + NADP+
2-butanone + NADPH + H+
the enzyme does not possess stereoselectivity on 2-butanol or 2-butanone as substrate
-
-
r
2-butanol + NADP+
butan-2-one + NADPH
2-butanol + NADP+
butanone + NADPH
-
1% activity compared to cinnamyl alcohol
-
-
r
2-butanone + NADP+
2-butanol + NADPH + H+
-
-
-
-
r
2-butanone + NADPH + H+
2-butanol + NADP+
the enzyme does not possess stereoselectivity on 2-butanol or 2-butanone as substrate
-
-
r
2-chloroheptanal + NADPH
2-chloroheptanol + NADP+
-
-
-
-
r
2-decanone + NADPH
2-decanol + NADP+
-
-
-
-
?
2-fluoro-1-(4-chlorophenyl)ethanone + NADPH + H+
(1S)-2-fluoro-1-(4-chlorophenyl)ethanol + NADP+
-
-
99% conversion, 99% enantiomeric excess
-
?
2-fluoro-1-(4-fluorophenyl)ethanone + NADPH + H+
(1S)-2-fluoro-1-(4-fluorophenyl)ethanol + NADP+
-
-
99% conversion, 99% enantiomeric excess
-
?
2-fluoro-1-(4-iodophenyl)ethanone + NADPH + H+
(1S)-2-fluoro-1-(4-iodophenyl)ethanol + NADP+
-
-
99% conversion, 99% enantiomeric excess
-
?
2-fluoro-1-phenylethanone + NADPH + H+
(1S)-2-fluoro-1-phenylethanol + NADP+
-
-
99% conversion, 99% enantiomeric excess
-
?
2-heptanol + NADP+
heptan-2-one + NADPH
-
-
-
-
r
2-hydroxytetrahydrofuran + NADP+
2-oxotetrahydrofuran + NADPH + H+
-
-
-
-
ir
2-methoxybenzaldehyde + NADPH + H+
2-methoxybenzyl alcohol + NADP+
2-methyl-1-propanol + NADP+
2-methylpropanal + NADPH
2-methylbutanal + NADPH
2-methyl-1-butanol + NADP+
2-methylbutanal + NADPH
2-methylbutanol + NADP+
-
-
-
-
r
2-methylbutanol + NADP+
2-methylbutyraldehyde + NADPH + H+
-
24% activity with 1 mM 2-methylbutanol, 22% activity with 10 mM 2-methylbutanol
-
-
r
2-methylbutanol + NADP+
? + NADPH + H+
-
30 mM Tris-HCl (pH 8.0) in the presence of 0.5 mM NADP+, 24% relative activity with 1 mM or 22% relative activity with 10 mM substrate
-
-
?
2-methylpropanal + NADPH
2-methyl-1-propanol + NADP+
2-methylpropanol + NADP+
2-methylpropanal + NADPH
-
1% of activity with cinnamyl alcohol
-
-
r
2-methylundecanal + NADPH
2-methylundecanol + NADP+
-
-
-
-
?
2-pentanol + NADP+
2-pentanone + NADPH + H+
2-pentanol + NADP+
pentan-2-one + NADPH
-
-
-
-
r
2-pentanol + NADP+
pentan-2-one + NADPH + H+
67% of the activity with 2-propanol
-
-
?
2-pentanone + NADP+
2-pentanol + NADPH + H+
-
-
-
-
r
2-pentanone + NADPH + H+
2-pentanol + NADP+
86.2% of the activity compared to the substrate 2-butanone
-
-
r
2-phenylacetaldehyde + NADPH + H+
2-phenylethanol + NADP+
-
-
-
-
r
2-phenylethanol + NADP+
2-phenylacetaldehyde + NADPH + H+
2-phenylethanol + NADP+
phenylacetaldehyde + NADPH
-
23% activity compared to cinnamyl alcohol
-
-
r
2-phenylethanol + NADP+
phenylacetaldehyde + NADPH + H+
2-propanol + NADP+
acetone + NADPH
2-propanol + NADP+
acetone + NADPH + H+
2-propanone + NADP+
2-propanol + NADPH + H+
-
-
-
-
r
2-propen-1-ol + NADP+
acrylaldehyde + NADPH
-
-
-
-
r
3,4-dihydro-1(2H)-naphthalenone + NADPH + H+
1,2,3,4-tetrahydronaphthalen-1-ol + NADP+
3,4-dihydroxyphenylacetaldehyde + NADPH + H+
3,4-dihydroxyphenylethanol + NADP+
-
-
-
-
r
3,4-dihydroxyphenylglycolaldehyde + NADPH
? + NADP+
3-cyanobenzaldehyde + NADPH
3-cyanobenzyl alcohol + NADP+
-
-
-
-
?
3-deoxyglucosone + NADPH
? + NADP+
-
-
-
-
r
3-heptanone + NADPH
3-heptanol + NADP+
-
-
-
-
?
3-hexanol + NADP+
hexan-3-one + NADPH
-
-
-
-
r
3-methyl-1,5-pentanediol + NADP+
?
-
-
-
?
3-methyl-1-butanol + NADP+
3-methylbutanal + NADPH
-
40% activity compared to cinnamyl alcohol
-
-
r
3-methylbutanal + NADPH
3-methyl-1-butanol + NADP+
-
79% activity compared to cinnamaldehyde
-
-
r
3-methylbutanal + NADPH
3-methylbutanol + NADP+
-
-
-
-
r
3-methylbutanal + NADPH + H+
3-methyl-1-butanol + NADP+
-
84% of activity with cinnamaldehyde
-
-
r
3-methylbutanol + NADP+
3-methylbutanal + NADPH
-
15% of activity with cinnamyl alcohol
-
-
r
3-nitrobenzaldehyde + NADH + H+
3-nitrobenzyl alcohol + NAD+
-
-
-
-
r
3-octanone + NADPH
3-octanol + NADP+
-
-
-
-
?
3-pyridinecarboxaldehyde + NADPH
3-pyridinemethanol + NADP+
3-pyridinemethanol + NADP+
3-pyridinecarboxaldehyde + NADPH
-
-
-
-
r
4-benzoylpyridine + ?
?
-
-
-
-
r
4-carboxyacetophenone + NADPH
? + NADP+
-
-
-
-
r
4-carboxyphenylglyoxal + NADPH
? + NADP+
-
-
-
-
r
4-hydroxy-3-methoxybenzyl alcohol + NADP+
4-hydroxy-3-methoxybenzaldehyde + NADPH
-
-
-
-
r
4-hydroxy-3-methoxyphenethylene glycol + NADP+
? + NADPH
-
-
-
-
r
4-hydroxybenzaldehyde + NADPH + H+
4-hydroxybenzyl alcohol + NADP+
-
-
-
-
?
4-hydroxybutyrate + NADP+
4-ketobutyrate + NADPH
-
-
-
-
r
4-methoxybenzaldehyde + NADPH + H+
4-methoxybenzyl alcohol + NADP+
4-methylbenzyl alcohol + NADP+
4-methylbenzaldehyde + NADPH + H+
-
-
-
-
r
4-nitroacetophenone + NADPH
1-(4-nitrophenyl)ethanol + NADP+
-
-
-
-
?
4-nitroacetophenone + NADPH + H+
1-(4-nitrophenyl)ethanol + NADP+
-
-
-
-
r
4-phenyl-2-butanone + NADPH + H+
(S)-4-phenyl-2-butanol + NADP+
-
-
-
-
?
4-pyridinecarboxaldehyde + NADPH
4-pyridinemethanol + NADP+
5-(hydroxymethyl)furan-2-carbaldehyde + NADPH + H+
(furan-2,5-diyl)dimethanol + NADP+
5-hydroxyindoleacetaldehyde + NADPH
? + NADP+
-
-
-
-
?
5-hydroxymethylfurfural + NADPH + H+
5-hydroxymethylfurfuryl alcohol + NADP+
5alpha-dihydrotestosterone + NADPH
? + NADP+
-
-
-
-
?
9-cis-retinal + NADPH
9-cis-retinol + NADP+
-
-
-
-
r
9-cis-retinol + NADP+
9-cis-retinal + NADPH
-
-
-
-
r
Ac-D-Leu-D-Trp-D-Leu-D-Trp-Gly + NADH + H+
Ac-D-Leu-D-Trp-D-Leu-D-Trp-Gly-al + NAD+ + H2O
-
-
-
-
?
Ac-D-Leu-D-Trp-D-Leu-D-Trp-Gly-al + NADPH + H+
Ac-D-Leu-D-Trp-D-Leu-D-Trp-Gly-ol + NADP+
-
-
-
-
?
Ac-D-Leu-L-Trp-D-Leu-L-Trp-D-Ala + NADH + H+
Ac-D-Leu-L-Trp-D-Leu-L-Trp-D-Ala-al + NAD+ + H2O
-
-
-
-
?
Ac-D-Leu-L-Trp-D-Leu-L-Trp-D-Ala-al + NADPH + H+
Ac-D-Leu-L-Trp-D-Leu-L-Trp-D-Ala-ol + NADP+
-
-
-
-
?
Ac-D-Leu-L-Trp-D-Leu-L-Trp-Gly + NADH + H+
Ac-D-Leu-L-Trp-D-Leu-L-Trp-Gly-al + NAD+ + H2O
-
-
-
-
?
Ac-D-Leu-L-Trp-D-Leu-L-Trp-Gly-al + NADPH + H+
Ac-D-Leu-L-Trp-D-Leu-L-Trp-Gly-ol + NADP+
-
-
-
-
?
Ac-D-Leu-L-Trp-D-Leu-L-Trp-Gly-S-CoA + NADPH + H+
?
-
-
-
-
?
Ac-D-Leu-L-Trp-D-Leu-L-Trp-L-Ala + NADH + H+
Ac-D-Leu-L-Trp-D-Leu-L-Trp-L-Ala-al + NAD+ + H2O
-
-
-
-
?
Ac-D-Leu-L-Trp-D-Leu-L-Trp-L-Ala-al + NADPH + H+
Ac-D-Leu-L-Trp-D-Leu-L-Trp-L-Ala-ol + NADP+
-
-
-
-
?
Ac-D-Leu-L-Trp-D-Leu-L-Trp-L-Asp + NADH + H+
Ac-D-Leu-L-Trp-D-Leu-L-Trp-L-Asp-al + NAD+ + H2O
-
-
-
-
?
Ac-D-Leu-L-Trp-D-Leu-L-Trp-L-Asp-al + NADPH + H+
Ac-D-Leu-L-Trp-D-Leu-L-Trp-L-Asp-ol + NADP+
-
-
-
-
?
Ac-D-Leu-L-Trp-D-Leu-L-Trp-L-Leu- + NADH + H+
Ac-D-Leu-L-Trp-D-Leu-L-Trp-L-Leu-al + NAD+ + H2O
-
-
-
-
?
Ac-D-Leu-L-Trp-D-Leu-L-Trp-L-Leu-al + NADPH + H+
Ac-D-Leu-L-Trp-D-Leu-L-Trp-L-Leu-ol + NADP+
-
-
-
-
?
Ac-D-Leu-L-Trp-D-Leu-L-Trp-L-Lys + NADH + H+
Ac-D-Leu-L-Trp-D-Leu-L-Trp-L-Lys-al + NAD+ + H2O
-
-
-
-
?
Ac-D-Leu-L-Trp-D-Leu-L-Trp-L-Lys-al + NADPH + H+
Ac-D-Leu-L-Trp-D-Leu-L-Trp-L-Lys-ol + NADP+
-
-
-
-
?
Ac-D-Leu-L-Trp-D-Leu-L-Trp-L-Phe + NADH + H+
Ac-D-Leu-L-Trp-D-Leu-L-Trp-L-Phe-al + NAD+ + H2O
-
-
-
-
?
Ac-D-Leu-L-Trp-D-Leu-L-Trp-L-Phe-al + NADPH + H+
Ac-D-Leu-L-Trp-D-Leu-L-Trp-L-Phe-ol + NADP+
-
-
-
-
?
Ac-L-Leu-L-Trp-L-Leu-L-Trp-Gly- + NADH + H+
Ac-L-Leu-L-Trp-L-Leu-L-Trp-Gly-al + NAD+ + H2O
-
-
-
-
?
Ac-L-Leu-L-Trp-L-Leu-L-Trp-Gly-al + NADPH + H+
Ac-L-Leu-L-Trp-L-Leu-L-Trp-Gly-ol + NADP+
-
-
-
-
?
acetaldehyde + NADH + H+
ethanol + NAD+
acetaldehyde + NADPH + H+
ethanol + NADP+
acetoin + NADPH + H+
2,3-butanediol + NADP+
93% of the activity compared to the substrate 2-butanone. The racemic R/S-acetoin is used since neither R- nor S-acetoin is commercially available. Consistently, the reduction of racemic R/S-acetoin formed (2R,3R)-2,3-butanediol (presumably from R-acetoin) and meso-2,3-butanediol (presumably from S-acetoin) with extremely high stereoselectivity (99% ee over (2S,3S)-(+)-2,3-butanediol)
-
-
r
acetoin + NADPH + H+
butan-2,3-diol + NADP+
-
isozyme AR3
-
-
?
acetone + NADP+
propan-2-ol + NADPH + H+
-
-
-
r
acetone + NADPH
2-propanol + NADP+
-
-
-
-
?
acetone + NADPH + H+
2-propanol + NADP+
149% of the activity compared to the substrate 2-butanone
-
-
r
acetone + NADPH + H+
propan-2-ol + NADP+
-
about 13% of the activity with butan-2-ol
-
-
?
acetophenone + NADH + H+
1-phenylethanol + NAD+
-
recombinant mutant G37D
recombinate mutant G37D
-
r
acetophenone + NADPH + H+
(R)-1-phenylethanol + NADP+
-
catalysed by Escherichia coli coexpressing enzyme with NAD+-dependent formate dehydrogenase and pyridine nucleotide transhydrogenase genes pnta and pntb
-
-
?
acetophenone + NADPH + H+
(S)-1-phenylethanol + NADP+
-
-
-
-
r
acetophenone + NADPH + H+
1-phenylethanol + NADP+
acetyl-CoA + NADPH
acetaldehyde + CoA + NADP+
-
-
-
-
?
acrolein + NADPH
propenol + NADP+
-
-
-
-
r
adonitol + NADP+
? + NADPH
-
-
-
-
r
aldehyde + NADPH + H+
alcohol + NADP+
-
the physiological role of this enzyme is likely to catalyze the reduction of aldehydes to alcohols
-
-
?
all-trans-retinal + NADPH + H+
all-trans-retinol + NADP+
-
-
-
-
r
all-trans-retinol + NADP+
all-trans-retinal + NADPH
-
-
-
-
r
allactose + NADPH
? + NADP+
-
-
-
-
?
alpha-diketone + NADPH
? + NADP+
-
-
-
-
?
androstane-3,17-dione + NADPH
? + NADP+
-
-
-
-
?
anisaldehyde + NADPH
4-methoxybenzyl alcohol + NADP+
anisaldehyde + NADPH + H+
anisyl alcohol + NADP+
anisyl alcohol + NADP+
anisaldehyde + NADPH
-
-
-
-
r
benzalacetone + NADPH
? + NADP+
-
-
-
-
?
benzaldehyde + NADPH
benzyl alcohol + NADP+
benzaldehyde + NADPH + H+
benzyl alcohol + NADP+
benzoic aldehyde + NADPH + H+
? + NADP+
-
-
-
-
?
benzyl alcohol + NAD+
benzaldehyde + NADH + H+
-
-
-
-
r
benzyl alcohol + NADP+
benzaldehyde + NADPH
benzyl alcohol + NADP+
benzaldehyde + NADPH + H+
butan-1-ol + NADP+
butanal + NADPH + H+
butan-2-ol + NADP+
butanone + NADPH + H+
butanal + NADPH + H+
1-butanol + NADP+
butanal + NADPH + H+
butan-1-ol + NADP+
butanal + NADPH + H+
butanol + NADP+
-
30 mM Tris-HCl (pH 8.0) in the presence of 0.2 mM NADPH, 73% relative activity with 0.1 mM or 120% relative activity with 1 mM substrate
-
-
r
butanaldehyde + NADPH
butanol + NADP+
-
-
-
-
r
butane 2,3-dione + NADPH
? + NADP+
-
-
-
-
r
butane-1,2-diol + NADP+
butanal-2-ol + NADPH
-
2% activity compared to cinnamyl alcohol
-
-
r
butane-1,3-diol + NADP+
butanal-3-ol + NADPH
-
5% activity compared to cinnamyl alcohol
-
-
r
butane-1,4-diol + NADP+
butanal-4-ol + NADPH
-
8% activity compared to cinnamyl alcohol
-
-
r
butanol + NADP+
butanal + NADPH
butanol + NADP+
butanal + NADPH + H+
butanone + NADPH + H+
butan-2-ol + NADP+
-
-
-
-
r
butyraldehyde + NADPH + H+
1-butanol + NADP+
112.4% of the activity compared to the substrate 2-butanone
-
-
r
butyraldehyde + NADPH + H+
? + NADP+
-
-
-
-
?
camphorquinone + NADPH + H+
1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol + NADP+
-
-
-
-
?
cellobiose + NADP+
? + NADPH + H+
chloral hydrate + NADPH
? + NADP+
-
-
-
-
?
cinnamaldehyde + NADPH
cinnamic alcohol + NADP+
5% of activity with acetaldehyde
-
-
r
cinnamaldehyde + NADPH
cinnamyl alcohol + NADP+
-
-
-
-
r
cinnamaldehyde + NADPH + H+
cinnamyl alcohol + NADP+
-
30 mM Tris-HCl (pH 8.0) in the presence of 0.2 mM NADPH, 61% relative activity with 0.1 mM or 7% relative activity with 1 mM substrate
-
-
r
cinnamic aldehyde + NADPH + H+
? + NADP+
-
-
-
-
?
cinnamyl alcohol + NADP+
cinnamaldehyde + NADPH
-
-
-
-
r
cinnamyl alcohol + NADP+
cinnamaldehyde + NADPH + H+
cinnamyl alcohol + NADP+
cinnamylaldehyde + NADPH
-
-
-
-
r
cis-11-hexadecenal + NADPH
cis-11-hexadecenol + NADP+
Marinobacter nauticus VT8
-
87% relative activity
-
-
ir
coniferaldehyde + NADPH
coniferyl alcohol + NADP+
coniferyl alcohol + NADP+
coniferaldehyde + NADPH + H+
-
7% activity compared to cinnamyl alcohol
-
-
r
coniferyl alcohol + NADP+
coniferylaldehyde + NADPH + H+
-
27% of activity with cinnamyl alcohol
-
-
r
cyclohexancarbaldehye + NADPH
cyclohexanol + NADP+
3% of activity with acetaldehyde
-
-
r
cyclohexanol + NADP+
cyclohexanone + NADPH + H+
cyclohexanone + NADPH
cyclohexanol + NADP+
cyclopentanol + NADP+
cyclopentanal + NADPH
-
-
-
-
r
D-arabinose + NADP+
D-arabitol + NADPH + H+
200% of the activity with 2-propanol. D-arabinose is preferred over L-arabinose
-
-
?
D-arabinose + NADPH
? + NADP+
D-arabitol + NADP+
? + NADPH
-
-
-
-
r
D-erythrose + NADPH
? + NADP+
-
-
-
-
?
D-fructose + NADPH
? + NADP+
-
-
-
-
?
D-galactose + NADPH
? + NADP+
D-galacturonate + NADPH
? + NADP+
-
-
-
-
?
D-glucose + NADP+
? + NADPH + H+
D-glucose + NADPH
? + NADP+
D-glucose + NADPH + H+
sorbitol + NADP+
D-glucuronate + NADPH
L-gulonate + NADP+
D-glucuronate + NADPH + H+
?
D-glucuronate + NADPH + H+
? + NADP+
D-glucuronolactone + NADPH
? + NADP+
D-glyceraldehyde + NADPH + H+
glycerol + NADP+
D-lactaldehyde + NADPH + H+
propane-1,2-diol + NADP+
D-ribose + NADPH
? + NADP+
D-sorbitol + NADP+
? + NADPH
-
-
-
-
r
D-xylose + NADP+
? + NADPH + H+
246% of the activity with 2-propanol
-
-
?
D-xylose + NADPH
? + NADP+
daunorubicin + NADPH
? + NADP+
decan-1-ol + NADP+
decanal + NADPH + H+
-
-
-
r
decanal + NADP+
decan-1-ol + NADPH + H+
-
-
-
r
decanal + NADPH
decanol + NADP+
Marinobacter nauticus VT8
-
no detectable catalysis of the reverse reaction, the oxidation of decanol by NADP+. 100% relative activity
-
-
ir
decanal + NADPH + H+
decanol + NADP+
-
30 mM Tris-HCl (pH 8.0) in the presence of 0.2 mM NADPH, 21% relative activity with 0.1 mM or 22% relative activity with 1 mM substrate
-
-
r
decanol + NADP+
decanal + NADPH + H+
dehydro-L-ascorbate + NADPH
? + NADP+
-
-
-
-
?
diacetyl + NADPH
? + NADP+
diacetyl + NADPH + H+
acetoin + NADP+
the enzyme can not oxidize acetoin to diacetyl
-
-
ir
dimethylglyoxal + NADPH + H+
? + NADP+
270% of the activity with pyruvaldehyde
-
-
?
DL-glyceraldehyde + NADPH + H+
? + NADP+
DL-glyceraldehyde + NADPH + H+
DL-glycerol + NADP+
-
-
-
?
DL-glyceraldehyde + NADPH + H+
glycerol + NADP+
dodecan-1-ol + NADP+
dodecanal + NADPH + H+
-
-
-
r
dodecanal + NADP+
dodecan-1-ol + NADPH + H+
-
-
-
r
dodecanal + NADPH
dodecanol + NADP+
Marinobacter nauticus VT8
-
55% relative activity
-
-
ir
eicosan-1-ol + NADP+
n-eicosanal + NADPH + H+
-
-
-
r
erythritol + NADP+
? + NADPH
-
-
-
-
r
ethanol + NAD+
acetaldehyde + NADH + H+
ethanol + NADP+
acetaldehyde + NADPH + H+
ethyl 4-bromo-3-oxobutanoate + NADPH
(R)-4-bromo-3-hydroxybutanoic acid ethyl ester + NADP+
-
-
-
-
?
ethyl 4-chloro-3-oxobutanoate + NADPH + H+
(R)-4-chloro-3-hydroxybutanoic acid ethyl ester + NADP+
-
-
-
-
?
ethyl 4-chloro-3-oxobutanoate + NADPH + H+
ethyl (S)-4-chloro-3-hydroxybutanoate + NADP+
ethyl-4-chloro-3-oxobutanoate + NADPH + H+
ethyl-4-chloro-3-hydroxybutanoate + NADP+
ethylacetoacetate + NADPH
ethyl L-(+)-3-hydroxybutyrate + NADP+
ethylene glycol + NADP+
? + NADPH
-
-
-
-
?
formaldehyde + NADPH
methanol + NADP+
formaldehyde + NADPH + H+
methanol + NADP+
furaldehyde + NADPH
furfuryl alcohol + NADP+
-
-
-
-
?
furan-2-carbaldehyde + NADPH + H+
? + NADP+
-
-
-
-
?
furfural + NADH + H+
furfuryl alcohol + NAD+
furfural + NADPH
furfuryl alcohol + NADP+
furfural + NADPH + H+
furfuryl alcohol + NADP+
glucuronate + NADPH + H+
?
glutaraldehyde + NADPH
? + NADP+
5% of activity with acetaldehyde
-
-
r
glyceraldehyde + NADPH + H+
glycerol + NADP+
-
-
-
-
r
glycerol + NADP+
dihydroxyacetone + NADPH + H+
glycerol + NADP+
DL-glyceraldehyde + NADPH + H+
glycolaldehyde + NADPH
ethane-1,2-diol + NADP+
heptanal + NADPH
1-heptanol + NADP+
heptanal + NADPH + H+
heptanol + NADP+
-
-
-
-
?
heptanaldehyde + NADPH + H+
? + NADP+
-
-
-
-
?
hexadecan-1-ol + NADP+
hexadecanal + NADPH + H+
-
-
-
r
hexadecanol + NADP+
hexadecanal + NADPH
-
-
-
-
r
hexan-1-ol + NADP+
hexanal + NADPH + H+
hexanal + NADPH + H+
1-hexanol + NADP+
hexanal + NADPH + H+
hexanol + NADP+
hexanal + NADPH + H+
n-hexanol + NADP+
-
-
-
-
?
hexanaldehyde + NADPH + H+
? + NADP+
-
-
-
-
?
hexanol + NADP+
hexanal + NADPH
hexanol + NADP+
hexanal + NADPH + H+
hexyl alcohol + NADP+
?
the native enzyme shows 137.8% activity with hexyl alcohol compared to ethanol
-
-
?
hexyl alcohol + NADP+
hexanal + NADPH + H+
-
-
-
-
?
hydroxyindol-3-ylacetaldehyde + NADPH
? + NADP+
-
-
-
-
r
hydroxypyruvate + ?
?
-
-
-
-
r
indol-3-ylacetaldehyde + NADPH
indol-3-ethanol + NADP+
indolacetaldehyde + NADPH
? + NADP+
-
-
-
-
?
iodoacetaldehyde + NADPH
iodoethan-2-ol + NADP+
-
-
-
-
r
iodohexadecanal + NADPH
iodohexadecanol + NADP+
-
-
-
-
r
isoamyl alcohol + NADP+
3-methylbutanol + NADPH
18% of activity with ethanol
-
-
r
isoamylalcohol + NADP+
3-methylbutanal + NADPH + H+
-
-
-
r
isobutanol + NADP+
isobutanal + NADPH + H+
isobutanol + NADP+
isobutyl aldehyde + NADPH + H+
-
isoform AdhA, 221% of the activity with acetaldehyde
-
-
r
isobutyl aldehyde + NADPH + H+
isobutanol + NADP+
-
isoform AdhA, 469%, isoform AdhB, 48% of the activity with acetaldehyde
-
-
r
isopentanol + NADP+
3-methylbutanal + NADPH + H+
9% of activity with ethanol
-
-
r
isopropanol + NADP+
acetone + NADPH
2% of activity with ethanol
-
-
r
isopropanol + NADP+
propan-2-one + NADPH + H+
-
-
-
r
L-arabitol + NADP+
? + NADPH
-
-
-
-
r
L-glyceraldehyde + NADPH
glycerol + NADP+
L-gulonic acid + NADP+
D-glucuronic acid + NADPH
L-gulonic acid + NADPH
D-glucuronic acid + NADP+
L-sorbose + NADPH + H+
? + NADP+
-
-
-
-
r
L-xylose + NADPH
? + NADP+
lauryl aldehyde + NADPH
lauryl alcohol + NADP+
m-chlorobenzaldehyde + NADPH + H+
m-chlorobenzyl alcohol + NADP+
-
-
-
-
r
m-fluorobenzaldehyde + NADPH + H+
m-fluorobenzyl alcohol + NADP+
m-methoxybenzaldehyde + NADPH + H+
m-methoxybenzyl alcohol + NADP+
m-methylbenzaldehyde + NADPH
m-methylbenzyl alcohol + NADP+
m-nitrobenzaldehyde + NADPH
m-nitrobenzylalcohol + NADP+
malondialdehyde + NADPH
?
-
-
-
-
r
menadione + NADPH
? + NADP+
-
G2
-
-
?
meso-2,3-butanediol + NADP+
(S)-2-acetoin + NADPH + H+
the enzyme shows higher oxidation activities on the (2R,3R)-(-)-2,3-butanediol and meso-2,3-butanediol than on the (2S,3S)-(+)-2,3-butanediol, indicating that the enzyme predominantly oxidizes the R-hydroxyl group of 2,3-butanediol and minorly functions on the S-hydroxyl group. When meso-2,3-butanediol is oxidized, (S)-2-acetoin is the predominant product, with an enantiomeric excess (ee) of 88%, while oxidation of meso-2,3-butanediol results in the production of (R)-2-acetoin with higher stereoselectivity (94% ee)
-
-
r
methanol + NAD+
formaldehyde + NADH + H+
methanol + NADP+
formaldehyde + NADPH + H+
-
-
-
-
r
methyl 4-bromo-3-oxobutanoate + NADPH + H+
methyl (S)-4-bromo-3-hydroxybutanoate + NADP+
methyl acetoacetate + NADH + H+
methyl (R)-3-hydroxy-butanoate + NAD+
-
-
-
-
?
methyl acetoacetate + NADPH + H+
methyl (R)-3-hydroxy-butanoate + NADP+
-
-
-
-
?
methylglyoxal + NADPH
? + NADP+
mevaldate + NADPH
? + NADP+
-
-
-
-
?
n-butanol + NADP+
butyraldehyde + NADPH
n-butyraldehyde + NADPH
n-butanol + NADP+
n-decanal + NADPH + H+
n-decanol + NADP+
n-dodecanal + NADPH + H+
n-dodecanol + NADP+
n-heptanal + NADPH
heptanol + NADP+
n-heptanol + NADP+
n-heptanal + NADPH
n-hexadecanal + NADPH + H+
n-hexadecanol + NADP+
n-hexanol + NADP+
n-hexanal + NADPH
n-octadecanal + NADPH + H+
n-octadecanol + NADP+
-
-
-
-
r
n-octanal + NADPH + H+
n-octanol + NADP+
n-propanol + NADP+
propionaldehyde + NADPH
n-tetradecanal + NADPH + H+
n-tetradecanol + NADP+
-
-
-
-
r
nonanal + NADPH
? + NADP+
-
-
-
-
?
o-fluorobenzaldehyde + NADPH + H+
o-fluorobenzyl alcohol + NADP+
o-methylbenzaldehyde + NADPH
o-methylbenzyl alcohol + NADP+
o-nitrobenzaldehyde + NADPH
o-nitrobenzylalcohol + NADP+
octacosan-1-ol + NADP+
octacosanal + NADPH + H+
-
-
-
r
octadecan-1-ol + NADP+
octadecanal + NADPH + H+
-
-
-
r
octan-1-ol + NADP+
octanal + NADPH + H+
octanal + NADP+
octan-1-ol + NADPH + H+
-
-
-
r
octanal + NADPH + H+
1-octanol + NADP+
octanal + NADPH + H+
octanol + NADP+
-
30 mM Tris-HCl (pH 8.0) in the presence of 0.2 mM NADPH, 42% relative activity with 0.1 mM or 80% relative activity with 1 mM substrate
-
-
r
octanaldehyde + NADPH + H+
? + NADP+
-
-
-
-
?
octanol + NAD+
octanal + NADH + H+
-
-
-
-
r
octanol + NADP+
octanal + NADPH
-
52% of activity with cinnamyl alcohol
-
-
r
octanol + NADP+
octanal + NADPH + H+
octyl 4-chloro-3-oxobutanoate + NADPH
(R)-4-chloro-3-hydroxybutanoic acid ethyl ester + NADP+
-
-
-
-
?
p-carboxybenzaldehyde + NADPH
p-carboxybenzyl alcohol + NADP+
p-chlorobenzaldehyde + NADPH + H+
p-chlorobenzyl alcohol + NADP+
p-cyanobenzaldehyde + NADPH
p-cyanobenzyl alcohol + NADP+
p-fluorobenzaldehyde + NADPH + H+
p-fluorobenzyl alcohol + NADP+
p-hydroxyphenylacetaldehyde + NADPH + H+
p-hydroxyphenylethanol + NADP+
p-hydroxyphenylglycolaldehyde + NADPH
4-hydroxyphenylethylalcohol + NADP+
p-methoxybenzaldehyde + NADPH + H+
p-methoxybenzyl alcohol + NADP+
p-methylbenzaldehyde + NADPH
p-methylbenzyl alcohol + NADP+
p-nitroacetophenone + NADPH
? + NADP+
-
-
-
-
r
p-nitrobenzaldehyde + NADPH
p-nitrobenzylalcohol + NADP+
p-tolualdehyde + NADPH
toluol + NADP+
-
-
-
-
?
pent-1-en-3-ol + NADP+
pent-1-en-3-one + NADPH + H+
-
good substrate
-
-
?
pentan-1-ol + NADP+
pentanal + NADPH + H+
pentanal + NADPH
1-pentanol + NADP+
pentanal + NADPH
pentanol + NADP+
pentanal + NADPH + H+
pentan-1-ol + NADP+
pentanal + NADPH + H+
pentanol + NADP+
-
30 mM Tris-HCl (pH 8.0) in the presence of 0.2 mM NADPH, 100% relative activity with 0.1 mM or 107% relative activity with 1 mM substrate
-
-
r
pentanol + NADP+
pentanal + NADPH
pentanol + NADP+
pentanal + NADPH + H+
phenylacetaldehyde + NADPH + H+
2-phenylethanol + NADP+
phenylacetaldehyde + NADPH + H+
phenylethanol + NADP+
phenylacetone + NADPH + H+
(S)-1-phenyl-2-propanol + NADP+
-
-
-
-
r
phenylethanediol + NADP+
?
-
-
-
-
r
phenylethanol + NADP+
? + NADPH + H+
-
30 mM Tris-HCl (pH 8.0) in the presence of 0.5 mM NADP+, 15% relative activity with 1 mM or 24% relative activity with 10 mM substrate
-
-
?
phenylethanol + NADP+
phenylacetaldehyde + NADPH + H+
phenylethylamine + ?
?
-
-
-
-
r
phenylglyoxal + NADPH
? + NADP+
propan-1-ol + NADP+
propanal + NADPH + H+
propan-2-ol + NADP+
acetone + NADPH + H+
-
good substrate
-
-
?
propan-2-ol + NADP+
propanone + NADPH
propanal + NADPH + H+
1-propanol + NADP+
propanal + NADPH + H+
propan-1-ol + NADP+
-
isoform AdhA, 50%, isoform AdhB, 62% of the activity with acetaldehyde
-
-
r
propanal + NADPH + H+
propanol + NADP+
propanaldehyde + NADPH
propanol + NADP+
-
-
-
-
r
propane-1,2-diol + NADP+
lactaldehyde + NADPH
propanol + NADP+
propanal + NADPH
propanol + NADP+
propanal + NADPH + H+
-
21% activity with 1 mM propanol, 84% activity with 10 mM propanol
26% activity with 0.1 mM propanal, 87% activity with 1 mM propanal
-
r
propionaldehyde + NADPH
propanol + NADP+
propionaldehyde + NADPH + H+
propanol + NADP+
-
-
-
-
?
propiophenone + NADPH
? + NADP+
-
-
-
-
?
pyridine 4-aldehyde + NADH + H+
4-pyridinemethanol + NAD+
-
-
-
-
r
pyridoxal + NADPH
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol + NADP+
-
-
-
-
?
pyruvaldehyde + NADP+
? + NADPH + H+
-
-
-
-
r
pyruvaldehyde + NADPH
? + NADP+
-
-
-
-
?
pyruvaldehyde + NADPH + H+
lactaldehyde + NADP+
pyruvate + NADPH
2-hydroxypropanoic acid + NADP+
-
-
-
-
?
salicylaldehyde + NADPH
2-hydroxymethylphenol + NADP+
-
-
-
-
?
salicylaldehyde + NADPH
salicylalcohol + NADP+
1% of activity with acetaldehyde
-
-
r
salicylaldehyde + NADPH
salicylic alcohol + NADP+
-
-
-
-
?
sinapaldehyde + NADPH + H+
sinapyl alcohol + NADP+
sodium D-glucuronate + NADPH + H+
sodium L-gulonate + NADP+
-
-
-
-
r
succinic semialdehyde + NADPH + H+
4-hydroxybutyrate + NADP+
tetracosanol-1-ol + NADP+
tetracosanal + NADPH + H+
-
-
-
r
tetradecan-1-ol + NADP+
tetradecanal + NADPH + H+
-
-
-
r
tetradecanal + NADPH
tetradecanol
-
-
-
-
r
trans-2-decenal + NADPH
trans-2-decen-1-ol + NADP+
-
-
-
-
?
trans-2-hexenal + NADPH
trans-2-hexen-1-ol + NADP+
-
-
-
-
?
trans-2-hexenol + NADP+
trans-2-hexenal + NADPH
trans-2-nonenal + NADPH
trans-2-nonen-1-ol + NADP+
-
33% activity compared to cinnamaldehyde
-
-
r
trans-2-nonenal + NADPH
trans-2-nonenol + NADP+
-
39% of activity with cinnamaldehyde
-
-
r
trans-2-nonenaldehyde + NADPH + H+
? + NADP+
-
-
-
-
?
trans-cinnamaldehyde + NADPH
cinnamyl alcohol + NADP+
triacontan-1-ol + NADP+
triacontanal + NADPH + H+
-
-
-
r
tridecanal + NADPH
tridecanol + NADP+
-
-
-
-
r
Tris + NADP+
? + NADPH
-
-
-
-
?
undecanal + NADPH
undecanol + NADP+
-
-
-
-
?
valeraldehyde + NADPH + H+
? + NADP+
-
-
-
-
?
vanillin + NADPH
4-hydroxy-3-methoxybenzyl alcohol + NADP+
veratraldehyde + NADPH
3,4-dimethoxybenzyl alcohol + NADP+
vitamin A aldehyde + NADPH
? + NADP+
-
-
-
-
?
additional information
?
-
(+)-camphorquinone + NADPH
? + NADP+
-
-
-
-
?
(+)-camphorquinone + NADPH
? + NADP+
-
-
-
-
?
1,3-propanediol + NADP+
? + NADPH
-
-
-
-
?
1,3-propanediol + NADP+
? + NADPH
-
primary alcohol dehydrogenase
-
-
?
1,3-propanediol + NADP+
? + NADPH
-
-
-
-
?
1,4-butanediol + NADP+
4-hydroxybutanal + NADPH + H+
-
-
-
r
1,4-butanediol + NADP+
4-hydroxybutanal + NADPH + H+
-
-
-
-
r
1-butanol + NADP+
butanal + NADPH
-
25% of activity with 1-hexanol
-
-
r
1-butanol + NADP+
butanal + NADPH
-
42% activity compared to cinnamyl alcohol
-
-
r
1-butanol + NADP+
butanal + NADPH + H+
-
-
-
-
?
1-butanol + NADP+
butanal + NADPH + H+
-
169% of the activity compared to ethanol
-
-
r
1-butanol + NADP+
butanal + NADPH + H+
-
130% of the activity with ethanol
-
-
r
1-butanol + NADP+
butanal + NADPH + H+
-
130% of the activity with ethanol
-
-
r
1-butanol + NADP+
butanal + NADPH + H+
the native enzyme shows 154.6% activity with 1-butanol compared to ethanol
-
-
?
1-butanol + NADP+
butanal + NADPH + H+
the native enzyme shows 154.6% activity with 1-butanol compared to ethanol
-
-
?
1-butanol + NADP+
butyraldehyde + NADPH + H+
-
-
-
-
r
1-butanol + NADP+
butyraldehyde + NADPH + H+
5.1% of the activity compared to the substrate 2-butanol
-
-
r
1-heptanol + NADP+
heptanal + NADPH + H+
-
-
-
-
?
1-heptanol + NADP+
heptanal + NADPH + H+
-
86% of the activity compared to ethanol
-
-
r
1-heptanol + NADP+
heptanal + NADPH + H+
-
114% of the activity with ethanol
-
-
r
1-heptanol + NADP+
heptanal + NADPH + H+
the native enzyme shows 94% activity with 1-heptanol compared to ethanol
-
-
?
1-heptanol + NADP+
heptanal + NADPH + H+
the native enzyme shows 94% activity with 1-heptanol compared to ethanol
-
-
?
1-hexanol + NADP+
hexanal + NADPH
-
-
-
-
r
1-hexanol + NADP+
hexanal + NADPH
-
45% activity compared to cinnamyl alcohol
-
-
r
1-hexanol + NADP+
hexanal + NADPH + H+
-
95% of the activity compared to ethanol
-
-
r
1-hexanol + NADP+
hexanal + NADPH + H+
-
165% of the activity with ethanol
-
-
r
1-octanol + NADP+
octanal + NADPH
-
31% of activity with 1-hexanol
-
-
r
1-octanol + NADP+
octanal + NADPH
-
-
-
-
r
1-octanol + NADP+
octanal + NADPH
-
30% activity compared to cinnamyl alcohol
-
-
r
1-octanol + NADP+
octanal + NADPH
-
-
-
-
r
1-octanol + NADP+
octanal + NADPH
-
-
-
-
r
1-octanol + NADP+
octanal + NADPH + H+
-
-
-
-
?
1-octanol + NADP+
octanal + NADPH + H+
-
57% of the activity compared to ethanol
-
-
r
1-octanol + NADP+
octanal + NADPH + H+
the native enzyme shows 68.8% activity with 1-octanol compared to ethanol
-
-
?
1-octanol + NADP+
octanal + NADPH + H+
the native enzyme shows 68.8% activity with 1-octanol compared to ethanol
-
-
?
1-pentanol + NADP+
n-pentanal + NADPH
-
-
-
-
r
1-pentanol + NADP+
n-pentanal + NADPH
-
-
-
-
r
1-pentanol + NADP+
n-pentanal + NADPH
-
-
-
-
r
1-pentanol + NADP+
n-pentanal + NADPH
-
primary alcohol dehydrogenase
-
-
r
1-pentanol + NADP+
n-pentanal + NADPH
-
-
-
-
r
1-pentanol + NADP+
n-pentanal + NADPH
-
-
-
-
r
1-pentanol + NADP+
n-pentanal + NADPH
-
-
-
-
r
1-pentanol + NADP+
pentanal + NADPH
-
58% of activity with 1-hexanol
-
-
r
1-pentanol + NADP+
pentanal + NADPH
-
46% activity compared to cinnamyl alcohol
-
-
r
1-pentanol + NADP+
pentanal + NADPH + H+
-
172% of the activity compared to ethanol
-
-
r
1-pentanol + NADP+
pentanal + NADPH + H+
-
135% of the activity with ethanol
-
-
r
1-pentanol + NADP+
pentanal + NADPH + H+
the native enzyme shows 184% activity with 1-pentanol compared to ethanol
-
-
?
1-pentanol + NADP+
pentanal + NADPH + H+
the native enzyme shows 184% activity with 1-pentanol compared to ethanol
-
-
?
1-propanol + NADP+
propanal + NADPH + H+
-
156% of the activity compared to ethanol
-
-
r
1-propanol + NADP+
propanal + NADPH + H+
-
30 mM Tris-HCl (pH 8.0) in the presence of 0.5 mM NADP+, 21% relative activity with 1 mM or 84% relative activity with 10 mM substrate
-
-
r
1-propanol + NADP+
propanal + NADPH + H+
15.1% of the activity compared to the substrate 2-butanol
-
-
?
1-propanol + NADP+
propanal + NADPH + H+
-
102% of the activity with ethanol
-
-
r
1-propanol + NADP+
propanal + NADPH + H+
-
-
-
?
1-propanol + NADP+
propanal + NADPH + H+
-
-
-
?
1-propanol + NADP+
propanal + NADPH + H+
the native enzyme shows 120.6% activity with 1-propanol compared to ethanol
-
-
?
2,3-pentanedione + NADPH + H+
? + NADP+
-
-
-
-
?
2,3-pentanedione + NADPH + H+
? + NADP+
-
secondary alcohol dehydrogenase
-
-
?
2-butanol + NADP+
?
-
-
-
?
2-butanol + NADP+
?
-
-
-
?
2-butanol + NADP+
butan-2-one + NADPH
-
-
-
-
r
2-butanol + NADP+
butan-2-one + NADPH
-
-
-
-
r
2-butanol + NADP+
butan-2-one + NADPH
-
-
-
-
r
2-butanol + NADP+
butan-2-one + NADPH
-
2° Adh
-
-
r
2-methoxybenzaldehyde + NADPH + H+
2-methoxybenzyl alcohol + NADP+
-
-
-
-
?
2-methoxybenzaldehyde + NADPH + H+
2-methoxybenzyl alcohol + NADP+
-
-
-
-
?
2-methyl-1-propanol + NADP+
2-methylpropanal + NADPH
-
28% activity compared to cinnamyl alcohol
-
-
r
2-methyl-1-propanol + NADP+
2-methylpropanal + NADPH
-
-
-
-
?
2-methylbutanal + NADPH
2-methyl-1-butanol + NADP+
-
89% activity compared to cinnamaldehyde
-
-
r
2-methylbutanal + NADPH
2-methyl-1-butanol + NADP+
-
92% of activity with cinnamaldehyde
-
-
r
2-methylpropanal + NADPH
2-methyl-1-propanol + NADP+
-
63% activity compared to cinnamaldehyde
-
-
r
2-methylpropanal + NADPH
2-methyl-1-propanol + NADP+
-
67% of activity with cinnamaldehyde
-
-
r
2-pentanol + NADP+
2-pentanone + NADPH + H+
-
-
-
-
?
2-pentanol + NADP+
2-pentanone + NADPH + H+
maximal activity in oxidative reaction
-
-
r
2-pentanol + NADP+
2-pentanone + NADPH + H+
66.3% of the activity compared to the substrate 2-butanol
-
-
r
2-phenylethanol + NADP+
2-phenylacetaldehyde + NADPH + H+
-
70% of the activity with ethanol
-
-
r
2-phenylethanol + NADP+
2-phenylacetaldehyde + NADPH + H+
the native enzyme shows 40.2% activity with 2-phenylethanol compared to ethanol
-
-
?
2-phenylethanol + NADP+
phenylacetaldehyde + NADPH + H+
-
-
-
-
?
2-phenylethanol + NADP+
phenylacetaldehyde + NADPH + H+
-
76% of the activity compared to ethanol
-
-
r
2-propanol + NADP+
acetone + NADPH
-
-
-
-
r
2-propanol + NADP+
acetone + NADPH
-
-
-
-
r
2-propanol + NADP+
acetone + NADPH + H+
-
-
-
?
2-propanol + NADP+
acetone + NADPH + H+
-
-
-
-
r
2-propanol + NADP+
acetone + NADPH + H+
88% of the activity compared to the substrate 2-butanol
-
-
r
2-propanol + NADP+
acetone + NADPH + H+
-
-
-
?
2-propanol + NADP+
acetone + NADPH + H+
-
-
-
?
3,4-dihydro-1(2H)-naphthalenone + NADPH + H+
1,2,3,4-tetrahydronaphthalen-1-ol + NADP+
3,4-dihydro-1(2H)-naphthalenone i.e. alpha-tetralone
-
-
r
3,4-dihydro-1(2H)-naphthalenone + NADPH + H+
1,2,3,4-tetrahydronaphthalen-1-ol + NADP+
3,4-dihydro-1(2H)-naphthalenone i.e. alpha-tetralone
-
-
r
3,4-dihydroxyphenylglycolaldehyde + NADPH
? + NADP+
-
-
-
-
r
3,4-dihydroxyphenylglycolaldehyde + NADPH
? + NADP+
-
low Km reductase
-
-
r
3-pyridinecarboxaldehyde + NADPH
3-pyridinemethanol + NADP+
-
-
-
-
?
3-pyridinecarboxaldehyde + NADPH
3-pyridinemethanol + NADP+
-
AR3
-
-
?
3-pyridinecarboxaldehyde + NADPH
3-pyridinemethanol + NADP+
-
-
-
-
r
3-pyridinecarboxaldehyde + NADPH
3-pyridinemethanol + NADP+
-
-
-
-
r
3-pyridinecarboxaldehyde + NADPH
3-pyridinemethanol + NADP+
-
-
-
-
r
3-pyridinecarboxaldehyde + NADPH
3-pyridinemethanol + NADP+
-
-
-
-
r
3-pyridinecarboxaldehyde + NADPH
3-pyridinemethanol + NADP+
-
-
-
-
?
3-pyridinecarboxaldehyde + NADPH
3-pyridinemethanol + NADP+
-
-
-
-
r
3-pyridinecarboxaldehyde + NADPH
3-pyridinemethanol + NADP+
-
-
-
-
r
3-pyridinecarboxaldehyde + NADPH
3-pyridinemethanol + NADP+
-
-
-
-
r
3-pyridinecarboxaldehyde + NADPH
3-pyridinemethanol + NADP+
-
-
-
-
r
3-pyridinecarboxaldehyde + NADPH
3-pyridinemethanol + NADP+
-
-
-
-
ir
3-pyridinecarboxaldehyde + NADPH
3-pyridinemethanol + NADP+
-
-
286165, 286167, 286172, 286174, 286176, 286177, 286178, 286179, 286180, 286181, 286182, 286185 -
-
r
4-methoxybenzaldehyde + NADPH + H+
4-methoxybenzyl alcohol + NADP+
-
-
-
-
?
4-methoxybenzaldehyde + NADPH + H+
4-methoxybenzyl alcohol + NADP+
-
-
-
-
?
4-methoxybenzaldehyde + NADPH + H+
4-methoxybenzyl alcohol + NADP+
-
-
-
-
?
4-pyridinecarboxaldehyde + NADPH
4-pyridinemethanol + NADP+
-
-
-
-
?
4-pyridinecarboxaldehyde + NADPH
4-pyridinemethanol + NADP+
-
-
-
-
r
4-pyridinecarboxaldehyde + NADPH
4-pyridinemethanol + NADP+
-
-
-
-
r
4-pyridinecarboxaldehyde + NADPH
4-pyridinemethanol + NADP+
-
-
-
-
r
4-pyridinecarboxaldehyde + NADPH
4-pyridinemethanol + NADP+
-
-
-
-
r
4-pyridinecarboxaldehyde + NADPH
4-pyridinemethanol + NADP+
-
-
-
-
r
4-pyridinecarboxaldehyde + NADPH
4-pyridinemethanol + NADP+
-
-
-
-
?
5-(hydroxymethyl)furan-2-carbaldehyde + NADPH + H+
(furan-2,5-diyl)dimethanol + NADP+
-
-
-
-
?
5-(hydroxymethyl)furan-2-carbaldehyde + NADPH + H+
(furan-2,5-diyl)dimethanol + NADP+
-
-
-
-
?
5-hydroxymethylfurfural + NADPH + H+
5-hydroxymethylfurfuryl alcohol + NADP+
-
-
-
?
5-hydroxymethylfurfural + NADPH + H+
5-hydroxymethylfurfuryl alcohol + NADP+
-
-
-
?
acetaldehyde + NADH + H+
ethanol + NAD+
-
-
-
r
acetaldehyde + NADH + H+
ethanol + NAD+
-
-
-
-
r
acetaldehyde + NADH + H+
ethanol + NAD+
-
-
-
-
r
acetaldehyde + NADH + H+
ethanol + NAD+
-
-
-
-
r
acetaldehyde + NADPH + H+
ethanol + NADP+
-
-
-
-
?
acetaldehyde + NADPH + H+
ethanol + NADP+
-
-
-
-
?
acetaldehyde + NADPH + H+
ethanol + NADP+
-
-
-
-
r
acetaldehyde + NADPH + H+
ethanol + NADP+
-
-
-
r
acetaldehyde + NADPH + H+
ethanol + NADP+
-
-
-
r
acetaldehyde + NADPH + H+
ethanol + NADP+
-
-
-
r
acetaldehyde + NADPH + H+
ethanol + NADP+
-
-
-
-
r
acetaldehyde + NADPH + H+
ethanol + NADP+
-
-
-
-
?
acetaldehyde + NADPH + H+
ethanol + NADP+
-
-
-
-
r
acetaldehyde + NADPH + H+
ethanol + NADP+
-
the proposed physiological role of NADP-dependent alcohol dehydrogenase in Pyrococcus furiosus is to both dispose of excess reducing equivalents and to detoxify the aldehydes produced by the fermentative pathways
-
-
?
acetaldehyde + NADPH + H+
ethanol + NADP+
-
-
-
-
?
acetaldehyde + NADPH + H+
ethanol + NADP+
-
-
-
-
?
acetaldehyde + NADPH + H+
ethanol + NADP+
-
-
-
-
?
acetaldehyde + NADPH + H+
ethanol + NADP+
-
-
-
?
acetaldehyde + NADPH + H+
ethanol + NADP+
-
-
-
?
acetaldehyde + NADPH + H+
ethanol + NADP+
-
-
-
-
?
acetaldehyde + NADPH + H+
ethanol + NADP+
-
30 mM Tris-HCl (pH 8.0) in the presence of 0.2 mM NADPH, 1% relative activity with 0.1 mM or 23% relative activity with 1 mM substrate
-
-
r
acetaldehyde + NADPH + H+
ethanol + NADP+
-
-
-
-
?
acetaldehyde + NADPH + H+
ethanol + NADP+
-
-
-
-
?
acetaldehyde + NADPH + H+
ethanol + NADP+
-
-
-
-
?
acetaldehyde + NADPH + H+
ethanol + NADP+
-
-
-
r
acetaldehyde + NADPH + H+
ethanol + NADP+
-
-
-
-
r
acetaldehyde + NADPH + H+
ethanol + NADP+
-
-
-
-
r
acetaldehyde + NADPH + H+
ethanol + NADP+
-
-
-
-
?
acetaldehyde + NADPH + H+
ethanol + NADP+
-
-
-
-
?
acetaldehyde + NADPH + H+
ethanol + NADP+
-
-
-
-
?
acetophenone + NADPH + H+
1-phenylethanol + NADP+
-
-
-
-
?
acetophenone + NADPH + H+
1-phenylethanol + NADP+
-
recombinant wild-type
recombinant wild-type
-
r
anisaldehyde + NADPH
4-methoxybenzyl alcohol + NADP+
-
72% of activity with cinnamaldehyde
-
-
r
anisaldehyde + NADPH
4-methoxybenzyl alcohol + NADP+
-
83% activity compared to cinnamaldehyde
-
-
r
anisaldehyde + NADPH + H+
anisyl alcohol + NADP+
-
-
-
-
r
anisaldehyde + NADPH + H+
anisyl alcohol + NADP+
-
-
-
-
r
anisaldehyde + NADPH + H+
anisyl alcohol + NADP+
-
-
-
-
r
benzaldehyde + NADPH
benzyl alcohol + NADP+
-
-
-
-
r
benzaldehyde + NADPH
benzyl alcohol + NADP+
-
-
-
-
r
benzaldehyde + NADPH
benzyl alcohol + NADP+
-
-
-
-
r
benzaldehyde + NADPH
benzyl alcohol + NADP+
-
-
-
-
r
benzaldehyde + NADPH
benzyl alcohol + NADP+
-
-
-
-
r
benzaldehyde + NADPH
benzyl alcohol + NADP+
-
-
-
-
?
benzaldehyde + NADPH
benzyl alcohol + NADP+
-
-
-
-
r
benzaldehyde + NADPH
benzyl alcohol + NADP+
8% of activity with acetaldehyde
-
-
r
benzaldehyde + NADPH
benzyl alcohol + NADP+
-
-
-
-
r
benzaldehyde + NADPH
benzyl alcohol + NADP+
-
-
-
-
r
benzaldehyde + NADPH
benzyl alcohol + NADP+
-
-
-
-
r
benzaldehyde + NADPH
benzyl alcohol + NADP+
-
-
-
-
r
benzaldehyde + NADPH
benzyl alcohol + NADP+
-
-
-
-
r
benzaldehyde + NADPH
benzyl alcohol + NADP+
-
-
-
-
r
benzaldehyde + NADPH
benzyl alcohol + NADP+
-
45% activity compared to cinnamaldehyde
-
-
r
benzaldehyde + NADPH
benzyl alcohol + NADP+
-
72% of activity with cinnamaldehyde
-
-
r
benzaldehyde + NADPH
benzyl alcohol + NADP+
-
-
-
-
r
benzaldehyde + NADPH
benzyl alcohol + NADP+
-
relative activity 4%
-
-
r
benzaldehyde + NADPH
benzyl alcohol + NADP+
-
-
-
-
r
benzaldehyde + NADPH
benzyl alcohol + NADP+
-
-
-
-
?
benzaldehyde + NADPH + H+
benzyl alcohol + NADP+
-
30 mM Tris-HCl (pH 8.0) in the presence of 0.2 mM NADPH, 30% relative activity with 0.1 mM or 14% relative activity with 1 mM substrate
-
-
r
benzaldehyde + NADPH + H+
benzyl alcohol + NADP+
-
-
-
-
r
benzyl alcohol + NADP+
benzaldehyde + NADPH
-
45% of activity with cinnamyl alcohol
-
-
r
benzyl alcohol + NADP+
benzaldehyde + NADPH
-
78% activity compared to cinnamyl alcohol
-
-
r
benzyl alcohol + NADP+
benzaldehyde + NADPH
-
-
-
-
r
benzyl alcohol + NADP+
benzaldehyde + NADPH
-
-
-
-
r
benzyl alcohol + NADP+
benzaldehyde + NADPH + H+
-
30 mM Tris-HCl (pH 8.0) in the presence of 0.5 mM NADP+, 42% relative activity with 1 mM or 79% relative activity with 10 mM substrate
-
-
r
benzyl alcohol + NADP+
benzaldehyde + NADPH + H+
-
42% activity with 1 mM benzyl alcohol, 79% activity with 10 mM benzyl alcohol
30% activity with 0.1 mM benzaldehyde, 14% activity with 1 mM benzaldehyde
-
r
benzyl alcohol + NADP+
benzaldehyde + NADPH + H+
-
-
-
-
r
benzyl alcohol + NADP+
benzaldehyde + NADPH + H+
180% of the activity with 2-propanol
-
-
?
benzyl alcohol + NADP+
benzaldehyde + NADPH + H+
180% of the activity with 2-propanol
-
-
?
butan-1-ol + NADP+
butanal + NADPH + H+
-
isoform ADH-I, 94%, isoform ADH II, 32% of the activity with hexan-1-ol
-
-
?
butan-1-ol + NADP+
butanal + NADPH + H+
-
isoform ADH-I, 94%, isoform ADH II, 32% of the activity with hexan-1-ol
-
-
?
butan-1-ol + NADP+
butanal + NADPH + H+
-
-
-
r
butan-1-ol + NADP+
butanal + NADPH + H+
-
-
-
r
butan-1-ol + NADP+
butanal + NADPH + H+
-
isoform AdhA, 238% of the activity with acetaldehyde
-
-
r
butan-1-ol + NADP+
butanal + NADPH + H+
-
-
-
?
butan-2-ol + NADP+
butanone + NADPH + H+
-
isoform ADH-I, 89%, isoform ADH II, 23% of the activity with hexan-1-ol
-
-
?
butan-2-ol + NADP+
butanone + NADPH + H+
-
isoform ADH-I, 89%, isoform ADH II, 23% of the activity with hexan-1-ol
-
-
?
butan-2-ol + NADP+
butanone + NADPH + H+
-
good substrate
-
-
r
butanal + NADPH + H+
1-butanol + NADP+
47% of activity with acetaldehyde
-
-
r
butanal + NADPH + H+
1-butanol + NADP+
-
19% activity compared to cinnamaldehyde
-
-
r
butanal + NADPH + H+
1-butanol + NADP+
-
57% of activity with cinnamaldehyde
-
-
r
butanal + NADPH + H+
butan-1-ol + NADP+
-
isoform AdhA, 625%, isoform AdhB, 108% of the activity with acetaldehyde
-
-
r
butanal + NADPH + H+
butan-1-ol + NADP+
-
-
-
?
butanal + NADPH + H+
butan-1-ol + NADP+
-
-
-
?
butanal + NADPH + H+
butan-1-ol + NADP+
-
-
-
-
?
butanol + NADP+
butanal + NADPH
68% of activity with ethanol
-
-
r
butanol + NADP+
butanal + NADPH
-
24% of activity with cinnamyl alcohol
-
-
r
butanol + NADP+
butanal + NADPH + H+
-
23% activity with 1 mM butanol, 70% activity with 10 mM butanol
73% activity with 0.1 mM butanal, 120% activity with 1 mM butanal
-
r
butanol + NADP+
butanal + NADPH + H+
-
30 mM Tris-HCl (pH 8.0) in the presence of 0.5 mM NADP+, 23% relative activity with 1 mM or 70% relative activity with 10 mM substrate
-
-
r
cellobiose + NADP+
? + NADPH + H+
71% of the activity with 2-propanol
-
-
?
cellobiose + NADP+
? + NADPH + H+
71% of the activity with 2-propanol
-
-
?
cinnamyl alcohol + NADP+
cinnamaldehyde + NADPH + H+
-
100% activity with 1 mM cinnamyl alcohol, 116% activity with 10 mM hexanol
61% activity with 0.1 mM cinnamaldehyde, 7% activity with 1 mM cinnamaldehyde
-
r
cinnamyl alcohol + NADP+
cinnamaldehyde + NADPH + H+
-
30 mM Tris-HCl (pH 8.0) in the presence of 0.5 mM NADP+, 100% relative activity with 1 mM or 116% relative activity with 10 mM substrate
-
-
r
coniferaldehyde + NADPH
coniferyl alcohol + NADP+
-
10% of activity with cinnamaldehyde
-
-
r
coniferaldehyde + NADPH
coniferyl alcohol + NADP+
-
15% activity compared to cinnamaldehyde
-
-
r
coniferaldehyde + NADPH
coniferyl alcohol + NADP+
-
converted less efficiently than eutypine
-
-
?
cyclohexanol + NADP+
cyclohexanone + NADPH + H+
-
-
-
-
r
cyclohexanol + NADP+
cyclohexanone + NADPH + H+
14% of activity with ethanol
-
-
r
cyclohexanol + NADP+
cyclohexanone + NADPH + H+
-
about 15% of the activity with butan-2-ol
-
-
?
cyclohexanone + NADPH
cyclohexanol + NADP+
-
-
-
-
?
cyclohexanone + NADPH
cyclohexanol + NADP+
-
G2
-
-
?
cyclohexanone + NADPH
cyclohexanol + NADP+
-
-
-
-
?
D-arabinose + NADPH
? + NADP+
-
-
-
-
?
D-arabinose + NADPH
? + NADP+
-
-
-
-
r
D-galactose + NADPH
? + NADP+
-
-
-
-
?
D-galactose + NADPH
? + NADP+
-
-
-
-
?
D-glucose + NADP+
? + NADPH + H+
146% of the activity with 2-propanol
-
-
?
D-glucose + NADP+
? + NADPH + H+
146% of the activity with 2-propanol
-
-
?
D-glucose + NADPH
? + NADP+
-
placenta aldehyde reductase I
-
-
?
D-glucose + NADPH
? + NADP+
-
-
-
-
?
D-glucose + NADPH + H+
sorbitol + NADP+
-
-
-
?
D-glucose + NADPH + H+
sorbitol + NADP+
-
-
-
?
D-glucuronate + NADPH
?
0.1 M phosphat buffer, pH 7.0
-
-
?
D-glucuronate + NADPH
?
0.1 M phosphat buffer, pH 7.0
-
-
?
D-glucuronate + NADPH
L-gulonate + NADP+
-
-
-
-
?
D-glucuronate + NADPH
L-gulonate + NADP+
-
-
-
-
r
D-glucuronate + NADPH
L-gulonate + NADP+
-
AR1
-
-
?
D-glucuronate + NADPH
L-gulonate + NADP+
-
-
-
-
?
D-glucuronate + NADPH
L-gulonate + NADP+
-
-
-
-
r
D-glucuronate + NADPH
L-gulonate + NADP+
-
-
-
-
?
D-glucuronate + NADPH
L-gulonate + NADP+
-
-
-
-
r
D-glucuronate + NADPH
L-gulonate + NADP+
-
-
-
-
?, r
D-glucuronate + NADPH
L-gulonate + NADP+
-
-
-
-
?, r
D-glucuronate + NADPH
L-gulonate + NADP+
-
-
-
-
?
D-glucuronate + NADPH
L-gulonate + NADP+
-
-
-
-
?
D-glucuronate + NADPH
L-gulonate + NADP+
-
-
-
-
r
D-glucuronate + NADPH
L-gulonate + NADP+
-
-
-
?, r
D-glucuronate + NADPH
L-gulonate + NADP+
-
aldehyde reductase II
-
-
?
D-glucuronate + NADPH
L-gulonate + NADP+
-
-
-
-
?
D-glucuronate + NADPH
L-gulonate + NADP+
-
-
-
-
r
D-glucuronate + NADPH
L-gulonate + NADP+
-
-
-
-
?, r
D-glucuronate + NADPH
L-gulonate + NADP+
-
-
-
-
?
D-glucuronate + NADPH
L-gulonate + NADP+
-
-
-
-
r
D-glucuronate + NADPH
L-gulonate + NADP+
-
-
-
-
?
D-glucuronate + NADPH
L-gulonate + NADP+
-
-
-
-
r
D-glucuronate + NADPH
L-gulonate + NADP+
-
-
286165, 286172, 286174, 286175, 286176, 286177, 286182, 286184, 286190, 286192, 286196 -
-
?
D-glucuronate + NADPH
L-gulonate + NADP+
-
-
-
-
r
D-glucuronate + NADPH
L-gulonate + NADP+
-
-
-
-
?, r
D-glucuronate + NADPH
L-gulonate + NADP+
-
-
286165, 286167, 286172, 286174, 286176, 286177, 286178, 286179, 286182, 286185, 286196 -
-
?
D-glucuronate + NADPH
L-gulonate + NADP+
-
-
-
-
r
D-glucuronate + NADPH + H+
?
0.1 M phosphate buffer, pH 7.0
-
-
?
D-glucuronate + NADPH + H+
?
0.1 M phosphate buffer, pH 7.0
-
-
?
D-glucuronate + NADPH + H+
? + NADP+
-
-
-
r
D-glucuronate + NADPH + H+
? + NADP+
-
-
-
r
D-glucuronate + NADPH + H+
? + NADP+
-
-
-
r
D-glucuronate + NADPH + H+
? + NADP+
-
-
-
r
D-glucuronolactone + NADPH
? + NADP+
-
-
-
-
?
D-glucuronolactone + NADPH
? + NADP+
-
-
-
-
?
D-glucuronolactone + NADPH
? + NADP+
-
-
-
-
?
D-glyceraldehyde + NADPH + H+
glycerol + NADP+
-
-
-
-
r
D-glyceraldehyde + NADPH + H+
glycerol + NADP+
-
-
-
-
r
D-glyceraldehyde + NADPH + H+
glycerol + NADP+
-
-
-
-
r
D-glyceraldehyde + NADPH + H+
glycerol + NADP+
-
-
-
-
r
D-glyceraldehyde + NADPH + H+
glycerol + NADP+
-
-
-
-
r
D-glyceraldehyde + NADPH + H+
glycerol + NADP+
-
-
286149, 286168, 286175, 286176, 286177, 286181, 286182, 286184, 286186, 286187, 286196, 286199 -
-
r
D-glyceraldehyde + NADPH + H+
glycerol + NADP+
-
-
-
-
r
D-glyceraldehyde + NADPH + H+
glycerol + NADP+
-
-
-
-
r
D-glyceraldehyde + NADPH + H+
glycerol + NADP+
-
-
-
-
r
D-glyceraldehyde + NADPH + H+
glycerol + NADP+
-
-
-
-
r
D-glyceraldehyde + NADPH + H+
glycerol + NADP+
-
-
286165, 286172, 286174, 286175, 286176, 286177, 286181, 286182, 286184, 286192, 286196, 286204 -
-
r
D-glyceraldehyde + NADPH + H+
glycerol + NADP+
-
-
-
-
r
D-glyceraldehyde + NADPH + H+
glycerol + NADP+
-
-
-
-
ir
D-glyceraldehyde + NADPH + H+
glycerol + NADP+
-
-
-
-
ir
D-glyceraldehyde + NADPH + H+
glycerol + NADP+
-
-
286165, 286167, 286168, 286171, 286172, 286174, 286176, 286177, 286178, 286179, 286181, 286182, 286196 -
-
r
D-lactaldehyde + NADPH + H+
propane-1,2-diol + NADP+
-
-
-
-
r
D-lactaldehyde + NADPH + H+
propane-1,2-diol + NADP+
-
-
-
-
r
D-lactaldehyde + NADPH + H+
propane-1,2-diol + NADP+
-
-
-
-
r
D-ribose + NADPH
? + NADP+
-
-
-
-
?
D-ribose + NADPH
? + NADP+
-
-
-
-
?
D-xylose + NADPH
? + NADP+
-
-
-
-
?
D-xylose + NADPH
? + NADP+
-
AR3
-
-
?
D-xylose + NADPH
? + NADP+
-
-
-
-
?
D-xylose + NADPH
? + NADP+
-
-
-
-
?
D-xylose + NADPH
? + NADP+
-
-
-
-
?
D-xylose + NADPH
? + NADP+
-
-
-
-
?
D-xylose + NADPH
? + NADP+
-
-
-
-
?
daunorubicin + NADPH
? + NADP+
-
-
-
-
?
daunorubicin + NADPH
? + NADP+
-
-
-
-
?
daunorubicin + NADPH
? + NADP+
-
-
-
-
?
decanol + NADP+
decanal + NADPH + H+
-
3% activity with 1 mM decanol, 6% activity with 10 mM decanol
21% activity with 0.1 mM decanal, 22% activity with 1 mM decanal
-
r
decanol + NADP+
decanal + NADPH + H+
-
30 mM Tris-HCl (pH 8.0) in the presence of 0.5 mM NADP+, 3% relative activity with 1 mM or 6% relative activity with 10 mM substrate
-
-
r
diacetyl + NADPH
? + NADP+
-
-
-
-
?
diacetyl + NADPH
? + NADP+
-
-
-
-
?
diacetyl + NADPH
? + NADP+
-
-
-
-
?
DL-glyceraldehyde + NADPH + H+
? + NADP+
-
-
-
?
DL-glyceraldehyde + NADPH + H+
? + NADP+
-
-
-
?
DL-glyceraldehyde + NADPH + H+
glycerol + NADP+
-
-
-
-
r
DL-glyceraldehyde + NADPH + H+
glycerol + NADP+
-
-
-
-
r
DL-glyceraldehyde + NADPH + H+
glycerol + NADP+
-
-
-
r
DL-glyceraldehyde + NADPH + H+
glycerol + NADP+
-
-
-
-
?
DL-glyceraldehyde + NADPH + H+
glycerol + NADP+
-
-
-
?
ethanol + NAD+
acetaldehyde + NADH + H+
-
-
-
r
ethanol + NAD+
acetaldehyde + NADH + H+
-
-
-
-
r
ethanol + NAD+
acetaldehyde + NADH + H+
-
kcat/Km for NAD+ is 1900fold lower compared to NADP+
-
-
r
ethanol + NAD+
acetaldehyde + NADH + H+
-
-
-
-
r
ethanol + NAD+
acetaldehyde + NADH + H+
-
-
-
-
r
ethanol + NADP+
acetaldehyde + NADPH + H+
-
-
-
-
r
ethanol + NADP+
acetaldehyde + NADPH + H+
-
-
-
-
r
ethanol + NADP+
acetaldehyde + NADPH + H+
-
-
-
-
r
ethanol + NADP+
acetaldehyde + NADPH + H+
-
-
-
-
r
ethanol + NADP+
acetaldehyde + NADPH + H+
-
-
-
-
r
ethanol + NADP+
acetaldehyde + NADPH + H+
-
-
-
-
r
ethanol + NADP+
acetaldehyde + NADPH + H+
-
-
-
-
r
ethanol + NADP+
acetaldehyde + NADPH + H+
-
-
-
-
r
ethanol + NADP+
acetaldehyde + NADPH + H+
-
-
-
-
?
ethanol + NADP+
acetaldehyde + NADPH + H+
-
-
-
-
?
ethanol + NADP+
acetaldehyde + NADPH + H+
-
-
-
-
r
ethanol + NADP+
acetaldehyde + NADPH + H+
ethanol is the best substrate
-
-
r
ethanol + NADP+
acetaldehyde + NADPH + H+
ethanol is the best substrate
-
-
r
ethanol + NADP+
acetaldehyde + NADPH + H+
-
-
-
-
?
ethanol + NADP+
acetaldehyde + NADPH + H+
-
-
-
-
r
ethanol + NADP+
acetaldehyde + NADPH + H+
-
-
-
r
ethanol + NADP+
acetaldehyde + NADPH + H+
-
-
-
-
r
ethanol + NADP+
acetaldehyde + NADPH + H+
-
isoform AdhB: no oxidation of ethanol
-
-
r
ethanol + NADP+
acetaldehyde + NADPH + H+
-
-
-
-
r
ethanol + NADP+
acetaldehyde + NADPH + H+
-
-
-
-
r
ethanol + NADP+
acetaldehyde + NADPH + H+
-
-
-
-
r
ethanol + NADP+
acetaldehyde + NADPH + H+
-
-
-
-
r
ethanol + NADP+
acetaldehyde + NADPH + H+
-
kcat/Km for NAD+ is 1900fold lower compared to NADP+
-
-
r
ethanol + NADP+
acetaldehyde + NADPH + H+
-
-
-
-
?
ethanol + NADP+
acetaldehyde + NADPH + H+
-
-
-
-
r
ethanol + NADP+
acetaldehyde + NADPH + H+
-
2% activity compared to cinnamyl alcohol
-
-
r
ethanol + NADP+
acetaldehyde + NADPH + H+
-
4% of activity with cinnamyl alcohol
-
-
r
ethanol + NADP+
acetaldehyde + NADPH + H+
-
19% activity with 1 mM ethanol, 91% activity with 10 mM ethanol
1% activity with 0.1 mM acetaldehyde, 23% activity with 1 mM acetaldehyde
-
r
ethanol + NADP+
acetaldehyde + NADPH + H+
-
30 mM Tris-HCl (pH 8.0) in the presence of 0.5 mM NADP+, 19% relative activity with 1 mM or 91% relative activity with 10 mM substrate
-
-
r
ethanol + NADP+
acetaldehyde + NADPH + H+
-
-
-
-
r
ethanol + NADP+
acetaldehyde + NADPH + H+
-
-
-
-
r
ethanol + NADP+
acetaldehyde + NADPH + H+
-
-
-
-
r
ethanol + NADP+
acetaldehyde + NADPH + H+
5.7% of the activity compared to the substrate 2-butanol
-
-
r
ethanol + NADP+
acetaldehyde + NADPH + H+
-
-
-
-
r
ethanol + NADP+
acetaldehyde + NADPH + H+
-
-
-
-
r
ethanol + NADP+
acetaldehyde + NADPH + H+
-
-
-
-
r
ethanol + NADP+
acetaldehyde + NADPH + H+
-
-
-
-
r
ethanol + NADP+
acetaldehyde + NADPH + H+
the native enzyme shows 100% activity with ethanol
-
-
?
ethanol + NADP+
acetaldehyde + NADPH + H+
-
-
-
-
r
ethanol + NADP+
acetaldehyde + NADPH + H+
the native enzyme shows 100% activity with ethanol
-
-
?
ethanol + NADP+
acetaldehyde + NADPH + H+
-
-
-
-
r
ethanol + NADP+
acetaldehyde + NADPH + H+
-
-
-
-
r
ethanol + NADP+
acetaldehyde + NADPH + H+
-
-
-
-
r
ethyl 4-chloro-3-oxobutanoate + NADPH + H+
ethyl (S)-4-chloro-3-hydroxybutanoate + NADP+
-
-
-
-
?
ethyl 4-chloro-3-oxobutanoate + NADPH + H+
ethyl (S)-4-chloro-3-hydroxybutanoate + NADP+
-
-
-
-
?
ethyl-4-chloro-3-oxobutanoate + NADPH + H+
ethyl-4-chloro-3-hydroxybutanoate + NADP+
-
-
-
-
?
ethyl-4-chloro-3-oxobutanoate + NADPH + H+
ethyl-4-chloro-3-hydroxybutanoate + NADP+
-
-
-
-
?
ethyl-4-chloro-3-oxobutanoate + NADPH + H+
ethyl-4-chloro-3-hydroxybutanoate + NADP+
-
-
-
-
?
ethylacetoacetate + NADPH
ethyl L-(+)-3-hydroxybutyrate + NADP+
-
-
-
-
?
ethylacetoacetate + NADPH
ethyl L-(+)-3-hydroxybutyrate + NADP+
-
-
-
-
?
formaldehyde + NADPH
methanol + NADP+
6% of activity with acetaldehyde
-
-
ir
formaldehyde + NADPH
methanol + NADP+
-
methanal
-
-
?
formaldehyde + NADPH
methanol + NADP+
-
-
-
-
?
formaldehyde + NADPH
methanol + NADP+
-
-
-
-
?
formaldehyde + NADPH
methanol + NADP+
-
-
-
-
?
formaldehyde + NADPH + H+
methanol + NADP+
-
-
-
r
formaldehyde + NADPH + H+
methanol + NADP+
-
-
-
?
formaldehyde + NADPH + H+
methanol + NADP+
-
-
-
?
furfural + NADH + H+
furfuryl alcohol + NAD+
-
-
-
?
furfural + NADH + H+
furfuryl alcohol + NAD+
-
-
-
?
furfural + NADPH
furfuryl alcohol + NADP+
-
27% of activity with cinnamaldehyde
-
-
r
furfural + NADPH
furfuryl alcohol + NADP+
-
54% activity compared to cinnamaldehyde
-
-
r
furfural + NADPH + H+
furfuryl alcohol + NADP+
-
-
-
?
furfural + NADPH + H+
furfuryl alcohol + NADP+
-
-
-
?
glucuronate + NADPH
?
-
-
-
?
glucuronate + NADPH
?
-
-
-
?
glucuronate + NADPH + H+
?
-
-
-
?
glucuronate + NADPH + H+
?
-
-
-
?
glycerol + NADP+
dihydroxyacetone + NADPH + H+
-
-
-
r
glycerol + NADP+
dihydroxyacetone + NADPH + H+
-
-
-
r
glycerol + NADP+
DL-glyceraldehyde + NADPH + H+
-
-
-
-
?
glycerol + NADP+
DL-glyceraldehyde + NADPH + H+
-
-
-
-
r
glycerol + NADP+
DL-glyceraldehyde + NADPH + H+
-
-
-
-
r
glycerol + NADP+
DL-glyceraldehyde + NADPH + H+
-
-
-
-
r
glycolaldehyde + NADPH
ethane-1,2-diol + NADP+
-
-
-
-
?
glycolaldehyde + NADPH
ethane-1,2-diol + NADP+
-
-
-
-
r
heptanal + NADPH
1-heptanol + NADP+
-
86% activity compared to cinnamaldehyde
-
-
r
heptanal + NADPH
1-heptanol + NADP+
-
88% of activity with cinnamaldehyde
-
-
r
hexan-1-ol + NADP+
hexanal + NADPH + H+
-
-
-
-
?
hexan-1-ol + NADP+
hexanal + NADPH + H+
-
best substrate tested
-
-
?
hexan-1-ol + NADP+
hexanal + NADPH + H+
-
-
-
-
?
hexan-1-ol + NADP+
hexanal + NADPH + H+
-
-
-
r
hexanal + NADPH + H+
1-hexanol + NADP+
-
88% activity compared to cinnamaldehyde
-
-
r
hexanal + NADPH + H+
1-hexanol + NADP+
-
89% of activity with cinnamaldehyde
-
-
r
hexanal + NADPH + H+
hexanol + NADP+
-
-
-
-
r
hexanal + NADPH + H+
hexanol + NADP+
-
-
-
-
r
hexanal + NADPH + H+
hexanol + NADP+
-
-
-
-
r
hexanal + NADPH + H+
hexanol + NADP+
-
-
-
-
r
hexanal + NADPH + H+
hexanol + NADP+
-
30 mM Tris-HCl (pH 8.0) in the presence of 0.2 mM NADPH, 53% relative activity with 0.1 mM or 100% relative activity with 1 mM substrate
-
-
r
hexanal + NADPH + H+
hexanol + NADP+
-
-
-
-
?
hexanol + NADP+
hexanal + NADPH
60% of activity with ethanol
-
-
r
hexanol + NADP+
hexanal + NADPH
-
154% of activity with cinnamyl alcohol
-
-
r
hexanol + NADP+
hexanal + NADPH + H+
-
27% activity with 1 mM hexanol, 40% activity with 10 mM hexanol
53% activity with 0.1 mM hexanal, 100% activity with 1 mM hexanal
-
r
hexanol + NADP+
hexanal + NADPH + H+
-
30 mM Tris-HCl (pH 8.0) in the presence of 0.5 mM NADP+, 27% relative activity with 1 mM or 40% relative activity with 10 mM substrate
-
-
r
indol-3-ylacetaldehyde + NADPH
indol-3-ethanol + NADP+
-
-
-
-
?
indol-3-ylacetaldehyde + NADPH
indol-3-ethanol + NADP+
-
-
-
-
r
indol-3-ylacetaldehyde + NADPH
indol-3-ethanol + NADP+
-
-
-
-
?
indol-3-ylacetaldehyde + NADPH
indol-3-ethanol + NADP+
-
-
-
-
r
isobutanol + NADP+
isobutanal + NADPH + H+
-
122% of the activity compared to ethanol
-
-
r
isobutanol + NADP+
isobutanal + NADPH + H+
-
-
-
-
r
isobutanol + NADP+
isobutanal + NADPH + H+
-
93% of the activity with ethanol
-
-
r
isobutanol + NADP+
isobutanal + NADPH + H+
-
93% of the activity with ethanol
-
-
r
L-glyceraldehyde + NADPH
glycerol + NADP+
-
-
-
-
r
L-glyceraldehyde + NADPH
glycerol + NADP+
-
-
-
-
r
L-glyceraldehyde + NADPH
glycerol + NADP+
-
-
-
-
r
L-glyceraldehyde + NADPH
glycerol + NADP+
-
-
-
-
r
L-glyceraldehyde + NADPH
glycerol + NADP+
-
-
-
-
r
L-glyceraldehyde + NADPH
glycerol + NADP+
-
-
286149, 286168, 286175, 286176, 286181, 286182, 286184, 286186, 286187, 286196, 286199 -
-
r
L-glyceraldehyde + NADPH
glycerol + NADP+
-
-
-
-
r
L-glyceraldehyde + NADPH
glycerol + NADP+
-
-
-
-
r
L-glyceraldehyde + NADPH
glycerol + NADP+
-
-
-
-
r
L-glyceraldehyde + NADPH
glycerol + NADP+
-
-
-
-
r
L-glyceraldehyde + NADPH
glycerol + NADP+
-
-
-
-
r
L-glyceraldehyde + NADPH
glycerol + NADP+
-
-
-
-
r
L-glyceraldehyde + NADPH
glycerol + NADP+
-
-
-
-
r
L-gulonic acid + NADP+
D-glucuronic acid + NADPH
-
-
-
-
?
L-gulonic acid + NADP+
D-glucuronic acid + NADPH
-
-
-
-
r
L-gulonic acid + NADP+
D-glucuronic acid + NADPH
-
-
-
-
r
L-gulonic acid + NADP+
D-glucuronic acid + NADPH
-
-
-
-
r
L-gulonic acid + NADP+
D-glucuronic acid + NADPH
-
-
-
-
?
L-gulonic acid + NADP+
D-glucuronic acid + NADPH
-
-
-
-
r
L-gulonic acid + NADPH
D-glucuronic acid + NADP+
-
-
-
-
?
L-gulonic acid + NADPH
D-glucuronic acid + NADP+
-
-
-
-
r
L-gulonic acid + NADPH
D-glucuronic acid + NADP+
-
-
-
-
r
L-gulonic acid + NADPH
D-glucuronic acid + NADP+
-
-
-
-
r
L-gulonic acid + NADPH
D-glucuronic acid + NADP+
-
-
-
-
?
L-gulonic acid + NADPH
D-glucuronic acid + NADP+
-
-
-
-
r
L-xylose + NADPH
? + NADP+
-
-
-
-
?
L-xylose + NADPH
? + NADP+
-
-
-
-
?
lauryl aldehyde + NADPH
lauryl alcohol + NADP+
-
-
-
-
?
lauryl aldehyde + NADPH
lauryl alcohol + NADP+
-
isozyme AR3
-
-
?
m-fluorobenzaldehyde + NADPH + H+
m-fluorobenzyl alcohol + NADP+
-
-
-
-
?
m-fluorobenzaldehyde + NADPH + H+
m-fluorobenzyl alcohol + NADP+
-
-
-
-
?
m-methoxybenzaldehyde + NADPH + H+
m-methoxybenzyl alcohol + NADP+
-
-
-
-
r
m-methoxybenzaldehyde + NADPH + H+
m-methoxybenzyl alcohol + NADP+
-
-
-
-
?
m-methylbenzaldehyde + NADPH
m-methylbenzyl alcohol + NADP+
-
-
-
-
?
m-methylbenzaldehyde + NADPH
m-methylbenzyl alcohol + NADP+
-
-
-
-
?
m-nitrobenzaldehyde + NADPH
m-nitrobenzylalcohol + NADP+
-
-
-
-
?
m-nitrobenzaldehyde + NADPH
m-nitrobenzylalcohol + NADP+
-
-
-
-
r
m-nitrobenzaldehyde + NADPH
m-nitrobenzylalcohol + NADP+
-
-
-
-
r
m-nitrobenzaldehyde + NADPH
m-nitrobenzylalcohol + NADP+
-
-
-
-
r
m-nitrobenzaldehyde + NADPH
m-nitrobenzylalcohol + NADP+
-
-
-
-
ir
m-nitrobenzaldehyde + NADPH
m-nitrobenzylalcohol + NADP+
-
-
-
-
ir
m-nitrobenzaldehyde + NADPH
m-nitrobenzylalcohol + NADP+
-
-
-
-
r
m-nitrobenzaldehyde + NADPH
m-nitrobenzylalcohol + NADP+
-
-
-
-
?
methanol + NAD+
formaldehyde + NADH + H+
-
-
-
r
methanol + NAD+
formaldehyde + NADH + H+
-
-
-
r
methyl 4-bromo-3-oxobutanoate + NADPH + H+
methyl (S)-4-bromo-3-hydroxybutanoate + NADP+
-
-
-
-
?
methyl 4-bromo-3-oxobutanoate + NADPH + H+
methyl (S)-4-bromo-3-hydroxybutanoate + NADP+
-
-
-
-
?
methylglyoxal + NADPH
?
-
-
-
-
?
methylglyoxal + NADPH
?
-
27% of the activity compared to ethanol
-
-
?
methylglyoxal + NADPH
? + NADP+
-
-
-
-
?
methylglyoxal + NADPH
? + NADP+
-
-
-
-
r
methylglyoxal + NADPH
? + NADP+
-
-
-
-
r
methylglyoxal + NADPH
? + NADP+
-
-
-
-
r
methylglyoxal + NADPH
? + NADP+
-
-
-
-
?
methylglyoxal + NADPH
? + NADP+
-
-
-
-
r
n-butanol + NADP+
butyraldehyde + NADPH
-
-
-
-
r
n-butanol + NADP+
butyraldehyde + NADPH
-
-
-
-
r
n-butanol + NADP+
butyraldehyde + NADPH
-
-
-
-
r
n-butanol + NADP+
butyraldehyde + NADPH
-
-
-
-
r
n-butanol + NADP+
butyraldehyde + NADPH
-
-
-
-
r
n-butanol + NADP+
butyraldehyde + NADPH
-
-
-
-
r
n-butanol + NADP+
butyraldehyde + NADPH
-
-
-
-
r
n-butanol + NADP+
butyraldehyde + NADPH
-
-
-
-
r
n-butanol + NADP+
butyraldehyde + NADPH
-
-
-
-
r
n-butyraldehyde + NADPH
n-butanol + NADP+
-
-
-
-
r
n-butyraldehyde + NADPH
n-butanol + NADP+
-
-
-
-
r
n-butyraldehyde + NADPH
n-butanol + NADP+
-
-
-
-
r
n-butyraldehyde + NADPH
n-butanol + NADP+
-
-
-
-
r
n-butyraldehyde + NADPH
n-butanol + NADP+
-
-
-
-
r
n-butyraldehyde + NADPH
n-butanol + NADP+
-
-
-
-
?
n-butyraldehyde + NADPH
n-butanol + NADP+
-
-
-
-
r
n-butyraldehyde + NADPH
n-butanol + NADP+
-
relative activity 2%
-
-
r
n-butyraldehyde + NADPH
n-butanol + NADP+
-
-
-
-
r
n-butyraldehyde + NADPH
n-butanol + NADP+
-
-
-
-
r
n-butyraldehyde + NADPH
n-butanol + NADP+
-
-
-
-
r
n-decanal + NADPH + H+
n-decanol + NADP+
-
-
-
-
r
n-decanal + NADPH + H+
n-decanol + NADP+
-
-
-
-
r
n-decanal + NADPH + H+
n-decanol + NADP+
-
converted less efficiently than eutypine
-
-
?
n-dodecanal + NADPH + H+
n-dodecanol + NADP+
-
-
-
-
r
n-dodecanal + NADPH + H+
n-dodecanol + NADP+
-
-
-
-
r
n-heptanal + NADPH
heptanol + NADP+
-
-
-
-
r
n-heptanal + NADPH
heptanol + NADP+
-
-
-
-
r
n-heptanol + NADP+
n-heptanal + NADPH
-
-
-
-
r
n-heptanol + NADP+
n-heptanal + NADPH
-
-
-
-
r
n-heptanol + NADP+
n-heptanal + NADPH
-
primary alcohol dehydrogenase
-
-
r
n-heptanol + NADP+
n-heptanal + NADPH
-
-
-
-
r
n-hexadecanal + NADPH + H+
n-hexadecanol + NADP+
-
-
-
-
r
n-hexadecanal + NADPH + H+
n-hexadecanol + NADP+
-
-
-
-
r
n-hexanol + NADP+
n-hexanal + NADPH
-
-
-
-
r
n-hexanol + NADP+
n-hexanal + NADPH
-
-
-
-
r
n-hexanol + NADP+
n-hexanal + NADPH
-
-
-
-
r
n-hexanol + NADP+
n-hexanal + NADPH
-
-
-
-
r
n-octanal + NADPH + H+
n-octanol + NADP+
-
-
-
-
r
n-octanal + NADPH + H+
n-octanol + NADP+
-
-
-
-
r
n-octanal + NADPH + H+
n-octanol + NADP+
-
-
-
-
r
n-octanal + NADPH + H+
n-octanol + NADP+
-
-
-
-
?
n-octanal + NADPH + H+
n-octanol + NADP+
-
-
-
-
r
n-octanal + NADPH + H+
n-octanol + NADP+
-
-
-
-
?
n-propanol + NADP+
propionaldehyde + NADPH
-
-
-
-
r
n-propanol + NADP+
propionaldehyde + NADPH
-
-
-
-
r
n-propanol + NADP+
propionaldehyde + NADPH
-
-
-
-
r
n-propanol + NADP+
propionaldehyde + NADPH
-
-
-
-
r
n-propanol + NADP+
propionaldehyde + NADPH
-
-
-
-
r
n-propanol + NADP+
propionaldehyde + NADPH
-
-
-
-
r
o-fluorobenzaldehyde + NADPH + H+
o-fluorobenzyl alcohol + NADP+
-
-
-
-
?
o-fluorobenzaldehyde + NADPH + H+
o-fluorobenzyl alcohol + NADP+
-
-
-
-
?
o-methylbenzaldehyde + NADPH
o-methylbenzyl alcohol + NADP+
-
-
-
-
?
o-methylbenzaldehyde + NADPH
o-methylbenzyl alcohol + NADP+
-
-
-
-
?
o-nitrobenzaldehyde + NADPH
o-nitrobenzylalcohol + NADP+
-
-
-
-
?
o-nitrobenzaldehyde + NADPH
o-nitrobenzylalcohol + NADP+
-
-
-
-
r
o-nitrobenzaldehyde + NADPH
o-nitrobenzylalcohol + NADP+
-
-
-
-
ir
o-nitrobenzaldehyde + NADPH
o-nitrobenzylalcohol + NADP+
-
-
-
-
ir
o-nitrobenzaldehyde + NADPH
o-nitrobenzylalcohol + NADP+
-
-
-
-
r
o-nitrobenzaldehyde + NADPH
o-nitrobenzylalcohol + NADP+
-
-
-
-
?
octan-1-ol + NADP+
octanal + NADPH + H+
-
-
-
-
?
octan-1-ol + NADP+
octanal + NADPH + H+
-
isoform ADH-I, 85%, isoform ADH II, 50% of the activity with hexan-1-ol
-
-
?
octan-1-ol + NADP+
octanal + NADPH + H+
-
-
-
r
octanal + NADPH + H+
1-octanol + NADP+
-
59% activity compared to cinnamaldehyde
-
-
r
octanal + NADPH + H+
1-octanol + NADP+
-
84% of activity with cinnamaldehyde
-
-
r
octanol + NADP+
octanal + NADPH + H+
-
-
-
-
r
octanol + NADP+
octanal + NADPH + H+
-
30 mM Tris-HCl (pH 8.0) in the presence of 0.5 mM NADP+, 8% relative activity with 1 mM or 17% relative activity with 10 mM substrate
-
-
r
octanol + NADP+
octanal + NADPH + H+
-
8% activity with 1 mM octanol, 17% activity with 10 mM octanol
42% activity with 0.1 mM octanal, 80% activity with 1 mM octanal
-
r
p-carboxybenzaldehyde + NADPH
p-carboxybenzyl alcohol + NADP+
-
-
-
-
r
p-carboxybenzaldehyde + NADPH
p-carboxybenzyl alcohol + NADP+
-
AR1
-
-
r
p-carboxybenzaldehyde + NADPH
p-carboxybenzyl alcohol + NADP+
-
-
-
-
?
p-carboxybenzaldehyde + NADPH
p-carboxybenzyl alcohol + NADP+
-
-
-
-
r
p-carboxybenzaldehyde + NADPH
p-carboxybenzyl alcohol + NADP+
-
-
-
-
r
p-carboxybenzaldehyde + NADPH
p-carboxybenzyl alcohol + NADP+
-
-
-
r
p-carboxybenzaldehyde + NADPH
p-carboxybenzyl alcohol + NADP+
-
-
-
-
r
p-carboxybenzaldehyde + NADPH
p-carboxybenzyl alcohol + NADP+
-
-
-
-
r
p-chlorobenzaldehyde + NADPH + H+
p-chlorobenzyl alcohol + NADP+
-
-
-
-
r
p-chlorobenzaldehyde + NADPH + H+
p-chlorobenzyl alcohol + NADP+
-
-
-
-
ir
p-chlorobenzaldehyde + NADPH + H+
p-chlorobenzyl alcohol + NADP+
-
-
-
-
r
p-cyanobenzaldehyde + NADPH
p-cyanobenzyl alcohol + NADP+
-
-
-
-
?
p-cyanobenzaldehyde + NADPH
p-cyanobenzyl alcohol + NADP+
-
-
-
-
r
p-cyanobenzaldehyde + NADPH
p-cyanobenzyl alcohol + NADP+
-
-
-
-
?
p-fluorobenzaldehyde + NADPH + H+
p-fluorobenzyl alcohol + NADP+
-
-
-
-
?
p-fluorobenzaldehyde + NADPH + H+
p-fluorobenzyl alcohol + NADP+
-
-
-
-
?
p-fluorobenzaldehyde + NADPH + H+
p-fluorobenzyl alcohol + NADP+
-
-
-
-
?
p-hydroxyphenylacetaldehyde + NADPH + H+
p-hydroxyphenylethanol + NADP+
-
-
-
-
r
p-hydroxyphenylacetaldehyde + NADPH + H+
p-hydroxyphenylethanol + NADP+
-
-
-
-
r
p-hydroxyphenylacetaldehyde + NADPH + H+
p-hydroxyphenylethanol + NADP+
-
-
-
-
r
p-hydroxyphenylglycolaldehyde + NADPH
4-hydroxyphenylethylalcohol + NADP+
-
-
-
-
r
p-hydroxyphenylglycolaldehyde + NADPH
4-hydroxyphenylethylalcohol + NADP+
-
-
-
-
r
p-hydroxyphenylglycolaldehyde + NADPH
4-hydroxyphenylethylalcohol + NADP+
-
-
-
-
r
p-methoxybenzaldehyde + NADPH + H+
p-methoxybenzyl alcohol + NADP+
-
-
-
-
r
p-methoxybenzaldehyde + NADPH + H+
p-methoxybenzyl alcohol + NADP+
-
-
-
-
?
p-methylbenzaldehyde + NADPH
p-methylbenzyl alcohol + NADP+
-
-
-
-
?
p-methylbenzaldehyde + NADPH
p-methylbenzyl alcohol + NADP+
-
-
-
-
?
p-nitrobenzaldehyde + NADPH
p-nitrobenzylalcohol + NADP+
-
-
-
-
r
p-nitrobenzaldehyde + NADPH
p-nitrobenzylalcohol + NADP+
-
AR1
-
-
r
p-nitrobenzaldehyde + NADPH
p-nitrobenzylalcohol + NADP+
-
cofactor NADPH
-
-
r
p-nitrobenzaldehyde + NADPH
p-nitrobenzylalcohol + NADP+
-
-
-
-
?
p-nitrobenzaldehyde + NADPH
p-nitrobenzylalcohol + NADP+
-
-
-
-
r
p-nitrobenzaldehyde + NADPH
p-nitrobenzylalcohol + NADP+
-
-
-
-
?
p-nitrobenzaldehyde + NADPH
p-nitrobenzylalcohol + NADP+
-
-
-
-
r
p-nitrobenzaldehyde + NADPH
p-nitrobenzylalcohol + NADP+
-
-
-
?
p-nitrobenzaldehyde + NADPH
p-nitrobenzylalcohol + NADP+
-
cofactor NADPH
-
-
r
p-nitrobenzaldehyde + NADPH
p-nitrobenzylalcohol + NADP+
-
-
-
-
r
p-nitrobenzaldehyde + NADPH
p-nitrobenzylalcohol + NADP+
-
-
-
-
r
p-nitrobenzaldehyde + NADPH
p-nitrobenzylalcohol + NADP+
-
-
-
-
?
p-nitrobenzaldehyde + NADPH
p-nitrobenzylalcohol + NADP+
-
-
286164, 286165, 286166, 286172, 286174, 286175, 286176, 286177, 286182, 286183, 286184, 286190, 286204, 288554 -
-
r
p-nitrobenzaldehyde + NADPH
p-nitrobenzylalcohol + NADP+
-
-
-
-
r
p-nitrobenzaldehyde + NADPH
p-nitrobenzylalcohol + NADP+
-
-
-
-
ir
p-nitrobenzaldehyde + NADPH
p-nitrobenzylalcohol + NADP+
-
-
-
-
ir
p-nitrobenzaldehyde + NADPH
p-nitrobenzylalcohol + NADP+
-
-
-
-
r
p-nitrobenzaldehyde + NADPH
p-nitrobenzylalcohol + NADP+
-
cofactor NADPH
-
-
r
p-nitrobenzaldehyde + NADPH
p-nitrobenzylalcohol + NADP+
-
-
-
-
?
p-nitrobenzaldehyde + NADPH
p-nitrobenzylalcohol + NADP+
-
-
-
-
?
pentan-1-ol + NADP+
pentanal + NADPH + H+
-
-
-
-
?
pentan-1-ol + NADP+
pentanal + NADPH + H+
-
isoform ADH-I, 93%, isoform ADH II, 90% of the activity with hexan-1-ol
-
-
?
pentanal + NADPH
1-pentanol + NADP+
-
109% of activity with cinnamaldehyde
-
-
r
pentanal + NADPH
1-pentanol + NADP+
-
153% activity compared to cinnamaldehyde
-
-
r
pentanal + NADPH
pentanol + NADP+
-
-
-
-
r
pentanal + NADPH
pentanol + NADP+
-
-
-
-
r
pentanal + NADPH
pentanol + NADP+
-
-
-
-
r
pentanal + NADPH
pentanol + NADP+
-
-
-
-
r
pentanal + NADPH + H+
pentan-1-ol + NADP+
-
-
-
?
pentanal + NADPH + H+
pentan-1-ol + NADP+
-
-
-
?
pentanal + NADPH + H+
pentan-1-ol + NADP+
-
-
-
-
?
pentanol + NADP+
pentanal + NADPH
75% of activity with ethanol
-
-
r
pentanol + NADP+
pentanal + NADPH
-
89% of activity with cinnamyl alcohol
-
-
r
pentanol + NADP+
pentanal + NADPH + H+
-
30 mM Tris-HCl (pH 8.0) in the presence of 0.5 mM NADP+, 31% relative activity with 1 mM or 52% relative activity with 10 mM substrate
-
-
r
pentanol + NADP+
pentanal + NADPH + H+
-
31% activity with 1 mM pentanol, 52% activity with 10 mM pentanol
100% activity with 0.1 mM pentanal, 107% activity with 1 mM pentanal
-
r
phenylacetaldehyde + NADPH + H+
2-phenylethanol + NADP+
-
-
-
-
?
phenylacetaldehyde + NADPH + H+
2-phenylethanol + NADP+
-
90% activity compared to cinnamaldehyde
-
-
r
phenylacetaldehyde + NADPH + H+
2-phenylethanol + NADP+
-
-
-
-
?
phenylacetaldehyde + NADPH + H+
phenylethanol + NADP+
-
-
-
-
r
phenylacetaldehyde + NADPH + H+
phenylethanol + NADP+
-
-
-
-
r
phenylacetaldehyde + NADPH + H+
phenylethanol + NADP+
-
-
-
-
r
phenylethanol + NADP+
phenylacetaldehyde + NADPH + H+
-
-
-
-
r
phenylethanol + NADP+
phenylacetaldehyde + NADPH + H+
-
-
-
-
r
phenylethanol + NADP+
phenylacetaldehyde + NADPH + H+
-
15% activity with 1 mM phenylethanol, 24% activity with 10 mM phenylethanol
-
-
r
phenylglyoxal + NADPH
? + NADP+
-
-
-
-
?
phenylglyoxal + NADPH
? + NADP+
-
-
-
-
r
phenylglyoxal + NADPH
? + NADP+
-
-
-
-
r
propan-1-ol + NADP+
propanal + NADPH + H+
-
-
-
-
?
propan-1-ol + NADP+
propanal + NADPH + H+
-
-
-
-
?
propan-1-ol + NADP+
propanal + NADPH + H+
-
isoform AdhA, 162% of the activity with acetaldehyde
-
-
r
propan-2-ol + NADP+
propanone + NADPH
-
-
-
-
r
propan-2-ol + NADP+
propanone + NADPH
-
2° Adh
-
-
r
propanal + NADPH + H+
1-propanol + NADP+
49% of activity with acetaldehyde
-
-
r
propanal + NADPH + H+
1-propanol + NADP+
-
21% of activity with cinnamaldehyde
-
-
r
propanal + NADPH + H+
1-propanol + NADP+
-
24% activity compared to cinnamaldehyde
-
-
r
propanal + NADPH + H+
1-propanol + NADP+
-
30 mM Tris-HCl (pH 8.0) in the presence of 0.2 mM NADPH, 26% relative activity with 0.1 mM or 87% relative activity with 1 mM substrate
-
-
r
propanal + NADPH + H+
propanol + NADP+
-
-
-
-
r
propanal + NADPH + H+
propanol + NADP+
-
-
-
-
r
propane-1,2-diol + NADP+
lactaldehyde + NADPH
-
-
-
-
r
propane-1,2-diol + NADP+
lactaldehyde + NADPH
-
-
-
-
r
propane-1,2-diol + NADP+
lactaldehyde + NADPH
-
-
-
-
r
propanol + NADP+
propanal + NADPH
70% of activity with ethanol
-
-
r
propanol + NADP+
propanal + NADPH
-
7% of activity with cinnamyl alcohol
-
-
r
propionaldehyde + NADPH
propanol + NADP+
-
-
-
-
?
propionaldehyde + NADPH
propanol + NADP+
-
-
-
-
r
propionaldehyde + NADPH
propanol + NADP+
-
-
-
-
r
propionaldehyde + NADPH
propanol + NADP+
-
-
-
-
r
propionaldehyde + NADPH
propanol + NADP+
-
-
-
-
r
propionaldehyde + NADPH
propanol + NADP+
-
-
-
-
?
pyruvaldehyde + NADPH + H+
lactaldehyde + NADP+
maximal activity in reductive reaction
-
-
r
pyruvaldehyde + NADPH + H+
lactaldehyde + NADP+
-
-
-
?
pyruvaldehyde + NADPH + H+
lactaldehyde + NADP+
-
-
-
?
sinapaldehyde + NADPH + H+
sinapyl alcohol + NADP+
-
3% of activity with cinnamaldehyde
-
-
r
sinapaldehyde + NADPH + H+
sinapyl alcohol + NADP+
-
converted less efficiently than eutypine
-
-
?
succinic semialdehyde + NADPH + H+
4-hydroxybutyrate + NADP+
-
-
-
-
?
succinic semialdehyde + NADPH + H+
4-hydroxybutyrate + NADP+
-
-
-
-
r
succinic semialdehyde + NADPH + H+
4-hydroxybutyrate + NADP+
-
AR1
-
-
r
succinic semialdehyde + NADPH + H+
4-hydroxybutyrate + NADP+
-
-
-
-
r
succinic semialdehyde + NADPH + H+
4-hydroxybutyrate + NADP+
-
-
-
-
r
succinic semialdehyde + NADPH + H+
4-hydroxybutyrate + NADP+
-
-
-
r
succinic semialdehyde + NADPH + H+
4-hydroxybutyrate + NADP+
-
-
-
-
r
succinic semialdehyde + NADPH + H+
4-hydroxybutyrate + NADP+
-
-
-
?
succinic semialdehyde + NADPH + H+
4-hydroxybutyrate + NADP+
-
-
-
-
r
succinic semialdehyde + NADPH + H+
4-hydroxybutyrate + NADP+
-
-
-
r
succinic semialdehyde + NADPH + H+
4-hydroxybutyrate + NADP+
-
-
-
-
r
succinic semialdehyde + NADPH + H+
4-hydroxybutyrate + NADP+
-
-
-
-
r
trans-2-hexenol + NADP+
trans-2-hexenal + NADPH
-
-
-
-
r
trans-2-hexenol + NADP+
trans-2-hexenal + NADPH
-
-
-
-
r
trans-cinnamaldehyde + NADPH
cinnamyl alcohol + NADP+
-
-
-
-
?
trans-cinnamaldehyde + NADPH
cinnamyl alcohol + NADP+
-
converted less efficiently than eutypine
-
-
?
vanillin + NADPH
4-hydroxy-3-methoxybenzyl alcohol + NADP+
-
57% of activity with cinnamaldehyde
-
-
r
vanillin + NADPH
4-hydroxy-3-methoxybenzyl alcohol + NADP+
-
84% activity compared to cinnamaldehyde
-
-
r
veratraldehyde + NADPH
3,4-dimethoxybenzyl alcohol + NADP+
-
79% activity compared to cinnamaldehyde
-
-
r
veratraldehyde + NADPH
3,4-dimethoxybenzyl alcohol + NADP+
-
82% of activity with cinnamaldehyde
-
-
r
additional information
?
-
-
-
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?
additional information
?
-
-
-
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?
additional information
?
-
-
-
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-
?
additional information
?
-
-
AR1 is not active with neutral sugars or with ketones, AR3 is capable of reducing neutral sugars, G2 is active with ketones, AR4 is inactive with 15-oxoprostaglandin B1
-
-
?
additional information
?
-
-
short chain aliphathic aldehydes such as actealdehyde or propionaldehyde are no substrates, benzyl-substituted ketones such as pyruvic acid are not reduced
-
-
?
additional information
?
-
-
D-hexose is no substrate
-
-
?
additional information
?
-
-
the enatiomeric excess with all substrates is over 99%
-
-
-
additional information
?
-
-
preference for alcohols longer than C3
-
-
?
additional information
?
-
-
YqhD mediates resistance to potassium tellurite and other reactive oxygen species elicitors in Escherichia coli, and protects from protein oxidation, YqhD lowers toxic acrolein concentrations, overview
-
-
?
additional information
?
-
-
YqhD does not show any detectable enzymatic activity when tested with short-chain alcohols as substrates, e.g. on methanol, ethanol, propanol, butanol, or isopropanol
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
glucose, galactose, fructose, sorbitol, galactitol, xylitol and glycerol are no substrates
-
-
?
additional information
?
-
-
enzyme is virtually inactive for aldo-sugars
-
-
?
additional information
?
-
-
enzyme is virtually inactive for aldo-sugars
-
-
?
additional information
?
-
-
no enzymatic activity in the presence of NADPH with acetaldehyde, pyridoxal, pyridoxal phosphate, glyceraldehyde phosphate, glucose or fructose, no activity in the reverse reaction with ethanol, cyclohexanol, phenylpropyl alcohol and glycerol phosphate
-
-
?
additional information
?
-
no substrate: methanol, 2-mercaptoethanol
-
-
?
additional information
?
-
-
specific for R-stereoisomers of alcohols
-
-
?
additional information
?
-
-
the chemoenzymatic synthesis of the tert-butyl (S)-6-chloro-5-hydroxy-3-ketohexanoate, a highly regio- and enantioselective reduction of a beta,delta-diketohexanoate ester, is catalyzed by the enzyme. The chlorinated diketo ester is converted to the general statin precursor acetonide via the hydroxy keto ester and hydroxyhexanoate, the reaction is reversible, overview
-
-
?
additional information
?
-
Marinobacter nauticus VT8
-
no activity with butanal, hexanal and benzaldehyde
-
-
?
additional information
?
-
enzyme does not catalyze the oxidation of alcoholic substrates butanol, propanol, ethanol, methanol, glycerol, 1,3-propanediol, and 1,2-propandiol with NAD(P)+ as cofactor
-
-
?
additional information
?
-
enzyme does not catalyze the oxidation of alcoholic substrates butanol, propanol, ethanol, methanol, glycerol, 1,3-propanediol, and 1,2-propandiol with NAD(P)+ as cofactor
-
-
?
additional information
?
-
-
enzyme does not catalyze the oxidation of alcoholic substrates butanol, propanol, ethanol, methanol, glycerol, 1,3-propanediol, and 1,2-propandiol with NAD(P)+ as cofactor
-
-
?
additional information
?
-
-
no activity with methanol, 2-propanol, 2-butanol and acetone
-
-
?
additional information
?
-
a broad range of primary alcohols could be oxidized by AdhA and includes substrates with 2-10 carbon atoms. It shows activity towards a broad range of secondary alcohols that on average are oxidized faster than the primary alcohols. Alcohols with a second or a third hydroxyl group are converted less efficiently
-
-
?
additional information
?
-
-
a broad range of primary alcohols could be oxidized by AdhA and includes substrates with 2-10 carbon atoms. It shows activity towards a broad range of secondary alcohols that on average are oxidized faster than the primary alcohols. Alcohols with a second or a third hydroxyl group are converted less efficiently
-
-
?
additional information
?
-
-
no activity with methanol, 2-propanol, glycerol, D-sorbitol
-
-
?
additional information
?
-
-
enzyme is virtually inactive for aldo-sugars
-
-
?
additional information
?
-
-
enzyme from rat brain microsomes do not reduce p-pyridinecarboxaldehyde, which is a very active substrate for high-Km aldehyde reductase from rat kidney cytosol
-
-
?
additional information
?
-
-
enzyme from rat brain microsomes do not reduce p-pyridinecarboxaldehyde, which is a very active substrate for high-Km aldehyde reductase from rat kidney cytosol
-
-
?
additional information
?
-
-
no subbstrate: acetone, methylglyoxal, cyclohexanone
-
-
?
additional information
?
-
-
the enzyme has a conserved catalytic site at Tyr169-X-X-X-Lys173. An indispensable reduction catalytic triad at Ser131, Tyr169, and Lys173, and an approved cofactor-binding motif at Gly11-X-XGly14-X-X-Ala17 near the N-terminus
-
-
?
additional information
?
-
-
the enzyme has a conserved catalytic site at Tyr169-X-X-X-Lys173. An indispensable reduction catalytic triad at Ser131, Tyr169, and Lys173, and an approved cofactor-binding motif at Gly11-X-XGly14-X-X-Ala17 near the N-terminus
-
-
?
additional information
?
-
-
preference for aromatic and alphatic aldehydes
-
-
?
additional information
?
-
-
D-glucuronate, D-glucose, D-xylose, D-galactose, formaldehyde, acetaldehyde, propionaldehyde, n-butyraldehyde, glycolaldehyde, acetone, acetol, lactaldehyde, dihydroacetone and acetoin are not reduced
-
-
?
additional information
?
-
-
D-glucuronate, D-glucose, D-xylose, D-galactose, formaldehyde, acetaldehyde, propionaldehyde, n-butyraldehyde, glycolaldehyde, acetone, acetol, lactaldehyde, dihydroacetone and acetoin are not reduced
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
-
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-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
5-hydroxyindol-3-ylacetaldehyde is no substrate
-
-
?
additional information
?
-
-
no activity with acetone, 3-pentanone, D-glucose, and 3-pentanol
-
-
?
additional information
?
-
-
activity of the reversible enzyme is highest for secondary alcohols and decreases in order of acetaldehyde, linear ketones, cyclic ketones and primary alcohols. It is active on five- to seven-membered ring ketones but not with cyclo-octanone as substrate
-
-
?
additional information
?
-
-
1° Adh specific for 1°alcohols and aldehydes, no detectable activity towards ketones, 2°alcohols or acetyl-CoA
-
-
?
additional information
?
-
-
1° Adh specific for 1°alcohols and aldehydes, no detectable activity towards ketones, 2°alcohols or acetyl-CoA
-
-
?
additional information
?
-
-
1° Adh specific for 1°alcohols and aldehydes, no detectable activity towards ketones, 2°alcohols or acetyl-CoA
-
-
?
additional information
?
-
the enzyme shows higher activities with the use of secondary alcohols such as 2-butanol and 2-pentanol as substrates, suggesting that the enzyme is a primary-secondary alcohol dehydrogenase. Alcohols oxidized at an acticity of less than 5% compared to the substrate 2-butanol: 1-pentanol, glycerol, 1,2-pentanediol. No oxidation of methanol, 1,4-butanediol, 1,5-pentanediol, ethanediol, phenylethanol, L-serine, L-threonine, acetoin
-
-
?
additional information
?
-
-
enzyme utilizes NADP(H) as a cofactor and preferentially catalyzes aldehyde reduction
-
-
?
additional information
?
-
-
enzyme utilizes NADP(H) as a cofactor and preferentially catalyzes aldehyde reduction
-
-
?
additional information
?
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-
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?
additional information
?
-
-
methanol, isopropanol and glycerol are no substrates
-
-
?
additional information
?
-
-
methanol, isopropanol and glycerol are no substrates
-
-
?
additional information
?
-
-
acetone is no substrate
-
-
?
additional information
?
-
-
the oxidation of 1,4-BD to 4-hydroxybutanal is the first, reversible, rate-limiting step in the NADPH regeneration system with 1,4-butanediol (1,4-BD). It is followed by spontaneous formation of 2-hydroxytetrahydrofuran (2-HTHF) from 4-hydroxybutanal via cyclization. The second enzymatic step, the reduction of 2-HTHF into gamma-butyrolactone, is irreversible, liberating 2 equiv. of NAD(P)H
-
-
-
additional information
?
-
-
dihydroquercitin and dihydromyricetin are no substrates
-
-
?
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(1H-indol-1-yl)acetic acid
-
(2,3-dihydrocyclopenta[b]indol-4(1H)-yl)acetic acid
-
(3-benzyl-2-oxoquinoxalin-1(2H)-yl)acetic acid
32.8% inhibition at 0.010 mM
(3-sulfanyl-5H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid
-
(3-[[(2-fluorophenyl)methyl]sulfanyl]-5H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid
-
(3-[[2-oxo-2-(2,4,6-trimethylanilino)ethyl]sulfanyl]-5H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid
-
(4-oxo-3,4-dihydro-5H-pyridazino[4,5-b]indol-5-yl)acetic acid
-
(6H-indolo[2,3-b]quinoxalin-6-yl)acetic acid
-
(7H-indolo[2',3':5,6][1,2,4]triazino[2,3-a]benzimidazol-7-yl)acetic acid
-
(8-methyl-3-[[2-oxo-2-(propylamino)ethyl]sulfanyl]-5H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid
-
1-(2-(bis-(4-fluorophenyl)methoxy)ethyl)-4-(3-phenyl-2-propenyl)piperazine
i.e. GBR13069. 0.08 mM, 61% inhibition
1-(2-diphenylmethoxyethyl)-4-(3-phenyl-2-propenyl)-piperazine
GBR12783, i.e. 0.08 mM, 59% inhibition
1-(4-nitrobenzyl)-3-(4-(2-morpholinoethyl) piperazin-1-yl)quinoxalin-2(1H)-one
23% inhibition
1-(4-nitrobenzyl)-3-(4-(3-(trifluoromethyl) phenyl)piperazin-1-yl) quinoxalin-2(1H)-one
43% inhibition
1-(4-nitrobenzyl)-3-(4-(4-methoxyphenyl) piperazin-1-yl)quinoxalin-2(1H)-one
26% inhibition
1-(4-nitrobenzyl)-3-(4-(pyrazin-2-yl) piperazin-1-yl)quinoxalin-2(1H)-one
24% inhibition
1-(4-nitrobenzyl)-3-styrylquinoxalin-2(1H)-one
30% inhibition
12-ketochenodeoxycholic acid
-
inhibition of the ADH from Lactobacillus brevis by bile acids, acetone prevents partially
2,3-dimethylsuccinic acid
2,4-dimethylglutaric acid
-
-
2,5-dihydro-3H-[1,2,4]triazino[5,6-b]indole-3-thione
-
2-(2-oxo-3-phenethylquinoxalin-1(2H)-yl) acetic acid
-
2-(2-oxo-3-styrylquinoxalin-1(2H)-yl) acetic acid
-
2-(3,7-bis(4-fluorophenyl)-2-oxoquinoxalin-1(2H)-yl)acetic acid
41.0% inhibition at 0.010 mM
2-(3-(2,4-difluorophenylamino)-6-nitro-2-oxoquinoxalin-1(2H)-yl) acetic acid
-
2-(3-(2,4-dihydroxyphenyl)-2-oxoquinoxalin-1(2H)-yl)acetic acid
36.6% inhibition at 0.010 mM
2-(3-(3-(tert-butylamino)-3-oxoprop-1-en-1-yl)-2-oxoquinoxalin-1(2H)-yl) acetic acid
-
2-(3-(3-indolyl)-2-oxoquinoxalin-1(2H)-yl)acetic acid
32.3% inhibition at 0.010 mM
2-(3-(4-(4-methoxyphenyl) piperazin-1-yl)-2-oxoquinoxalin-1(2H)-yl) acetic acid
-
2-(3-(4-bromothiophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid
12.8% inhibition at 0.010 mM
2-(3-(4-chlorothiophenoxy)-2-oxoquinoxalin-1(2H)-yl)acetic acid
42.4% inhibition at 0.010 mM
2-(3-(4-fluorophenethyl)-2-oxoquinoxalin-1(2H)-yl) acetic acid
-
2-(3-(4-fluorophenyl)-2-oxoquinoxalin-1(2H)-yl)acetic acid
31.8% inhibition at 0.010 mM
2-(3-(4-fluorostyryl)-2-oxoquinoxalin-1(2H)-yl) acetic acid
-
2-(3-(4-fluorostyryl)-6-nitro-2-oxoquinoxalin-1(2H)-yl)acetic acid
-
2-(3-(4-hydroxyphenyl)-2-oxoquinoxalin-1(2H)-yl)acetic acid
34.6% inhibition at 0.010 mM
2-(3-phenoxy-2-oxoquinoxalin-1(2H)-yl)acetic acid
6.6% inhibition at 0.010 mM
2-(3-phenyl-2-oxoquinoxalin-1(2H)-yl)acetic acid
25.4% inhibition at 0.010 mM
2-(3-thiophenoxy-2-oxoquinoxalin-1(2H)-yl)acetic acid
32.2% inhibition at 0.010 mM
2-(6-bromo-3-(2,4-dihydroxyphenyl)-2-oxoquinoxalin-1(2H)-yl)-acetic acid
38.1% inhibition at 0.010 mM
2-(6-bromo-3-(4-bromothiophenoxy)-2-oxoquinoxalin-1(2H)-yl)-acetic acid
8.7% inhibition at 0.010 mM
2-(6-chloro-3-(2,4-dihydroxyphenyl)-2-oxoquinoxalin-1(2H)-yl)-acetic acid
46.5% inhibition at 0.010 mM
2-(6-chloro-3-(4-fluorostyryl)-2-oxoquinoxalin-1(2H)-yl)acetic acid
-
2-(6-fluoro-3-(2,4-dihydroxyphenyl)-2-oxoquinoxalin-1(2H)-yl)-acetic acid
42.5% inhibition at 0.010 mM
2-(7-(4-fluorobenzyl)-3-(2,4-dihydroxyphenyl)-2-oxoquinoxalin-1(2H)-yl)acetic acid
11.6% inhibition at 0.010 mM
2-(7-bromo-3-(2,4-dihydroxyphenyl)-2-oxoquinoxalin-1(2H)-yl)-acetic acid
35.9% inhibition at 0.010 mM
2-(7-bromo-3-(3-indolyl)-2-oxoquinoxalin-1(2H)-yl)acetic acid
17.5% inhibition at 0.010 mM
2-(7-bromo-3-(4-bromothiophenoxy)-2-oxoquinoxalin-1(2H)-yl)-acetic acid
24.0% inhibition at 0.010 mM
2-(7-bromo-3-(4-chlorothiophenoxy)-2-oxoquinoxalin-1(2H)-yl)-acetic acid
10.2% inhibition at 0.010 mM
2-(7-chloro-2-oxo-3-styrylquinoxalin-1(2H)-yl) acetic acid
-
2-(7-chloro-3-(2,4-dihydroxyphenyl)-2-oxoquinoxalin-1(2H)-yl)-acetic acid
44.5% inhibition at 0.010 mM
2-(7-chloro-3-(2-benzothiophene)-2-oxoquinoxalin-1(2H)-yl)-acetic acid
53.3% inhibition at 0.010 mM
2-(7-chloro-3-(4-bromothiophenoxy)-2-oxoquinoxalin-1(2H)-yl)-acetic acid
14.1% inhibition at 0.010 mM
2-(7-chloro-3-(4-chlorothiophenoxy)-2-oxoquinoxalin-1(2H)-yl)-acetic acid
17.3% inhibition at 0.010 mM
2-(7-chloro-3-(4-fluorophenyl)-2-oxoquinoxalin-1(2H)-yl)acetic acid
23.6% inhibition at 0.010 mM
2-(7-fluoro-3-(2,4-dihydroxyphenyl)-2-oxoquinoxalin-1(2H)-yl)-acetic acid
46.2% inhibition at 0.010 mM
2-(7-fluoro-3-(4-bromothiophenoxy)-2-oxoquinoxalin-1(2H)-yl)-acetic acid
45.5% inhibition at 0.010 mM
2-(7-fluoro-3-(4-chlorothiophenoxy)-2-oxoquinoxalin-1(2H)-yl)-acetic acid
29.5% inhibition at 0.010 mM
2-(7-fluoro-3-(4-fluorophenyl)-2-oxoquinoxalin-1(2H)-yl)acetic acid
35.8% inhibition at 0.010 mM
20alpha-hydroxysteroid dehydrogenase
competitive inhibition, the inhibitor forms a 10fold stronger binding interaction with the catalytic residue (Tyr55), non-conserved hydrogen bonding interaction with His222, and additional van der Waals contacts with the non-conserved C-terminal residues Leu306, Leu308 and Phe311 that contribute to the inhibitor's selectivity advantage for 20alpha-hydroxysteroid dehydrogenase over 3,5-dichlorosalicylic acid
-
3,3'-tetramethylenglutaric acid
3,3-dimethylglutaric acid
-
-
3,5-dichlorosalicylic acid
mixed type of competitive and non-competitive patterns with respect to the substrate. The inhibitor forms a network of hydrogen bonds with the active site residues Trp22, Tyr50, His113, Trp114 and Arg312. Is a less potent inhibitor of ALR1 (256fold) when compared to 20alpha-hydroxysteroid dehydrogenase
3-(1H-indol-1-yl)propanoic acid
-
3-(4-fluorostyryl)-1-(4-nitrobenzyl) quinoxalin-2(1H)-one
24% inhibition
3-(benzo[b] thiophen-3-yl)-1-(4-nitrobenzyl)quinoxalin-2(1H)-one
32% inhibition
3-[3-[(diethylamino)methyl]-1H-indol-1-yl]propanoic acid
-
4-carboxybenzaldehyde
-
uncompetitive substrate inhibition
4-chloromercuribenzoate
-
1 mM, complete inactivation
5,5'-dithiobis-(2-nitrobenzoate)
-
-
AL-1576
0.5 microM, (10 x KI), 13fold higher affinity for aldehyde reductase than for aldose reductase; 0.5 microM, (10 x KI), 13fold higher affinity for aldehyde reductase than for aldose reductase, reversible
Al3+
1 mM, 14.7% of initial activity
ascorbic acid
Marinobacter nauticus VT8
-
in 100 mM MES buffer (pH 6.5) with 200 mM NADPH, 0.25 mM decanal, and 125 microg of FALDR fusion protein. 1 mM inhibits by 24%
ATP-ribose
-
competitive inhibition
beta-mercaptoethanol
Marinobacter nauticus VT8
-
in 100 mM MES buffer (pH 6.5) with 200 mM NADPH, 0.25 mM decanal, and 125 microg of FALDR fusion protein. 1 mM inhibits by 25%
Cd2+
1 mM, complete inhibition
cholic acid
-
inhibition of the ADH from Lactobacillus brevis by bile acids, acetone prevents partially
D-glucuronate
-
high concentrations, inhibition in a non-competitive manner
diethyldicarbonate
-
kidney aldehyde reductase
diethyldithiocarbamate
Marinobacter nauticus VT8
-
in 100 mM MES buffer (pH 6.5) with 200 mM NADPH, 0.25 mM decanal, and 125 microg of FALDR fusion protein. 1 mM inhibits by 50%, 0.25 mM inhibits by 39%
dipyridyl
Marinobacter nauticus VT8
-
in 100 mM MES buffer (pH 6.5) with 200 mM NADPH, 0.25 mM decanal, and 125 microg of FALDR fusion protein. 1 mM inhibits by 54%, 0.25 mM inhibits by 41%
Dithionite
Marinobacter nauticus VT8
-
in 100 mM MES buffer (pH 6.5) with 200 mM NADPH, 0.25 mM decanal, and 125 microg of FALDR fusion protein. 1 mM inhibits by 75%, 0.25 mM inhibits by 92%
dithiothreitol
Marinobacter nauticus VT8
-
in 100 mM MES buffer (pH 6.5) with 200 mM NADPH, 0.25 mM decanal, and 125 microg of FALDR fusion protein. 1 mM inhibits by 24%
Dodecanol
Marinobacter nauticus VT8
-
in 100 mM MES buffer (pH 6.5) with 200 mM NADPH, 0.25 mM decanal, and 125 microg of FALDR fusion protein. 1 mM inhibits by 46%, 0.25 mM inhibits by 45%
flunarizine
0.08 mM, 54% inhibition
glycerol
-
non-competitive inhibitor with D-glyceraldehyde as substrate
K+
1 mM, 82.3% of initial activity
L-Gulonic acid
-
product inhibition
lidorestat
binding mode, overview
N-(tert-butyl)-3-(4-(4-nitrobenzyl)-3-oxo-3, 4-dihydroquinoxalin-2-yl) acryl amide
36% inhibition
NaN3
1 mM, complete loss of activity
Phenylmethylsulfonylfluoride
-
lower molecular weight form
phenylpyruvic acid
-
low-molecular weight aldehyde reductase, noncompetitively inhibition
SDS
1 mM,0% of initial activity
[(5H-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]acetic acid
-
[2-oxo-3-(2-phenylethyl)quinoxalin-1(2H)-yl]acetic acid
22.0% inhibition at 0.010 mM
[2-oxo-3-[(Z)-2-phenylethenyl]quinoxalin-1(2H)-yl]acetic acid
32.0% inhibition at 0.010 mM
[3-(2,2-dimethylpropanoyl)-1H-indol-1-yl]acetic acid
-
[3-[(diethylamino)methyl]-1H-indol-1-yl]acetic acid
-
[3-[(dimethylamino)methyl]-2-methyl-1H-indol-1-yl]acetic acid
-
[3-[(E)-2-(4-hydroxy-3-methoxyphenyl)ethenyl]-2-oxoquinoxalin-1(2H)-yl]acetic acid
32.6% inhibition at 0.010 mM
[3-[(E)-2-(4-hydroxyphenyl)ethenyl]-2-oxoquinoxalin-1(2H)-yl]acetic acid
42.4% inhibition at 0.010 mM
[3-[(E)-2-(4-methoxyphenyl)ethenyl]-2-oxoquinoxalin-1(2H)-yl]acetic acid
21.8% inhibition at 0.010 mM
[3-[(morpholin-4-yl)methyl]-1H-indol-1-yl]acetic acid
-
[3-[(propan-2-yl)sulfanyl]-5H-[1,2,4]triazino[5,6-b]indol-5-yl]acetic acid
-
[3-[(pyrrolidin-1-yl)methyl]-1H-indol-1-yl]acetic acid
-
[3-[2-(4-hydroxyphenyl)ethyl]-2-oxoquinoxalin-1(2H)-yl]acetic acid
12.2% inhibition at 0.010 mM
[5-(3-carboxymethoxy-4-methoxybenzylidene)-2,4-dioxothiazolidin-3-yl]acetic acid
crystallization data. The rotameric state of the conserved residue Trp220 in aldehyde reductase ALR1, i.e Trp 219 in aldose reductase ALR2, is important in forming a pi-stacking interaction with the inhibitor in aldose reductase and contributes to the difference in the binding of the inhibitor to the enzymes; i.e. CMD, a potent inhibitor of ALR2, but not for ALR1. For binding to ALR1, the partially disordered inhibitor forms a tight network of hydrogen bonds with the active site residues Tyr50 and His113 and NADPH, structure molecular modelling, overview. The non-conserved C-terminal residue Leu300 in ALR2, which is Pro301 in ALR1, contributes to inhibitor selectivity
[5-(3-hydroxy-4-methoxybenzylidene)-2,4-dioxothiazolidin-3-yl]acetic acid
i.e. HMD, modelling of inhibitor-enzyme active site complex
[7-fluoro-3-[(E)-2-(4-hydroxyphenyl)ethenyl]-2-oxoquinoxalin-1(2H)-yl]acetic acid
36.2% inhibition at 0.010 mM
[7-fluoro-3-[2-(4-hydroxyphenyl)ethyl]-2-oxoquinoxalin-1(2H)-yl]acetic acid
23.0% inhibition at 0.010 mM
1,10-phenanthroline
-
in 250 mM glycine-NaOH buffer (pH 9.0), purified water and 20 mM heptanal, at 5 mM inhibits by 16% and at 10 mM inhibits by 68% in the presence of 10 mM NADH, at 5 mM inhibits by 25% and at 10 mM inhibits by 63% in the presence of 10 mM NADPH
2,3-dimethylsuccinic acid
-
-
2,3-dimethylsuccinic acid
-
-
3,3'-tetramethylenglutaric acid
-
-
3,3'-tetramethylenglutaric acid
-
AR1 and AR3
3,3'-tetramethylenglutaric acid
-
-
3,3'-tetramethylenglutaric acid
-
3,3'-tetramethylenglutaric acid
-
-
acetone
-
at high concentrations of e.g. 3.4 M
acetone
-
at high concentrations of e.g. 3.4 M
AL1576
-
-
Alconil
-
-
Alrestatin
-
-
benzodiazepine
-
-
Ca2+
-
26% inhibition
Ca2+
1 mM, 0% of initial activity
chlorpromazine
-
-
chlorpromazine
-
isozyme AR3
Cibacron blue F3GA
-
dead-end inhibitor
Co2+
-
91% inhibition
Co2+
1 mM, 68.7% of initial activity
Cu2+
1 mM, 14.0% of initial activity
Cu2+
1 mM, complete loss of activity
Cu2+
1 mM, complete inhibition
Diphenic acid
-
-
EDTA
-
0.5 mM, about 15% residual activity
EDTA
Marinobacter nauticus VT8
-
in 100 mM MES buffer (pH 6.5) with 200 mM NADPH, 0.25 mM decanal, and 125 microg of FALDR fusion protein. 1 mM inhibits by 19%
EDTA
0.1 mM, 38% residual activity. Activity is completely restored by the addition of 1 mM Co2+ and to 37% by addition of Ni2+, respectively
EDTA
-
lower molecular weight form
EDTA
1 mM, slightly decreased the enzyme activity
EDTA
5 mM, 80% of initial activity
epalrestat
-
-
epalrestat
73.6% inhibition at 0.010 mM
Fe2+
1 mM, 10-20% decrease in activity
Fe2+
10 mM, 74% of initial activity
fidarestat
-
interaction with the residues Tyr50, His113, Trp114 and Pro301
fidarestat
-
van der Waals contacts, with residues His110, Tyr48, and Trp111
FK366
-
-
Hg2+
-
100% inhibition
Hg2+
1 mM, complete inhibition
iodoacetamide
-
-
iodoacetic acid
1 mM, 72.6% residual activity
Li2SO4
-
aldehyde reductase I inhibited by 86%, aldehyde reductase II is not affected
Li2SO4
-
0.4 mM completely inhibits aldehyde reductase II
Li2SO4
-
both aldehyde reductase I and II are susceptible to inhibition
Mg2+
1 mM, 0.3% of initial activity
Mg2+
10 mM, 78% of initial activity
Mn2+
-
29% inhibition
Mn2+
1 mM, 23.4% of initial activity
N-ethylmaleimide
-
-
NaCl
-
aldehyde reductase I and II
NADP+
-
product inhibition
NADP+
-
competitive inhibition
NADPH
-
product inhibition
NADPH
strong inhibition at high NADPH concentrations, assay below 0.8 mM
NADPH
-
competitive inhibitor for reductase I
Ni2+
-
84% inhibition
Ni2+
1 mM, 18.2% of initial activity
Ni2+
1 mM, 10-20% decrease in activity
p-chloromercuribenzoate
-
-
p-chloromercuribenzoate
-
-
p-hydroxymercuribenzoate
-
-
p-hydroxymercuribenzoate
-
in 250 mM glycine-NaOH buffer (pH 9.0), purified water and 20 mM heptanal, at 10 mM inhibits by 100% in the presence of 10 mM NADH, at 10 mM inhibits by 95% and at 15 mM inhibits by 100% in the presence of 10 mM NADPH
p-mercuribenzoate
-
-
p-mercuribenzoate
-
aldehyde reductase I is more sensitive than aldehyde reductase II
p-mercuribenzoate
-
above 1 mM
Phenobarbital
-
-
ponalrestat
-
-
pyrazole
-
-
pyridine 3-aldehyde
-
-
quercetin
-
-
Sodium barbitone
-
-
sodium phenobarbital
-
-
sodium phenobarbital
-
aldehyde reductase II activity diminished by 84%
sodium valproate
-
-
sodium valproate
-
liver ALR1
sorbinil
-
-
Tolrestat
-
-
Zn2+
-
100% inhibition
Zn2+
1 mM, 14.1% of initial activity
Zn2+
1 mM, complete inhibition
Zn2+
10 mM, 79% of initial activity
zopolrestat
-
-
additional information
structure-activity relationships study of quinoxalinone derivatives as aldose reductase inhibitors. Among them, N1-acetate derivatives have significant activity, molecular modeling and docking, overview. Both C3-phenethyl and C6-NO2 groups play an important role in enhancing the activity and selectivity of the quinoxalinone based inhibitors
-
additional information
design and synthesis of inhibitors based on quinoxalinones, overview. Phenolic structure is installed in the compounds for the combination of antioxidant activity and strengthening the ability to fight against diabetic complications, radical scavenging activity using the model reaction with the stable free radicals of 2,2-diphenyl-1-picrylhydrazyl
-
additional information
identification of aldose reductase inhibitors based on carboxymethylated mercaptotriazinoindole scaffold, the compouds have also lower inhibitory potency against aldehyde reductase, structure-activity relationships, overview
-
additional information
-
enzyme active site interactions with the 3-carboxymethoxy-4-methoxy-phenyl moiety of the inhibitor, binding structure, overview
-
additional information
enzyme active site interactions with the 3-carboxymethoxy-4-methoxy-phenyl moiety of the inhibitor, binding structure, overview
-
additional information
-
not inhibitory: EDTA (5 mM), MgCl2 (10 mM), CaCl2 (1O mM), CuCl2 (1 mM) and ZnCl2 (1 mM)
-
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0.33
(+)-Camphorquinone
-
-
15
(2E,4E)-hexa-2,4-dienal
-
pH 7.4, 25°C, with NAD(P)H
15.2
(2R,3R)-2,3-butanediol
cosubstrate: NADP+, pH 7.5, 80°C
246
(2S,3S)-2,3-butanediol
cosubstrate: NADP+, pH 7.5, 80°C
5.4 - 327.6
(2S,5S)-hexanediol
0.0063
(4-hydroxy-3-[3-methyl-3-butene-1-ynyl]benzaldehyde)
-
eutypine
0.112
(S)-1-phenylethanol
-
-
0.46 - 0.8
1,2-Cyclohexanedione
15.1
1,4-Butanediol
-
pH 9.5, 30°C, recombinant mutant V84I/Y127M
23.38
1,5-pentanediol
pH 7.0. 30°C
0.00273 - 0.99
1-Pentanol
2.9 - 55.5
1-phenylethanol
56.4 - 79
2,5-hexanedione
0.31
2-butanone
cosubstrate: NADPH, pH 7.5, 80°C
0.85 - 6.38
2-hydroxytetrahydrofuran
-
0.049 - 4.8
2-Methoxybenzaldehyde
1.85 - 17.7
2-methylbutanal
0.05
2-phenylacetaldehyde
-
pH 8.0, 80°C
15
2-phenylethanol
-
pH 8.0, 80°C
6.1
3,4-dihydroxyphenylacetaldehyde
-
-
12
3,4-dihydroxyphenylglycolaldehyde
-
-
0.0054
3-Fluorobenzaldehyde
-
-
10.27
3-methyl-1,5-pentanediol
pH 7.0. 30°C
1.61 - 4.6
3-methyl-1-butanol
0.048 - 1.89
3-Methylbutanal
0.008 - 8.61
3-Pyridinecarboxaldehyde
5.5
3-Pyridinemethanol
-
-
1.6
4-Carboxyacetophenone
-
-
0.1
4-Carboxyphenylglyoxal
-
-
21.8
4-hydroxybenzaldehyde
-
pH 6.5, 30°C
24.1
4-methoxybenzaldehyde
-
pH 6.5, 30°C
1.4
4-Nitroacetophenone
-
-
0.0053
4-nitrobenzaldehyde
-
-
0.0045
4-pyridine carboxaldehyde
-
-
0.062 - 1.2
4-Pyridinecarboxaldehyde
27
5-Hydroxyindoleacetaldehyde
-
-
0.11 - 4
5alpha-dihydrotestosterone
0.32
acetoin
cosubstrate: NADPH, pH 7.5, 80°C
0.034 - 10.9
acetophenone
4.81
acrolein
-
pH 7.0, 37°C
0.008
all-trans-retinal
-
-
0.02
all-trans-retinol
-
-
0.099 - 13
androstane-3,17-dione
0.67
butanaldehyde
-
pH 7.0, 37°C
0.083 - 7.69
Butyraldehyde
0.017 - 0.172
cinnamaldehyde
0.08 - 0.7
cinnamyl alcohol
0.177
cis-11-hexadecenal
Marinobacter nauticus VT8
-
-
0.06
coniferylaldehyde
-
-
1.18 - 36.77
cyclohexanone
8.45 - 19.33
Cyclopentanol
543
D-galactose
-
aldehyde reductase II
1.1
D-galacturonate
-
AR1
1.29 - 2.99
D-glucuronic acid
19.6 - 67
D-glucuronolactone
0.43 - 8.2
D-glyceraldehyde
0.08
daunorubicin
-
reductase I
1.3 - 76
DL-glyceraldehyde
0.091
ethyl 4-bromo-3-oxobutanoate
-
-
0.36
ethyl 4-chloro-3-oxobutanoate
-
-
24 - 25
ethyl acetoacetate
2.7 - 26
ethylacetoacetate
1.6
formaldehyde
-
1° Adh
0.07 - 7.59
glyceraldehyde
0.0038
hydroxyindol-3-ylacetaldehyde
-
low-Km reductase
0.0059 - 0.2
indol-3-ylacetaldehyde
0.6
indolacetaldehyde
-
-
0.32 - 3.7
Indole-3-acetaldehyde
4.9 - 11.1
L-glyceraldehyde
0.31
laurylaldehyde
-
AR2
0.007
m-chlorobenzaldehyde
-
-
0.027 - 0.212
m-methoxybenzaldehyde
0.02
m-methylbenzaldehyde
-
-
0.002 - 4.4
m-nitrobenzaldehyde
1.78
malondialdehyde
-
pH 7.0, 37°C
19.3
meso-2,3-butanediol
cosubstrate: NADP+, pH 7.5, 80°C
1.2
methyl 4-bromo-3-oxobutanoate
1.1 - 150
n-Butyraldehyde
0.702
o-fluorobenzaldehyde
-
-
0.125
o-methylbenzaldehyde
-
-
0.376 - 4.6
o-nitrobenzaldehyde
3.88
octan-1-ol
pH 8, 60°C
0.1
octyl 4-chloro-3-oxobutanoate
-
-
0.004 - 4
p-Carboxybenzaldehyde
0.94 - 6.7
p-chlorobenzaldehyde
0.005 - 0.51
p-cyanobenzaldehyde
0.04
p-fluorobenzaldehyde
-
-
0.0023 - 0.91
p-hydroxyphenylacetaldehyde
0.0007 - 0.65
p-hydroxyphenylglycolaldehyde
0.141 - 0.15
p-Methoxybenzaldehyde
0.041
p-methylbenzaldehyde
-
-
10
p-nitroacetophenone
-
-
0.0013 - 5.9
p-nitrobenzaldehyde
0.091
phenylacetaldehyde
-
80°C, pH not specified in the publication
2.2
Phenylethanol
-
pH 10.0, 25°C
0.008 - 14.54
propionaldehyde
0.042 - 3
pyridine 3-aldehyde
4 - 5.2
pyridine 4-aldehyde
1.2 - 17.75
Pyruvaldehyde
0.066 - 6.9
Salicylaldehyde
0.126
sinapylaldehyde
-
-
2.95
sodium D-glucuronate
0.028 - 18
Succinic semialdehyde
0.06 - 27.1
trans-2-hexenal
0.22 - 1.69
trans-2-hexenol
0.058 - 0.073
veratraldehyde
additional information
additional information
-
5.4
(2S,5S)-hexanediol
-
wild type enzyme, at 70°C
327.6
(2S,5S)-hexanediol
-
mutant enzyme R11L/A180V, at 70°C
0.46
1,2-Cyclohexanedione
-
AR3
0.8
1,2-Cyclohexanedione
-
AR2
0.00251
1-Hexanol
-
-
6.79
1-Hexanol
-
pH 8.8, 30°C
0.00273
1-Pentanol
-
-
0.99
1-Pentanol
-
pH 10.0, 25°C
2.9
1-phenylethanol
-
cofactor NADP+, oxidation, recombinate wild-type, 30°C, pH 7.0
10.8
1-phenylethanol
-
NAD+, oxidation, recombinante mutant G37D, 30°C, pH 7.0
55.5
1-phenylethanol
-
cofactor NADP+, oxidation, recombinate mutant G37D, 30°C, pH 7.0
56.4
2,5-hexanedione
-
wild type enzyme, at 70°C
79
2,5-hexanedione
-
mutant enzyme R11L/A180V, at 70°C
0.38
2-butanol
cosubstrate: NADP+, pH 7.5, 80°C
7
2-butanol
-
r-TBADH, wild-type, mutant D150C-TBADH
7.17
2-butanol
-
mutant H59Q-TBADH
9.2
2-butanol
-
mutant C37A-TBADH
0.85
2-hydroxytetrahydrofuran
-
pH 9.5, 30°C, recombinant mutant S196A/F197W
-
1.55
2-hydroxytetrahydrofuran
-
pH 9.5, 30°C, recombinant mutant S196A
-
1.59
2-hydroxytetrahydrofuran
-
pH 9.5, 30°C, recombinant mutant F197W
-
1.9
2-hydroxytetrahydrofuran
-
pH 9.5, 30°C, recombinant mutant V84I
-
2.23
2-hydroxytetrahydrofuran
-
pH 9.5, 30°C, recombinant wild-type enzyme
-
2.4
2-hydroxytetrahydrofuran
-
pH 9.5, 30°C, recombinant mutant V127C
-
4.39
2-hydroxytetrahydrofuran
-
pH 9.5, 30°C, recombinant mutant V84I/Y127M
-
4.7
2-hydroxytetrahydrofuran
-
pH 9.5, 30°C, recombinant mutant V84I/Y127C
-
5.9
2-hydroxytetrahydrofuran
-
pH 9.5, 30°C, recombinant mutant V127M
-
6.38
2-hydroxytetrahydrofuran
-
pH 9.5, 30°C, recombinant mutant Y127C/S196A
-
0.049
2-Methoxybenzaldehyde
-
-
4.8
2-Methoxybenzaldehyde
-
pH 6.5, 30°C
1.85
2-methylbutanal
-
coenzyme NADPH
17.7
2-methylbutanal
-
coenzyme NADH
30.3
2-Pentanol
-
wild type enzyme, at 70°C
51.1
2-Pentanol
-
mutant enzyme R11L/A180V, at 70°C
60.8
2-Pentanol
pH 10.0, 70°C
0.408
2-propanol
-
-
168
2-propanol
pH 10.5, 60°C
1.61
3-methyl-1-butanol
-
pH 10.0, 25°C
4.6
3-methyl-1-butanol
-
pH 7.0, 25°C
0.048
3-Methylbutanal
-
pH 7.0, 25°C
0.129
3-Methylbutanal
-
pH 7.0, 25°C
0.21
3-Methylbutanal
-
coenzyme NADPH
1.89
3-Methylbutanal
-
coenzyme NADH
0.008
3-Pyridinecarboxaldehyde
-
AR3
0.02
3-Pyridinecarboxaldehyde
-
AR I
0.29
3-Pyridinecarboxaldehyde
-
aldehyde reductase II
0.606
3-Pyridinecarboxaldehyde
-
aldehyde reductase II
0.751
3-Pyridinecarboxaldehyde
-
G2
0.934
3-Pyridinecarboxaldehyde
-
AR1
1.18
3-Pyridinecarboxaldehyde
-
aldehyde reductase I
1.5
3-Pyridinecarboxaldehyde
-
-
2.4
3-Pyridinecarboxaldehyde
-
-
2.6
3-Pyridinecarboxaldehyde
-
-
2.9
3-Pyridinecarboxaldehyde
-
AR3
5
3-Pyridinecarboxaldehyde
-
AR4
8.61
3-Pyridinecarboxaldehyde
-
AR II
0.062
4-Pyridinecarboxaldehyde
-
AR2
0.69
4-Pyridinecarboxaldehyde
-
-
1.2
4-Pyridinecarboxaldehyde
-
enzyme from kidney, brain or liver
0.11
5alpha-dihydrotestosterone
-
AR2
4
5alpha-dihydrotestosterone
-
AR3
0.12 - 0.13
acetaldehyde
-
-
0.17
acetaldehyde
-
80°C, pH not specified in the publication
0.22
acetaldehyde
pH 8.0, 25°C, mutant G225A/A274F
0.25
acetaldehyde
-
1° Adh
0.25
acetaldehyde
-
pH 8.0, 80°C
0.51
acetaldehyde
-
in 30 mM Tris-HCl (pH 8.0)
0.84
acetaldehyde
recombinant enzyme, with 0.4 mM NADP+ as cosubstrate, in 100 mM EPPS buffer (pH 8.8)
1
acetaldehyde
native enzyme, with 0.4 mM NADP+ as cosubstrate, in 100 mM EPPS buffer (pH 8.8)
1.58
acetaldehyde
pH 8.0, 25°C, mutant A274F
2.1
acetaldehyde
-
2° Adh
2.1
acetaldehyde
pH 8.0, 25°C, mutant G225A
2.25
acetaldehyde
pH 8, 60°C
2.33
acetaldehyde
pH 8.0, 25°C, wild-type
3.1
acetaldehyde
-
pH 8.0, 80°C
10
acetaldehyde
-
isoform AdhA, pH 8.0, 60°C
28.47
acetaldehyde
-
pH 7.0, 37°C
44.8
acetaldehyde
-
secondary alcohol dehydrogenase
55.8
acetaldehyde
-
isoform AdhB, pH 8.0, 60°C
210
acetaldehyde
-
primary alcohol dehydrogenase
0.7
acetone
-
pH 7.8, 40°C
0.034
acetophenone
-
-
2.8
acetophenone
-
cofactor NADPH, reduction, recombinante wild-type, 30°C, pH 7.0
10.9
acetophenone
-
cofactor NADH, reduction, recombinante mutant G37D, 30°C, pH 7.0
0.099
androstane-3,17-dione
-
AR2
13
androstane-3,17-dione
-
AR3
0.01
benzaldehyde
-
co-substrate NADP
0.023
benzaldehyde
-
aldehyde reductase I
9.09
benzaldehyde
-
aldehyde reductase II
1.43
benzyl alcohol
-
-
2
benzyl alcohol
-
co-substrate NADP
10
butan-1-ol
-
2° Adh
43.75
butan-1-ol
pH 7.0. 30°C
0.31
butan-2-ol
-
pH 7.8, 40°C
0.11
Butanal
-
-
0.11
Butanal
-
in 30 mM Tris-HCl (pH 8.0)
2.76
Butanal
-
coenzyme NADPH
6.8
Butanal
pH 7.0, temperature not specified in the publication
23.1
Butanal
-
coenzyme NADH
1.4
butanol
-
-
1.9
butanol
-
pH 11.0, 80°C
3.28
butanol
-
in 30 mM Tris-HCl (pH 8.0)
0.12
Butanone
-
pH 7.8, 40°C
0.083
Butyraldehyde
-
aldehyde reductase I
0.45
Butyraldehyde
-
pH 8.0, 80°C
7.69
Butyraldehyde
-
aldehyde reductase II
0.017
cinnamaldehyde
-
-
0.017
cinnamaldehyde
-
in 30 mM Tris-HCl (pH 8.0)
0.043
cinnamaldehyde
-
pH 7.0, 25°C
0.172
cinnamaldehyde
-
pH 7.0, 25°C
0.08
cinnamyl alcohol
-
pH 10.0, 25°C
0.11
cinnamyl alcohol
-
pH 7.0, 25°C
0.27
cinnamyl alcohol
-
-
0.27
cinnamyl alcohol
-
in 30 mM Tris-HCl (pH 8.0)
0.436
cinnamyl alcohol
-
pH 7.0, 25°C
0.7
cinnamyl alcohol
-
pH 10.0, 25°C
1.18
cyclohexanone
-
G2
36.77
cyclohexanone
-
AR4
8.45
Cyclopentanol
-
r-TBADH, wild-type
8.7
Cyclopentanol
-
mutant H59Q-TBADH
16.71
Cyclopentanol
-
mutant D150C-TBADH
19.33
Cyclopentanol
-
mutant C37S-TBADH
1.5
D-glucuronate
-
-
2.5
D-glucuronate
-
outer medulla enzyme
3.22
D-glucuronate
-
inner medulla enzyme
3.34
D-glucuronate
-
cortex enzyme
4.2
D-glucuronate
-
wild-type aldehyde reductase
4.2
D-glucuronate
wild-type aldehyde reductase
4.2
D-glucuronate
-
aldehyde reductase, mutant V299C
7.5
D-glucuronate
aldehyde reductase, mutant R308A
19.5
D-glucuronate
-
aldehyde reductase, mutant I298C
26.3
D-glucuronate
-
aldehyde reductase, mutant I298A
42
D-glucuronate
-
enzyme from brain
43
D-glucuronate
-
enzyme from kidney, or liver
48
D-glucuronate
-
aldehyde reductase, mutant H112Q
364
D-glucuronate
aldehyde reductase, mutant R311A
1.29
D-glucuronic acid
-
AR1
2.48
D-glucuronic acid
-
G2
2.99
D-glucuronic acid
-
AR3
19.6
D-glucuronolactone
-
AR2
67
D-glucuronolactone
-
AR1
0.43
D-glyceraldehyde
-
AR2
8.2
D-glyceraldehyde
-
AR3
54.4
D-xylose
pH 10.5, 60°C
500
D-xylose
-
aldehyde reductase II
845
D-xylose
-
outer medulla enzyme
1152
D-xylose
-
inner medulla enzyme
1497
D-xylose
-
cortex enzyme
0.21
diacetyl
cosubstrate: NADPH, pH 7.5, 80°C
1.3
DL-glyceraldehyde
-
-
1.5
DL-glyceraldehyde
-
-
1.5
DL-glyceraldehyde
-
-
1.7
DL-glyceraldehyde
-
wild-type aldehyde reductase
1.7
DL-glyceraldehyde
wild-type aldehyde reductase
1.7
DL-glyceraldehyde
-
wild type enzyme, at pH 7.0 and 25°C
1.7
DL-glyceraldehyde
wild type enzyme, at pH 7.0 and 25°C
1.8
DL-glyceraldehyde
-
aldehyde reductase, mutant V299C
1.8
DL-glyceraldehyde
-
mutant enzyme V299C, at pH 7.0 and 25°C
2.2
DL-glyceraldehyde
aldehyde reductase, mutant R311A
2.2
DL-glyceraldehyde
mutant enzyme R311A, at pH 7.0 and 25°C
2.3
DL-glyceraldehyde
aldehyde reductase, mutant R308A
2.3
DL-glyceraldehyde
mutant enzyme R308A, at pH 7.0 and 25°C
2.94
DL-glyceraldehyde
-
aldehyde reductase II
2.94
DL-glyceraldehyde
-
aldehyde reductase II, at pH 7.0 and 37°C
4.67
DL-glyceraldehyde
-
inner medulla enzyme
4.67
DL-glyceraldehyde
-
enzyme from inner medulla, at pH 6.2 and 25°C
4.68
DL-glyceraldehyde
-
cortex enzyme
4.68
DL-glyceraldehyde
-
enzyme from brain cortex, at pH 6.2 and 25°C
5.92
DL-glyceraldehyde
-
outer medulla enzyme
5.92
DL-glyceraldehyde
-
enzyme from outer medulla, at pH 6.2 and 25°C
8.35
DL-glyceraldehyde
-
-
11.5
DL-glyceraldehyde
-
aldehyde reductase, mutant I298C
11.5
DL-glyceraldehyde
-
mutant enzyme I298C, at pH 7.0 and 25°C
12.5
DL-glyceraldehyde
-
aldehyde reductase I
12.5
DL-glyceraldehyde
-
aldehyde reductase I, at pH 7.3 and 37°C
33
DL-glyceraldehyde
-
aldehyde reductase, mutant I298A
33
DL-glyceraldehyde
-
mutant enzyme I298A, at pH 7.0 and 25°C
76
DL-glyceraldehyde
-
aldehyde reductase, mutant H112Q
76
DL-glyceraldehyde
-
mutant enzyme H112Q, at pH 7.0 and 25°C
0.013
ethanol
-
NADP+
0.5
ethanol
pH 8.0, 25°C, wild-type
0.74
ethanol
pH 8.0, 25°C, mutant G225A
0.85
ethanol
pH 8.0, 25°C, mutant G225A/A274F
1.02
ethanol
pH 8.0, 25°C, mutant A274F
9.7
ethanol
-
pH 11.0, 80°C
9.7
ethanol
recombinant enzyme, with 0.4 mM NADP+ as cosubstrate, in 100 mM EPPS buffer (pH 8.8)
10.4
ethanol
native enzyme, with 0.4 mM NADP+ as cosubstrate, in 100 mM EPPS buffer (pH 8.8)
16.4
ethanol
-
primary alcohol dehydrogenase
18.8
ethanol
-
in 30 mM Tris-HCl (pH 8.0)
29.4
ethanol
-
80°C, pH not specified in the publication
40
ethanol
-
isoform AdhA, pH 8.0, 60°C
49
ethanol
-
secondary alcohol dehydrogenase
24
ethyl acetoacetate
-
enzyme from brain or liver
25
ethyl acetoacetate
-
enzyme from kidney
2.7
ethylacetoacetate
-
AR2
26
ethylacetoacetate
-
AR3
2.5
glucuronate
-
aldehyde reductase II
0.07
glyceraldehyde
-
AR I
0.07
glyceraldehyde
-
aldehyde reductase I, at pH 7.3 and 37°C
6.67
glyceraldehyde
-
AR II
6.67
glyceraldehyde
-
aldehyde reductase II, at pH 7.0 and 37°C
7.59
glyceraldehyde
-
aldehyde reductase II
0.27
Heptanal
-
coenzyme NADPH
4.25
Heptanal
-
coenzyme NADH
0.04
hexanal
-
-
0.152
hexanal
-
pH 7.0, 25°C
0.18
hexanal
-
coenzyme NADPH
0.83
hexanal
-
coenzyme NADH
5.5
hexanal
-
pH 6.5, 30°C
0.35
Hexanol
-
-
1.22
Hexanol
-
coenzyme NADPH
9.1
Hexanol
-
pH 7.0, 25°C
0.0059
indol-3-ylacetaldehyde
-
low-Km reductase
0.2
indol-3-ylacetaldehyde
-
high-Km aldehyde reductase
0.32
Indole-3-acetaldehyde
-
AR2
3
Indole-3-acetaldehyde
-
AR3
3.7
Indole-3-acetaldehyde
-
AR1
4.9
L-glyceraldehyde
-
AR2
11.1
L-glyceraldehyde
-
AR3
0.027
m-methoxybenzaldehyde
-
-
0.212
m-methoxybenzaldehyde
-
-
0.002
m-nitrobenzaldehyde
-
-
0.0029
m-nitrobenzaldehyde
-
-
0.082
m-nitrobenzaldehyde
-
AR2
2.4
m-nitrobenzaldehyde
-
-
3.9
m-nitrobenzaldehyde
-
AR1
4
m-nitrobenzaldehyde
-
AR3
4.4
m-nitrobenzaldehyde
-
-
0.009
menadione
-
AR4
1.2
methyl 4-bromo-3-oxobutanoate
-
wild-type, pH 6.5, 30°C
1.2
methyl 4-bromo-3-oxobutanoate
-
mutant L54Q, pH 6.5, 30°C
0.2
methylglyoxal
-
80°C, pH not specified in the publication
0.0033
n-butanol
-
-
47.1
n-butanol
-
primary alcohol dehydrogenase
1.1
n-Butyraldehyde
-
AR2
0.019
n-dodecanal
-
enzyme from brain
0.02
n-dodecanal
-
enzyme from liver and kidney
12
n-Propanol
-
-
0.096
NAD+
-
1° Adh, ethanol as substrate
0.2
NAD+
-
ethanol as substrate
0.39
NAD+
pH 8.0, 25°C, wild-type
0.39
NAD+
wild type enzyme, at 25°C, pH not specified in the publication
0.57
NAD+
pH 8.0, 25°C, mutant G225A/A274F
0.57
NAD+
mutant enzyme G225A/A274F, at 25°C, pH not specified in the publication
0.75
NAD+
-
reduction, recombinant mutant G37D, 30°C, pH 7.0
0.8
NAD+
-
octanol as substrate
0.98
NAD+
pH 8.0, 25°C, mutant A274F
0.98
NAD+
mutant enzyme A274F, at 25°C, pH not specified in the publication
1
NAD+
pH 8.0, 25°C, mutant G225A
1
NAD+
mutant enzyme G225A, at 25°C, pH not specified in the publication
1.44
NAD+
cosubstrate octan-1-ol, pH 8, 60°C
9.7
NAD+
-
in 30 mM Tris-HCl (pH 8.0)
20
NAD+
-
80°C, pH not specified in the publication
0.025
NADH
-
1° Adh, acetaldehyde as substrate
0.025
NADH
pH 8.0, 25°C, wild-type
0.025
NADH
wild type enzyme, at 25°C, pH not specified in the publication
0.045
NADH
pH 8.0, 25°C, mutant G225A
0.045
NADH
mutant enzyme G225A, at 25°C, pH not specified in the publication
0.052
NADH
-
aldehyde reductase 2, at pH 6.0 and 25°C
0.06
NADH
pH 8.0, 25°C, mutant G225A/A274F
0.06
NADH
mutant enzyme G225A/A274F, at 25°C, pH not specified in the publication
0.07
NADH
pH 8.0, 25°C, mutant A274F
0.07
NADH
mutant enzyme A274F, at 25°C, pH not specified in the publication
0.52
NADH
-
m-nitrobenzaldehyde as substrate
0.84
NADH
cosubstrate octanal, pH 8, 60°C
1.31
NADH
-
in 30 mM Tris-HCl (pH 8.0)
1.6
NADH
-
oxidation, recombinante mutant G37D, 30°C, pH 7.0
20.55
NADH
substrate furfural, pH 7.2, 30°C
23.84
NADH
substrate furfural, pH 7.2, 30°C
0.007
NADP+
-
-
0.013
NADP+
-
pH 10.0, 25°C
0.015
NADP+
-
reduction, recombinant wild-type, 30°C, pH 7.0
0.02
NADP+
-
1° Adh, ethanol as substrate
0.02
NADP+
-
pH 11.0, 80°C
0.022
NADP+
-
secondary alcohol dehydrogenase
0.022
NADP+
pH 10.5, 60°C
0.049
NADP+
-
2° Adh, butan-2-ol as substrate
0.05
NADP+
-
in 30 mM Tris-HCl (pH 8.0)
0.06
NADP+
-
ethanol as substrate
0.061
NADP+
-
pH 10.0, 25°C
0.0648
NADP+
-
pH 9.5, 30°C, recombinant wild-type enzyme, with 2-hydroxytetrahydrofuran
0.07
NADP+
-
2° Adh, ethanol as substrate
0.071
NADP+
-
80°C, pH not specified in the publication
0.0768
NADP+
-
pH 9.5, 30°C, recombinant mutant V127M, with 2-hydroxytetrahydrofuran
0.0807
NADP+
-
pH 9.5, 30°C, recombinant mutant V84I/Y127M, with 2-hydroxytetrahydrofuran
0.1
NADP+
-
pH 9.5, 30°C, recombinant mutant S196A/F197W, with 2-hydroxytetrahydrofuran
0.107
NADP+
-
pH 9.5, 30°C, recombinant mutant F197W, with 2-hydroxytetrahydrofuran
0.107
NADP+
-
pH 9.5, 30°C, recombinant mutant V127C, with 2-hydroxytetrahydrofuran
0.15
NADP+
-
primary alcohol dehydrogenase
0.159
NADP+
-
pH 9.5, 30°C, recombinant mutant V84I, with 2-hydroxytetrahydrofuran
0.2
NADP+
-
wild type enzyme, at 70°C
0.35
NADP+
-
secondary alcohol dehydrogenase
0.4
NADP+
cosubstrate: 2-butanol, pH 7.5, 80°C
0.456
NADP+
-
pH 9.5, 30°C, recombinant mutant S196A, with 2-hydroxytetrahydrofuran
0.462
NADP+
-
pH 9.5, 30°C, recombinant mutant V84I/Y127C, with 2-hydroxytetrahydrofuran
0.565
NADP+
-
pH 9.5, 30°C, recombinant mutant Y127C/S196A, with 2-hydroxytetrahydrofuran
0.7
NADP+
-
mutant enzyme R11L/A180V, at 70°C
0.8
NADP+
-
benzyl aclohol as substrate
0.83
NADP+
-
primary alcohol dehydrogenase
2.4
NADP+
cosubstrate octan-1-ol, pH 8, 60°C
2.64
NADP+
pH 8.0, 25°C, wild-type
2.77
NADP+
pH 8.0, 25°C, mutant G225A
5.5
NADP+
pH 8.0, 25°C, mutant G225A/A274F
6.21
NADP+
pH 8.0, 25°C, mutant A274F
9.1
NADP+
-
reduction, recombinant mutant G37D, 30°C, pH 7.0
9.7
NADP+
recombinant enzyme, with 90 mM ethanol as cosubstrate, in 100 mM EPPS buffer (pH 8.8)
10.4
NADP+
native enzyme, with 90 mM ethanol as cosubstrate, in 100 mM EPPS buffer (pH 8.8)
46.7
NADP+
-
pH 8.8, 30°C
0.001
NADPH
-
-
0.001
NADPH
-
p-nitrobenzaldehyde as substrate
0.0012
NADPH
-
low-Km reductase
0.0016
NADPH
-
pyridine 3-aldehyde as substrate
0.0019
NADPH
-
D-glucuronate as substrate
0.004
NADPH
-
n-propanol as substrate
0.005
NADPH
-
benzaldehyde as substrate
0.006
NADPH
-
pH 8.0, 80°C
0.006
NADPH
recombinant enzyme, with 90 mM ethanol as cosubstrate, in 100 mM EPPS buffer (pH 8.8)
0.007
NADPH
native enzyme, with 90 mM ethanol as cosubstrate, in 100 mM EPPS buffer (pH 8.8)
0.011
NADPH
-
pH 7.0, 25°C
0.011
NADPH
cosubstrate: 2-butanone, pH 7.5, 80°C
0.012
NADPH
-
m-nitrobenzaldehyde as substrate
0.013
NADPH
-
aldehyde reductase II
0.014
NADPH
-
propionaldehyde as substrate
0.014
NADPH
-
pH 8.0, 80°C
0.019
NADPH
-
aldehyde reductase II
0.021
NADPH
-
benzyl alcohol as substrate
0.022
NADPH
-
aldehyde reductase I
0.025
NADPH
-
in 30 mM Tris-HCl (pH 8.0)
0.029
NADPH
-
pH 7.0, 25°C
0.033
NADPH
-
2° Adh, propanone as substrate
0.04
NADPH
-
oxidation, recombinante wild-typ, 30°C, pH 7.0
0.05
NADPH
pH 8.0, 25°C, mutant G225A/A274F
0.055
NADPH
-
2° Adh, acetaldehyde as substrate
0.071
NADPH
-
80°C, pH not specified in the publication
0.094
NADPH
-
1°Adh, acetaldehyde as substrate
0.1
NADPH
-
mutant enzyme R11L/A180V, at 70°C
0.1
NADPH
pH 7.0, temperature not specified in the publication
0.13
NADPH
-
benzaldehyde as substrate
0.21
NADPH
pH 8.0, 25°C, wild-type
0.24
NADPH
substrate furfural, pH 7.2, 30°C
0.25
NADPH
-
high-Km aldehyde reductase
0.26
NADPH
substrate 5-hydroxymethylfurfural, pH 7.2, 30°C
0.36
NADPH
-
secondary alcohol dehydrogenase
0.37
NADPH
pH 8.0, 25°C, mutant A274F
0.37
NADPH
pH 8.0, 25°C, mutant G225A
0.4
NADPH
-
wild type enzyme, at 70°C
1.5
NADPH
-
primary alcohol dehydrogenase
4.11
NADPH
substrate furfural, pH 7.2, 30°C
0.376
o-nitrobenzaldehyde
-
-
1.3
o-nitrobenzaldehyde
-
-
2.8
o-nitrobenzaldehyde
-
AR2
4.6
o-nitrobenzaldehyde
-
AR1
4.6
o-nitrobenzaldehyde
-
AR3
0.01
octanal
-
-
0.09
Octanol
-
-
0.004
p-Carboxybenzaldehyde
-
-
0.018
p-Carboxybenzaldehyde
-
AR1
0.025
p-Carboxybenzaldehyde
-
-
0.031
p-Carboxybenzaldehyde
-
-
0.038
p-Carboxybenzaldehyde
-
wild-type aldehyde reductase
0.038
p-Carboxybenzaldehyde
wild-type aldehyde reductase
0.05
p-Carboxybenzaldehyde
-
-
0.056
p-Carboxybenzaldehyde
-
AR1
0.062
p-Carboxybenzaldehyde
-
AR3
0.078
p-Carboxybenzaldehyde
-
-
0.1
p-Carboxybenzaldehyde
-
aldehyde reductase, mutant V299C
0.11
p-Carboxybenzaldehyde
aldehyde reductase, mutant R308A
0.258
p-Carboxybenzaldehyde
-
AR3
0.32
p-Carboxybenzaldehyde
-
AR2
0.38
p-Carboxybenzaldehyde
-
aldehyde reductase, mutant I298A
0.43
p-Carboxybenzaldehyde
-
aldehyde reductase, mutant I298C
2.8
p-Carboxybenzaldehyde
-
aldehyde reductase, mutant H112Q
4
p-Carboxybenzaldehyde
aldehyde reductase, mutant R311A
0.94
p-chlorobenzaldehyde
-
-
6.7
p-chlorobenzaldehyde
-
-
0.005
p-cyanobenzaldehyde
-
-
0.51
p-cyanobenzaldehyde
-
-
0.0023
p-hydroxyphenylacetaldehyde
-
low-Km reductase
0.057
p-hydroxyphenylacetaldehyde
-
-
0.85
p-hydroxyphenylacetaldehyde
-
high-Km aldehyde reductase
0.91
p-hydroxyphenylacetaldehyde
-
-
0.0007
p-hydroxyphenylglycolaldehyde
-
low-Km reductase
0.016
p-hydroxyphenylglycolaldehyde
-
-
0.059
p-hydroxyphenylglycolaldehyde
-
-
0.65
p-hydroxyphenylglycolaldehyde
-
high-Km aldehyde reductase
0.141
p-Methoxybenzaldehyde
-
-
0.15
p-Methoxybenzaldehyde
-
-
0.0013
p-nitrobenzaldehyde
-
low-Km reductase
0.0026
p-nitrobenzaldehyde
-
low-Km reductase
0.004
p-nitrobenzaldehyde
-
low-Km aldehyde reductase
0.006
p-nitrobenzaldehyde
-
-
0.0084
p-nitrobenzaldehyde
-
AR3
0.029
p-nitrobenzaldehyde
-
aldehyde reductase I
0.034
p-nitrobenzaldehyde
-
AR2
0.041
p-nitrobenzaldehyde
-
high-Km reductase
0.044
p-nitrobenzaldehyde
-
-
0.071
p-nitrobenzaldehyde
-
AR1
0.08
p-nitrobenzaldehyde
-
-
0.12
p-nitrobenzaldehyde
-
-
0.129
p-nitrobenzaldehyde
-
G2
0.15
p-nitrobenzaldehyde
-
-
0.16
p-nitrobenzaldehyde
-
wild-type aldehyde reductase
0.16
p-nitrobenzaldehyde
wild-type aldehyde reductase
0.169
p-nitrobenzaldehyde
-
aldehyde reductase II
0.2
p-nitrobenzaldehyde
-
enzyme from kidney, brain or liver
0.23
p-nitrobenzaldehyde
-
-
0.25
p-nitrobenzaldehyde
aldehyde reductase, mutant R308A
0.25
p-nitrobenzaldehyde
-
high-Km aldehyde reductase
0.262
p-nitrobenzaldehyde
-
AR4
0.27
p-nitrobenzaldehyde
-
-
0.29
p-nitrobenzaldehyde
-
high-Km aldehyde reductase
0.31
p-nitrobenzaldehyde
-
-
0.35
p-nitrobenzaldehyde
-
-
0.38
p-nitrobenzaldehyde
-
aldehyde reductase, mutant V299C
0.38
p-nitrobenzaldehyde
mutant R311A
0.8
p-nitrobenzaldehyde
-
-
1.1
p-nitrobenzaldehyde
-
AR3
1.2
p-nitrobenzaldehyde
-
-
1.2
p-nitrobenzaldehyde
-
AR1
1.2
p-nitrobenzaldehyde
-
aldehyde reductase, mutant I298C
2.8
p-nitrobenzaldehyde
-
aldehyde reductase, mutant I298A
5.9
p-nitrobenzaldehyde
-
aldehyde reductase, mutant H112Q
0.049
pentanal
-
pH 7.0, 25°C
0.06
pentanal
-
pH 7.0, 25°C
0.075
pentanal
-
in 30 mM Tris-HCl (pH 8.0)
0.16
pentanal
-
coenzyme NADPH
0.4
pentanal
pH 7.0, temperature not specified in the publication
3.01
pentanal
-
coenzyme NADH
0.22
Pentanol
-
at pH 10
1.54
Pentanol
-
in 30 mM Tris-HCl (pH 8.0)
0.11
Phenylglyoxal
-
AR2
0.56
propan-2-ol
-
2° Adh
16.4
propan-2-ol
-
secondary alcohol dehydrogenase
27
propanal
-
coenzyme NADH
38.9
propanal
-
coenzyme NADPH
0.008
propionaldehyde
-
aldehyde reductase I
0.087
propionaldehyde
-
-
0.21
propionaldehyde
-
AR I
2.63
propionaldehyde
-
AR II
3.31
propionaldehyde
-
pH 7.0, 37°C
14.28
propionaldehyde
-
aldehyde reductase II
14.54
propionaldehyde
-
aldehyde reductase II
0.042
pyridine 3-aldehyde
-
AR2
0.26
pyridine 3-aldehyde
-
-
3
pyridine 3-aldehyde
-
AR1
4
pyridine 4-aldehyde
-
AR1
5.2
pyridine 4-aldehyde
-
AR3
1.2
Pyruvaldehyde
-
wild type enzyme, at 70°C
3.3
Pyruvaldehyde
pH 7.0, 70°C
4.2
Pyruvaldehyde
-
mutant enzyme R11L/A180V, at 70°C
17.75
Pyruvaldehyde
pH 7.5, 60°C
0.066
Salicylaldehyde
-
-
6.9
Salicylaldehyde
-
pH 6.5, 30°C
2.95
sodium D-glucuronate
-
aldehyde reductase II
2.95
sodium D-glucuronate
-
aldehyde reductase II, at pH 7.0 and 37°C
0.028
Succinic semialdehyde
-
AR4
0.029
Succinic semialdehyde
-
AR1
0.036
Succinic semialdehyde
-
G2
0.037
Succinic semialdehyde
-
-
0.064
Succinic semialdehyde
-
AR3
0.1
Succinic semialdehyde
-
reductase I
0.13
Succinic semialdehyde
-
-
0.17
Succinic semialdehyde
-
wild-type aldehyde reductase
0.17
Succinic semialdehyde
wild-type aldehyde reductase
0.2
Succinic semialdehyde
aldehyde reductase, mutant R308A
0.41
Succinic semialdehyde
-
aldehyde reductase, mutant V299C
1.5
Succinic semialdehyde
-
aldehyde reductase, mutant I298C
2.8
Succinic semialdehyde
-
aldehyde reductase, mutant I298A
10.9
Succinic semialdehyde
-
liver enzyme
14.1
Succinic semialdehyde
aldehyde reductase, mutant R311A
18
Succinic semialdehyde
-
aldehyde reductase, mutant H112Q
0.06
trans-2-hexenal
-
-
27.1
trans-2-hexenal
-
pH 6.5, 30°C
0.22
trans-2-hexenol
-
-
1.69
trans-2-hexenol
-
coenzyme NADPH
0.058
veratraldehyde
-
pH 7.0, 25°C
0.073
veratraldehyde
-
pH 7.0, 25°C
41
xylose
-
AR3
additional information
additional information
-
kinetic analysis of recombinant wild-type an d mutant enzymes, overview
-
additional information
additional information
-
kinetic analysis of wild-type and mutant enzymes, fit to the ordered bi-bi rate equation, steady-state kinetics, detailed overview. For some mutants (G211S, G211C, G211InsA and G211InsS), with NAD+ as a cofactor, the KA or KB values are observed to be higher than the maximum concentration of substrate or cofactor utilized. So, for mutants G211S, G211C, G211InsA and G211InsS, kinetic data is also measured using assay reaction mixtures containing 1-450 mM 2,3-butanediol and 0.001-5.50 mM NAD+
-
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