Reference on EC 1.1.1.2 - alcohol dehydrogenase (NADP+)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bhatnagar, A.; Das, B.; Liu, S.Q.; Srivastava, S.K.
Human liver aldehyde reductase: pH dependence of steady-state kinetic parameters
Arch. Biochem. Biophys.
287
329-336
1991
Homo sapiens
Manually annotated by BRENDA team
Shinoda, M.; Mori, S.; Shintani, S.; Ishikura, S.; Hara, A.
Inhibition of human aldehyde reductase by drugs for testing the function of liver and kidney
Biol. Pharm. Bull.
22
741-744
1999
Homo sapiens, Sus scrofa
Manually annotated by BRENDA team
Tabakoff, B.; Erwin, G.
Purification and characterization of a reduced nicotinamide adenine dinucleotide phosphate-linked aldehyde reductase from brain
J. Biol. Chem.
245
3263-3268
1970
Bos taurus, Oryctolagus cuniculus, Rattus norvegicus
Manually annotated by BRENDA team
Bosron, W.F.; Prairie, R.L.
Triphosphopyridine nucleotide-linked aldehyde reductase I. Purification and properties of the enzyme from pig kidney cortex
J. Biol. Chem.
217
4480-4485
1972
Bos taurus, Oryctolagus cuniculus, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Turner, A.J.; Tipton, K.F.
The characterization of two reduced nicotinamide-adenine dinucleotide phosphate-linked aldehyde reductases from pig brain
Biochem. J.
130
765-772
1972
Bos taurus, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Flynn, T.G.; Shires, J.; Walton, D.J.
Properties of the nicotinamide adenine dinucleotide phosphate-dependent aldehyde reductase from pig kidney. Amino acid composition, reactivity of cysteinyl residues, and stereochemistry of D-glyceraldehyde reduction
J. Biol. Chem.
250
2933-2940
1975
Oryctolagus cuniculus, Sus scrofa
Manually annotated by BRENDA team
Wermuth, B.; Muench, J.D.B.; von Wartburg, J.P.
Purification and properties of NADPH-dependent aldehyde reductase from human liver
J. Biol. Chem.
252
3821-3828
1977
Equus sp., Homo sapiens, Pecten maximus, Sus scrofa
Manually annotated by BRENDA team
Hartz, T.K.; Houston, M.R.; Lockwood, L.B.
Substrate specificity and kinetic properties of NADP+-dependent alcohol dehydrogenase of Phycomyces blakesleeanus
Mycologia
70
586-593
1978
Candida tropicalis, Cucumis melo, Mycobacterium tuberculosis, Neurospora crassa, Penicillium urticae, Phycomyces blakesleeanus, Pseudomonas aeruginosa, Rhizopus oryzae, Saccharomyces cerevisiae, Solanum tuberosum
-
Manually annotated by BRENDA team
Davidson, W.S.; Weihrauch, L.; Flynn, T.G.
Purification and compositional relatedness of aldehyde reductase from several species
Biochem. Soc. Trans.
576
940-943
1978
Drosophila melanogaster, Gallus sp., Homo sapiens, Pecten maximus, Rattus norvegicus, Saccharomyces cerevisiae, Sus scrofa
Manually annotated by BRENDA team
Davidson, W.S.; Flynn, T.G.
Kinetics and mechanism of action of aldehyde reductase from pig kidney
Biochem. Soc. Trans.
576
943-945
1978
Pecten maximus, Sus scrofa
Manually annotated by BRENDA team
Branlant, G.M; Biellmann, J.F.
Purification and some properties of aldehyde reductases from pig liver
Eur. J. Biochem.
105
611-621
1980
Equus sp., Mus musculus, Ovis aries, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Morpeth, F.F.; Dickinson, F.M.
Some properties of pig kidney-cortex aldehyde reductase
Biochem. J.
191
619-626
1980
Homo sapiens, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Turner, A.J.; Hryszko, J.
Isolation and characterization of rat liver aldehyde reductase
Biochim. Biophys. Acta
613
256-265
1980
Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Rivett, A.J.; Smith, I.L.; Tipton, K.F.
Purification of the high-Km aldehyde reductase from rat brain and liver and from ox brain
Biochem. J.
197
473-481
1981
Bos taurus, Cricetinae, Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Sawada, H.; Hara, A.; Nakayama, T.; Hayashibara, M.
Kinetic mechanisms in the reduction of aldehydes and ketones catalyzed by rabbit liver aldehyde reductases and hydroxysteroid dehydrogenases
J. Biochem.
92
185-191
1982
Bos taurus, Homo sapiens, Oryctolagus cuniculus, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Flynn, T.G.
Aldehyde reductases: Monomeric NADPH-dependent oxidoreductases with multifunctional potential
Biochem. Pharmacol.
31
2705-2712
1982
Cavia porcellus, Drosophila melanogaster, Homo sapiens, Mus musculus, Oryctolagus cuniculus, Rattus norvegicus, Saccharomyces cerevisiae, Sus scrofa
Manually annotated by BRENDA team
Daly, A.K.; Mantle, T.J.
Purification and characterization of the multiple forms of aldehyde reductase in ox kidney
Biochem. J.
205
373-380
1982
Bos taurus, Cavia porcellus, Sus scrofa
Manually annotated by BRENDA team
Daly, A.K.; Mantle, T.J.
The kinetic mechanism of the major form of ox kidney aldehyde reductase with D-glucuronic acid
Biochem. J.
205
381-388
1982
Bos taurus, Saccharomyces cerevisiae, Sus scrofa
Manually annotated by BRENDA team
Branlant, G.
Properties of an aldose reductase from pig lens. Comparative studies of an aldehyde reductase from pig lens
Eur. J. Biochem.
129
99-104
1982
Sus scrofa
Manually annotated by BRENDA team
Petrash, J.M.; Srivastava, S.K.
Purification and properties of human liver aldehyde reductases
Biochim. Biophys. Acta
707
105-114
1982
Bos taurus, Gallus sp., Homo sapiens, Mus musculus, Ovis aries, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Markus, H.B.; Raducha, M.; Harris, H.
Tissue distribution of mammalian aldose reductase and related enzymes
Biochem. Med.
29
31-45
1983
Canis lupus familiaris, Cavia porcellus, Cavia porcellus Hartley, Felis sp., Gallus sp., Homo sapiens, Mus musculus, Mus musculus B10.A, Oryctolagus cuniculus, Ovis aries, Rattus norvegicus, Saimiri, Sus scrofa
Manually annotated by BRENDA team
Takahashi, N.; Saito, T.; Tomita, K.
Purification and properties of an NADPH-linked aldehyde reductase from rat kidney
Biochim. Biophys. Acta
748
444-452
1983
Bos taurus, Cavia porcellus, Rattus norvegicus
Manually annotated by BRENDA team
Hara, A.; Deyashiki, Y.; Nakayama, T.; Sawada, H.
Isolation and characterization of multiforms of aldehyde reductase in chicken kidney
Eur. J. Biochem.
133
207-214
1983
Bos taurus, Gallus sp., Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Magnien, A.; Branlant, G.
The kinetics and mechanism of pig-liver aldehyde reductase. Comparative studies with pyridine-3-aldehyde and p-carboxybenzaldehyde
Eur. J. Biochem.
131
375-381
1983
Sus scrofa
Manually annotated by BRENDA team
Das, B.; Srivastava, S.K.
Purification and properties of aldose reductase and aldehyde reductase II from human erythrocyte
Arch. Biochem. Biophys.
238
670-679
1985
Homo sapiens
Manually annotated by BRENDA team
Das, B.; Srivastava, S.K.
Purification and properties of aldehyde reductases from human placenta
Biochim. Biophys. Acta
840
324-333
1985
Cavia porcellus, Homo sapiens
Manually annotated by BRENDA team
Kovar, J.; Plocek, J.
Purification of aldehyde reductase 1 from pig liver
J. Chromatogr.
351
371-375
1986
Sus scrofa
Manually annotated by BRENDA team
De Jongh, K.S.; Schofield, P.J.; Edwards, M.R.
Kinetic mechanism of sheep liver NADPH-dependent aldehyde reductase
Biochem. J.
242
143-150
1987
Bos taurus, Ovis aries, Rattus norvegicus
Manually annotated by BRENDA team
Bryant, F.O.; Wiegel, J.; Ljungdahl, L.G.
Purification and properties of primary and secondary alcohol dehydrogenases from Thermoanaerobacter ethanolicus
Appl. Environ. Microbiol.
2
460-465
1988
Acinetobacter sp., Clostridium beijerinckii, Escherichia coli, Geobacillus stearothermophilus, Saccharomyces cerevisiae, Thermoanaerobacter brockii, Thermoanaerobacter ethanolicus, Thermoanaerobacter thermohydrosulfuricus, Zymomonas mobilis
-
Manually annotated by BRENDA team
Kawasaki, N.; Tanimoto, T.; Tanaka, A.
Characterization of aldose reductase and aldehyde reductase from rat testis
Biochim. Biophys. Acta
996
30-36
1989
Rattus norvegicus
Manually annotated by BRENDA team
Arauzo, S.; Cazzulo, J.J.
The NADP-linked aldehyde reductase from Trypanosoma cruzi subcellular localization and some properties
FEMS Microbiol. Lett.
58
283-286
1989
Crithidia fasciculata, Neurospora crassa, Trypanosoma cruzi
Manually annotated by BRENDA team
Yamada, H.; Shimizu, S.; Kataoka, M.; Sakai, H.; Miyoshi, T.
A novel NADPH-dependent aldehyde reductase, catalyzing asymmetric reduction of beta-keto acid esters, from Sporobolomyces salmonicolor: purification and characterization
FEMS Microbiol. Lett.
70
45-48
1990
Sporidiobolus salmonicolor, Sporidiobolus salmonicolor AKU 4429
-
Manually annotated by BRENDA team
Ohta, M.; Tanimoto, T.; Tanaka, A.
Localization, isolation and properties of three NADPH-dependent aldehyde reducing enzymes from dog kidney
Biochim. Biophys. Acta
1078
395-403
1991
Bos taurus, Canis lupus familiaris, Cavia porcellus, Homo sapiens, Mus musculus, Oryctolagus cuniculus, Ovis aries, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Burdette, D.; Zeikus, J.G.
Purification of acetaldehyde dehydrogenase and alcohol dehydrogenases from Thermoanaerobacter ethanolicus 39E and characterization of the secondary-alcohol dehydrogenase (2 degrees Adh) as a bifunctional alcohol dehydrogenase-acetyl-CoA reductive thioesterase
Biochem. J.
302
163-170
1994
Clostridium acetobutylicum, Clostridium acetobutylicum NRRL B643, Clostridium beijerinckii, Clostridium beijerinckii NRRL B592, Clostridium kluyveri, Escherichia coli, Leuconostoc mesenteroides, Propionibacterium freudenreichii, Ruminiclostridium thermocellum, Saccharomyces cerevisiae, Thermoanaerobacter brockii, Thermoanaerobacter ethanolicus, Thermoanaerobacter ethanolicus JW 200, Thermoanaerobacter thermohydrosulfuricus, Vibrio harveyi, Zymomonas mobilis
Manually annotated by BRENDA team
Ma, K.; Robb, F.T.; Adams, M.W.
Purification and characterization of NADP-specific alcohol dehydrogenase and glutamate dehydrogenase from the hyperthermophilic archaeon Thermococcus litoralis
Appl. Environ. Microbiol.
60
562-568
1994
Acetobacter aceti, Drosophila melanogaster, Methanobacterium palustre, Methanoculleus thermophilus, Methanofollis liminatans, Saccharomyces cerevisiae, Thermoanaerobacter brockii, Thermococcus litoralis, Zymomonas mobilis
Manually annotated by BRENDA team
Barski, O.A.; Gabbay, K.H.; Grimshaw, C.E.; Bohren, K.M.
Mechanism of human aldehyde reductase: characterization of the active site pocket
Biochemistry
34
11264-11275
1995
Homo sapiens
Manually annotated by BRENDA team
Barski, O.A.; Gabbay, K.H.; Bohren, K.M.
The C-terminal loop of aldehyde reductase determines the substrate and inhibitor specificity
Biochemistry
35
14276-14280
1996
Homo sapiens, Homo sapiens (P14550)
Manually annotated by BRENDA team
Bogin, O.; Peretz, M.; Burstein, Y.
Thermoanaerobacter brockii alcohol dehydrogenase: characterization of the active site metal and its ligand amino acids
Protein Sci.
6
450-458
1997
Equus sp., Homo sapiens, Saccharomyces cerevisiae, Thermoanaerobacter brockii
Manually annotated by BRENDA team
Li, D.; Stevenson, K.J.
Purification and sequence analysis of a novel NADP(H)-dependent type III alcohol dehydrogenase from Thermococcus strain AN1
J. Bacteriol.
179
4433-4437
1997
Bacillus methanolicus, Clostridium acetobutylicum, Drosophila melanogaster, Escherichia coli, Saccharomyces cerevisiae, Thermococcus sp., Thermococcus sp. AN1, Zymomonas mobilis
Manually annotated by BRENDA team
Van Iersel, M.F.; Eppink, M.H.; van Berkel, W.J.; Rombouts, F.M.; Abee, T.
Purification and characterization of a novel NADP-dependent branched-chain alcohol dehydrogenase from Saccharomyces cerevisiae
Appl. Environ. Microbiol.
63
4079-4082
1997
Acinetobacter calcoaceticus, Saccharomyces cerevisiae
Manually annotated by BRENDA team
Udovikova, E.A.; Wojtczak, L.
Mitochondrial aldehyde reductase: identification and characterization in rat liver and kidney cortex
Int. J. Biochem. Cell Biol.
30
597-608
1998
Rattus norvegicus
Manually annotated by BRENDA team
Colrat, S.; Latche, A.; Guis, M.; Pech, J.C.; Bouzayen, M.; Fallot, J.; Roustan, J.P.
Purification and characterization of a NADPH-dependent aldehyde reductase from mung bean that detoxifies eutypine, a toxin from Eutypa lata1
Plant Physiol.
119
621-626
1999
Thermococcus sp., Vigna radiata
Manually annotated by BRENDA team
Peralba, J.M.; Cederlund, E.; Crosas, B.; Moreno, A.; Julia, P.; Martinez, S.E.; Persson, B.; Farr s, J.; Pares, X.; Jornvall, H.
Structural and enzymatic properties of a gastric NADP(H)-dependent and retinal-active alcohol dehydrogenase
J. Biol. Chem.
274
26021-26026
1999
Clostridium beijerinckii, Entamoeba histolytica, Pelophylax perezi, Thermoanaerobacter brockii, Thermoanaerobacter ethanolicus
Manually annotated by BRENDA team
Antoine, E.; Rolland, J.L.; Raffin, J.P.; Dietrich, J.
Cloning and over-expression in Escherichia coli of the gene encoding NADPH group III alcohol dehydrogenase from Thermococcus hydrothermalis. Characterization and comparison of the native and the recombinant enzymes
Eur. J. Biochem.
264
880-889
1999
Aquifex aeolicus, Archaeoglobus fulgidus, Bacillus methanolicus, Clostridium acetobutylicum, Pyrococcus furiosus, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Thermococcus hydrothermalis, Thermococcus litoralis, Thermococcus zilligii, Zymomonas mobilis
Manually annotated by BRENDA team
Li, C.; Heatwole, J.; Soelaiman, S.; Shoham, M.
Crystal structure of a thermophilic alcohol dehydrogenase substrate complex suggests determinants of substrate specificity and thermostability
Proteins
37
619-627
1999
Thermoanaerobacter brockii
Manually annotated by BRENDA team
Tani, A.; Sakai, Y.; Ishige, T.; Kato, N.
Thermostable NADP(+)-dependent medium-chain alcohol dehydrogenase from Acinetobacter sp. strain M-1: purification and characterization and gene expression in Escherichia coli
Appl. Environ. Microbiol.
66
5231-5235
2000
Acinetobacter calcoaceticus, Acinetobacter sp., Acinetobacter sp. M-1
Manually annotated by BRENDA team
Galamba, A.; Soetaert, K.; Buyssens, P.; Monnaie, D.; Jacobs, P.; Content, J.
Molecular and biochemical characterization of Mycobacterium smegmatis alcohol dehydrogenase C
FEMS Microbiol. Lett.
196
51-56
2001
Bacillus subtilis, Equus sp., Escherichia coli, Helicobacter pylori, Mycobacterium avium, Mycobacterium avium subsp. paratuberculosis, Mycobacterium bovis, Mycobacterium leprae, Mycobacterium smegmatis, Mycobacterium tuberculosis
Manually annotated by BRENDA team
Ye, Q.; Hyndman, D.; Green, N.; Li, X.; Korithoski, B.; Jia, Z.; Flynn, T.G.
Crystal structure of an aldehyde reductase Y50F mutant-NADP complex and its implications for substrate binding
Proteins
44
12-19
2001
Sus scrofa
Manually annotated by BRENDA team
Bronaugh, R.L.; Erwin, V.
Partial purification and characterization of NADPH-linked aldehyde reductase from monkey brain
J. Neurochem.
21
809-815
1973
Platyrrhini
Manually annotated by BRENDA team
Reyes, E.; Erwin, V.
Distribution and properties of NADPH-linked aldehyde reductases from rat brain synaptosomes
Neurochem. Res.
2
87-97
1977
Rattus norvegicus
Manually annotated by BRENDA team
Cash, C.; Maitre, M.; Mandel, P.
Purification from human brain and some properties of two NADPH-linked aldehyde reductases which reduce succinic semialdehyde to 4-hydroxybutyrate
J. Neurochem.
33
1169-1175
1979
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Lo, H.S.; Chang, C.J.
Purification and properties of NADP-linked, alcohol dehydrogenase from Entamoeba histolytica
J. Parasitol.
68
372-377
1982
Entamoeba histolytica, Homo sapiens
Manually annotated by BRENDA team
Cromlish, J.A.; Yoshimoto, C.K.; Flynn, T.G.
Purification and characterization of four NADPH-dependent aldehyde reductases from pig brain
J. Neurochem.
44
1477-1484
1985
Sus scrofa
Manually annotated by BRENDA team
Worrall, D.M.; Daly, A.K.; mantle, T.J.
Kinetic studies on the major form of aldehyde reductase in ox kidney: a general kinetic mechanism to explain substrate-dependent mechanisms and the inhibition by anticonsulvants
J. Enzyme Inhib.
1
163-168
1986
Bos taurus
Manually annotated by BRENDA team
Das, B.; Song, H.P.; Ansari, N.H.; Hair, G.A.; Srivastava, S.K.
Purification and properties of aldose reductase and aldehyde reductase II from human lens
Lens Res.
4
309-335
1987
Homo sapiens
-
Manually annotated by BRENDA team
Das, B.; Hair, G.A.; Ansari, N.H.; Srivastava, S.K.
Isolation and characterization of aldose reductase and aldehyde reductase II from bovine lens
Lens Res.
5
233-247
1988
Bos taurus
-
Manually annotated by BRENDA team
Tanimoto, T.; Ohta, M.; Tanaka, A.; Ikemoto, I.; Machida, T.
Purification and characterization of human testis aldose and aldehyde reductase
Int. J. Biochem.
23
421-428
1991
Homo sapiens
Manually annotated by BRENDA team
Takahashi, N.; Saito, T.; Goda, Y.; Tomita, K.
Characterization of microsomal NADPH-dependent aldehyde reductase from rat brain
J. Biochem.
99
513-519
1986
Rattus norvegicus
Manually annotated by BRENDA team
Shimon, L.J.; Peretz, M.; Goihberg, E.; Burstein, Y.; Frolow, F.
Thermophilic alcohol dehydrogenase from the mesophile Entamoeba histolytica: crystallization and preliminary X-ray characterization
Acta Crystallogr. Sect. D
58
546-548
2002
Entamoeba histolytica
Manually annotated by BRENDA team
Valencia, E.; Rosell, A.; Larroy, C.; Farres, J.; Biosca, J.A.; Fita, I.; Pares, X.; Ochoa, W.F.
Crystallization and preliminary X-ray analysis of NADP(H)-dependent alcohol dehydrogenases from Saccharomyces cerevisiae and Rana perezi
Acta Crystallogr. Sect. D
59
334-337
2003
Pelophylax perezi, Saccharomyces cerevisiae
Manually annotated by BRENDA team
King, M.T.
Thermodynamics of the reduction of NADP with 2-propanol catalyzed by an NADP-dependent alcohol dehydrogenase
Arch. Biochem. Biophys.
410
280-286
2003
Thermoanaerobacter brockii
Manually annotated by BRENDA team
Larroy, C.; Fernandez, M.R.; Gonzalez, E.; Pares, X.; Biosca, J.A.
Characterization of the Saccharomyces cerevisiae YMR318C (ADH6) gene product as a broad specificity NADPH-dependent alcohol dehydrogenase: relevance in aldehyde reduction
Biochem. J.
361
163-172
2002
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Brisdelli, F.; Saliola, M.; Pascarella, S.; Luzi, C.; Franceschini, N.; Falcone, C.; Martini, F.; Bozzi, A.
Kinetic properties of native and mutagenized isoforms of mitochondrial alcohol dehydrogenase III purified from Kluyveromyces lactis
Biochimie
86
705-712
2004
Kluyveromyces lactis (P49384)
Manually annotated by BRENDA team
Weckbecker, A.; Hummel, W.
Improved synthesis of chiral alcohols with Escherichia coli cells co-expressing pyridine nucleotide transhydrogenase, NADP(+)-dependent alcohol dehydrogenase and NAD(+)-dependent formate dehydrogenase
Biotechnol. Lett.
26
1739-1744
2004
Lactobacillus kefiri
Manually annotated by BRENDA team
Munir, I.; Nakazawa, M.; Harano, K.; Yamaji, R.; Inui, H.; Miyatake, K.; Nakano, Y.
Occurrence of a novel NADP(+)-linked alcohol dehydrogenase in Euglena gracilis
Comp. Biochem. Physiol. B
132
535-540
2002
Euglena gracilis
Manually annotated by BRENDA team
Niefind, K.; Muller, J.; Riebel, B.; Hummel, W.; Schomburg, D.
The crystal structure of R-specific alcohol dehydrogenase from Lactobacillus brevis suggests the structural basis of its metal dependency
J. Mol. Biol.
327
317-328
2003
Lactobacillus brevis
Manually annotated by BRENDA team
Rosell, A.; Valencia, E.; Pares, X.; Fita, I.; Farres, J.; Ochoa, W.F.
Crystal structure of the vertebrate NADP(H)-dependent alcohol dehydrogenase (ADH8)
J. Mol. Biol.
330
75-85
2003
Pelophylax perezi
Manually annotated by BRENDA team
Sulzenbacher, G.; Alvarez, K.; Van Den Heuvel, R.H.; Versluis, C.; Spinelli, S.; Campanacci, V.; Valencia, C.; Cambillau, C.; Eklund, H.; Tegoni, M.
Crystal structure of E. coli alcohol dehydrogenase YqhD: evidence of a covalently modified NADP coenzyme
J. Mol. Biol.
342
489-502
2004
Escherichia coli
Manually annotated by BRENDA team
Montesano, M.; Hyytiainen, H.; Wettstein, R.; Palva, E.T.
A novel potato defence-related alcohol:NADP+ oxidoreductase induced in response to Erwinia carotovora
Plant Mol. Biol.
52
177-189
2003
Solanum tuberosum
Manually annotated by BRENDA team
Barski, O.A.; Papusha, V.Z.; Ivanova, M.M.; Rudman, D.M.; Finegold, M.J.
Developmental expression and function of aldehyde reductase in proximal tubules of the kidney
Am. J. Physiol. Renal Physiol.
289
F200-F207
2005
Mus musculus (Q9JII6), Mus musculus C57BL/6 (Q9JII6)
Manually annotated by BRENDA team
Fossati, E.; Polentini, F.; Carrea, G.; Riva, S.
Exploitation of the alcohol dehydrogenase-acetone NADP-regeneration system for the enzymatic preparative-scale production of 12-ketochenodeoxycholic acid
Biotechnol. Bioeng.
93
1216-1220
2006
Lactobacillus brevis, Thermoanaerobacter brockii
Manually annotated by BRENDA team
Findrik, Z.; Vasic-Racki, D.; Luetz, S.; Daussmann, T.; Wandrey, C.
Kinetic modeling of acetophenone reduction catalyzed by alcohol dehydrogenase from Thermoanaerobacter sp.
Biotechnol. Lett.
27
1087-1095
2005
Thermoanaerobacter sp.
Manually annotated by BRENDA team
El-Kabbani, O.; Carbone, V.; Darmanin, C.; Oka, M.; Mitschler, A.; Podjarny, A.; Schulze-Briese, C.; Chung, R.P.
Structure of aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity
J. Med. Chem.
48
5536-5542
2005
Sus scrofa
Manually annotated by BRENDA team
Ernst, M.; Kaup, B.; Mueller, M.; Bringer-Meyer, S.; Sahm, H.
Enatioselective reduction of carbonyl compounds by whole-cell biotransformation, combining a formate dehydrogenase and (R)-specific alcohol dehydrogenase
Appl. Microbiol. Biotechnol.
66
629-634
2005
Lactobacillus brevis
Manually annotated by BRENDA team
Schracke, N.H.; Linne, U.; Christoph Mahlert, C.; Marahiel, M.A.
Synthesis of linear gramicidin requires the cooperation of two independent reductases
Biochemistry
44
8507-8513
2005
Brevibacillus brevis
Manually annotated by BRENDA team
Liu, Y.; Jing, K.; Jiang, X.; Lin, J.; Wang, F.; Cen, P.
Asymmetric reduction of ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate with two co-existing, recombinant Escherichia coli strains
Biotechnol. Lett.
27
119-125
2005
Sporidiobolus salmonicolor, Sporidiobolus salmonicolor ZJU0307
Manually annotated by BRENDA team
Petroval, T.; Steuber, H.; Hazemann, I.; Cousido-Siah, A.; Mitschler, A.; Chung, R.; Oka, M.; Klebe, G.; El-Kabbani, O.; Joachimiak, A.; Podjarny, A.
Factorizing selectivity determinants of inhibitor binding toward aldose and aldehyde reductases: structural and thermodynamic properties of the aldose reductase mutant Leu300Pro-fidarestat complex
J. Med. Chem.
48
5659-5665
2005
Sus scrofa
Manually annotated by BRENDA team
Schlieben, N.H.; Niefind, K.; Mueller, J.; Riebel, B.; Hummel, W.; Schomburg, D.
Atomic resolution of R-specific alcohol dehydrogenase from Lactobacillus brevis provide the structual bases of its substrate and cosubstrate specificity
J. Mol. Biol.
349
801-813
2005
Lactobacillus brevis
Manually annotated by BRENDA team
Jing, K.; Xu, Y.; Liu, Y.; Jiang, X.; Peng, L.; Cen, P.
Efficient production of recombinant aldehyde reductase and its application for asymmetric reduction of ethyl-4-chloro-3-oxobutanoate to ethyl (R)-4-hydoxybutanoate
Prep. Biochem. Biotechnol.
35
203-215
2005
Sporidiobolus salmonicolor, Sporidiobolus salmonicolor ZJUB 105
Manually annotated by BRENDA team
Short, D.M.; Lyon, R.; Watson, D.G.; Barski, O.A.; McGarvie, G.; Ellis, E.M.
Metabolism of trans, trans-muconaldehyde, acytotoxic metabolite of benzene, in mouse liver by alcohol dehydrogenase Adh1 and aldehyde reductase AKR1A4
Toxicol. Appl. Pharmacol.
210
163-170
2006
Mus musculus
Manually annotated by BRENDA team
Ying, X.; Wang, Y.; Badiei, H.R.; Karanassios, V.; Ma, K.
Purification and characterization of an iron-containing alcohol dehydrogenase in extremely thermophilic bacterium Thermotoga hypogea
Arch. Microbiol.
187
499-510
2007
Pseudothermotoga hypogea
Manually annotated by BRENDA team
Wolberg, M.; Filho, M.V.; Bode, S.; Geilenkirchen, P.; Feldmann, R.; Liese, A.; Hummel, W.; Mueller, M.
Chemoenzymatic synthesis of the chiral side-chain of statins: application of an alcohol dehydrogenase catalysed ketone reduction on a large scale
Bioprocess Biosyst. Eng.
31
183-191
2008
Lactobacillus brevis
Manually annotated by BRENDA team
Perez, J.M.; Arenas, F.A.; Pradenas, G.A.; Sandoval, J.M.; Vasquez, C.C.
Escherichia coli YqhD exhibits aldehyde reductase activity and protects from the harmful effect of lipid peroxidation-derived aldehydes
J. Biol. Chem.
283
7346-7353
2008
Escherichia coli
Manually annotated by BRENDA team
Goihberg, E.; Dym, O.; Tel-Or, S.; Shimon, L.; Frolow, F.; Peretz, M.; Burstein, Y.
Thermal stabilization of the protozoan Entamoeba histolytica alcohol dehydrogenase by a single proline substitution
Proteins
72
711-719
2008
Entamoeba histolytica, Entamoeba histolytica (P35630), Thermoanaerobacter brockii (P14941), Thermoanaerobacter brockii
Manually annotated by BRENDA team
Wahlen, B.D.; Oswald, W.S.; Seefeldt, L.C.; Barney, B.M.
Purification, characterization, and potential bacterial wax production role of an NADPH-dependent fatty aldehyde reductase from Marinobacter aquaeolei VT8
Appl. Environ. Microbiol.
75
2758-2764
2009
Marinobacter hydrocarbonoclasticus VT8
Manually annotated by BRENDA team
Carbone, V.; Chung, R.; Endo, S.; Hara, A.; El-Kabbani, O.
Structure of aldehyde reductase in ternary complex with coenzyme and the potent 20alpha-hydroxysteroid dehydrogenase inhibitor 3,5-dichlorosalicylic acid: implications for inhibitor binding and selectivity
Arch. Biochem. Biophys.
479
82-87
2008
Sus scrofa (P50578)
Manually annotated by BRENDA team
Quynh, C.T.; Iijima, Y.; Morimitsu, Y.; Kubota, K.
Aliphatic aldehyde reductase activity related to the formation of volatile alcohols in Vietnamese coriander leaves
Biosci. Biotechnol. Biochem.
73
641-647
2009
Persicaria odorata
Manually annotated by BRENDA team
Machielsen, R.; Leferink, N.G.; Hendriks, A.; Brouns, S.J.; Hennemann, H.G.; Daussmann, T.; van der Oost, J.
Laboratory evolution of Pyrococcus furiosus alcohol dehydrogenase to improve the production of (2S,5S)-hexanediol at moderate temperatures
Extremophiles
12
587-594
2008
Pyrococcus furiosus
Manually annotated by BRENDA team
Ying, X.; Grunden, A.M.; Nie, L.; Adams, M.W.; Ma, K.
Molecular characterization of the recombinant iron-containing alcohol dehydrogenase from the hyperthermophilic Archaeon, Thermococcus strain ES1
Extremophiles
13
299-311
2009
Thermococcus sp. (C1IWT4), Thermococcus sp. ES1 (C1IWT4)
Manually annotated by BRENDA team
Liu, Z.L.; Moon, J.
A novel NADPH-dependent aldehyde reductase gene from Saccharomyces cerevisiae NRRL Y-12632 involved in the detoxification of aldehyde inhibitors derived from lignocellulosic biomass conversion
Gene
446
1-10
2009
Saccharomyces cerevisiae, Saccharomyces cerevisiae NRRL Y-12632
Manually annotated by BRENDA team
Vidal, R.; Lopez-Maury, L.; Guerrero, M.G.; Florencio, F.J.
Characterization of an alcohol dehydrogenase from the cyanobacterium Synechocystis sp. strain PCC 6803 that responds to environmental stress conditions via the Hik34-Rre1 two-component system
J. Bacteriol.
191
4383-4391
2009
Synechocystis sp.
Manually annotated by BRENDA team
Breicha, K.; Mueller, M.; Hummel, W.; Niefind, K.
Crystallization and preliminary crystallographic analysis of Gre2p, an NADP(+)-dependent alcohol dehydrogenase from Saccharomyces cerevisiae
Acta Crystallogr. Sect. F
66
838-841
2010
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Carbone, V.; Giglio, M.; Chung, R.; Huyton, T.; Adams, J.; Maccari, R.; Ottana, R.; Hara, A.; El-Kabbani, O.
Structure of aldehyde reductase in ternary complex with a 5-arylidene-2,4-thiazolidinedione aldose reductase inhibitor
Eur. J. Med. Chem.
45
1140-1145
2010
Sus scrofa (P50578), Sus scrofa
Manually annotated by BRENDA team
Bezsudnova, E.Y.; Boyko, K.M.; Polyakov, K.M.; Dorovatovskiy, P.V.; Stekhanova, T.N.; Gumerov, V.M.; Ravin, N.V.; Skryabin, K.G.; Kovalchuk, M.V.; Popov, V.O.
Structural insight into the molecular basis of polyextremophilicity of short-chain alcohol dehydrogenase from the hyperthermophilic archaeon Thermococcus sibiricus
Biochimie
94
2628-2638
2012
Thermococcus sibiricus (C6A190), Thermococcus sibiricus, Thermococcus sibiricus MM 739 (C6A190)
Manually annotated by BRENDA team
van der Oost, J.; Voorhorst, W.G.; Kengen, S.W.; Geerling, A.C.; Wittenhorst, V.; Gueguen, Y.; de Vos, W.M.
Genetic and biochemical characterization of a short-chain alcohol dehydrogenase from the hyperthermophilic archaeon Pyrococcus furiosus
Eur. J. Biochem.
268
3062-3068
2001
Pyrococcus furiosus (O73949), Pyrococcus furiosus
Manually annotated by BRENDA team
Alsafadi, D.; Paradisi, F.
Effect of organic solvents on the activity and stability of halophilic alcohol dehydrogenase (ADH2) from Haloferax volcanii
Extremophiles
17
115-122
2013
Haloferax volcanii
Manually annotated by BRENDA team
Ma, K.; Adams, M.W.
An unusual oxygen-sensitive, iron- and zinc-containing alcohol dehydrogenase from the hyperthermophilic archaeon Pyrococcus furiosus
J. Bacteriol.
181
1163-1170
1999
Pyrococcus furiosus
Manually annotated by BRENDA team
Lyashenko, A.V.; Bezsudnova, E.Y.; Gumerov, V.M.; Lashkov, A.A.; Mardanov, A.V.; Mikhailov, A.M.; Polyakov, K.M.; Popov, V.O.; Ravin, N.V.; Skryabin, K.G.; Zabolotniy, V.K.; Stekhanova, T.N.; Kovalchuk, M.V.
Expression, purification and crystallization of a thermostable short-chain alcohol dehydrogenase from the archaeon Thermococcus sibiricus
Acta Crystallogr. Sect. F
66
655-657
2010
Thermococcus sibiricus (C6A190), Thermococcus sibiricus, Thermococcus sibiricus DSM 12597 (C6A190)
Manually annotated by BRENDA team
Stekhanova, T.N.; Mardanov, A.V.; Bezsudnova, E.Y.; Gumerov, V.M.; Ravin, N.V.; Skryabin, K.G.; Popov, V.O.
Characterization of a thermostable short-chain alcohol dehydrogenase from the hyperthermophilic archaeon Thermococcus sibiricus
Appl. Environ. Microbiol.
76
4096-4098
2010
Thermococcus sibiricus (C6A190), Thermococcus sibiricus, Thermococcus sibiricus DSM 12597 (C6A190)
Manually annotated by BRENDA team
Ausili, A.; Vitale, A.; Labella, T.; Rosso, F.; Barbarisi, A.; Gómez-Fernández, J.C.; D'Auria, S.
Alcohol dehydrogenase from the hyperthermophilic archaeon Pyrobaculum aerophilum: stability at high temperature
Arch. Biochem. Biophys.
525
40-46
2012
Pyrobaculum aerophilum (Q8ZUP0), Pyrobaculum aerophilum DSM 7523 (Q8ZUP0)
Manually annotated by BRENDA team
Alsafadi, D.; Paradisi, F.
Covalent immobilization of alcohol dehydrogenase (ADH2) from Haloferax volcanii: how to maximize activity and optimize performance of halophilic enzymes
Mol. Biotechnol.
56
240-247
2014
Haloferax volcanii
Manually annotated by BRENDA team
Vitale, A.; Thorne, N.; Lovell, S.; Battaile, K.P.; Hu, X.; Shen, M.; D'Auria, S.; Auld, D.S.
Physicochemical characterization of a thermostable alcohol dehydrogenase from Pyrobaculum aerophilum
PLoS One
8
e63828
2013
Pyrobaculum aerophilum, Pyrobaculum aerophilum (Q8ZUP0), Pyrobaculum aerophilum DSM 7523 (Q8ZUP0)
Manually annotated by BRENDA team
Asako, H.; Shimizu, M.; Itoh, N.
Engineering of NADPH-dependent aldo-keto reductase from Penicillium citrinum by directed evolution to improve thermostability and enantioselectivity
Appl. Microbiol. Biotechnol.
80
805-812
2008
Penicillium citrinum, Penicillium citrinum IFO 4631
Manually annotated by BRENDA team
Inokuma, K.; Nakashimada, Y.; Akahoshi, T.; Nishio, N.
Characterization of enzymes involved in the ethanol production of Moorella sp. HUC22-1
Arch. Microbiol.
188
37-45
2007
Moorella sp., Moorella sp. HUC22-1
Manually annotated by BRENDA team
Lamed, R.J.; Zeikus, J.G.
Novel NADP-linked alcohol-aldehyde/ketone oxidoreductase in thermophilic ethanologenic bacteria
Biochem. J.
195
183-190
1981
Thermoanaerobacter brockii
Manually annotated by BRENDA team
Chung, D.; Verbeke, T.J.; Cross, K.L.; Westpheling, J.; Elkins, J.G.
Expression of a heat-stable NADPH-dependent alcohol dehydrogenase in Caldicellulosiruptor bescii results in furan aldehyde detoxification
Biotechnol. Biofuels
8
102
2015
Thermoanaerobacter pseudethanolicus (B0KB53), Thermoanaerobacter pseudethanolicus ATCC 33223 (B0KB53)
Manually annotated by BRENDA team
Ma, K.; Loessner, H.; Heider, J.; Johnson, M.K.; Adams, M.W.
Effects of elemental sulfur on the metabolism of the deep-sea hyperthermophilic archaeon Thermococcus strain ES-1: characterization of a sulfur-regulated, non-heme iron alcohol dehydrogenase
J. Bacteriol.
177
4748-4756
1995
Thermococcus paravinellae, Thermococcus paravinellae ES-1
Manually annotated by BRENDA team
Patel, J.M.; Musa, M.M.; Rodriguez, L.; Sutton, D.A.; Popik, V.V.; Phillips, R.S.
Mutation of Thermoanaerobacter ethanolicus secondary alcohol dehydrogenase at Trp-110 affects stereoselectivity of aromatic ketone reduction
Org. Biomol. Chem.
12
5905-5910
2014
Thermoanaerobacter ethanolicus
Manually annotated by BRENDA team
Munir, I.; Swati, Z.; Rashid, M.; Yamaji, R.; Inui, H.; Nakano, Y.
Separation and properties of two novel NADP+-dependent alcohol dehydrogenases from Euglena gracilis Z
Pak. J. Biol. Sci.
9
2743-2747
2006
Euglena gracilis, Euglena gracilis Z
-
Manually annotated by BRENDA team
Basen, M.; Schut, G.J.; Nguyen, D.M.; Lipscomb, G.L.; Benn, R.A.; Prybol, C.J.; Vaccaro, B.J.; Poole, F.L.; Kelly, R.M.; Adams, M.W.
Single gene insertion drives bioalcohol production by a thermophilic archaeon
Proc. Natl. Acad. Sci. USA
111
17618-17623
2014
Thermoanaerobacter sp. (B0K3U7)
Manually annotated by BRENDA team
Ma, M.; Wang, X.; Zhang, X.; Zhao, X.
Alcohol dehydrogenases from Scheffersomyces stipitis involved in the detoxification of aldehyde inhibitors derived from lignocellulosic biomass conversion
Appl. Microbiol. Biotechnol.
97
8411-8425
2013
Scheffersomyces stipitis (A3GHL4), Scheffersomyces stipitis (A3GHR6), Scheffersomyces stipitis ATCC 58785 (A3GHL4), Scheffersomyces stipitis ATCC 58785 (A3GHR6)
Manually annotated by BRENDA team
Elleuche, S.; Fodor, K.; von der Heyde, A.; Klippel, B.; Wilmanns, M.; Antranikian, G.
Group III alcohol dehydrogenase from Pectobacterium atrosepticum: insights into enzymatic activity and organization of the metal ion-containing region
Appl. Microbiol. Biotechnol.
98
4041-4051
2014
Pectobacterium atrosepticum (U6CL97), Pectobacterium atrosepticum DSM 18077 (U6CL97)
Manually annotated by BRENDA team
Choi, Y.N.; Park, J.M.
Enhancing biomass and ethanol production by increasing NADPH production in Synechocystis sp. PCC 6803
Biores. Technol.
213
54-57
2016
Escherichia coli (Q46856)
Manually annotated by BRENDA team
Takeda, M.; Matsumura, A.T.; Kurosaki, K.; Chhetri, R.T.; Motomatsu, S.; Suzuki, I.; Sahabi, D.M.
An enantioselective NADP(+)-dependent alcohol dehydrogenase responsible for cooxidative production of (3S)-5-hydroxy-3-methyl-pentanoic acid
Biosci. Biotechnol. Biochem.
80
1155-1163
2016
Mycobacterium sp. (A0A125SUY5), Mycobacterium sp. B-009 (A0A125SUY5)
Manually annotated by BRENDA team
Hussain, S.; Parveen, S.; Hao, X.; Zhang, S.; Wang, W.; Qin, X.; Yang, Y.; Chen, X.; Zhu, S.; Zhu, C.; Ma, B.
Structure-activity relationships studies of quinoxalinone derivatives as aldose reductase inhibitors
Eur. J. Med. Chem.
80
383-392
2014
Rattus norvegicus (P51635), Rattus norvegicus Wistar (P51635)
Manually annotated by BRENDA team
Ying, X.; Ma, K.
Characterization of a zinc-containing alcohol dehydrogenase with stereoselectivity from the hyperthermophilic archaeon Thermococcus guaymasensis
J. Bacteriol.
183
3009-3019
2011
Thermococcus guaymasensis (F8S123)
Manually annotated by BRENDA team
Qin, X.; Hao, X.; Han, H.; Zhu, S.; Yang, Y.; Wu, B.; Hussain, S.; Parveen, S.; Jing, C.; Ma, B.; Zhu, C.
Design and synthesis of potent and multifunctional aldose reductase inhibitors based on quinoxalinones
J. Med. Chem.
58
1254-1267
2015
Rattus norvegicus (P51635), Rattus norvegicus Wistar (P51635)
Manually annotated by BRENDA team
Stefek, M.; Soltesova Prnova, M.; Majekova, M.; Rechlin, C.; Heine, A.; Klebe, G.
Identification of novel aldose reductase inhibitors based on carboxymethylated mercaptotriazinoindole scaffold
J. Med. Chem.
58
2649-2657
2015
Rattus norvegicus (P07943), Rattus norvegicus Wistar (P07943)
Manually annotated by BRENDA team
Borzecka, W.; Lavandera, I.; Gotor, V.
Synthesis of enantiopure fluorohydrins using alcohol dehydrogenases at high substrate concentrations
J. Org. Chem.
78
7312-7317
2013
Lactobacillus brevis
Manually annotated by BRENDA team
Wang, Y.; Zhai, A.; Zhang, Y.; Qiu, K.; Wang, J.; Li, Q.
Degradation of swainsonine by the NADP-dependent alcohol dehydrogenase A1R6C3 in Arthrobacter sp. HW08
Toxins
8
145
2016
Paenarthrobacter aurescens (A1R6C3), Paenarthrobacter aurescens TC1 (A1R6C3)
Manually annotated by BRENDA team