Application | Comment | Organism |
---|---|---|
medicine | - |
Rattus norvegicus |
medicine | daunorubicin, a cancer chemotherapeutic agent can be reduced by aldehyde reductase | Sus scrofa |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,10-phenanthroline | - |
Sus scrofa | |
2-mercaptoethanol | - |
Sus scrofa | |
NADPH | competitive inhibitor for reductase I | Sus scrofa | |
Phenobarbital | - |
Rattus norvegicus | |
Phenobarbital | - |
Sus scrofa | |
pyrazole | - |
Equus sp. | |
pyrazole | - |
Sus scrofa |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0056 | - |
NADPH | - |
Sus scrofa | |
0.008 | - |
NADPH | - |
Sus scrofa | |
0.05 | - |
p-Carboxybenzaldehyde | - |
Sus scrofa | |
0.08 | - |
daunorubicin | reductase I | Sus scrofa | |
0.1 | - |
4-Carboxyphenylglyoxal | - |
Sus scrofa | |
0.1 | - |
Succinic semialdehyde | reductase I | Sus scrofa | |
0.27 | - |
p-nitrobenzaldehyde | - |
Sus scrofa | |
0.6 | - |
indolacetaldehyde | - |
Sus scrofa | |
1.2 | - |
Phenylglyoxal | - |
Sus scrofa | |
1.5 | - |
D-glucuronate | - |
Sus scrofa | |
1.5 | - |
3-Pyridinecarboxaldehyde | - |
Sus scrofa | |
1.6 | - |
4-Carboxyacetophenone | - |
Sus scrofa | |
2 | - |
2-chloroheptanal | - |
Sus scrofa | |
4.5 | - |
D-glyceraldehyde | - |
Sus scrofa | |
10 | - |
Heptanal | - |
Sus scrofa | |
10 | - |
p-nitroacetophenone | - |
Sus scrofa | |
14 | - |
butane 2,3-dione | - |
Sus scrofa | |
150 | - |
n-Butyraldehyde | - |
Sus scrofa |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
34000 | - |
liver enzyme, aldehyde reductase I, gel filtration | Sus scrofa |
35000 | - |
liver enzyme, reductase II, gel filtration | Sus scrofa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucuronate + NADPH | Mus musculus | - |
L-gulonate + NADP+ | - |
r | |
D-glucuronate + NADPH | Rattus norvegicus | - |
L-gulonate + NADP+ | - |
r | |
D-glucuronate + NADPH | Sus scrofa | - |
L-gulonate + NADP+ | - |
r | |
D-glucuronate + NADPH | Ovis aries | - |
L-gulonate + NADP+ | - |
r | |
D-glyceraldehyde + NADPH + H+ | Mus musculus | - |
glycerol + NADP+ | - |
r | |
D-glyceraldehyde + NADPH + H+ | Rattus norvegicus | - |
glycerol + NADP+ | - |
r | |
D-glyceraldehyde + NADPH + H+ | Sus scrofa | - |
glycerol + NADP+ | - |
r | |
D-glyceraldehyde + NADPH + H+ | Ovis aries | - |
glycerol + NADP+ | - |
r | |
L-gulonic acid + NADP+ | Rattus norvegicus | - |
D-glucuronic acid + NADPH | - |
r | |
L-gulonic acid + NADP+ | Sus scrofa | - |
D-glucuronic acid + NADPH | - |
r | |
succinic semialdehyde + NADPH + H+ | Rattus norvegicus | - |
4-hydroxybutyrate + NADP+ | - |
r | |
succinic semialdehyde + NADPH + H+ | Sus scrofa | - |
4-hydroxybutyrate + NADP+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Equus sp. | - |
horse | - |
Mus musculus | - |
mouse | - |
Ovis aries | - |
sheep | - |
Ovis aries | - |
Suffolk-Hampshire | - |
Rattus norvegicus | - |
rat | - |
Sus scrofa | - |
pig | - |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
aldehyde reductase I | Ovis aries |
aldehyde reductase I and II from brain, no recuctase II activity could be detected in pig kidney | Sus scrofa |
reductase I | Equus sp. |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
brain | - |
Rattus norvegicus | - |
brain | - |
Sus scrofa | - |
brain | - |
Ovis aries | - |
kidney | - |
Mus musculus | - |
kidney | - |
Rattus norvegicus | - |
kidney | - |
Sus scrofa | - |
kidney | - |
Ovis aries | - |
liver | - |
Mus musculus | - |
liver | - |
Rattus norvegicus | - |
liver | - |
Sus scrofa | - |
liver | - |
Ovis aries | - |
liver | - |
Equus sp. | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
35 | - |
- |
Sus scrofa |
Storage Stability | Organism |
---|---|
-20°C, stable for several months if stored as an ammonium sulfate precipitate | Sus scrofa |
20°C reductase I stable for more than 1 month | Sus scrofa |
4°C reductase I and II are stable for several months | Sus scrofa |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-chloroheptanal + NADPH | - |
Sus scrofa | 2-chloroheptanol + NADP+ | - |
r | |
3-pyridinecarboxaldehyde + NADPH | - |
Rattus norvegicus | 3-pyridinemethanol + NADP+ | - |
r | |
3-pyridinecarboxaldehyde + NADPH | - |
Sus scrofa | 3-pyridinemethanol + NADP+ | - |
r | |
3-pyridinecarboxaldehyde + NADPH | - |
Ovis aries | 3-pyridinemethanol + NADP+ | - |
r | |
4-carboxyacetophenone + NADPH | - |
Sus scrofa | ? + NADP+ | - |
r | |
4-carboxyphenylglyoxal + NADPH | - |
Sus scrofa | ? + NADP+ | - |
r | |
benzyl alcohol + NADP+ | - |
Sus scrofa | benzaldehyde + NADPH | - |
r | |
butane 2,3-dione + NADPH | - |
Sus scrofa | ? + NADP+ | - |
r | |
D-glucuronate + NADPH | - |
Mus musculus | L-gulonate + NADP+ | - |
? | |
D-glucuronate + NADPH | - |
Mus musculus | L-gulonate + NADP+ | - |
r | |
D-glucuronate + NADPH | - |
Rattus norvegicus | L-gulonate + NADP+ | - |
? | |
D-glucuronate + NADPH | - |
Rattus norvegicus | L-gulonate + NADP+ | - |
r | |
D-glucuronate + NADPH | - |
Sus scrofa | L-gulonate + NADP+ | - |
? | |
D-glucuronate + NADPH | - |
Sus scrofa | L-gulonate + NADP+ | - |
r | |
D-glucuronate + NADPH | - |
Ovis aries | L-gulonate + NADP+ | - |
? | |
D-glucuronate + NADPH | - |
Ovis aries | L-gulonate + NADP+ | - |
r | |
D-glyceraldehyde + NADPH + H+ | - |
Mus musculus | glycerol + NADP+ | - |
r | |
D-glyceraldehyde + NADPH + H+ | - |
Rattus norvegicus | glycerol + NADP+ | - |
r | |
D-glyceraldehyde + NADPH + H+ | - |
Sus scrofa | glycerol + NADP+ | - |
r | |
D-glyceraldehyde + NADPH + H+ | - |
Ovis aries | glycerol + NADP+ | - |
r | |
daunorubicin + NADPH | - |
Rattus norvegicus | ? + NADP+ | - |
? | |
daunorubicin + NADPH | - |
Sus scrofa | ? + NADP+ | - |
? | |
indol-3-ylacetaldehyde + NADPH | - |
Sus scrofa | indol-3-ethanol + NADP+ | - |
? | |
indolacetaldehyde + NADPH | - |
Sus scrofa | ? + NADP+ | - |
? | |
L-gulonic acid + NADP+ | - |
Rattus norvegicus | D-glucuronic acid + NADPH | - |
r | |
L-gulonic acid + NADP+ | - |
Sus scrofa | D-glucuronic acid + NADPH | - |
r | |
L-gulonic acid + NADPH | - |
Rattus norvegicus | D-glucuronic acid + NADP+ | - |
r | |
L-gulonic acid + NADPH | - |
Sus scrofa | D-glucuronic acid + NADP+ | - |
r | |
n-butyraldehyde + NADPH | - |
Sus scrofa | n-butanol + NADP+ | - |
? | |
n-heptanal + NADPH | - |
Sus scrofa | heptanol + NADP+ | - |
r | |
p-carboxybenzaldehyde + NADPH | - |
Rattus norvegicus | p-carboxybenzyl alcohol + NADP+ | - |
r | |
p-carboxybenzaldehyde + NADPH | - |
Sus scrofa | p-carboxybenzyl alcohol + NADP+ | - |
r | |
p-nitroacetophenone + NADPH | - |
Sus scrofa | ? + NADP+ | - |
r | |
p-nitrobenzaldehyde + NADPH | - |
Rattus norvegicus | p-nitrobenzylalcohol + NADP+ | - |
r | |
p-nitrobenzaldehyde + NADPH | - |
Sus scrofa | p-nitrobenzylalcohol + NADP+ | - |
r | |
p-nitrobenzaldehyde + NADPH | - |
Ovis aries | p-nitrobenzylalcohol + NADP+ | - |
r | |
phenylglyoxal + NADPH | - |
Sus scrofa | ? + NADP+ | - |
r | |
succinic semialdehyde + NADPH + H+ | - |
Rattus norvegicus | 4-hydroxybutyrate + NADP+ | - |
r | |
succinic semialdehyde + NADPH + H+ | - |
Sus scrofa | 4-hydroxybutyrate + NADP+ | - |
r |
Subunits | Comment | Organism |
---|---|---|
monomer | - |
Rattus norvegicus |
monomer | 1 * 35000 | Sus scrofa |
Synonyms | Comment | Organism |
---|---|---|
liver alcohol dehydrogenase | - |
Equus sp. |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.9 | - |
aldehyde reductase I | Sus scrofa |
6.2 | - |
aldehyde reductase II | Sus scrofa |