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Literature summary for 1.1.1.2 extracted from

  • Perez, J.M.; Arenas, F.A.; Pradenas, G.A.; Sandoval, J.M.; Vasquez, C.C.
    Escherichia coli YqhD exhibits aldehyde reductase activity and protects from the harmful effect of lipid peroxidation-derived aldehydes (2008), J. Biol. Chem., 283, 7346-7353.
    View publication on PubMed
Search for more literature for 1.1.1.2

Cloned(Commentary)

Cloned (Comment) Organism
expression of wild-type and mutant enzymes Escherichia coli

Protein Variants

Protein Variants Comment Organism
additional information a yqhD knockout mutant does not confer resistance to potassium tellurite and other ROS elicitors Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.67
-
 butanaldehyde pH 7.0, 37°C Escherichia coli
1.78
-
 malondialdehyde pH 7.0, 37°C Escherichia coli
3.31
-
 propionaldehyde pH 7.0, 37°C Escherichia coli
4.81
-
 acrolein pH 7.0, 37°C Escherichia coli
28.47
-
 acetaldehyde pH 7.0, 37°C Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Escherichia coli YqhD mediates resistance to potassium tellurite and other reactive oxygen species elicitors in Escherichia coli, and protects from protein oxidation, YqhD lowers toxic acrolein concentrations, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
 gene yphD
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetaldehyde + NADPH + H+
-
 Escherichia coli ethanol + NADP+
-
 r
acrolein + NADPH
-
 Escherichia coli propenol + NADP+
-
 r
butanaldehyde + NADPH
-
 Escherichia coli butanol + NADP+
-
 r
malondialdehyde + NADPH
-
 Escherichia coli ?
-
 r
additional information YqhD mediates resistance to potassium tellurite and other reactive oxygen species elicitors in Escherichia coli, and protects from protein oxidation, YqhD lowers toxic acrolein concentrations, overview Escherichia coli ?
-
 ?
additional information YqhD does not show any detectable enzymatic activity when tested with short-chain alcohols as substrates, e.g. on methanol, ethanol, propanol, butanol, or isopropanol Escherichia coli ?
-
 ?
propanaldehyde + NADPH
-
 Escherichia coli propanol + NADP+
-
 r

Synonyms

Synonyms Comment Organism
NADPH-dependent aldehyde reductase
-
 Escherichia coli
YqhD
-
 Escherichia coli

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Escherichia coli

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
45.1
-
 propionaldehyde pH 7.0, 37°C Escherichia coli
53.5
-
 acetaldehyde pH 7.0, 37°C Escherichia coli
59.5
-
 butanaldehyde pH 7.0, 37°C Escherichia coli
60.1
-
 malondialdehyde pH 7.0, 37°C Escherichia coli
62.5
-
 acrolein pH 7.0, 37°C Escherichia coli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Escherichia coli

Cofactor

Cofactor Comment Organism Structure
NADPH dependent on Escherichia coli