Activating Compound | Comment | Organism | Structure |
---|---|---|---|
PO43- | stimulates the enzymatic reduction of 3-pyridinecarboxaldehyde | Sus scrofa | |
SO42- | stimulates the enzymatic reduction of 3-pyridinecarboxaldehyde | Sus scrofa |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Amobarbital | - |
Sus scrofa | |
hydroxylamine | - |
Sus scrofa | |
iodoacetic acid | - |
Sus scrofa | |
Sodium fluoride | - |
Sus scrofa |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.078 | - |
p-Carboxybenzaldehyde | - |
Sus scrofa | |
0.33 | - |
(+)-Camphorquinone | - |
Sus scrofa | |
0.35 | - |
p-nitrobenzaldehyde | - |
Sus scrofa | |
0.51 | - |
p-cyanobenzaldehyde | - |
Sus scrofa | |
0.69 | - |
4-Pyridinecarboxaldehyde | - |
Sus scrofa | |
2.6 | - |
3-Pyridinecarboxaldehyde | - |
Sus scrofa | |
5.5 | - |
3-Pyridinemethanol | - |
Sus scrofa | |
775 | - |
glycerol | - |
Sus scrofa | |
1360 | - |
L-arabitol | - |
Sus scrofa |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
25000 | - |
gel filtration, ultracentrifugation, specific activity corresponding to molecular weight | Sus scrofa |
30200 | - |
gel filtration, sedimentation equilibrium determination | Sus scrofa |
38000 | - |
1 * 38000, SDS-PAGE | Sus scrofa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha-diketone + NADPH | Sus scrofa | - |
? + NADP+ | - |
? | |
D-glucuronate + NADPH | Rattus norvegicus | - |
L-gulonate + NADP+ | - |
r | |
D-glucuronate + NADPH | Sus scrofa | - |
L-gulonate + NADP+ | - |
r | |
D-glucuronate + NADPH | Bos taurus | - |
L-gulonate + NADP+ | - |
r | |
D-glucuronate + NADPH | Oryctolagus cuniculus | - |
L-gulonate + NADP+ | - |
r | |
D-glyceraldehyde + NADPH + H+ | Rattus norvegicus | - |
glycerol + NADP+ | - |
r | |
D-glyceraldehyde + NADPH + H+ | Sus scrofa | - |
glycerol + NADP+ | - |
r | |
D-glyceraldehyde + NADPH + H+ | Oryctolagus cuniculus | - |
glycerol + NADP+ | - |
r | |
L-gulonic acid + NADP+ | Rattus norvegicus | - |
D-glucuronic acid + NADPH | - |
r | |
L-gulonic acid + NADP+ | Sus scrofa | - |
D-glucuronic acid + NADPH | - |
r | |
L-gulonic acid + NADP+ | Bos taurus | - |
D-glucuronic acid + NADPH | - |
r | |
L-gulonic acid + NADP+ | Oryctolagus cuniculus | - |
D-glucuronic acid + NADPH | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
bovine | - |
Oryctolagus cuniculus | - |
rabbit | - |
Rattus norvegicus | - |
rat | - |
Sus scrofa | - |
pig | - |
Purification (Comment) | Organism |
---|---|
- |
Sus scrofa |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Rattus norvegicus | - |
kidney | - |
Bos taurus | - |
kidney | cortex | Sus scrofa | - |
kidney | cortex | Oryctolagus cuniculus | - |
liver | - |
Rattus norvegicus | - |
liver | - |
Sus scrofa | - |
liver | - |
Bos taurus | - |
liver | - |
Oryctolagus cuniculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
17.1 | - |
- |
Sus scrofa |
Storage Stability | Organism |
---|---|
-20°C, stable for several months if stored as an ammonium sulfate precipitate | Sus scrofa |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(+)-camphorquinone + NADPH | - |
Sus scrofa | ? + NADP+ | - |
? | |
(-)-camphorquinone + NADPH | relative activity 2% | Sus scrofa | ? + NADP+ | - |
? | |
2,3-pentanedione + NADPH + H+ | - |
Sus scrofa | ? + NADP+ | - |
? | |
3-cyanobenzaldehyde + NADPH | - |
Sus scrofa | 3-cyanobenzyl alcohol + NADP+ | - |
? | |
3-pyridinecarboxaldehyde + NADPH | - |
Rattus norvegicus | 3-pyridinemethanol + NADP+ | - |
r | |
3-pyridinecarboxaldehyde + NADPH | - |
Sus scrofa | 3-pyridinemethanol + NADP+ | - |
r | |
3-pyridinecarboxaldehyde + NADPH | - |
Bos taurus | 3-pyridinemethanol + NADP+ | - |
? | |
3-pyridinecarboxaldehyde + NADPH | - |
Oryctolagus cuniculus | 3-pyridinemethanol + NADP+ | - |
r | |
3-pyridinemethanol + NADP+ | - |
Sus scrofa | 3-pyridinecarboxaldehyde + NADPH | - |
r | |
4-methylbenzyl alcohol + NADP+ | - |
Sus scrofa | 4-methylbenzaldehyde + NADPH + H+ | - |
r | |
4-nitroacetophenone + NADPH | - |
Sus scrofa | 1-(4-nitrophenyl)ethanol + NADP+ | - |
? | |
4-pyridinecarboxaldehyde + NADPH | - |
Rattus norvegicus | 4-pyridinemethanol + NADP+ | - |
r | |
4-pyridinecarboxaldehyde + NADPH | - |
Sus scrofa | 4-pyridinemethanol + NADP+ | - |
r | |
4-pyridinecarboxaldehyde + NADPH | - |
Oryctolagus cuniculus | 4-pyridinemethanol + NADP+ | - |
r | |
acetaldehyde + NADPH + H+ | - |
Rattus norvegicus | ethanol + NADP+ | - |
? | |
acetaldehyde + NADPH + H+ | - |
Sus scrofa | ethanol + NADP+ | - |
? | |
adonitol + NADP+ | - |
Sus scrofa | ? + NADPH | - |
r | |
allactose + NADPH | - |
Sus scrofa | ? + NADP+ | - |
? | |
alpha-diketone + NADPH | - |
Sus scrofa | ? + NADP+ | - |
? | |
anisaldehyde + NADPH + H+ | - |
Sus scrofa | anisyl alcohol + NADP+ | - |
r | |
anisyl alcohol + NADP+ | - |
Sus scrofa | anisaldehyde + NADPH | - |
r | |
benzaldehyde + NADPH | - |
Rattus norvegicus | benzyl alcohol + NADP+ | - |
r | |
benzaldehyde + NADPH | - |
Bos taurus | benzyl alcohol + NADP+ | - |
r | |
benzaldehyde + NADPH | relative activity 4% | Sus scrofa | benzyl alcohol + NADP+ | - |
r | |
benzyl alcohol + NADP+ | - |
Sus scrofa | benzaldehyde + NADPH | - |
r | |
cyclohexanone + NADPH | - |
Sus scrofa | cyclohexanol + NADP+ | - |
? | |
cyclohexanone + NADPH | - |
Bos taurus | cyclohexanol + NADP+ | - |
? | |
D-arabinose + NADPH | - |
Sus scrofa | ? + NADP+ | - |
r | |
D-arabitol + NADP+ | - |
Sus scrofa | ? + NADPH | - |
r | |
D-erythrose + NADPH | - |
Sus scrofa | ? + NADP+ | - |
? | |
D-fructose + NADPH | - |
Sus scrofa | ? + NADP+ | - |
? | |
D-galactose + NADPH | - |
Sus scrofa | ? + NADP+ | - |
? | |
D-glucose + NADPH | - |
Sus scrofa | ? + NADP+ | - |
? | |
D-glucuronate + NADPH | - |
Rattus norvegicus | L-gulonate + NADP+ | - |
? | |
D-glucuronate + NADPH | - |
Rattus norvegicus | L-gulonate + NADP+ | - |
r | |
D-glucuronate + NADPH | - |
Sus scrofa | L-gulonate + NADP+ | - |
? | |
D-glucuronate + NADPH | - |
Sus scrofa | L-gulonate + NADP+ | - |
r | |
D-glucuronate + NADPH | - |
Bos taurus | L-gulonate + NADP+ | - |
? | |
D-glucuronate + NADPH | - |
Bos taurus | L-gulonate + NADP+ | - |
r | |
D-glucuronate + NADPH | - |
Oryctolagus cuniculus | L-gulonate + NADP+ | - |
? | |
D-glucuronate + NADPH | - |
Oryctolagus cuniculus | L-gulonate + NADP+ | - |
r | |
D-glucuronolactone + NADPH | - |
Rattus norvegicus | ? + NADP+ | - |
? | |
D-glucuronolactone + NADPH | - |
Sus scrofa | ? + NADP+ | - |
? | |
D-glyceraldehyde + NADPH + H+ | - |
Rattus norvegicus | glycerol + NADP+ | - |
r | |
D-glyceraldehyde + NADPH + H+ | - |
Sus scrofa | glycerol + NADP+ | - |
r | |
D-glyceraldehyde + NADPH + H+ | - |
Oryctolagus cuniculus | glycerol + NADP+ | - |
r | |
D-lactaldehyde + NADPH + H+ | - |
Sus scrofa | propane-1,2-diol + NADP+ | - |
r | |
D-lactaldehyde + NADPH + H+ | - |
Bos taurus | propane-1,2-diol + NADP+ | - |
r | |
D-ribose + NADPH | - |
Sus scrofa | ? + NADP+ | - |
? | |
D-sorbitol + NADP+ | - |
Sus scrofa | ? + NADPH | - |
r | |
D-xylose + NADPH | - |
Rattus norvegicus | ? + NADP+ | - |
? | |
D-xylose + NADPH | - |
Sus scrofa | ? + NADP+ | - |
? | |
D-xylose + NADPH | - |
Bos taurus | ? + NADP+ | - |
? | |
dehydro-L-ascorbate + NADPH | - |
Sus scrofa | ? + NADP+ | - |
? | |
diacetyl + NADPH | - |
Sus scrofa | ? + NADP+ | - |
? | |
erythritol + NADP+ | - |
Sus scrofa | ? + NADPH | - |
r | |
glycerol + NADP+ | - |
Rattus norvegicus | DL-glyceraldehyde + NADPH + H+ | - |
r | |
glycerol + NADP+ | - |
Sus scrofa | DL-glyceraldehyde + NADPH + H+ | - |
r | |
indolacetaldehyde + NADPH | - |
Sus scrofa | ? + NADP+ | - |
? | |
L-arabitol + NADP+ | - |
Sus scrofa | ? + NADPH | - |
r | |
L-gulonic acid + NADP+ | - |
Rattus norvegicus | D-glucuronic acid + NADPH | - |
r | |
L-gulonic acid + NADP+ | - |
Sus scrofa | D-glucuronic acid + NADPH | - |
r | |
L-gulonic acid + NADP+ | - |
Bos taurus | D-glucuronic acid + NADPH | - |
r | |
L-gulonic acid + NADP+ | - |
Oryctolagus cuniculus | D-glucuronic acid + NADPH | - |
r | |
L-gulonic acid + NADPH | - |
Rattus norvegicus | D-glucuronic acid + NADP+ | - |
r | |
L-gulonic acid + NADPH | - |
Sus scrofa | D-glucuronic acid + NADP+ | - |
r | |
L-gulonic acid + NADPH | - |
Bos taurus | D-glucuronic acid + NADP+ | - |
r | |
L-gulonic acid + NADPH | - |
Oryctolagus cuniculus | D-glucuronic acid + NADP+ | - |
r | |
L-sorbose + NADPH + H+ | - |
Sus scrofa | ? + NADP+ | - |
r | |
L-xylose + NADPH | - |
Sus scrofa | ? + NADP+ | - |
? | |
m-nitrobenzaldehyde + NADPH | - |
Sus scrofa | m-nitrobenzylalcohol + NADP+ | - |
r | |
methylglyoxal + NADPH | - |
Rattus norvegicus | ? + NADP+ | - |
r | |
methylglyoxal + NADPH | - |
Sus scrofa | ? + NADP+ | - |
r | |
n-butanol + NADP+ | - |
Sus scrofa | butyraldehyde + NADPH | - |
r | |
n-butyraldehyde + NADPH | relative activity 2% | Sus scrofa | n-butanol + NADP+ | - |
r | |
o-nitrobenzaldehyde + NADPH | - |
Sus scrofa | o-nitrobenzylalcohol + NADP+ | - |
r | |
p-carboxybenzaldehyde + NADPH | - |
Rattus norvegicus | p-carboxybenzyl alcohol + NADP+ | - |
r | |
p-carboxybenzaldehyde + NADPH | - |
Sus scrofa | p-carboxybenzyl alcohol + NADP+ | - |
r | |
p-carboxybenzaldehyde + NADPH | - |
Bos taurus | p-carboxybenzyl alcohol + NADP+ | - |
r | |
p-chlorobenzaldehyde + NADPH + H+ | - |
Sus scrofa | p-chlorobenzyl alcohol + NADP+ | - |
r | |
p-cyanobenzaldehyde + NADPH | - |
Sus scrofa | p-cyanobenzyl alcohol + NADP+ | - |
? | |
p-cyanobenzaldehyde + NADPH | - |
Bos taurus | p-cyanobenzyl alcohol + NADP+ | - |
? | |
p-fluorobenzaldehyde + NADPH + H+ | - |
Sus scrofa | p-fluorobenzyl alcohol + NADP+ | - |
? | |
p-nitrobenzaldehyde + NADPH | - |
Rattus norvegicus | p-nitrobenzylalcohol + NADP+ | - |
r | |
p-nitrobenzaldehyde + NADPH | - |
Sus scrofa | p-nitrobenzylalcohol + NADP+ | - |
r | |
p-nitrobenzaldehyde + NADPH | - |
Bos taurus | p-nitrobenzylalcohol + NADP+ | - |
r | |
p-nitrobenzaldehyde + NADPH | - |
Oryctolagus cuniculus | p-nitrobenzylalcohol + NADP+ | - |
r | |
propiophenone + NADPH | - |
Sus scrofa | ? + NADP+ | - |
? | |
pyridoxal + NADPH | - |
Sus scrofa | 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol + NADP+ | - |
? | |
pyruvaldehyde + NADPH | - |
Sus scrofa | ? + NADP+ | - |
? | |
pyruvate + NADPH | - |
Sus scrofa | 2-hydroxypropanoic acid + NADP+ | - |
? | |
Tris + NADP+ | - |
Sus scrofa | ? + NADPH | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | - |
Rattus norvegicus |
monomer | - |
Bos taurus |
monomer | 1 * 38000, SDS-PAGE | Sus scrofa |
Synonyms | Comment | Organism |
---|---|---|
bovine brain aldehyde reductase | - |
Bos taurus |
rabbit kidney aldehyde-ketone reductase | - |
Oryctolagus cuniculus |
TPNH-linked aldehyde reductase | - |
Sus scrofa |
TPNH-specific aldehyde reductase | - |
Sus scrofa |
triphosphopyridine nucleotide-linked aldehyde reductase | - |
Sus scrofa |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.07 | - |
3-Pyridinemethanol | - |
Sus scrofa | |
0.612 | - |
glycerol | - |
Sus scrofa | |
1.77 | - |
L-arabitol | - |
Sus scrofa | |
5.6 | - |
(+)-Camphorquinone | - |
Sus scrofa | |
11.6 | - |
D-glucuronate | - |
Sus scrofa | |
13.7 | - |
D-Lactaldehyde | - |
Sus scrofa | |
14.4 | - |
D-glyceraldehyde | - |
Sus scrofa | |
16.6 | - |
4-cyanobenzaldehyde | - |
Sus scrofa | |
19.3 | - |
4-Pyridinecarboxaldehyde | - |
Sus scrofa | |
21.7 | - |
4-carboxybenzaldehyde | - |
Sus scrofa | |
22 | - |
4-nitrobenzaldehyde | - |
Sus scrofa | |
26.8 | - |
3-Pyridinecarboxaldehyde | - |
Sus scrofa |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
- |
Bos taurus |
7 | - |
reduction of 3-pyridinecarboxaldehyde | Sus scrofa |
10 | - |
oxidation of 3-pyridinemethanol | Sus scrofa |