Application | Comment | Organism |
---|---|---|
synthesis | synthetic pathway for bioalcohol production at 70°C by insertion of the gene for bacterial alcohol dehydrogenase AdhA into the archaeon Pyrococcus furiosus. The engineered strain converts glucose to ethanol via acetate and acetaldehyde, catalyzed by the host-encoded aldehyde ferredoxin oxidoreductase AOR and heterologously expressed AdhA, in an energy-conserving, redox-balanced pathway. The AOR/AdhA pathway also converts exogenously added aliphatic and aromatic carboxylic acids to the corresponding alcohol using glucose, pyruvate, and/or hydrogen as the source of reductant. By heterologous coexpression of a membrane-bound carbon monoxide dehydrogenase, CO is used as a reductant for converting carboxylic acids to alcoholsThe AOR/AdhA pathway is a potentially game-changing strategy for syngas fermentation, especially in combination with carbon chain elongation pathways | Thermoanaerobacter sp. |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Thermoanaerobacter sp. | B0K3U7 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
AdhA | - |
Thermoanaerobacter sp. |
Teth514_0564 | - |
Thermoanaerobacter sp. |