Any feedback?
Literature summary for 1.1.1.2 extracted from
- Purification and characterization of the multiple forms of aldehyde reductase in ox kidney (1982), Biochem. J., 205, 373-380.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| benzodiazepine | - |
Bos taurus |  |
| Sodium barbitone | - |
Bos taurus | |
| Sodium barbitone | - |
Sus scrofa | |
| sodium valproate | - |
Bos taurus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.002 | - |
NADPH | AR1 | Bos taurus | |
| 0.003 | - |
NADPH | G2 | Bos taurus | |
| 0.007 | - |
NADPH | AR4 | Bos taurus | |
| 0.008 | - |
NADPH | AR3 | Bos taurus | |
| 0.008 | - |
3-Pyridinecarboxaldehyde | AR3 | Bos taurus | |
| 0.0084 | - |
p-nitrobenzaldehyde | AR3 | Bos taurus | |
| 0.009 | - |
menadione | AR4 | Bos taurus | |
| 0.018 | - |
p-Carboxybenzaldehyde | AR1 | Bos taurus | |
| 0.028 | - |
Succinic semialdehyde | AR4 | Bos taurus | |
| 0.029 | - |
Succinic semialdehyde | AR1 | Bos taurus | |
| 0.03 | - |
menadione | G2 | Bos taurus | |
| 0.036 | - |
Succinic semialdehyde | G2 | Bos taurus | |
| 0.064 | - |
Succinic semialdehyde | AR3 | Bos taurus | |
| 0.071 | - |
p-nitrobenzaldehyde | AR1 | Bos taurus | |
| 0.129 | - |
p-nitrobenzaldehyde | G2 | Bos taurus | |
| 0.258 | - |
p-Carboxybenzaldehyde | AR3 | Bos taurus | |
| 0.262 | - |
p-nitrobenzaldehyde | AR4 | Bos taurus | |
| 0.751 | - |
3-Pyridinecarboxaldehyde | G2 | Bos taurus | |
| 0.934 | - |
3-Pyridinecarboxaldehyde | AR1 | Bos taurus | |
| 1.18 | - |
cyclohexanone | G2 | Bos taurus | |
| 1.29 | - |
D-glucuronic acid | AR1 | Bos taurus | |
| 2.48 | - |
D-glucuronic acid | G2 | Bos taurus | |
| 2.99 | - |
D-glucuronic acid | AR3 | Bos taurus | |
| 5 | - |
3-Pyridinecarboxaldehyde | AR4 | Bos taurus | |
| 36.77 | - |
cyclohexanone | AR4 | Bos taurus | |
| 41 | - |
xylose | AR3 | Bos taurus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Bos taurus | 5829 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 25500 | - |
G2, gel filtration | Bos taurus |
| 26300 | - |
gel filtration | Bos taurus |
| 30000 | - |
- |
Sus scrofa |
| 30000 | - |
AR1, gel filtration | Bos taurus |
| 31000 | - |
AR3, gel filtration | Bos taurus |
| 33500 | - |
1 * 33500, AR1, SDS-PAGE | Bos taurus |
| 34700 | - |
1 * 34700, AR3, SDS-PAGE | Bos taurus |
| 56000 | - |
AR4, gel filtration | Bos taurus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-glucuronate + NADPH | Cavia porcellus | - |
L-gulonate + NADP+ | - |
r | |
| D-glucuronate + NADPH | Sus scrofa | - |
L-gulonate + NADP+ | - |
r | |
| D-glucuronate + NADPH | Bos taurus | - |
L-gulonate + NADP+ | - |
r | |
| D-glyceraldehyde + NADPH + H+ | Cavia porcellus | - |
glycerol + NADP+ | - |
r | |
| D-glyceraldehyde + NADPH + H+ | Sus scrofa | - |
glycerol + NADP+ | - |
r | |
| L-glyceraldehyde + NADPH | Cavia porcellus | - |
glycerol + NADP+ | - |
r | |
| L-glyceraldehyde + NADPH | Sus scrofa | - |
glycerol + NADP+ | - |
r | |
| L-gulonic acid + NADP+ | Sus scrofa | - |
D-glucuronic acid + NADPH | - |
r | |
| L-gulonic acid + NADP+ | Bos taurus | - |
D-glucuronic acid + NADPH | - |
r | |
| succinic semialdehyde + NADPH + H+ | Sus scrofa | - |
4-hydroxybutyrate + NADP+ | - |
r | |
| succinic semialdehyde + NADPH + H+ | Bos taurus | - |
4-hydroxybutyrate + NADP+ | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
ox | - |
| Cavia porcellus | - |
guinea pig | - |
| Sus scrofa | - |
pig | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Sus scrofa |
- |
Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Cavia porcellus | - |
| brain | - |
Sus scrofa | - |
| brain | - |
Bos taurus | - |
| kidney | - |
Cavia porcellus | - |
| kidney | - |
Sus scrofa | - |
| kidney | - |
Bos taurus | - |
| liver | - |
Cavia porcellus | - |
| liver | - |
Sus scrofa | - |
| liver | - |
Bos taurus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.55 | - |
AR3 | Bos taurus |
| 8.94 | - |
AR1 | Bos taurus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C AR1 stable for at least 6 months | Bos taurus |
| -20°C AR3 loses most of its activity | Bos taurus |
| 4°C AR1 loses all activity after storage for 1 month | Bos taurus |
| 4°C AR3 stable for at least 1 month in presence of NaN3 | Bos taurus |
| 4°C in 0.01% NaN3 stable for at least 1 month, the gel-filtered enzyme is stable for approximately 2 weeks | Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-pyridinecarboxaldehyde + NADPH | - |
Cavia porcellus | 3-pyridinemethanol + NADP+ | - |
r | |
| 3-pyridinecarboxaldehyde + NADPH | - |
Sus scrofa | 3-pyridinemethanol + NADP+ | - |
r | |
| 3-pyridinecarboxaldehyde + NADPH | AR3 | Bos taurus | 3-pyridinemethanol + NADP+ | - |
? | |
| cyclohexanol + NADP+ | - |
Bos taurus | cyclohexanone + NADPH + H+ | - |
r | |
| cyclohexanone + NADPH | - |
Sus scrofa | cyclohexanol + NADP+ | - |
? | |
| cyclohexanone + NADPH | G2 | Bos taurus | cyclohexanol + NADP+ | - |
? | |
| D-glucuronate + NADPH | - |
Cavia porcellus | L-gulonate + NADP+ | - |
? | |
| D-glucuronate + NADPH | - |
Cavia porcellus | L-gulonate + NADP+ | - |
r | |
| D-glucuronate + NADPH | - |
Sus scrofa | L-gulonate + NADP+ | - |
? | |
| D-glucuronate + NADPH | - |
Sus scrofa | L-gulonate + NADP+ | - |
r | |
| D-glucuronate + NADPH | - |
Bos taurus | L-gulonate + NADP+ | - |
r | |
| D-glucuronate + NADPH | AR1 | Bos taurus | L-gulonate + NADP+ | - |
? | |
| D-glyceraldehyde + NADPH + H+ | - |
Cavia porcellus | glycerol + NADP+ | - |
r | |
| D-glyceraldehyde + NADPH + H+ | - |
Sus scrofa | glycerol + NADP+ | - |
r | |
| D-xylose + NADPH | - |
Sus scrofa | ? + NADP+ | - |
? | |
| D-xylose + NADPH | AR3 | Bos taurus | ? + NADP+ | - |
? | |
| L-glyceraldehyde + NADPH | - |
Cavia porcellus | glycerol + NADP+ | - |
r | |
| L-glyceraldehyde + NADPH | - |
Sus scrofa | glycerol + NADP+ | - |
r | |
| L-gulonic acid + NADP+ | - |
Sus scrofa | D-glucuronic acid + NADPH | - |
r | |
| L-gulonic acid + NADP+ | - |
Bos taurus | D-glucuronic acid + NADPH | - |
r | |
| L-gulonic acid + NADPH | - |
Sus scrofa | D-glucuronic acid + NADP+ | - |
r | |
| L-gulonic acid + NADPH | - |
Bos taurus | D-glucuronic acid + NADP+ | - |
r | |
| menadione + NADPH | G2 | Bos taurus | ? + NADP+ | - |
? | |
| additional information | - |
Sus scrofa | ? | - |
? | |
| additional information | AR1 is not active with neutral sugars or with ketones, AR3 is capable of reducing neutral sugars, G2 is active with ketones, AR4 is inactive with 15-oxoprostaglandin B1 | Bos taurus | ? | - |
? | |
| p-carboxybenzaldehyde + NADPH | - |
Sus scrofa | p-carboxybenzyl alcohol + NADP+ | - |
r | |
| p-carboxybenzaldehyde + NADPH | AR1 | Bos taurus | p-carboxybenzyl alcohol + NADP+ | - |
r | |
| p-nitrobenzaldehyde + NADPH | - |
Sus scrofa | p-nitrobenzylalcohol + NADP+ | - |
r | |
| p-nitrobenzaldehyde + NADPH | AR1 | Bos taurus | p-nitrobenzylalcohol + NADP+ | - |
r | |
| propane-1,2-diol + NADP+ | - |
Sus scrofa | lactaldehyde + NADPH | - |
r | |
| propane-1,2-diol + NADP+ | - |
Bos taurus | lactaldehyde + NADPH | - |
r | |
| succinic semialdehyde + NADPH + H+ | - |
Sus scrofa | 4-hydroxybutyrate + NADP+ | - |
r | |
| succinic semialdehyde + NADPH + H+ | - |
Bos taurus | 4-hydroxybutyrate + NADP+ | - |
r | |
| succinic semialdehyde + NADPH + H+ | AR1 | Bos taurus | 4-hydroxybutyrate + NADP+ | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | - |
Sus scrofa |
| monomer | 1 * 33500, AR1, SDS-PAGE | Bos taurus |
| monomer | 1 * 34700, AR3, SDS-PAGE | Bos taurus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| aldehyde/ketone reductase | - |
Cavia porcellus |
| hexogenate dehydrogenase | - |
Bos taurus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
