Information on EC 1.1.1.44 - phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)

New: Word Map on EC 1.1.1.44
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Mark a special word or phrase in this record:
Search Reference ID:
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)


The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
1.1.1.44
-
RECOMMENDED NAME
GeneOntology No.
phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
reduction
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Biosynthesis of antibiotics
-
-
Biosynthesis of secondary metabolites
-
-
Glutathione metabolism
-
-
Metabolic pathways
-
-
pentose phosphate pathway
-
-
Pentose phosphate pathway
-
-
pentose phosphate pathway (oxidative branch)
-
-
SYSTEMATIC NAME
IUBMB Comments
6-phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating)
The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce NADPH and pentose for biosynthetic reactions. Highly specific for NADP+. cf. EC 1.1.1.343, phosphogluconate dehydrogenase (NAD+-dependent, decarboxylating).
CAS REGISTRY NUMBER
COMMENTARY hide
9073-95-4
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Columbia, strain T87
-
-
Manually annotated by BRENDA team
VKM B-175
-
-
Manually annotated by BRENDA team
VKM B-175
-
-
Manually annotated by BRENDA team
wild oat
-
-
Manually annotated by BRENDA team
gene yqjI, enzyme YpjI
SwissProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
silver beet
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
crucian carp
-
-
Manually annotated by BRENDA team
strain B/S
-
-
Manually annotated by BRENDA team
strain B/S
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
hazel nut
-
-
Manually annotated by BRENDA team
Corynebacterium glutamicum ssp. flavum
-
-
-
Manually annotated by BRENDA team
fragment. Its is proposed that plastid-lacking excavata acquire cyanobacterial gnd genes via eukaryote-to-eukaryote lateral gene transfer or primary endosymbiotic gene transfer early in eukaryotic evolution, and then lose either their pre-existing or cyanobacterial gene
SwissProt
Manually annotated by BRENDA team
fragment. Its is proposed that plastid-lacking excavata acquire cyanobacterial gnd genes via eukaryote-to-eukaryote lateral gene transfer or primary endosymbiotic gene transfer early in eukaryotic evolution, and then lose either their pre-existing or cyanobacterial gene
SwissProt
Manually annotated by BRENDA team
carrot
-
-
Manually annotated by BRENDA team
cellular slime mould, strain NC-4, haploid
-
-
Manually annotated by BRENDA team
fragment. Its is proposed that plastid-lacking excavata acquire cyanobacterial gnd genes via eukaryote-to-eukaryote lateral gene transfer or primary endosymbiotic gene transfer early in eukaryotic evolution, and then lose either their pre-existing or cyanobacterial gene
SwissProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Escherichia coli JM109 M15
JM109, M15
-
-
Manually annotated by BRENDA team
strain K12
UniProt
Manually annotated by BRENDA team
MRE 600
-
-
Manually annotated by BRENDA team
Escherichia coli RW226/pLC33-5
RW226/pLC33-5
-
-
Manually annotated by BRENDA team
fragment. Its is proposed that plastid-lacking excavata acquire cyanobacterial gnd genes via eukaryote-to-eukaryote lateral gene transfer or primary endosymbiotic gene transfer early in eukaryotic evolution, and then lose either their pre-existing or cyanobacterial gene
SWissProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
chicken
-
-
Manually annotated by BRENDA team
fragment. Its is proposed that plastid-lacking excavata acquire cyanobacterial gnd genes via eukaryote-to-eukaryote lateral gene transfer or primary endosymbiotic gene transfer early in eukaryotic evolution, and then lose either their pre-existing or cyanobacterial gene
SwissProt
Manually annotated by BRENDA team
soybean
-
-
Manually annotated by BRENDA team
strain NTUH-K2044
UniProt
Manually annotated by BRENDA team
strain NTUH-K2044
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
W-38
-
-
Manually annotated by BRENDA team
rabbit, Primiparous New Zealand white
-
-
Manually annotated by BRENDA team
fragment. Its is proposed that plastid-lacking excavata acquire cyanobacterial gnd genes via eukaryote-to-eukaryote lateral gene transfer or primary endosymbiotic gene transfer early in eukaryotic evolution, and then lose either their pre-existing or cyanobacterial gene
SwissProt
Manually annotated by BRENDA team
filamentous cyanobacterium
-
-
Manually annotated by BRENDA team
C
-
-
Manually annotated by BRENDA team
Rattus norvegicus Sprague-Dawley
Sprague-Dawley
-
-
Manually annotated by BRENDA team
Wistar strain
-
-
Manually annotated by BRENDA team
fission yeast, NCYC 132S2-2
-
-
Manually annotated by BRENDA team
strain WU2
-
-
Manually annotated by BRENDA team
strain WU2
-
-
Manually annotated by BRENDA team
pig
-
-
Manually annotated by BRENDA team
heterotrophic strain, formerly called Aphanocapsa sp.
-
-
Manually annotated by BRENDA team
black gram, mung bean
-
-
Manually annotated by BRENDA team
black gram, mung bean
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-deoxy-3-oxo 6-phosphogluconate + ?
?
show the reaction diagram
2-deoxy-6-phospho-D-gluconate + NADP+
3-oxo-2-deoxy-6-phosphogluconate + NADPH
show the reaction diagram
-
-
-
-
?
2-deoxy-6-phosphogluconate + NADP+
2-deoxy-3-oxo 6-phosphogluconate + NADPH
show the reaction diagram
2-deoxy-6-phosphogluconate + NADP+
3-oxo-2-deoxy-6-phosphogluconate + NADPH
show the reaction diagram
3-keto-6-phosphono-D-gluconate + ?
D-ribulose 5-phosphate + CO2
show the reaction diagram
3-keto-6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2
show the reaction diagram
3-oxo-2-deoxy-6-phosphogluconate + NADP+
1-deoxyribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
3-oxo-2-deoxy-6-phosphogluconate + NADPH
2-deoxy-6-phosphogluconate + NADP+
show the reaction diagram
6,7-dideoxy-7-phosphono-D-glucoheptonate + NADP+
?
show the reaction diagram
6-phospho-D-gluconate + NAD+
D-ribulose 5-phosphate + CO2 + NADH
show the reaction diagram
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
show the reaction diagram
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + NADPH + CO2 + H+
show the reaction diagram
-
-
-
-
ir
6-phosphomannoate + NADP+
? + NADPH
show the reaction diagram
6-phosphono-D-gluconate + NADP+
3-keto-6-phosphono-D-gluconate + NADPH
show the reaction diagram
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + NADPH
show the reaction diagram
beta-3-acetylpyridine adenine dinucleotide 2'-phosphate + 6-phosphogluconate
?
show the reaction diagram
-
-
-
-
?
beta-nicotinamide 1-N6-ethenoadenine dinucleotide 2'-phosphate + 6-phosphogluconate
?
show the reaction diagram
-
-
-
-
?
beta-nicotinamide adenine dinucleotide 3'-phosphate + 6-phosphogluconate
?
show the reaction diagram
-
-
-
-
?
beta-nicotinamide hypoxanthine dinucleotide 2'-phosphate + 6-phosphogluconate
?
show the reaction diagram
-
-
-
-
?
D-ribulose 5-phosphate + CO2 + NADPH
6-phospho-D-gluconate + NADP+
show the reaction diagram
ribulose 5-phosphate + H2O + NADPH
?
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
show the reaction diagram
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3-acetylpyridine adenine dinucleotide phosphate
-
APADP
3-acetylpyridine-NADP+
-
-
deamino-NADP+
-
-
nicotinamide 1,N6-ethenoadenine dinucleotide phosphate
-
epsilon-NADP+
nicotinamide adenine dinucleotide 3'-phosphate
-
3'-NADP+
nicotinamide hypoxanthine dinucleotide phosphate
-
HX-NADP+
thio-NADP+
-
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Co2+
-
activated by divalent metal ions
KCl
-
activates the enzyme at high concentrations
MgCl2
-
10 mM are included in assay medium
NaCl
-
activates the enzyme at high concentrations
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(-)-catechin gallate
-
NADP+-competitive inhibitor of glucose-6-phosphate dehydrogenase
(-)-epicatechin gallate
-
-
(-)-epigallocatechin
-
NADP+-competitive inhibitor of glucose-6-phosphate dehydrogenase
(-)-epigallocatechin gallate
-
NADP+-competitive inhibitor of glucose-6-phosphate dehydrogenase
(-)-gallocatechin gallate
-
NADP+-competitive inhibitor of glucose-6-phosphate dehydrogenase
(2E)-2-cyano-3-(5-nitrofuran-2-yl)prop-2-enoic acid
-
-
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
(2R)-[3-(bis(benzyloxy)phosphoryloxy)-2-(tetrahydropyran-2-yloxy)propane-1-sulfinyl]acetic acid
(2R,3R)-2,3,4,N-tetrahydroxybutyramide
(3aR,6aR)-2,2-dimethyldihydrofuro[3,4-d][1,3]dioxol-4-one
(3R,4R)-3,4-di(tetrahydro-2H-pyranyloxy)tetrahydro-2-furanone
(4R,5R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid benzyloxyamide
(4S)-trans-4-ethylammonio-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
-
i.e. dorzolamide, competitive
(5-(dimethylamine)naphthalin-1-sulfonylchloride)
-
dansyl chloride, DNSCl, rapid inactivation at pH 7.5, 95% inhibition at pH 6.2
1,5-diphospho-D-ribulose
1,5-diphospho-ribitol
2-deoxy-6-phosphono-D-gluconate
2-methyl-5-nitrofuran-3-carboxylic acid
-
-
3,3',4,4'-tetramethyl-1H,1'H-2,2'-bipyrrole-5,5'-dicarboxylic acid
-
-
3-methyl-4-oxo-4,7-dihydro-5H-thiopyrano[3,4-b]furan-2-carboxylic acid
-
-
3-Oxo-2-deoxy-6-phosphogluconate
-
competitive inhibitor
4,5-dichloro-1H-pyrrole-2-carboxylic acid
-
-
4,N-dihydroxy(2R,3R)-2,3-bis(tetrahydropyran-2-yloxy)butyramide
4-chloro-1H-pyrrole-2-carboxylic acid
-
-
4-phospho-D-erythronamide
4-phospho-D-erythronate
4-phospho-D-erythronohydroxamic acid
4-phospho-D-erythrose
4H-thieno[3,2-b]pyrrole-5-carboxylic acid
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
5,6-dideoxy-6-phosphono-D-arabino-hexonate
5-(3,7,12-trioxo-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
weak inhibition
5-(3alpha,7alpha,12alpha-triacetoxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
competitive
5-(3alpha,7alpha,12alpha-trihydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
competitive
5-(ethoxycarbonyl)-3,4-dimethyl-1H-pyrrole-2-carboxylic acid
-
-
5-deoxy-5-phosphonoD-arabinonate
5-phospho-D-arabinonamide
5-phospho-D-arabinonate
5-phospho-D-arabinonhydrazide
5-phospho-D-arabinono-1,4-lactone
5-phospho-D-arabinonohydroxamic acid
5-phospho-D-arabinose
5-phospho-D-ribonate
6-deoxy-6-phosphono-D-gluconate
6-methoxy-7-hydroxycoumarin
-
scopolin
6-phospho-D-allonate
-
-
6-phospho-D-galactonate
6-phosphono-D-mannonate
7-Chloro-4-nitrobenzo-2-oxa-1,3-diazole
-
NBD-Cl
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester
acetyl-CoA
-
-
adenosine
-
-
amikacin
-
in vitro inhibition
amikacin sulfate
-
in vitro and in vivo inhibition
amoxicillin
-
competitive
ampicillin
Butan-2,3-dione
-
-
caffeic acid
-
-
cefepime
ceftazidim
-
in vitro inhibition
Chloramphenicol
-
in vitro inhibition
chlorogenic acid
-
-
Ciprofloxacin
-
in vitro inhibition
citrate
clindamycin
-
competitive
CO2
-
-
D-2-deoxyglucose
D-5-phosphoarabonate
-
-
D-5-phosphoribonate
-
-
D-5-phosphoribosyl-1-diphosphate
D-6-phosphogluconate
-
competitive substrate inhibition at pH 7
D-6-sulfogluconate
D-ATP-ribose
-
-
D-erythrose 4-phosphate
D-fructose 1,6-diphosphate
D-Fructose 1-phosphate
-
-
D-fructose 2,6-bisphosphate
-
-
D-fructose 6-phosphate
D-Glucose 1,6-bisphosphate
D-glucose 6-phosphate
-
-
D-glyceraldehyde 3-phosphate
D-phosphate
D-ribulose 5-phosphate
D-xylulose 5-phosphate
-
-
diethyldicarbonate
-
-
diphosphate
esculetin
-
-
ferulic acid
-
-
gentamicin sulfate
-
in vitro inhibition
hexachloroplatinate
-
-
Imipenem
-
noncompetitive
iodoacetamide
isepamycin
-
in vitro inhibition
levofloxacin
-
in vitro inhibition
lornoxicam
-
noncompetitive
metronidazole
-
noncompetitive
Mg2+
-
acts as an inhibitor above 20 mM
N-ethylmaleimide
-
-
netilmicin
-
-
netilmicin sulfate
nicotinamide
-
-
ofloxacin
-
in vitro inhibition
ornidazole
-
noncompetitive
oxalate
-
-
oxaloacetate
p-chloromercuribenzoate
p-coumaric acid
-
-
p-hydroxymercuribenzoate
penicillin G
-
in vitro inhibition
perchlorate
-
-
Permanganate
-
-
phosphoenolpyruvate
-
-
phosphoric acid dibenzyl ester (2R,3R)-3-benzyloxycarbamoyl-2,3-dihydroxypropyl ester
phosphoric acid dibenzyl ester (4R,5R)-5-benzyloxycarbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
potassium 3,4-dioxo-3,4-dihydronaphthalene-1-sulfonate
-
-
pyridoxal 5'-phosphate
Rose bengal
scopoletin
-
-
sodium (4E)-4-(hydroxyimino)-3-oxo-1,2,3,4-tetrahydronaphthalene-1-sulfonate
-
-
sulfate
teicoplanin
-
in vitro inhibition
Tetranitromethane
-
irreversible loss of catalytic activity
Vancomycin
-
competitive
[(2R)-2,3-dihydroxypropylsulfanyl]acetic acid benzyl ester
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propylsulfanyl]acetic acid
[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid
[(4R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethylsulfanyl]acetic acid benzyl ester
[(5-nitrofuran-2-yl)methylidene]propanedioic acid
-
-
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid benzyl ester
additional information
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
17beta-estradiol
-
administration causes an increase in liver enzyme, but not in white adipose tissue enzyme, activity and mRNA level in female and male rats
2,3-diphosphoglycerate
-
activates both isoenzymes up to 200% of their original activity
5-(3alpha-acetoxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
activates
5-(3alpha-hydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
activates
6-phosphogluconate
-
bona fide allosteric activator
AMP
-
1 mM, relative activity 105%
D-Fructose 1-phosphate
-
-
D-fructose 6-phosphate
-
slight activation
D-gluconate
-
induced by
gluconate
6-phosphogluconate dehydrogenase, although constituvely expressed, shows a 3-fold higher specific level in gluconate grown cells than those grown in fructose under similar conditions
glycylglycine
-
-
L-aspartate
-
-
L-histidine
-
-
L-tryptophan
-
-
metimazole
-
in vitro activation
additional information
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0096 - 1.42
2-deoxy-3-oxo-6-phosphogluconate
0.55 - 1.42
2-deoxy-6-phosphogluconate
0.0048 - 0.011
6,7-dideoxy-7-phosphono-D-glucoheptonate
0.00013 - 3.4
6-phospho-D-gluconate
0.006 - 3.13
6-phosphogluconate
0.0035 - 0.03
6-phosphono-D-gluconate
34 - 50
CO2
1.7 - 2.4
MgCl2
0.38 - 114
NAD+
0.00088 - 0.6211
NADP+
0.00022 - 0.002
NADPH
0.02 - 1
ribulose-5-phosphate