Information on EC 1.1.1.44 - phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY
1.1.1.44
-
RECOMMENDED NAME
GeneOntology No.
phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)
-
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+
show the reaction diagram
-
-
-
-
6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+
show the reaction diagram
reductive carboxylation of ribulose-5-phosphate by 6PGDH is investigated using kinetic isotope effects. In the absence of 6-phosphogluconate, a slow step, which precedes the chemical process, is rate-limiting for the reaction, whereas in the presence of 6-phosphogluconate, the rate-limiting step follows the isotope-sensitive step. Full activity of 6PGDH is achieved when one subunit carries out the catalysis and the other subunit carries an unreacted 6-phosphogluconate (allosteric activator)
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
pentose phosphate pathway (oxidative branch)
-
-
pentose phosphate pathway
-
-
Pentose phosphate pathway
-
-
Glutathione metabolism
-
-
Metabolic pathways
-
-
Biosynthesis of secondary metabolites
-
-
Biosynthesis of antibiotics
-
-
SYSTEMATIC NAME
IUBMB Comments
6-phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating)
The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce NADPH and pentose for biosynthetic reactions. Highly specific for NADP+. cf. EC 1.1.1.343, phosphogluconate dehydrogenase (NAD+-dependent, decarboxylating).
SYNONYMS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
6-P-gluconate dehydrogenase
-
6-PGDHase
-
-
6-phospho-D-gluconate dehydrogenase
-
-
-
-
6-phospho-D-gluconate-NADP+ oxidoreductase, decarboxylating
-
-
6-phosphogluconate dehydrogenase
-
-
6-phosphogluconate dehydrogenase
-
-
6-phosphogluconate dehydrogenase
Azospirillum brasilense Cd
-
-
-
6-phosphogluconate dehydrogenase
-
-
6-phosphogluconate dehydrogenase
-
-
6-phosphogluconate dehydrogenase
-
-
6-phosphogluconate dehydrogenase
-
6-phosphogluconate dehydrogenase
-
6-phosphogluconate dehydrogenase
-
6-phosphogluconate dehydrogenase
-
6-phosphogluconate dehydrogenase
-
6-phosphogluconate dehydrogenase
Escherichia coli K12
-
-
6-phosphogluconate dehydrogenase
-
6-phosphogluconate dehydrogenase
-
-
6-phosphogluconate dehydrogenase
-
-
6-phosphogluconate dehydrogenase
-
6-phosphogluconate dehydrogenase
-
-
6-phosphogluconate dehydrogenase
-
6-phosphogluconate dehydrogenase
Klebsiella pneumoniae NTUH-K2044
-
-
6-phosphogluconate dehydrogenase
-
-
6-phosphogluconate dehydrogenase
-
-
6-phosphogluconate dehydrogenase
-
-
6-phosphogluconate dehydrogenase
-
-
6-phosphogluconate dehydrogenase
-
6-phosphogluconate dehydrogenase
-
-
6-phosphogluconate dehydrogenase
-
-
6-phosphogluconate dehydrogenase
-
-
6-phosphogluconate dehydrogenase
-
-
6-phosphogluconate dehydrogenase
-
-
6-phosphogluconate dehydrogenase
-
-
6-phosphogluconate dehydrogenase (decarboxylating)
-
-
-
-
6-phosphogluconate dehydrogenase Gnd1
-
6-phosphogluconate dehydrogenase, decarboxylating
-
-
6-phosphogluconate-dehydrogenase
-
-
6-phosphogluconate-dehydrogenase
-
-
-
6-phosphogluconate:NADP oxidoreductase
-
-
6-phosphogluconic carboxylase
-
-
-
-
6-phosphogluconic dehydrogenase
-
-
-
-
6-phosphonogluconate dehydrogenase
-
-
6-phosphonogluconate dehydrogenase
-
6-phosphonogluconate dehydrogenase
-
-
6-phosphonogluconate dehydrogenase
-
6PGD
-
-
6PGDH
Escherichia coli K12
-
-
6PGDH
Klebsiella pneumoniae NTUH-K2044
-
-
6PGDH
-
-
6PGDH
-
-
6PGDH
-
-
D-gluconate-6-phosphate dehydrogenase
-
-
GNTZII
-
-
-
-
Os6PGDH2
-
-
phosphogluconic acid dehydrogenase
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
9073-95-4
-
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
sycamore cells
-
-
Manually annotated by BRENDA team
Columbia, strain T87
-
-
Manually annotated by BRENDA team
Arthrobacter globiformis VKM B-175
VKM B-175
-
-
Manually annotated by BRENDA team
wild oat
-
-
Manually annotated by BRENDA team
gene yqjI, enzyme YpjI
SwissProt
Manually annotated by BRENDA team
silver beet
-
-
Manually annotated by BRENDA team
No. 2247 ATCC 14067
-
-
Manually annotated by BRENDA team
ATCC 32195; methanol utilizing yeast
-
-
Manually annotated by BRENDA team
methanol utilizing yeast
-
-
Manually annotated by BRENDA team
crucian carp
-
-
Manually annotated by BRENDA team
strain B/S
-
-
Manually annotated by BRENDA team
Catharanthus roseus B/S
strain B/S
-
-
Manually annotated by BRENDA team
hazel nut
-
-
Manually annotated by BRENDA team
Corynebacterium glutamicum ssp. flavum
-
-
-
Manually annotated by BRENDA team
fragment. Its is proposed that plastid-lacking excavata acquire cyanobacterial gnd genes via eukaryote-to-eukaryote lateral gene transfer or primary endosymbiotic gene transfer early in eukaryotic evolution, and then lose either their pre-existing or cyanobacterial gene
SwissProt
Manually annotated by BRENDA team
fragment. Its is proposed that plastid-lacking excavata acquire cyanobacterial gnd genes via eukaryote-to-eukaryote lateral gene transfer or primary endosymbiotic gene transfer early in eukaryotic evolution, and then lose either their pre-existing or cyanobacterial gene
SwissProt
Manually annotated by BRENDA team
type I, type II
-
-
Manually annotated by BRENDA team
cellular slime mould, strain NC-4, haploid
-
-
Manually annotated by BRENDA team
fragment. Its is proposed that plastid-lacking excavata acquire cyanobacterial gnd genes via eukaryote-to-eukaryote lateral gene transfer or primary endosymbiotic gene transfer early in eukaryotic evolution, and then lose either their pre-existing or cyanobacterial gene
SwissProt
Manually annotated by BRENDA team
ATCC 27792, formerly designated as strain MR
-
-
Manually annotated by BRENDA team
JM109, M15
-
-
Manually annotated by BRENDA team
MRE 600
-
-
Manually annotated by BRENDA team
RW226/pLC33-5
-
-
Manually annotated by BRENDA team
strain K12
UniProt
Manually annotated by BRENDA team
Escherichia coli JM109 M15
JM109, M15
-
-
Manually annotated by BRENDA team
Escherichia coli K12
strain K12
UniProt
Manually annotated by BRENDA team
Escherichia coli MRE 600
MRE 600
-
-
Manually annotated by BRENDA team
Escherichia coli RW226/pLC33-5
RW226/pLC33-5
-
-
Manually annotated by BRENDA team
fragment. Its is proposed that plastid-lacking excavata acquire cyanobacterial gnd genes via eukaryote-to-eukaryote lateral gene transfer or primary endosymbiotic gene transfer early in eukaryotic evolution, and then lose either their pre-existing or cyanobacterial gene
SWissProt
Manually annotated by BRENDA team
chicken
-
-
Manually annotated by BRENDA team
Geobacillus stearothermophilus NCA 1503
NCA 1503
-
-
Manually annotated by BRENDA team
fragment. Its is proposed that plastid-lacking excavata acquire cyanobacterial gnd genes via eukaryote-to-eukaryote lateral gene transfer or primary endosymbiotic gene transfer early in eukaryotic evolution, and then lose either their pre-existing or cyanobacterial gene
SwissProt
Manually annotated by BRENDA team
soybean
-
-
Manually annotated by BRENDA team
human; Krebs ascites cells
-
-
Manually annotated by BRENDA team
strain NTUH-K2044
UniProt
Manually annotated by BRENDA team
Klebsiella pneumoniae NTUH-K2044
strain NTUH-K2044
UniProt
Manually annotated by BRENDA team
mouse
-
-
Manually annotated by BRENDA team
cv. Samsun, healthy plants and plants infected with potato virus Y
-
-
Manually annotated by BRENDA team
Nicotiana tabacum W-38
W-38
-
-
Manually annotated by BRENDA team
rabbit, Primiparous New Zealand white
-
-
Manually annotated by BRENDA team
cytosolic isozyme
SwissProt
Manually annotated by BRENDA team
lamb; sheep
-
-
Manually annotated by BRENDA team
fragment. Its is proposed that plastid-lacking excavata acquire cyanobacterial gnd genes via eukaryote-to-eukaryote lateral gene transfer or primary endosymbiotic gene transfer early in eukaryotic evolution, and then lose either their pre-existing or cyanobacterial gene
SwissProt
Manually annotated by BRENDA team
filamentous cyanobacterium
-
-
Manually annotated by BRENDA team
L. cv. Lincoln
-
-
Manually annotated by BRENDA team
P. fluorescens
-
-
Manually annotated by BRENDA team
Charles River albino; rat
-
-
Manually annotated by BRENDA team
male and femal Wistar rats, age 1-20 months
-
-
Manually annotated by BRENDA team
rat; Sprague-Dawley
-
-
Manually annotated by BRENDA team
rat; Wistar strain
-
-
Manually annotated by BRENDA team
Rattus norvegicus Sprague-Dawley
Sprague-Dawley
-
-
Manually annotated by BRENDA team
Rattus norvegicus Wistar
Wistar strain
-
-
Manually annotated by BRENDA team
castor bean, Baker 296 'Dwarf'
-
-
Manually annotated by BRENDA team
baker's yeast
-
-
Manually annotated by BRENDA team
Salmonella enterica subsp. enterica serovar Typhimurium LT2
LT2
-
-
Manually annotated by BRENDA team
fission yeast, NCYC 132S2-2
-
-
Manually annotated by BRENDA team
spinach, var. Long Standing Bloomsdale
-
-
Manually annotated by BRENDA team
serotype 2
SwissProt
Manually annotated by BRENDA team
serotype 2
-
-
Manually annotated by BRENDA team
mesophilic cyanobacterium, formerly called Coccochloris peniocystis; thermophilic cyanobacterium, formerly called Synechococcus lividus
-
-
Manually annotated by BRENDA team
Synechococcus sp. PCC 6307
-
-
-
Manually annotated by BRENDA team
Synechococcus sp. PCC 6307
mesophilic cyanobacterium, formerly called Coccochloris peniocystis
-
-
Manually annotated by BRENDA team
thermophilic cyanobacterium, formerly called Synechococcus lividus
-
-
Manually annotated by BRENDA team
heterotrophic strain, formerly called Aphanocapsa sp.
-
-
Manually annotated by BRENDA team
parasitic protozoan
Uniprot
Manually annotated by BRENDA team
CL Brener clone
SwissProt
Manually annotated by BRENDA team
black gram, mung bean
-
-
Manually annotated by BRENDA team
black gram, mung bean
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
metabolism
pentose phosphate pathway
metabolism
-
phosphogluconate pathway, bacterial 6-phosphogluconate dehydrogenase is a constitutive enzyme, bacterial enzyme is active in young, non-inoculated mesquite seedlings growing under hydroponic conditions, external gluconate has no effect on the activity of 6-phosphogluconate dehydrogenase
metabolism
Azospirillum brasilense Cd
-
phosphogluconate pathway, bacterial 6-phosphogluconate dehydrogenase is a constitutive enzyme, bacterial enzyme is active in young, non-inoculated mesquite seedlings growing under hydroponic conditions, external gluconate has no effect on the activity of 6-phosphogluconate dehydrogenase
-
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-deoxy-3-oxo 6-phosphogluconate + ?
?
show the reaction diagram
-
-
-
-
?
2-deoxy-3-oxo 6-phosphogluconate + ?
?
show the reaction diagram
-
no decarboxylation by the liver enzyme
-
-
-
2-deoxy-6-phospho-D-gluconate + NADP+
3-oxo-2-deoxy-6-phosphogluconate + NADPH
show the reaction diagram
-
-
-
?
2-deoxy-6-phosphogluconate + NADP+
3-oxo-2-deoxy-6-phosphogluconate + NADPH
show the reaction diagram
-
-
-
r
2-deoxy-6-phosphogluconate + NADP+
3-oxo-2-deoxy-6-phosphogluconate + NADPH
show the reaction diagram
-
oxidation, 1.5% activity of that of 6-phosphogluconate
-
r
2-deoxy-6-phosphogluconate + NADP+
2-deoxy-3-oxo 6-phosphogluconate + NADPH
show the reaction diagram
-
-
-
r
2-deoxy-6-phosphogluconate + NADP+
2-deoxy-3-oxo 6-phosphogluconate + NADPH
show the reaction diagram
-
-
-
r
2-deoxy-6-phosphogluconate + NADP+
2-deoxy-3-oxo 6-phosphogluconate + NADPH
show the reaction diagram
-
-
-
r
2-deoxy-6-phosphogluconate + NADP+
2-deoxy-3-oxo 6-phosphogluconate + NADPH
show the reaction diagram
-
-
-
-
2-deoxy-6-phosphogluconate + NADP+
2-deoxy-3-oxo 6-phosphogluconate + NADPH
show the reaction diagram
-
-
-
r
2-deoxy-6-phosphogluconate + NADP+
2-deoxy-3-oxo 6-phosphogluconate + NADPH
show the reaction diagram
-
-
-
r
3-keto-6-phosphono-D-gluconate + ?
D-ribulose 5-phosphate + CO2
show the reaction diagram
via 1,2-enediol intermediate
-
-
3-keto-6-phosphono-D-gluconate + ?
D-ribulose 5-phosphate + CO2
show the reaction diagram
-
via 1,2-enediol intermediate
-
-
3-keto-6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2
show the reaction diagram
-
via 1,2-enediol intermediate
-
?
3-keto-6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2
show the reaction diagram
via 1,2-enediol intermediate
-
?
3-keto-6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2
show the reaction diagram
-
via 1,2-enediol intermediate
-
?
3-oxo-2-deoxy-6-phosphogluconate + NADP+
1-deoxyribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
reaction requires presence of NADPH, but the reduced coenzyme does not play a redox role
-
-
3-oxo-2-deoxy-6-phosphogluconate + NADP+
1-deoxyribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
decarboxylation
-
r
3-oxo-2-deoxy-6-phosphogluconate + NADPH
2-deoxy-6-phosphogluconate + NADP+
show the reaction diagram
-
-
-
r
3-oxo-2-deoxy-6-phosphogluconate + NADPH
2-deoxy-6-phosphogluconate + NADP+
show the reaction diagram
-
reduction
-
r
6,7-dideoxy-7-phosphono-D-glucoheptonate + NADP+
?
show the reaction diagram
-
-
-
?
6,7-dideoxy-7-phosphono-D-glucoheptonate + NADP+
?
show the reaction diagram
-
-
-
?
6-phospho-D-gluconate + NAD+
D-ribulose 5-phosphate + CO2 + NADH
show the reaction diagram
-
-
-
-
6-phospho-D-gluconate + NAD+
D-ribulose 5-phosphate + CO2 + NADH
show the reaction diagram
-
-
-
-
6-phospho-D-gluconate + NAD+
D-ribulose 5-phosphate + CO2 + NADH
show the reaction diagram
-
the enzyme prefers NADP+ to NAD+ as an electron acceptor
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
ir
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Corynebacterium glutamicum ssp. flavum
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
endosperm contains both cytosolic and plastic glycolytic and pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
mammary gland enzyme involved in NADPH production which is essential for lipogenesis
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
pivotal enzyme links the gluconate route and the oxidative phase of the pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
oxidative enzyme of pentose phosphate pathway
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
the enzyme prefers NADP+ to NAD+ as an electron acceptor
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
6-phosphogluconate modulates 6PGDH activity. In the forward reaction, it suppresses inhibition by NADP and decreases inhibition by NADPH by increasing the Kd of the reduced coenzyme 6fold it increases the rate of decarboxylation of the 3-keto intermediate , whereas in the reverse reaction, it decreases the Km and removes the slow step
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Escherichia coli JM109 M15
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Rattus norvegicus Sprague-Dawley
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Nicotiana tabacum W-38
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Nicotiana tabacum W-38
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Azospirillum brasilense Cd
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Escherichia coli RW226/pLC33-5
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Synechococcus sp. PCC 6307
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Synechococcus sp. PCC 6307
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Escherichia coli MRE 600
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Catharanthus roseus B/S
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Rattus norvegicus Wistar
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Rattus norvegicus Wistar
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Geobacillus stearothermophilus NCA 1503
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Geobacillus stearothermophilus NCA 1503
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Geobacillus stearothermophilus NCA 1503
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Geobacillus stearothermophilus NCA 1503
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Geobacillus stearothermophilus NCA 1503
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Geobacillus stearothermophilus NCA 1503
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Escherichia coli K12
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Salmonella enterica subsp. enterica serovar Typhimurium LT2
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Klebsiella pneumoniae NTUH-K2044
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Arthrobacter globiformis VKM B-175
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
show the reaction diagram
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
show the reaction diagram
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
show the reaction diagram
Azospirillum brasilense Cd
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + NADPH + CO2 + H+
show the reaction diagram
-
-
-
ir
6-phosphomannoate + NADP+
? + NADPH
show the reaction diagram
-
-
-
?
6-phosphomannoate + NADP+
? + NADPH
show the reaction diagram
-
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
one of the key enzymes in the pentose phosphate pathway, may be important for cell division and salt response
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
part of oxidative pentosephosphate pathway, predominant enzyme in glucose and cluconate catabolism, pathway regulation, overview
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
the enzyme expression and activity is independently regulated in different tissues
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
the glucose-6-phosphate dehydrogenase/6-phosphogluconate dehydrogenase ratio in plants infected with potato virus Y is lower than in healthy plants, with glucose 6-phosphate dehydrogenase being the regulating enzyme of the oxidative pentosephosphate pathway
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
third step in pentose phosphate metabolic pathway
-
?
6-phosphono-D-gluconate + NADP+
3-keto-6-phosphono-D-gluconate + NADPH
show the reaction diagram
-
-
-
6-phosphono-D-gluconate + NADP+
3-keto-6-phosphono-D-gluconate + NADPH
show the reaction diagram
-
-
-
?
6-phosphono-D-gluconate + NADP+
3-keto-6-phosphono-D-gluconate + NADPH
show the reaction diagram
-
-
-
-
6-phosphono-D-gluconate + NADP+
3-keto-6-phosphono-D-gluconate + NADPH
show the reaction diagram
-
-
?
6-phosphono-D-gluconate + NADP+
3-keto-6-phosphono-D-gluconate + NADPH
show the reaction diagram
-
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + NADPH
show the reaction diagram
overall reaction
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + NADPH
show the reaction diagram
-
overall reaction
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + NADPH
show the reaction diagram
overall reaction
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + NADPH
show the reaction diagram
-
overall reaction
-
?
beta-3-acetylpyridine adenine dinucleotide 2'-phosphate + 6-phosphogluconate
?
show the reaction diagram
-
-
-
-
?
beta-nicotinamide 1-N6-ethenoadenine dinucleotide 2'-phosphate + 6-phosphogluconate
?
show the reaction diagram
-
-
-
-
?
beta-nicotinamide adenine dinucleotide 3'-phosphate + 6-phosphogluconate
?
show the reaction diagram
-
-
-
-
?
beta-nicotinamide hypoxanthine dinucleotide 2'-phosphate + 6-phosphogluconate
?
show the reaction diagram
-
-
-
-
?
D-ribulose 5-phosphate + CO2 + NADPH
6-phospho-D-gluconate + NADP+
show the reaction diagram
-
-
-
r
ribulose 5-phosphate + H2O + NADPH
?
show the reaction diagram
-
-
-
-
?
ribulose 5-phosphate + H2O + NADPH
?
show the reaction diagram
-
tritium exchange reaction between tritiated ribulose 5-phosphate and water, reaction requires presence of NADPH, but the reduced coenzyme does not play a redox role
-
-
?
D-ribulose 5-phosphate + CO2 + NADPH
6-phospho-D-gluconate + NADP+
show the reaction diagram
-
reverse reaction only to a very limited extent
-
r
additional information
?
-
-
-
-
-
-
additional information
?
-
-
6-phosphogalactonate is no substrate
-
-
-
additional information
?
-
-
neither gluconic acid nor glucose-6-phosphate can replace 6-phosphogluconate as substrate
-
-
-
additional information
?
-
-
glucose-6-phosphate is no substrate
-
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
P31072
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
ir
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Corynebacterium glutamicum ssp. flavum
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
endosperm contains both cytosolic and plastic glycolytic and pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
mammary gland enzyme involved in NADPH production which is essential for lipogenesis
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
pivotal enzyme links the gluconate route and the oxidative phase of the pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
oxidative enzyme of pentose phosphate pathway
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
show the reaction diagram
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
show the reaction diagram
Q6NHC5
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Escherichia coli JM109 M15
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Rattus norvegicus Sprague-Dawley
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Nicotiana tabacum W-38
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Nicotiana tabacum W-38
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH + H+
show the reaction diagram
Azospirillum brasilense Cd
-
-
-
?
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Escherichia coli RW226/pLC33-5
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Synechococcus sp. PCC 6307
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Synechococcus sp. PCC 6307
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Escherichia coli MRE 600
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Catharanthus roseus B/S
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Rattus norvegicus Wistar
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Rattus norvegicus Wistar
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Geobacillus stearothermophilus NCA 1503
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Geobacillus stearothermophilus NCA 1503
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Geobacillus stearothermophilus NCA 1503
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Geobacillus stearothermophilus NCA 1503
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Geobacillus stearothermophilus NCA 1503
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Geobacillus stearothermophilus NCA 1503
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
enzyme specific for the oxidative pentose phosphate pathway
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Salmonella enterica subsp. enterica serovar Typhimurium LT2
-
-
-
r
6-phospho-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Arthrobacter globiformis VKM B-175
-
-
-
r
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
-
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
Q9LI00
one of the key enzymes in the pentose phosphate pathway, may be important for cell division and salt response
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
P80859
part of oxidative pentosephosphate pathway, predominant enzyme in glucose and cluconate catabolism, pathway regulation, overview
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
the enzyme expression and activity is independently regulated in different tissues
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
the glucose-6-phosphate dehydrogenase/6-phosphogluconate dehydrogenase ratio in plants infected with potato virus Y is lower than in healthy plants, with glucose 6-phosphate dehydrogenase being the regulating enzyme of the oxidative pentosephosphate pathway
-
?
6-phosphono-D-gluconate + NADP+
D-ribulose 5-phosphate + CO2 + NADPH
show the reaction diagram
-
third step in pentose phosphate metabolic pathway
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
3-acetylpyridine adenine dinucleotide phosphate
-
APADP
3-acetylpyridine-NADP+
-
-
deamino-NADP+
-
-
NAD+
-
reacts also with NADP+
NAD+
-
some activity with NAD+
NAD+
-
NAD+ specific
NAD+
-
uses NAD+ very poorly as a substrate
NAD+
-
the enzyme prefers NADP+ to NAD+ as an electron acceptor
NADP+
-
no reaction with NAD+
NADP+
-
reacts also with NAD+
NADP+
-
does not utilize NAD+
NADP+
-
NAD+ is completely ineffective as hydrogen acceptor
NADP+
-
specific for NADP+, no activity observed when NAD+ is substituted for NADP+
NADP+
-
strictly specific for NADP+, no activity observed with NAD+
NADP+
-
specific for NADP+, unable to utilize NAD+
NADP+
-
NAD+ being totally inactive
NADP+
-
no activity observed when NAD+ is substituted for NADP+
NADP+
-
specific to NADP+
NADP+
-
absolutely specific with respect to NADP+, no reaction can be detected in the presence of NAD+
NADP+
-
uses NAD+ very poorly as a substrate
NADP+
-
requires NADP+ obligatorily for activity
NADP+
dependent on
NADP+
-
-
NADP+
-
-
NADP+
-
-
NADP+
-
the enzyme prefers NADP+ to NAD+ as an electron acceptor
nicotinamide 1,N6-ethenoadenine dinucleotide phosphate
-
epsilon-NADP+
nicotinamide adenine dinucleotide 3'-phosphate
-
3'-NADP+
nicotinamide hypoxanthine dinucleotide phosphate
-
HX-NADP+
thio-NADP+
-
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Ca2+
-
activated by 1 mM CaCl2, relative activity 146.6%
Co2+
-
activated by divalent metal ions
KCl
-
activates the enzyme at high concentrations
Mg2+
-
activates the enzyme at low concentrations 0.01-0.04 M
Mg2+
-
-
Mg2+
-
MgCl2 stimulation for the oxidative decarboxylation of 6-phosphogluconate
Mg2+
-
requires Mg2+ for full activity
Mg2+
-
activated by MgCl2
MgCl2
-
10 mM are included in assay medium
Mn2+
-
activated by 1 mM MnCl2, relative activity 142.1%
Mn2+
-
activated by divalent metal ions
NaCl
-
activates the enzyme at high concentrations
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
(-)-catechin gallate
-
NADP+-competitive inhibitor of glucose-6-phosphate dehydrogenase
(-)-epicatechin gallate
-
-
(-)-epigallocatechin
-
NADP+-competitive inhibitor of glucose-6-phosphate dehydrogenase
(-)-epigallocatechin gallate
-
NADP+-competitive inhibitor of glucose-6-phosphate dehydrogenase
(-)-gallocatechin gallate
-
NADP+-competitive inhibitor of glucose-6-phosphate dehydrogenase
(2E)-2-cyano-3-(5-nitrofuran-2-yl)prop-2-enoic acid
-
-
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
-
compound shows in vitro antiparasitic activity
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
-
-
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
-
compound shows in vitro antiparasitic activity
(2R)-[3-(bis(benzyloxy)phosphoryloxy)-2-(tetrahydropyran-2-yloxy)propane-1-sulfinyl]acetic acid
-
compound shows in vitro antiparasitic activity
(2R,3R)-2,3,4,N-tetrahydroxybutyramide
-
compound shows in vitro antiparasitic activity
(3aR,6aR)-2,2-dimethyldihydrofuro[3,4-d][1,3]dioxol-4-one
-
compound shows in vitro antiparasitic activity
(3R,4R)-3,4-di(tetrahydro-2H-pyranyloxy)tetrahydro-2-furanone
-
compound shows in vitro antiparasitic activity
(4R,5R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid benzyloxyamide
-
compound shows in vitro antiparasitic activity
(4S)-trans-4-ethylammonio-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
-
i.e. dorzolamide, competitive
(5-(dimethylamine)naphthalin-1-sulfonylchloride)
-
dansyl chloride, DNSCl, rapid inactivation at pH 7.5, 95% inhibition at pH 6.2
1,5-diphospho-D-ribulose
-
-
1,5-diphospho-D-ribulose
-
1,5-diphospho-ribitol
-
-
1,5-diphospho-ribitol
-
2-deoxy-6-phosphono-D-gluconate
-
2-deoxy-6-phosphono-D-gluconate
-
compound shows in vitro antiparasitic activity
2-deoxy-6-phosphono-D-gluconate
-
-
2-deoxy-6-phosphono-D-gluconate
-
compound shows in vitro antiparasitic activity
2-methyl-5-nitrofuran-3-carboxylic acid
-
-
3,3',4,4'-tetramethyl-1H,1'H-2,2'-bipyrrole-5,5'-dicarboxylic acid
-
-
3-methyl-4-oxo-4,7-dihydro-5H-thiopyrano[3,4-b]furan-2-carboxylic acid
-
-
3-Oxo-2-deoxy-6-phosphogluconate
-
competitive inhibitor
4,5-dichloro-1H-pyrrole-2-carboxylic acid
-
-
4,N-dihydroxy(2R,3R)-2,3-bis(tetrahydropyran-2-yloxy)butyramide
-
compound shows in vitro antiparasitic activity
4-chloro-1H-pyrrole-2-carboxylic acid
-
-
4-phospho-D-erythronamide
-
compound shows in vitro antiparasitic activity
4-phospho-D-erythronamide
-
-
4-phospho-D-erythronamide
-
compound shows in vitro antiparasitic activity
4-phospho-D-erythronate
-
bio-isosteric analogue
4-phospho-D-erythronate
bio-isosteric analogue
4-phospho-D-erythronate
-
compound shows in vitro antiparasitic activity
4-phospho-D-erythronate
-
-
4-phospho-D-erythronate
-
compound shows in vitro antiparasitic activity
4-phospho-D-erythronate
-
mimics the transition state of dehydrogenation. The inhibitor forces the catalytic lysine 185 into the protonated state
4-phospho-D-erythronohydroxamic acid
-
compound shows low in vitro antiparasitic activity
4-phospho-D-erythronohydroxamic acid
-
-
4-phospho-D-erythronohydroxamic acid
-
compound shows low in vitro antiparasitic activity
4-phospho-D-erythronohydroxamic acid
-
conversion of the 6-PGDH inhibitor into prodrugs to increase its activity against the Trypanosoma brucei by enhancing uptake by passive permeation across the plasma membrane. Production of five different phosphate-masking groups (phosphoramidate, bis-S-acyl thioethyl esters, bis-pivaloxymethyl, cycloSaligenyl and phenyl, S-acyl thioethyl mixed phosphate esters). Prodrugs are studied for stability and activity against the intact parasites. Most prodrugs cause inhibition of the growth of the parasites. The activity of the prodrugs against the parasites appears to be related to their stability in aqueous buffer
4-phospho-D-erythronohydroxamic acid
-
4-phospho-D-erythrose
-
bio-isosteric analogue
4-phospho-D-erythrose
bio-isosteric analogue
4H-thieno[3,2-b]pyrrole-5-carboxylic acid
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
-
DTNB
5,5'-dithiobis(2-nitrobenzoic acid)
-
Ellman's reagent
5,5'-dithiobis(2-nitrobenzoic acid)
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
-
-
5,6-dideoxy-6-phosphono-D-arabino-hexonate
-
-
5,6-dideoxy-6-phosphono-D-arabino-hexonate
-
5-(3,7,12-trioxo-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
weak inhibition
5-(3alpha,7alpha,12alpha-triacetoxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
competitive
5-(3alpha,7alpha,12alpha-trihydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
competitive
5-(ethoxycarbonyl)-3,4-dimethyl-1H-pyrrole-2-carboxylic acid
-
-
5-deoxy-5-phosphonoD-arabinonate
-
-
5-deoxy-5-phosphonoD-arabinonate
-
5-phospho-D-arabinonamide
-
-
5-phospho-D-arabinonamide
-
5-phospho-D-arabinonate
-
-
5-phospho-D-arabinonate
-
5-phospho-D-arabinonhydrazide
-
-
5-phospho-D-arabinonhydrazide
-
5-phospho-D-arabinono-1,4-lactone
-
-
5-phospho-D-arabinono-1,4-lactone
-
5-phospho-D-arabinonohydroxamic acid
-
-
5-phospho-D-arabinonohydroxamic acid
-
5-phospho-D-arabinose
-
-
5-phospho-D-arabinose
-
5-phospho-D-ribonate
-
-
5-phospho-D-ribonate
-
5-phospho-D-ribonate
-
substrate analogue
6-deoxy-6-phosphono-D-gluconate
-
-
6-deoxy-6-phosphono-D-gluconate
-
6-methoxy-7-hydroxycoumarin
-
scopolin
6-phospho-D-allonate
-
-
6-phospho-D-galactonate
-
-
6-phospho-D-galactonate
-
6-phosphono-D-mannonate
-
competitive
6-phosphono-D-mannonate
competitive
7-Chloro-4-nitrobenzo-2-oxa-1,3-diazole
-
NBD-Cl
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
-
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
compound shows in vitro antiparasitic activity
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester
-
-
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester
-
compound shows in vitro antiparasitic activity
acetyl-CoA
-
-
adenosine
-
-
ADP
-
-
amikacin
-
in vitro inhibition
amikacin sulfate
-
in vitro and in vivo inhibition
amoxicillin
-
competitive
ampicillin
-
in vitro inhibition
ampicillin
-
in vitro inhibition
Butan-2,3-dione
-
-
caffeic acid
-
-
cefepime
-
in vitro inhibition
cefepime
-
in vitro and in vivo inhibition, noncompetitive
ceftazidim
-
in vitro inhibition
Chloramphenicol
-
in vitro inhibition
chlorogenic acid
-
-
Ciprofloxacin
-
in vitro inhibition
clindamycin
-
competitive
CO2
-
-
D-2-deoxyglucose
-
-
D-2-deoxyglucose
-
-
D-5-phosphoarabonate
-
-
D-5-phosphoribonate
-
-
D-5-phosphoribosyl-1-diphosphate
-
-
D-5-phosphoribosyl-1-diphosphate
-
-
D-6-phosphogluconate
-
competitive substrate inhibition at pH 7
D-6-sulfogluconate
-
-
D-6-sulfogluconate
-
-
D-ATP-ribose
-
-
D-erythrose 4-phosphate
-
-
D-erythrose 4-phosphate
-
-
D-erythrose 4-phosphate
-
-
D-fructose 1,6-diphosphate
-
-
D-fructose 1,6-diphosphate
-
-
D-fructose 1,6-diphosphate
-
-
D-fructose 1,6-diphosphate
-
-
D-fructose 1,6-diphosphate
-
-
D-fructose 1,6-diphosphate
-
-
D-fructose 1,6-diphosphate
-
-
D-fructose 1,6-diphosphate
-
-
D-fructose 1,6-diphosphate
-
-
D-Fructose 1-phosphate
-
-
D-fructose 2,6-bisphosphate
-
-
D-fructose 6-phosphate
-
-
D-fructose 6-phosphate
-
-
D-Glucose 1,6-bisphosphate
-
-
D-Glucose 1,6-bisphosphate
-
-
D-Glucose 1,6-bisphosphate
-
-
D-glucose 6-phosphate
-
-
D-glyceraldehyde 3-phosphate
-
-
D-glyceraldehyde 3-phosphate
-
-
D-phosphate
-
competitive inhibitor of the substrates
-
D-phosphate
-
-
-
D-ribulose 5-phosphate
-
-
D-ribulose 5-phosphate
-
-
D-ribulose 5-phosphate
-
-
D-ribulose 5-phosphate
-
-
D-ribulose 5-phosphate
-
-
D-ribulose 5-phosphate
-
-
D-ribulose 5-phosphate
-
-
D-xylulose 5-phosphate
-
-
diethyldicarbonate
-
-
diphosphate
-
-
diphosphate
-
-
esculetin
-
-
ferulic acid
-
-
gentamicin sulfate
-
in vitro inhibition
hexachloroplatinate
-
-
Hg2+
-
HgCl2
Imipenem
-
noncompetitive
iodoacetamide
-
-
iodoacetamide
-
-
isepamycin
-
in vitro inhibition
levofloxacin
-
in vitro inhibition
lornoxicam
-
noncompetitive
metronidazole
-
noncompetitive
Mg2+
-
acts as an inhibitor above 20 mM
N-ethylmaleimide
-
-
NADP+
-
-
NADPH
-
product inhibition
NADPH
-
-
NADPH
-
noncompetitive inhibition versus 6-phosphogluconate
NADPH
-
competitive inhibition
NADPH
-
competitive inhibition
NADPH
-
competitive inhibition
NADPH
-
competitive inhibition
NADPH
-
competitive inhibition versus NADP+ with 6-phospho-D-gluconate equal to its Km and at a saturating concentration
NADPH
-
saturating concentration at pH 7.5
NADPH
-
complete inhibition
NADPH
-
6-phosphogluconate modulates 6PGDH activity. In the forward reaction, it suppresses inhibition by NADP and decreases inhibition by NADPH by increasing the Kd of the reduced coenzyme 6fold it increases the rate of decarboxylation of the 3-keto intermediate , whereas in the reverse reaction, it decreases the Km and removes the slow step
netilmicin
-
-
netilmicin sulfate
-
in vitro inhibition
netilmicin sulfate
-
in vitro and in vivo inhibition, competitive
netilmicin sulfate
-
in vitro and in vivo inhibition
Nicotinamide
-
-
ofloxacin
-
in vitro inhibition
ornidazole
-
noncompetitive
oxalate
-
-
oxaloacetate
-
-
p-chloromercuribenzoate
-
-
p-chloromercuribenzoate
-
-
p-chloromercuribenzoate
-
-
p-coumaric acid
-
-
p-hydroxymercuribenzoate
-
-
p-hydroxymercuribenzoate
-
-
p-hydroxymercuribenzoate
-
-
penicillin G
-
in vitro inhibition
perchlorate
-
-
Permanganate
-
-
phosphoenolpyruvate
-
-
phosphoric acid dibenzyl ester (2R,3R)-3-benzyloxycarbamoyl-2,3-dihydroxypropyl ester
-
compound shows in vitro antiparasitic activity
phosphoric acid dibenzyl ester (4R,5R)-5-benzyloxycarbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester
-
compound shows in vitro antiparasitic activity
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester
-
-
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester
-
compound shows in vitro antiparasitic activity
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
-
compound shows low in vitro antiparasitic activity
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
-
-
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
-
compound shows low in vitro antiparasitic activity
potassium 3,4-dioxo-3,4-dihydronaphthalene-1-sulfonate
-
-
pyridoxal 5'-phosphate
-
photooxidation
pyridoxal 5'-phosphate
-
photooxidation
pyridoxal 5'-phosphate
-
-
Rose bengal
-
photooxidation
scopoletin
-
-
sodium (4E)-4-(hydroxyimino)-3-oxo-1,2,3,4-tetrahydronaphthalene-1-sulfonate
-
-
sulfate
-
-
teicoplanin
-
in vitro inhibition
Tetranitromethane
-
irreversible loss of catalytic activity
Vancomycin
-
competitive
[(2R)-2,3-dihydroxypropylsulfanyl]acetic acid benzyl ester
-
compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester
-
compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propylsulfanyl]acetic acid
-
compound shows in vitro antiparasitic activity
[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid
-
-
[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid
-
compound shows in vitro antiparasitic activity
[(4R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethylsulfanyl]acetic acid benzyl ester
-
compound shows low in vitro antiparasitic activity
[(5-nitrofuran-2-yl)methylidene]propanedioic acid
-
-
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid
-
compound shows in vitro antiparasitic activity
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid benzyl ester
-
compound shows in vitro antiparasitic activity
additional information
-
infection with potato virus Y increases the enzyme activity but decreases the 6-phosphono-D-gluconate content, maximal decrease of 30-50% at period of the highest virus replication
-
additional information
-
ovariectomized rats show a decrease in mRNA level and enzyme activity in the liver, but not in white adipose tissue, which can be restored by 17beta-estradiol administration
-
additional information
-
no inhibition by cefozin, decefin, streptomycin, combisid, and meronem
-
additional information
-
IC50 for antiparasitic activity of inhibitors, overview
-
additional information
-
no inhibition by [3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid, [(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester, (2R)-[3-(bis(benzyloxy)phosphoryloxy)-2-(tetrahydropyran-2-yloxy)propane-1-sulfinyl]acetic acid, and acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
additional information
-
IC50 for antiparasitic activity of inhibitors, overview
-
additional information
-
IC50 values for antiparasitic activity of inhibitors, overview
-
additional information
-
not inhibited by ungallated catechins like (-)-epigallocatechin, (-)-gallocatechin, (-)-epicatechin, (-)-catechin, and dehydroepiandrosterone
-
additional information
-
the activityand transcript level of 6PGDH decreases to 67% of its initial activity after 7 days of phosphate starvation
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
17beta-estradiol
-
administration causes an increase in liver enzyme, but not in white adipose tissue enzyme, activity and mRNA level in female and male rats
2,3-diphosphoglycerate
-
activates both isoenzymes up to 200% of their original activity
5-(3alpha-acetoxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
activates
5-(3alpha-hydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
activates
6-phosphogluconate
-
bona fide allosteric activator
AMP
-
1 mM, relative activity 105%
D-Fructose 1-phosphate
-
-
D-fructose 6-phosphate
-
slight activation
D-gluconate
-
induced by
gluconate
6-phosphogluconate dehydrogenase, although constituvely expressed, shows a 3-fold higher specific level in gluconate grown cells than those grown in fructose under similar conditions
glycylglycine
-
-
L-aspartate
-
-
L-histidine
-
-
L-tryptophan
-
-
metimazole
-
in vitro activation
additional information
the enzyme is upregulated during salt stress
-
additional information
-
external gluconate has no effect on the activity of 6-phosphogluconate dehydrogenase
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.0096
2-deoxy-3-oxo-6-phosphogluconate
-
-
0.082
2-deoxy-3-oxo-6-phosphogluconate
-
-
1.42
2-deoxy-3-oxo-6-phosphogluconate
-
-
0.55
2-deoxy-6-phosphogluconate
-
-
1.4
2-deoxy-6-phosphogluconate
-
-
1.42
2-deoxy-6-phosphogluconate
-
-
0.0048
6,7-dideoxy-7-phosphono-D-glucoheptonate
pH 8.0, 20C
0.011
6,7-dideoxy-7-phosphono-D-glucoheptonate
-
pH 8.0, 20C
0.00013
6-phospho-D-gluconate
-
-
0.0102
6-phospho-D-gluconate
-
pH 7.6, 25C
0.011
6-phospho-D-gluconate
-
in 50 mM HEPES buffer (pH 7.5) containing 5 mM Mg2+, 0.5 mM Mn2+, and 0.5 mg bovine serum albumin, at 80C
0.0121
6-phospho-D-gluconate
-
mutant enzyme H186A
0.024
6-phospho-D-gluconate
-
mutant enzyme T262A
0.028
6-phospho-D-gluconate
-
wild type enzyme
0.0284
6-phospho-D-gluconate
-
wild type enzyme
0.04
6-phospho-D-gluconate
-
dimeric enzyme with two 6-phospho-D-gluconate bound, pH not specified in the publication, temperature not specified in the publication
0.0509
6-phospho-D-gluconate
pH 7.5
0.07
6-phospho-D-gluconate
-
dimeric enzyme with one 6-phospho-D-gluconate bound, pH not specified in the publication, temperature not specified in the publication
0.093
6-phospho-D-gluconate
in 50 mM Tris-HCl buffer (pH 8.0), 20 mM MgCl2, at 25C
0.095
6-phospho-D-gluconate
-
mutant enzyme S128A
0.107
6-phospho-D-gluconate
in 50 mM Tris-HCl buffer (pH 8.0), 20 mM MgCl2, at 25C
0.15
6-phospho-D-gluconate
-
mutant enzyme K260A
0.53
6-phospho-D-gluconate
-
mutant enzyme N187A
0.595
6-phospho-D-gluconate
-
-
1.04
6-phospho-D-gluconate
-
mutant enzyme Y191A
2 - 3
6-phospho-D-gluconate
-
mutant enzyme R287A
3.4
6-phospho-D-gluconate
-
mutant enzyme R446A
0.006
6-phosphogluconate
-
-
0.0068
6-phosphogluconate
-
pH 10
0.0069
6-phosphogluconate
-
-
0.007
6-phosphogluconate
-
-
0.0096
6-phosphogluconate
-
proplastid isoenzyme
0.01
6-phosphogluconate
-
-
0.011
6-phosphogluconate
-
-
0.012
6-phosphogluconate
-
cytosolic isoenzyme
0.0135
6-phosphogluconate
-
-
0.014
6-phosphogluconate
-
60C or 65C
0.0149
6-phosphogluconate
-
50 mM Tris-acetate, 5-10 mM MgCl2, pH 7.7
0.015
6-phosphogluconate
-
-
0.015
6-phosphogluconate
-
cytosolic isoenzyme
0.016
6-phosphogluconate
-
30C
0.016
6-phosphogluconate
-
-
0.0161
6-phosphogluconate
-
50 mM Tris-acetate, pH 7.7
0.0167
6-phosphogluconate
-
10 mM Tris-acetate, 80 mM KCl, pH 7.7
0.018
6-phosphogluconate
-
plastid isoenzyme
0.02
6-phosphogluconate
-
43C
0.02
6-phosphogluconate
-
-
0.022
6-phosphogluconate
-
45C
0.0227
6-phosphogluconate
-
-
0.023
6-phosphogluconate
-
-
0.024
6-phosphogluconate
-
-
0.02666
6-phosphogluconate
-
-
0.031
6-phosphogluconate
-
type II
0.034
6-phosphogluconate
-
-
0.0343
6-phosphogluconate
-
-
0.035
6-phosphogluconate
-
-
0.036
6-phosphogluconate
-
-
0.04 - 0.05
6-phosphogluconate
-
heterocaryon col-3-wild-type
0.04
6-phosphogluconate
-
-
0.04
6-phosphogluconate
-
-
0.0413
6-phosphogluconate
-
10 mM Tris-acetate, pH 7.7
0.043
6-phosphogluconate
-
-
0.045
6-phosphogluconate
-
-
0.05
6-phosphogluconate
-
50 mM Tris-acetate, 20 mM MgCl2, KCl, pH 7.7
0.05
6-phosphogluconate
-
heterocaryon col-10-wild-type
0.05
6-phosphogluconate
-
-
0.052
6-phosphogluconate
-
type I
0.054
6-phosphogluconate
-
-
0.054
6-phosphogluconate
-
-
0.06
6-phosphogluconate
-
col-3-col-10
0.065
6-phosphogluconate
-
-
0.068
6-phosphogluconate
-
pH 5.93
0.071
6-phosphogluconate
-
-
0.071
6-phosphogluconate
-
source embryo
0.071
6-phosphogluconate
-
pH 7
0.08
6-phosphogluconate
-
isoenzyme 2
0.085
6-phosphogluconate
-
pH 8
0.09
6-phosphogluconate
-
mutant col 3
0.09
6-phosphogluconate
-
-
0.098
6-phosphogluconate
-
-
0.1
6-phosphogluconate
-
isoenzyme 1
0.109
6-phosphogluconate
-
plastid isoenzyme
0.11
6-phosphogluconate
-
mutant col 10
0.11
6-phosphogluconate
-
-
0.11
6-phosphogluconate
-
-
0.153
6-phosphogluconate
-
pH 8.0
0.157
6-phosphogluconate
-
-
0.204
6-phosphogluconate
-
pH 9
0.22
6-phosphogluconate
-
-
0.29
6-phosphogluconate
-
-
0.313
6-phosphogluconate
-
23.5C
0.402
6-phosphogluconate
-
source endosperm
0.64
6-phosphogluconate
-
pH 9.5
3.13
6-phosphogluconate
-
pH 9.03
0.0035
6-phosphono-D-gluconate
-
pH 7.5, 20C
0.0053
6-phosphono-D-gluconate
pH 8.0, 20C
0.016
6-phosphono-D-gluconate
-
pH 7.5, 20C
0.022
6-phosphono-D-gluconate
pH 7.5, 30C, purified native wild-type enzyme
0.0222
6-phosphono-D-gluconate
pH 7.5, 30C, purified recombinant mutant enzyme
0.03
6-phosphono-D-gluconate
-
pH 8.0, 20C
34
CO2
-
-
1.7
MgCl2
-
cytosolic isoenzyme
2.4
MgCl2
-
proplastid isoenzyme
0.38
NAD+
-
in 50 mM HEPES buffer (pH 7.5) containing 5 mM Mg2+, 0.5 mM Mn2+, and 0.5 mg bovine serum albumin, at 80C
3.5
NAD+
-
30C
16
NAD+
-
pH 7
17
NAD+
-
pH 9.5
18
NAD+
-
pH 9
114
NAD+
-
pH 10
0.00088
NADP+
-
-
0.002
NADP+
-
wild type enzyme
0.002
NADP+
-
mutant enzyme H186A
0.0041
NADP+
-
cytosolic isoenzyme
0.0042
NADP+
-
mutant enzyme T262A
0.0046
NADP+
pH 7.5, 30C, purified native wild-type enzyme
0.005
NADP+
-
wild type enzyme
0.0054
NADP+
-
proplastid isoenzyme
0.0054
NADP+
-
mutant enzyme S128A
0.00571
NADP+
-
10 mM Tris-acetate, 10 mM MgCl2, pH 7.7
0.0059
NADP+
pH 7.5, 30C, purified recombinant mutant enzyme
0.006
NADP+
-
source endosperm
0.00631
NADP+
-
10 mM Tris-acetate, 80 mM KCl, pH 7.7
0.0064
NADP+
-
mutant enzyme M13C
0.00676
NADP+
-
50 mM Tris-acetate, pH 7.7
0.0068
NADP+
-
-
0.007
NADP+
-
-
0.007
NADP+
-
-
0.008
NADP+
-
cytosolic isoenzyme
0.008
NADP+
-
-
0.00861
NADP+
-
50 mM Tris-acetate, 20 mM MgCl2, pH 7.7
0.00893
NADP+
-
10 mM Tris-acetate, pH 7.7
0.01
NADP+
-
-
0.01
NADP+
-
wild-type, mutant col 10, heterocaryon col-10-wild-type
0.01
NADP+
-
in 50 mM HEPES buffer (pH 7.5) containing 5 mM Mg2+, 0.5 mM Mn2+, and 0.5 mg bovine serum albumin, at 80C
0.011
NADP+
-
plastid isoenzyme
0.011
NADP+
-
-
0.013
NADP+
-
-
0.013
NADP+
-
-
0.013
NADP+
-
-
0.014
NADP+
-
mutant enzyme Y191A
0.015
NADP+
-
heterocaryon col 3-wild-type
0.015
NADP+
-
-
0.016
NADP+
-
-
0.016
NADP+
-
-
0.016
NADP+
-
mutant enzyme K260A
0.018
NADP+
-
heterocaryon col-3-col-10
0.019
NADP+
-
mutant enzyme M13F; mutant enzyme M13Q
0.02
NADP+
-
type I and II
0.0217
NADP+
-
23.5C
0.023
NADP+
-
-
0.023
NADP+
-
plastid isoenzyme
0.025
NADP+
-
source of enzyme: peak I
0.025
NADP+
-
pH 8.0
0.025
NADP+
-
-
0.025
NADP+
-
-
0.026
NADP+
-
mutant enzyme M13V
0.029
NADP+
-
-
0.0298
NADP+
-
mutant enzyme N187A
0.03
NADP+
-
source of enzyme: whole cells
0.03
NADP+
-
mutant col-3
0.03
NADP+
-
-
0.031
NADP+
-
pH 9.03
0.032
NADP+
-
source embryo
0.032
NADP+
-
mutant enzyme M13I
0.033
NADP+
-
source of enzyme: peak II
0.033
NADP+
-
pH 5.93
0.036
NADP+
-
-
0.049
NADP+
in 50 mM Tris-HCl buffer (pH 8.0), 20 mM MgCl2, at 25C
0.053
NADP+
-
-
0.064
NADP+
-
mutant enzyme R446A
0.073
NADP+
-
mutant enzyme R287A
0.118
NADP+
in 50 mM Tris-HCl buffer (pH 8.0), 20 mM MgCl2, at 25C
0.258
NADP+
-
-
0.6211
NADP+
-
-
0.00022
NADPH
-
-
0.002
NADPH
-
-
0.02
ribulose-5-phosphate
-
-
1
ribulose-5-phosphate
-
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.53
6,7-dideoxy-7-phosphono-D-glucoheptonate
Ovis aries
-
pH 8.0, 20C
1.4
6,7-dideoxy-7-phosphono-D-glucoheptonate
Trypanosoma brucei
P31072
pH 8.0, 20C
0.217
6-phosphogluconate
Homo sapiens
-
-
9
6-phosphono-D-gluconate
Ovis aries
-
pH 8.0, 20C
31.8
6-phosphono-D-gluconate
Trypanosoma brucei
P31072
pH 8.0, 20C
98
6-phosphono-D-gluconate
Trypanosoma cruzi
Q6WAT5
pH 7.5, 30C, purified native wild-type enzyme
98
NADP+
Trypanosoma cruzi
Q6WAT5
pH 7.5, 30C, purified native wild-type enzyme
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.198
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
-
pH 7.5, 20C
0.784
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
-
pH 7.5, 20C
3.14
(4S)-trans-4-ethylammonio-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
-
-
0.274
1,5-diphospho-D-ribulose
pH 8.0, 20C
1
1,5-diphospho-D-ribulose
-
pH 8.0, 20C
0.122
1,5-diphospho-ribitol
pH 8.0, 20C
0.5
1,5-diphospho-ribitol
-
pH 8.0, 20C
0.0044
2-deoxy-6-phosphono-D-gluconate
pH 8.0, 20C
0.0044
2-deoxy-6-phosphono-D-gluconate
-
pH 7.5, 20C
0.77
2-deoxy-6-phosphono-D-gluconate
-
pH 8.0, 20C
0.77
2-deoxy-6-phosphono-D-gluconate
-
pH 7.5, 20C
0.0015
4-phopho-D-erythronamide
-
pH 7.5, 20C
0.039
4-phospho-D-erythronamide
-
pH 7.5, 20C
0.00013
4-phospho-D-erythronate
pH 8.0, 20C
0.00013
4-phospho-D-erythronate
-
pH 7.5, 20C
0.00013
4-phospho-D-erythronate
-
-
0.011
4-phospho-D-erythronate
-
pH 8.0, 20C
0.011
4-phospho-D-erythronate
-
pH 7.5, 20C
0.00001
4-phospho-D-erythronohydroxamic acid
-
pH 7.5, 20C
0.0025
4-phospho-D-erythronohydroxamic acid
-
pH 7.5, 20C
0.175
4-phospho-D-erythrose
pH 8.0, 20C
1.59
4-phospho-D-erythrose
-
pH 8.0, 20C
0.0212
5,6-dideoxy-6-phosphono-D-arabino-hexonate
pH 8.0, 20C
1
5,6-dideoxy-6-phosphono-D-arabino-hexonate
-
pH 8.0, 20C
0.0042
5-(3alpha,7alpha,12alpha-triacetoxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
-
0.0878
5-(3alpha,7alpha,12alpha-trihydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
-
0.007
5-deoxy-5-phosphonoD-arabinonate
pH 8.0, 20C
0.433
5-deoxy-5-phosphonoD-arabinonate
-
pH 8.0, 20C
0.0056
5-phospho-D-arabinonamide
pH 8.0, 20C
0.0803
5-phospho-D-arabinonamide
-
pH 8.0, 20C
0.0034
5-phospho-D-arabinonate
pH 8.0, 20C
0.109
5-phospho-D-arabinonate
-
pH 8.0, 20C
0.0267
5-phospho-D-arabinonhydrazide
pH 8.0, 20C
0.128
5-phospho-D-arabinonhydrazide
-
pH 8.0, 20C
0.011
5-phospho-D-arabinono-1,4-lactone
pH 8.0, 20C
0.147
5-phospho-D-arabinono-1,4-lactone
-
pH 8.0, 20C
0.0058
5-phospho-D-arabinonohydroxamic acid
pH 8.0, 20C
0.307
5-phospho-D-arabinonohydroxamic acid
-
pH 8.0, 20C
0.025
5-phospho-D-arabinose
pH 8.0, 20C
0.71
5-phospho-D-arabinose
-
pH 8.0, 20C
0.00095
5-phospho-D-ribonate
pH 8.0, 20C
0.00095
5-phospho-D-ribonate
-
-
0.067
5-phospho-D-ribonate
-
pH 8.0, 20C
0.0013
6-deoxy-6-phosphono-D-gluconate
pH 8.0, 20C
0.0358
6-deoxy-6-phosphono-D-gluconate
-
pH 8.0, 20C
0.19
6-phospho-D-galactonate
pH 8.0, 20C
0.565
6-phospho-D-galactonate
-
pH 8.0, 20C
0.135
6-phosphono-D-mannonate
-
pH 8.0, 20C
0.8
6-phosphono-D-mannonate
pH 8.0, 20C
0.109
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
pH 7.5, 20C
0.192
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
pH 7.5, 20C
0.00008
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester
-
pH 7.5, 20C
0.00036
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester
-
pH 7.5, 20C
287.6
amoxicillin
-
25C, pH 8.0
2.579
cefepime
-
pH 8.0, 25C
130.2
clindamycin
-
25C, pH 8.0
0.77
Imipenem
-
25C, pH 8.0
0.4
lornoxicam
-
25C, pH 8.0
0.57
metronidazole
-
25C, pH 8.0
0.00065
NADPH
-
mutant enzyme M13C, at a saturating concentration
0.001
NADPH
-
mutant enzyme M13I, at a saturating concentration
0.0011
NADPH
-
wild type enzyme, at a saturating concentration
0.0015
NADPH
-
mutant enzyme M13F, at a saturating concentration
0.0021
NADPH
-
mutant enzyme M13Q, at a saturating concentration
0.006
NADPH
-
mutant enzyme M13V, at a saturating concentration
0.008
NADPH
-
wild type enzyme, at a saturating concentration of NADPH at pH 7.5
0.0093
NADPH
-
mutant enzyme N187A, at a saturating concentration of NADPH at pH 7.5
0.019
NADPH
-
mutant enzyme S128A, at a saturating concentration of NADPH at pH 7.5
0.027
NADPH
-
mutant enzyme H186A, at a saturating concentration of NADPH at pH 7.5
0.03191
NADPH
-
competitive inhibitor
0.939
netilmicin
-
pH 8.0, 25C
42.4
ornidazole
-
25C, pH 8.0
0.588
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester
-
pH 7.5, 20C
0.714
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester
-
pH 7.5, 20C
0.000035
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
-
pH 7.5, 20C
0.0011
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
-
pH 7.5, 20C
65.6
Vancomycin
-
25C, pH 8.0
0.04
[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid
-
pH 7.5, 20C
0.625
[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid
-
pH 7.5, 20C
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.00128
(-)-catechin gallate
Mus musculus
-
in 0.1 M Tris buffer (pH 7.5), 150 mM NaCl, 6 mM MgCl2, at 30C
0.00121
(-)-epicatechin gallate
Mus musculus
-
in 0.1 M Tris buffer (pH 7.5), 150 mM NaCl, 6 mM MgCl2, at 30C
0.00072
(-)-epigallocatechin gallate
Mus musculus
-
in 0.1 M Tris buffer (pH 7.5), 150 mM NaCl, 6 mM MgCl2, at 30C
0.00145
(-)-gallocatechin gallate
Mus musculus
-
in 0.1 M Tris buffer (pH 7.5), 150 mM NaCl, 6 mM MgCl2, at 30C
0.0058
(2E)-2-cyano-3-(5-nitrofuran-2-yl)prop-2-enoic acid
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
1.41
(4S)-trans-4-ethylammonio-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
Homo sapiens
-
-
0.028
2-methyl-5-nitrofuran-3-carboxylic acid
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
0.114
3,3',4,4'-tetramethyl-1H,1'H-2,2'-bipyrrole-5,5'-dicarboxylic acid
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
0.051
3-methyl-4-oxo-4,7-dihydro-5H-thiopyrano[3,4-b]furan-2-carboxylic acid
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
0.042
4,5-dichloro-1H-pyrrole-2-carboxylic acid
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
0.043
4-chloro-1H-pyrrole-2-carboxylic acid
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
0.042
4H-thieno[3,2-b]pyrrole-5-carboxylic acid
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
0.00253
5-(3alpha,7alpha,12alpha-triacetoxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
Homo sapiens
-
-
0.0601
5-(3alpha,7alpha,12alpha-trihydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
Homo sapiens
-
-
0.045
5-(ethoxycarbonyl)-3,4-dimethyl-1H-pyrrole-2-carboxylic acid
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
287.4
amoxicillin
Homo sapiens
-
25C, pH 8.0
117.4
clindamycin
Homo sapiens
-
25C, pH 8.0
0.43
Imipenem
Homo sapiens
-
25C, pH 8.0
0.17
lornoxicam
Homo sapiens
-
25C, pH 8.0
0.23
metronidazole
Homo sapiens
-
25C, pH 8.0
21.79
ornidazole
Homo sapiens
-
25C, pH 8.0
0.053
potassium 3,4-dioxo-3,4-dihydronaphthalene-1-sulfonate
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
0.073
sodium (4E)-4-(hydroxyimino)-3-oxo-1,2,3,4-tetrahydronaphthalene-1-sulfonate
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
46.39
Vancomycin
Homo sapiens
-
25C, pH 8.0
0.056
[(5-nitrofuran-2-yl)methylidene]propanedioic acid
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
0.025
activity of 6-phosphogluconate dhydrogenase in Corynebacterium glutamicum (ATCC 13032) culture in MCGC medium at 37C, supplemented with glucoronate
0.032
-
supernantant
0.094
activity of 6-phosphogluconate dhydrogenase in Corynebacterium glutamicum (ATCC 13032) culture in MCGC medium at 37C, supplemented with 0.5% fructose
0.1207
-
kidney enzyme, optimum conditions, pH 8.0, 37C
0.152
activity of 6-phosphogluconate dhydrogenase expressed in transformed Escherichia coli mutants, supplemented with 0.5% fructose as carbon source
0.177
-
homogenate
0.291
activity of 6-phosphogluconate dhydrogenase in Corynebacterium glutamicum (ATCC 13032) culture in MCGC medium at 37C, supplemented with 0.5% gluconate
0.41
-
-
0.4242
-
liver enzyme, optimum conditions, pH 8.0, 37C
1.33
-
-
1.89
-
supernatant fraction
1.89
-
purified enzyme
4.7
-
recombinant enzyme
12
-
total enzyme after gel filtration in presence of 6-phosphogluconate
15.12
-
after 473fold purification
17.4
-
-
18.7
-
ultrafiltration
19
-
pure enzyme
21.2
-
-
22
-
150fold purification
25.75
-
-
32
purified recombinant enzyme
33.5
-
total enzyme after gel filtration in absence of 6-phosphogluconate
38
-
cytoplasmic isoenzyme
61
-
after 344fold purification
80
-
pH 7.5, 25C
92.3
-
-
175
-
cell-free extract
additional information
-
plastid isoenzyme 4.8 nkat mg-1 protein, cytosolic isoenzyme 2.5 nkat mg-1 protein
additional information
-
activity in healthy and infected leaves during 9 days
additional information
-
6-phosphogluconate dehydrogenase activity in not enhanced in inoculated mesquite plants incubated for 15 or 23 days
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
6.8 - 7.2
-
decarboxylation in absence of activators
6.9
-
assay at
7
-
assay at
7 - 9
-
both isoenzymes
7.5
-
in 50 mM Tris-HCl
7.7
-
low substrate concentrations
7.8 - 8
-
cytosolic and proplastid isoenzymes
8
-
liver and kidney cortex enzyme
8
-
6-phosphogluconate oxidation
8
-
assay at
8
-
assay at
8.3
-
Tris-Cl orbicine-acetate buffers
8.5
-
-
8.6 - 8.8
-
both Tris and tricine buffers, more active in tricine buffers
9
-
isoenzyme 1, chloroplasts
9
-
6-phosphogluconate-activated decarboxylation
9.1
-
-
9.1
-
reduction
9.3
-
isoenzyme 2, cytoplasm
pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
4 - 9.6
-
-
5.5 - 9
-
-
5.5 - 9.1
-
-
6 - 9
-
about 70% of 6PGDH activities remain at pH 6.0 and 9.0
7.5 - 10
-
-
7.5 - 8.5
-
-
TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
7 - 9
-
with increasing phosphate buffer concentration from 25 to 150 mM
20 - 95
-
the enzyme has an approximately 90% of its maximum activity at 80C, and retains about 2 and about 20% of its maximum activity at 30 and 60C, respectively
25 - 70
-
retains full activity at 60C
50 - 60
-
-
pI VALUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
5.1
-
isoelectric focusing, pH-gradient: 3.5-7.0
6.6
-
calculated from sequence
6.9
electric focusing
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
-
a 6PGD gene expression pattern in ovines differing in weight is not followed by analogous changes of its enzymatic activity suggesting that other post transcription or post translation regulation is involved
Manually annotated by BRENDA team
-
low activity in female and male rats, constant at age 2 months to age 9 months
Manually annotated by BRENDA team
-
high activity in female and male rats, decreasing from age 2 months to age 9 months
Manually annotated by BRENDA team
low enzyme expression level
Manually annotated by BRENDA team
-
low activity in female and male rats, constant at age 2 months to age 9 months
Manually annotated by BRENDA team
-
nicotine has no effect on enzyme activity
Manually annotated by BRENDA team
Rattus norvegicus Wistar
-
-
-
Manually annotated by BRENDA team
high enzyme expression level
Manually annotated by BRENDA team
-
cortex, low activity in female and male rats, decreasing from age 2 months to age 9 months
Manually annotated by BRENDA team
Rattus norvegicus Wistar
-
cortex
-
Manually annotated by BRENDA team
very low enzyme expression level
Manually annotated by BRENDA team
Nicotiana tabacum W-38
-
-
-
Manually annotated by BRENDA team
-
moderate activity in female and male rats, decreasing from age 2 months to age 9 months
Manually annotated by BRENDA team
-
nicotine has no effect on enzyme activity. Vitamin E may favourably increase 6PGD activity
Manually annotated by BRENDA team
Rattus norvegicus Sprague-Dawley, Rattus norvegicus Wistar
-
-
-
Manually annotated by BRENDA team
-
nicotine activates enzyme activity, increase in activity is eliminated by vitamin E
Manually annotated by BRENDA team
-
leg and skeletal
Manually annotated by BRENDA team
-
nicotine activates enzyme activity, when administered with vitamin E the increase in enzyme activity is lower
Manually annotated by BRENDA team
low enzyme expression level
Manually annotated by BRENDA team
-
transcript levels of both Os6PGDH1 and Os6PGDH2 are up-regulated in rice seedlings under drought, cold, high salinity and abscisic acid treatments
Manually annotated by BRENDA team
the enzyme is upregulated during salt stress
Manually annotated by BRENDA team
-
low activity in female and male rats, constant at age 2 months to age 9 months
Manually annotated by BRENDA team
-
antibodies to 6-phosphogluconate dehydrogenase, decarboxylating are present in serum samples of ASA-positive (antisperm antibodies) infertile men
Manually annotated by BRENDA team
-
nicotine activates enzyme activity, when administered with vitamin E the increase in enzyme activity is lower
Manually annotated by BRENDA team
-
moderate activity in female and male rats, decreasing from age 2 months to age 9 months
Manually annotated by BRENDA team
additional information
-
enzyme mRNA concentration show age- and sex-related differences, especially in the liver, overview
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
Catharanthus roseus B/S
-
-
-
Manually annotated by BRENDA team
Rattus norvegicus Sprague-Dawley, Synechococcus sp. PCC 6307, Synechococcus sp. PCC 6716
-
-
-
Manually annotated by BRENDA team
cytosolic isozyme
Manually annotated by BRENDA team
-
dual localization to cytosol (95%) and peroxisomes
Manually annotated by BRENDA team
Catharanthus roseus B/S, Rattus norvegicus Wistar
-
-
-
Manually annotated by BRENDA team
-
dual localization to cytosol and peroxisomes
Manually annotated by BRENDA team
Catharanthus roseus B/S
-
-
-
Manually annotated by BRENDA team
PDB
SCOP
CATH
ORGANISM
UNIPROT
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Geobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210)
Lactococcus lactis subsp. cremoris (strain MG1363)
Lactococcus lactis subsp. cremoris (strain MG1363)
Lactococcus lactis subsp. cremoris (strain MG1363)