BRENDA - Enzyme Database show
show all sequences of 1.1.1.44

Selective inhibition of Trypanosoma brucei 6-phosphogluconate dehydrogenase by high-energy intermediate and transition-state analogues

Dardonville, C.; Rinaldi, E.; Barrett, M.P.; Brun, R.; Gilbert, I.H.; Hanau, S.; J. Med. Chem. 47, 3427-3437 (2004)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
compound shows in vitro antiparasitic activity
Leishmania donovani
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
-
Ovis aries
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
compound shows in vitro antiparasitic activity
Plasmodium falciparum
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
compound shows in vitro antiparasitic activity
Trypanosoma brucei
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
(2R)-[3-(bis(benzyloxy)phosphoryloxy)-2-(tetrahydropyran-2-yloxy)propane-1-sulfinyl]acetic acid
compound shows in vitro antiparasitic activity
Plasmodium falciparum
(2R)-[3-(bis(benzyloxy)phosphoryloxy)-2-(tetrahydropyran-2-yloxy)propane-1-sulfinyl]acetic acid
compound shows in vitro antiparasitic activity
Trypanosoma brucei
(2R)-[3-(bis(benzyloxy)phosphoryloxy)-2-(tetrahydropyran-2-yloxy)propane-1-sulfinyl]acetic acid
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
(2R,3R)-2,3,4,N-tetrahydroxybutyramide
compound shows in vitro antiparasitic activity
Leishmania donovani
(2R,3R)-2,3,4,N-tetrahydroxybutyramide
compound shows in vitro antiparasitic activity
Plasmodium falciparum
(2R,3R)-2,3,4,N-tetrahydroxybutyramide
compound shows in vitro antiparasitic activity
Trypanosoma brucei
(2R,3R)-2,3,4,N-tetrahydroxybutyramide
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
(3aR,6aR)-2,2-dimethyldihydrofuro[3,4-d][1,3]dioxol-4-one
compound shows in vitro antiparasitic activity
Leishmania donovani
(3aR,6aR)-2,2-dimethyldihydrofuro[3,4-d][1,3]dioxol-4-one
compound shows in vitro antiparasitic activity
Plasmodium falciparum
(3aR,6aR)-2,2-dimethyldihydrofuro[3,4-d][1,3]dioxol-4-one
compound shows in vitro antiparasitic activity
Trypanosoma brucei
(3aR,6aR)-2,2-dimethyldihydrofuro[3,4-d][1,3]dioxol-4-one
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
(3R,4R)-3,4-di(tetrahydro-2H-pyranyloxy)tetrahydro-2-furanone
compound shows in vitro antiparasitic activity
Leishmania donovani
(3R,4R)-3,4-di(tetrahydro-2H-pyranyloxy)tetrahydro-2-furanone
compound shows in vitro antiparasitic activity
Plasmodium falciparum
(3R,4R)-3,4-di(tetrahydro-2H-pyranyloxy)tetrahydro-2-furanone
compound shows in vitro antiparasitic activity
Trypanosoma brucei
(3R,4R)-3,4-di(tetrahydro-2H-pyranyloxy)tetrahydro-2-furanone
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
(4R,5R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid benzyloxyamide
compound shows in vitro antiparasitic activity
Leishmania donovani
(4R,5R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid benzyloxyamide
compound shows in vitro antiparasitic activity
Plasmodium falciparum
(4R,5R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid benzyloxyamide
compound shows in vitro antiparasitic activity
Trypanosoma brucei
(4R,5R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid benzyloxyamide
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
2-deoxy-6-phosphono-D-gluconate
compound shows in vitro antiparasitic activity
Leishmania donovani
2-deoxy-6-phosphono-D-gluconate
-
Ovis aries
2-deoxy-6-phosphono-D-gluconate
compound shows in vitro antiparasitic activity
Plasmodium falciparum
2-deoxy-6-phosphono-D-gluconate
compound shows in vitro antiparasitic activity
Trypanosoma brucei
2-deoxy-6-phosphono-D-gluconate
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
4,N-dihydroxy(2R,3R)-2,3-bis(tetrahydropyran-2-yloxy)butyramide
compound shows in vitro antiparasitic activity
Leishmania donovani
4,N-dihydroxy(2R,3R)-2,3-bis(tetrahydropyran-2-yloxy)butyramide
compound shows in vitro antiparasitic activity
Plasmodium falciparum
4,N-dihydroxy(2R,3R)-2,3-bis(tetrahydropyran-2-yloxy)butyramide
compound shows in vitro antiparasitic activity
Trypanosoma brucei
4,N-dihydroxy(2R,3R)-2,3-bis(tetrahydropyran-2-yloxy)butyramide
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
4-phospho-D-erythronamide
compound shows in vitro antiparasitic activity
Leishmania donovani
4-phospho-D-erythronamide
-
Ovis aries
4-phospho-D-erythronamide
compound shows in vitro antiparasitic activity
Plasmodium falciparum
4-phospho-D-erythronamide
compound shows in vitro antiparasitic activity
Trypanosoma brucei
4-phospho-D-erythronamide
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
4-phospho-D-erythronate
compound shows in vitro antiparasitic activity
Leishmania donovani
4-phospho-D-erythronate
-
Ovis aries
4-phospho-D-erythronate
compound shows in vitro antiparasitic activity
Plasmodium falciparum
4-phospho-D-erythronate
compound shows in vitro antiparasitic activity
Trypanosoma brucei
4-phospho-D-erythronate
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
4-phospho-D-erythronohydroxamic acid
compound shows low in vitro antiparasitic activity
Leishmania donovani
4-phospho-D-erythronohydroxamic acid
-
Ovis aries
4-phospho-D-erythronohydroxamic acid
compound shows low in vitro antiparasitic activity
Plasmodium falciparum
4-phospho-D-erythronohydroxamic acid
compound shows low in vitro antiparasitic activity
Trypanosoma brucei
4-phospho-D-erythronohydroxamic acid
compound shows low in vitro antiparasitic activity
Trypanosoma cruzi
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
compound shows in vitro antiparasitic activity
Leishmania donovani
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
Ovis aries
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
compound shows in vitro antiparasitic activity
Plasmodium falciparum
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
compound shows in vitro antiparasitic activity
Trypanosoma brucei
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester
compound shows in vitro antiparasitic activity
Leishmania donovani
acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester
compound shows in vitro antiparasitic activity
Plasmodium falciparum
acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester
compound shows in vitro antiparasitic activity
Trypanosoma brucei
acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester
-
Ovis aries
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester
compound shows in vitro antiparasitic activity
Plasmodium falciparum
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester
compound shows in vitro antiparasitic activity
Trypanosoma brucei
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
additional information
IC50 for antiparasitic activity of inhibitors, overview
Leishmania donovani
additional information
no inhibition by [3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid, [(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester, (2R)-[3-(bis(benzyloxy)phosphoryloxy)-2-(tetrahydropyran-2-yloxy)propane-1-sulfinyl]acetic acid, and acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester
Ovis aries
additional information
IC50 for antiparasitic activity of inhibitors, overview
Plasmodium falciparum
additional information
IC50 values for antiparasitic activity of inhibitors, overview
Trypanosoma brucei
additional information
IC50 values for antiparasitic activity of inhibitors, overview
Trypanosoma cruzi
phosphoric acid dibenzyl ester (2R,3R)-3-benzyloxycarbamoyl-2,3-dihydroxypropyl ester
compound shows in vitro antiparasitic activity
Leishmania donovani
phosphoric acid dibenzyl ester (2R,3R)-3-benzyloxycarbamoyl-2,3-dihydroxypropyl ester
compound shows in vitro antiparasitic activity
Plasmodium falciparum
phosphoric acid dibenzyl ester (2R,3R)-3-benzyloxycarbamoyl-2,3-dihydroxypropyl ester
compound shows in vitro antiparasitic activity
Trypanosoma brucei
phosphoric acid dibenzyl ester (2R,3R)-3-benzyloxycarbamoyl-2,3-dihydroxypropyl ester
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
phosphoric acid dibenzyl ester (4R,5R)-5-benzyloxycarbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester
compound shows in vitro antiparasitic activity
Leishmania donovani
phosphoric acid dibenzyl ester (4R,5R)-5-benzyloxycarbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester
compound shows in vitro antiparasitic activity
Plasmodium falciparum
phosphoric acid dibenzyl ester (4R,5R)-5-benzyloxycarbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester
compound shows in vitro antiparasitic activity
Trypanosoma brucei
phosphoric acid dibenzyl ester (4R,5R)-5-benzyloxycarbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester
-
Ovis aries
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester
compound shows in vitro antiparasitic activity
Plasmodium falciparum
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester
compound shows in vitro antiparasitic activity
Trypanosoma brucei
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
compound shows low in vitro antiparasitic activity
Leishmania donovani
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
-
Ovis aries
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
compound shows low in vitro antiparasitic activity
Plasmodium falciparum
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
compound shows low in vitro antiparasitic activity
Trypanosoma brucei
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
compound shows low in vitro antiparasitic activity
Trypanosoma cruzi
[(2R)-2,3-dihydroxypropylsulfanyl]acetic acid benzyl ester
compound shows in vitro antiparasitic activity
Leishmania donovani
[(2R)-2,3-dihydroxypropylsulfanyl]acetic acid benzyl ester
compound shows in vitro antiparasitic activity
Plasmodium falciparum
[(2R)-2,3-dihydroxypropylsulfanyl]acetic acid benzyl ester
compound shows in vitro antiparasitic activity
Trypanosoma brucei
[(2R)-2,3-dihydroxypropylsulfanyl]acetic acid benzyl ester
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester
compound shows in vitro antiparasitic activity
Leishmania donovani
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester
compound shows in vitro antiparasitic activity
Plasmodium falciparum
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester
compound shows in vitro antiparasitic activity
Trypanosoma brucei
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propylsulfanyl]acetic acid
compound shows in vitro antiparasitic activity
Leishmania donovani
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propylsulfanyl]acetic acid
compound shows in vitro antiparasitic activity
Plasmodium falciparum
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propylsulfanyl]acetic acid
compound shows in vitro antiparasitic activity
Trypanosoma brucei
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propylsulfanyl]acetic acid
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid
-
Ovis aries
[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid
compound shows in vitro antiparasitic activity
Plasmodium falciparum
[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid
compound shows in vitro antiparasitic activity
Trypanosoma brucei
[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
[(4R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethylsulfanyl]acetic acid benzyl ester
compound shows low in vitro antiparasitic activity
Leishmania donovani
[(4R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethylsulfanyl]acetic acid benzyl ester
compound shows low in vitro antiparasitic activity
Plasmodium falciparum
[(4R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethylsulfanyl]acetic acid benzyl ester
compound shows low in vitro antiparasitic activity
Trypanosoma brucei
[(4R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethylsulfanyl]acetic acid benzyl ester
compound shows low in vitro antiparasitic activity
Trypanosoma cruzi
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid
compound shows in vitro antiparasitic activity
Leishmania donovani
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid
compound shows in vitro antiparasitic activity
Plasmodium falciparum
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid
compound shows in vitro antiparasitic activity
Trypanosoma brucei
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid benzyl ester
compound shows in vitro antiparasitic activity
Leishmania donovani
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid benzyl ester
compound shows in vitro antiparasitic activity
Plasmodium falciparum
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid benzyl ester
compound shows in vitro antiparasitic activity
Trypanosoma brucei
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid benzyl ester
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0035
-
6-phosphono-D-gluconate
pH 7.5, 20C
Trypanosoma brucei
0.016
-
6-phosphono-D-gluconate
pH 7.5, 20C
Ovis aries
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Leishmania donovani
-
-
-
Ovis aries
-
-
-
Plasmodium falciparum
-
-
-
Trypanosoma brucei
-
-
-
Trypanosoma cruzi
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Ovis aries
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3-keto-6-phosphono-D-gluconate + ?
via 1,2-enediol intermediate
656470
Trypanosoma brucei
D-ribulose 5-phosphate + CO2
-
-
-
-
3-keto-6-phosphono-D-gluconate + NADP+
via 1,2-enediol intermediate
656470
Ovis aries
D-ribulose 5-phosphate + CO2
-
-
-
?
3-keto-6-phosphono-D-gluconate + NADP+
via 1,2-enediol intermediate
656470
Leishmania donovani
D-ribulose 5-phosphate + CO2
-
-
-
?
3-keto-6-phosphono-D-gluconate + NADP+
via 1,2-enediol intermediate
656470
Trypanosoma cruzi
D-ribulose 5-phosphate + CO2
-
-
-
?
3-keto-6-phosphono-D-gluconate + NADP+
via 1,2-enediol intermediate
656470
Plasmodium falciparum
D-ribulose 5-phosphate + CO2
-
-
-
?
6-phosphono-D-gluconate + NADP+
-
656470
Ovis aries
3-keto-6-phosphono-D-gluconate + NADPH
-
-
-
?
6-phosphono-D-gluconate + NADP+
-
656470
Trypanosoma brucei
3-keto-6-phosphono-D-gluconate + NADPH
-
-
-
-
6-phosphono-D-gluconate + NADP+
-
656470
Leishmania donovani
3-keto-6-phosphono-D-gluconate + NADPH
-
-
-
?
6-phosphono-D-gluconate + NADP+
-
656470
Trypanosoma cruzi
3-keto-6-phosphono-D-gluconate + NADPH
-
-
-
?
6-phosphono-D-gluconate + NADP+
-
656470
Plasmodium falciparum
3-keto-6-phosphono-D-gluconate + NADPH
-
-
-
?
6-phosphono-D-gluconate + NADP+
overall reaction
656470
Ovis aries
D-ribulose 5-phosphate + NADPH
-
-
-
?
6-phosphono-D-gluconate + NADP+
overall reaction
656470
Trypanosoma brucei
D-ribulose 5-phosphate + NADPH
-
-
-
?
6-phosphono-D-gluconate + NADP+
overall reaction
656470
Leishmania donovani
D-ribulose 5-phosphate + NADPH
-
-
-
?
6-phosphono-D-gluconate + NADP+
overall reaction
656470
Trypanosoma cruzi
D-ribulose 5-phosphate + NADPH
-
-
-
?
6-phosphono-D-gluconate + NADP+
overall reaction
656470
Plasmodium falciparum
D-ribulose 5-phosphate + NADPH
-
-
-
?
Temperature Optimum [C]
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
20
-
assay at
Ovis aries
20
-
assay at
Trypanosoma brucei
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.5
-
assay at
Ovis aries
7.5
-
assay at
Trypanosoma brucei
Cofactor
Cofactor
Commentary
Organism
Structure
NADP+
-
Leishmania donovani
NADP+
-
Plasmodium falciparum
NADP+
-
Trypanosoma brucei
NADP+
-
Trypanosoma cruzi
NADP+
-
Ovis aries
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.00001
-
4-phospho-D-erythronohydroxamic acid
pH 7.5, 20C
Trypanosoma brucei
0.000035
-
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
pH 7.5, 20C
Trypanosoma brucei
0.00008
-
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester
pH 7.5, 20C
Trypanosoma brucei
0.00013
-
4-phospho-D-erythronate
pH 7.5, 20C
Trypanosoma brucei
0.00036
-
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester
pH 7.5, 20C
Ovis aries
0.0011
-
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
pH 7.5, 20C
Ovis aries
0.0015
-
4-phopho-D-erythronamide
pH 7.5, 20C
Trypanosoma brucei
0.0025
-
4-phospho-D-erythronohydroxamic acid
pH 7.5, 20C
Ovis aries
0.0044
-
2-deoxy-6-phosphono-D-gluconate
pH 7.5, 20C
Trypanosoma brucei
0.011
-
4-phospho-D-erythronate
pH 7.5, 20C
Ovis aries
0.039
-
4-phospho-D-erythronamide
pH 7.5, 20C
Ovis aries
0.04
-
[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid
pH 7.5, 20C
Trypanosoma brucei
0.109
-
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
pH 7.5, 20C
Trypanosoma brucei
0.192
-
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
pH 7.5, 20C
Ovis aries
0.198
-
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
pH 7.5, 20C
Trypanosoma brucei
0.588
-
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester
pH 7.5, 20C
Trypanosoma brucei
0.625
-
[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid
pH 7.5, 20C
Ovis aries
0.714
-
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester
pH 7.5, 20C
Ovis aries
0.77
-
2-deoxy-6-phosphono-D-gluconate
pH 7.5, 20C
Ovis aries
0.784
-
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
pH 7.5, 20C
Ovis aries
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADP+
-
Leishmania donovani
NADP+
-
Plasmodium falciparum
NADP+
-
Trypanosoma brucei
NADP+
-
Trypanosoma cruzi
NADP+
-
Ovis aries
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
compound shows in vitro antiparasitic activity
Leishmania donovani
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
-
Ovis aries
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
compound shows in vitro antiparasitic activity
Plasmodium falciparum
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
compound shows in vitro antiparasitic activity
Trypanosoma brucei
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
(2R)-[3-(bis(benzyloxy)phosphoryloxy)-2-(tetrahydropyran-2-yloxy)propane-1-sulfinyl]acetic acid
compound shows in vitro antiparasitic activity
Plasmodium falciparum
(2R)-[3-(bis(benzyloxy)phosphoryloxy)-2-(tetrahydropyran-2-yloxy)propane-1-sulfinyl]acetic acid
compound shows in vitro antiparasitic activity
Trypanosoma brucei
(2R)-[3-(bis(benzyloxy)phosphoryloxy)-2-(tetrahydropyran-2-yloxy)propane-1-sulfinyl]acetic acid
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
(2R,3R)-2,3,4,N-tetrahydroxybutyramide
compound shows in vitro antiparasitic activity
Leishmania donovani
(2R,3R)-2,3,4,N-tetrahydroxybutyramide
compound shows in vitro antiparasitic activity
Plasmodium falciparum
(2R,3R)-2,3,4,N-tetrahydroxybutyramide
compound shows in vitro antiparasitic activity
Trypanosoma brucei
(2R,3R)-2,3,4,N-tetrahydroxybutyramide
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
(3aR,6aR)-2,2-dimethyldihydrofuro[3,4-d][1,3]dioxol-4-one
compound shows in vitro antiparasitic activity
Leishmania donovani
(3aR,6aR)-2,2-dimethyldihydrofuro[3,4-d][1,3]dioxol-4-one
compound shows in vitro antiparasitic activity
Plasmodium falciparum
(3aR,6aR)-2,2-dimethyldihydrofuro[3,4-d][1,3]dioxol-4-one
compound shows in vitro antiparasitic activity
Trypanosoma brucei
(3aR,6aR)-2,2-dimethyldihydrofuro[3,4-d][1,3]dioxol-4-one
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
(3R,4R)-3,4-di(tetrahydro-2H-pyranyloxy)tetrahydro-2-furanone
compound shows in vitro antiparasitic activity
Leishmania donovani
(3R,4R)-3,4-di(tetrahydro-2H-pyranyloxy)tetrahydro-2-furanone
compound shows in vitro antiparasitic activity
Plasmodium falciparum
(3R,4R)-3,4-di(tetrahydro-2H-pyranyloxy)tetrahydro-2-furanone
compound shows in vitro antiparasitic activity
Trypanosoma brucei
(3R,4R)-3,4-di(tetrahydro-2H-pyranyloxy)tetrahydro-2-furanone
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
(4R,5R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid benzyloxyamide
compound shows in vitro antiparasitic activity
Leishmania donovani
(4R,5R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid benzyloxyamide
compound shows in vitro antiparasitic activity
Plasmodium falciparum
(4R,5R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid benzyloxyamide
compound shows in vitro antiparasitic activity
Trypanosoma brucei
(4R,5R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid benzyloxyamide
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
2-deoxy-6-phosphono-D-gluconate
compound shows in vitro antiparasitic activity
Leishmania donovani
2-deoxy-6-phosphono-D-gluconate
-
Ovis aries
2-deoxy-6-phosphono-D-gluconate
compound shows in vitro antiparasitic activity
Plasmodium falciparum
2-deoxy-6-phosphono-D-gluconate
compound shows in vitro antiparasitic activity
Trypanosoma brucei
2-deoxy-6-phosphono-D-gluconate
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
4,N-dihydroxy(2R,3R)-2,3-bis(tetrahydropyran-2-yloxy)butyramide
compound shows in vitro antiparasitic activity
Leishmania donovani
4,N-dihydroxy(2R,3R)-2,3-bis(tetrahydropyran-2-yloxy)butyramide
compound shows in vitro antiparasitic activity
Plasmodium falciparum
4,N-dihydroxy(2R,3R)-2,3-bis(tetrahydropyran-2-yloxy)butyramide
compound shows in vitro antiparasitic activity
Trypanosoma brucei
4,N-dihydroxy(2R,3R)-2,3-bis(tetrahydropyran-2-yloxy)butyramide
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
4-phospho-D-erythronamide
compound shows in vitro antiparasitic activity
Leishmania donovani
4-phospho-D-erythronamide
-
Ovis aries
4-phospho-D-erythronamide
compound shows in vitro antiparasitic activity
Plasmodium falciparum
4-phospho-D-erythronamide
compound shows in vitro antiparasitic activity
Trypanosoma brucei
4-phospho-D-erythronamide
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
4-phospho-D-erythronate
compound shows in vitro antiparasitic activity
Leishmania donovani
4-phospho-D-erythronate
-
Ovis aries
4-phospho-D-erythronate
compound shows in vitro antiparasitic activity
Plasmodium falciparum
4-phospho-D-erythronate
compound shows in vitro antiparasitic activity
Trypanosoma brucei
4-phospho-D-erythronate
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
4-phospho-D-erythronohydroxamic acid
compound shows low in vitro antiparasitic activity
Leishmania donovani
4-phospho-D-erythronohydroxamic acid
-
Ovis aries
4-phospho-D-erythronohydroxamic acid
compound shows low in vitro antiparasitic activity
Plasmodium falciparum
4-phospho-D-erythronohydroxamic acid
compound shows low in vitro antiparasitic activity
Trypanosoma brucei
4-phospho-D-erythronohydroxamic acid
compound shows low in vitro antiparasitic activity
Trypanosoma cruzi
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
compound shows in vitro antiparasitic activity
Leishmania donovani
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
-
Ovis aries
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
compound shows in vitro antiparasitic activity
Plasmodium falciparum
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
compound shows in vitro antiparasitic activity
Trypanosoma brucei
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester
compound shows in vitro antiparasitic activity
Leishmania donovani
acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester
compound shows in vitro antiparasitic activity
Plasmodium falciparum
acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester
compound shows in vitro antiparasitic activity
Trypanosoma brucei
acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester
-
Ovis aries
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester
compound shows in vitro antiparasitic activity
Plasmodium falciparum
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester
compound shows in vitro antiparasitic activity
Trypanosoma brucei
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
additional information
IC50 for antiparasitic activity of inhibitors, overview
Leishmania donovani
additional information
no inhibition by [3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid, [(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester, (2R)-[3-(bis(benzyloxy)phosphoryloxy)-2-(tetrahydropyran-2-yloxy)propane-1-sulfinyl]acetic acid, and acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester
Ovis aries
additional information
IC50 for antiparasitic activity of inhibitors, overview
Plasmodium falciparum
additional information
IC50 values for antiparasitic activity of inhibitors, overview
Trypanosoma brucei
additional information
IC50 values for antiparasitic activity of inhibitors, overview
Trypanosoma cruzi
phosphoric acid dibenzyl ester (2R,3R)-3-benzyloxycarbamoyl-2,3-dihydroxypropyl ester
compound shows in vitro antiparasitic activity
Leishmania donovani
phosphoric acid dibenzyl ester (2R,3R)-3-benzyloxycarbamoyl-2,3-dihydroxypropyl ester
compound shows in vitro antiparasitic activity
Plasmodium falciparum
phosphoric acid dibenzyl ester (2R,3R)-3-benzyloxycarbamoyl-2,3-dihydroxypropyl ester
compound shows in vitro antiparasitic activity
Trypanosoma brucei
phosphoric acid dibenzyl ester (2R,3R)-3-benzyloxycarbamoyl-2,3-dihydroxypropyl ester
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
phosphoric acid dibenzyl ester (4R,5R)-5-benzyloxycarbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester
compound shows in vitro antiparasitic activity
Leishmania donovani
phosphoric acid dibenzyl ester (4R,5R)-5-benzyloxycarbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester
compound shows in vitro antiparasitic activity
Plasmodium falciparum
phosphoric acid dibenzyl ester (4R,5R)-5-benzyloxycarbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester
compound shows in vitro antiparasitic activity
Trypanosoma brucei
phosphoric acid dibenzyl ester (4R,5R)-5-benzyloxycarbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester
-
Ovis aries
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester
compound shows in vitro antiparasitic activity
Plasmodium falciparum
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester
compound shows in vitro antiparasitic activity
Trypanosoma brucei
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
compound shows low in vitro antiparasitic activity
Leishmania donovani
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
-
Ovis aries
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
compound shows low in vitro antiparasitic activity
Plasmodium falciparum
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
compound shows low in vitro antiparasitic activity
Trypanosoma brucei
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
compound shows low in vitro antiparasitic activity
Trypanosoma cruzi
[(2R)-2,3-dihydroxypropylsulfanyl]acetic acid benzyl ester
compound shows in vitro antiparasitic activity
Leishmania donovani
[(2R)-2,3-dihydroxypropylsulfanyl]acetic acid benzyl ester
compound shows in vitro antiparasitic activity
Plasmodium falciparum
[(2R)-2,3-dihydroxypropylsulfanyl]acetic acid benzyl ester
compound shows in vitro antiparasitic activity
Trypanosoma brucei
[(2R)-2,3-dihydroxypropylsulfanyl]acetic acid benzyl ester
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester
compound shows in vitro antiparasitic activity
Leishmania donovani
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester
compound shows in vitro antiparasitic activity
Plasmodium falciparum
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester
compound shows in vitro antiparasitic activity
Trypanosoma brucei
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propylsulfanyl]acetic acid
compound shows in vitro antiparasitic activity
Leishmania donovani
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propylsulfanyl]acetic acid
compound shows in vitro antiparasitic activity
Plasmodium falciparum
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propylsulfanyl]acetic acid
compound shows in vitro antiparasitic activity
Trypanosoma brucei
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propylsulfanyl]acetic acid
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid
-
Ovis aries
[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid
compound shows in vitro antiparasitic activity
Plasmodium falciparum
[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid
compound shows in vitro antiparasitic activity
Trypanosoma brucei
[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
[(4R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethylsulfanyl]acetic acid benzyl ester
compound shows low in vitro antiparasitic activity
Leishmania donovani
[(4R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethylsulfanyl]acetic acid benzyl ester
compound shows low in vitro antiparasitic activity
Plasmodium falciparum
[(4R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethylsulfanyl]acetic acid benzyl ester
compound shows low in vitro antiparasitic activity
Trypanosoma brucei
[(4R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethylsulfanyl]acetic acid benzyl ester
compound shows low in vitro antiparasitic activity
Trypanosoma cruzi
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid
compound shows in vitro antiparasitic activity
Leishmania donovani
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid
compound shows in vitro antiparasitic activity
Plasmodium falciparum
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid
compound shows in vitro antiparasitic activity
Trypanosoma brucei
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid benzyl ester
compound shows in vitro antiparasitic activity
Leishmania donovani
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid benzyl ester
compound shows in vitro antiparasitic activity
Plasmodium falciparum
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid benzyl ester
compound shows in vitro antiparasitic activity
Trypanosoma brucei
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid benzyl ester
compound shows in vitro antiparasitic activity
Trypanosoma cruzi
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.00001
-
4-phospho-D-erythronohydroxamic acid
pH 7.5, 20C
Trypanosoma brucei
0.000035
-
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
pH 7.5, 20C
Trypanosoma brucei
0.00008
-
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester
pH 7.5, 20C
Trypanosoma brucei
0.00013
-
4-phospho-D-erythronate
pH 7.5, 20C
Trypanosoma brucei
0.00036
-
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester
pH 7.5, 20C
Ovis aries
0.0011
-
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
pH 7.5, 20C
Ovis aries
0.0015
-
4-phopho-D-erythronamide
pH 7.5, 20C
Trypanosoma brucei
0.0025
-
4-phospho-D-erythronohydroxamic acid
pH 7.5, 20C
Ovis aries
0.0044
-
2-deoxy-6-phosphono-D-gluconate
pH 7.5, 20C
Trypanosoma brucei
0.011
-
4-phospho-D-erythronate
pH 7.5, 20C
Ovis aries
0.039
-
4-phospho-D-erythronamide
pH 7.5, 20C
Ovis aries
0.04
-
[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid
pH 7.5, 20C
Trypanosoma brucei
0.109
-
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
pH 7.5, 20C
Trypanosoma brucei
0.192
-
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
pH 7.5, 20C
Ovis aries
0.198
-
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
pH 7.5, 20C
Trypanosoma brucei
0.588
-
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester
pH 7.5, 20C
Trypanosoma brucei
0.625
-
[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid
pH 7.5, 20C
Ovis aries
0.714
-
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester
pH 7.5, 20C
Ovis aries
0.77
-
2-deoxy-6-phosphono-D-gluconate
pH 7.5, 20C
Ovis aries
0.784
-
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
pH 7.5, 20C
Ovis aries
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0035
-
6-phosphono-D-gluconate
pH 7.5, 20C
Trypanosoma brucei
0.016
-
6-phosphono-D-gluconate
pH 7.5, 20C
Ovis aries
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Ovis aries
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3-keto-6-phosphono-D-gluconate + ?
via 1,2-enediol intermediate
656470
Trypanosoma brucei
D-ribulose 5-phosphate + CO2
-
-
-
-
3-keto-6-phosphono-D-gluconate + NADP+
via 1,2-enediol intermediate
656470
Ovis aries
D-ribulose 5-phosphate + CO2
-
-
-
?
3-keto-6-phosphono-D-gluconate + NADP+
via 1,2-enediol intermediate
656470
Leishmania donovani
D-ribulose 5-phosphate + CO2
-
-
-
?
3-keto-6-phosphono-D-gluconate + NADP+
via 1,2-enediol intermediate
656470
Trypanosoma cruzi
D-ribulose 5-phosphate + CO2
-
-
-
?
3-keto-6-phosphono-D-gluconate + NADP+
via 1,2-enediol intermediate
656470
Plasmodium falciparum
D-ribulose 5-phosphate + CO2
-
-
-
?
6-phosphono-D-gluconate + NADP+
-
656470
Ovis aries
3-keto-6-phosphono-D-gluconate + NADPH
-
-
-
?
6-phosphono-D-gluconate + NADP+
-
656470
Trypanosoma brucei
3-keto-6-phosphono-D-gluconate + NADPH
-
-
-
-
6-phosphono-D-gluconate + NADP+
-
656470
Leishmania donovani
3-keto-6-phosphono-D-gluconate + NADPH
-
-
-
?
6-phosphono-D-gluconate + NADP+
-
656470
Trypanosoma cruzi
3-keto-6-phosphono-D-gluconate + NADPH
-
-
-
?
6-phosphono-D-gluconate + NADP+
-
656470
Plasmodium falciparum
3-keto-6-phosphono-D-gluconate + NADPH
-
-
-
?
6-phosphono-D-gluconate + NADP+
overall reaction
656470
Ovis aries
D-ribulose 5-phosphate + NADPH
-
-
-
?
6-phosphono-D-gluconate + NADP+
overall reaction
656470
Trypanosoma brucei
D-ribulose 5-phosphate + NADPH
-
-
-
?
6-phosphono-D-gluconate + NADP+
overall reaction
656470
Leishmania donovani
D-ribulose 5-phosphate + NADPH
-
-
-
?
6-phosphono-D-gluconate + NADP+
overall reaction
656470
Trypanosoma cruzi
D-ribulose 5-phosphate + NADPH
-
-
-
?
6-phosphono-D-gluconate + NADP+
overall reaction
656470
Plasmodium falciparum
D-ribulose 5-phosphate + NADPH
-
-
-
?
Temperature Optimum [C] (protein specific)
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
20
-
assay at
Ovis aries
20
-
assay at
Trypanosoma brucei
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.5
-
assay at
Ovis aries
7.5
-
assay at
Trypanosoma brucei
Other publictions for EC 1.1.1.44
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
722302
Strijbis
Alternative splicing directs d ...
Candida albicans
FEMS Yeast Res.
12
61-68
2012
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2
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1
1
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699855
Chen
Conformational changes associa ...
Escherichia coli, Escherichia coli K12, Klebsiella pneumoniae, Klebsiella pneumoniae NTUH-K2044
J. Struct. Biol.
169
25-35
2010
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4
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2
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2
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2
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710864
Laliotis
Enzymatic and mRNA transcript ...
Ovis aries
Anim. Biotechnol.
21
149-155
2010
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2
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1
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-
711463
Ruda
Virtual fragment screening for ...
Trypanosoma brucei
Bioorg. Med. Chem.
18
5056-5062
2010
-
-
1
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-
11
-
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1
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1
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1
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1
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11
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1
1
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11
11
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1
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1
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-
712444
Hanau
6-Phosphogluconate dehydrogena ...
Cyberlindnera jadinii
J. Biol. Chem.
285
21366-21371
2010
-
-
-
-
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1
2
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1
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1
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1
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1
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1
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1
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1
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1
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2
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1
-
1
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-
1
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-
-
-
-
-
-
-
-
695382
Cameron
Geobacillus stearothermophilus ...
Geobacillus stearothermophilus
Acta Crystallogr. Sect. F
65
450-454
2009
-
-
1
1
-
-
-
-
-
-
-
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1
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1
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1
1
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1
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1
1
1
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1
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1
1
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-
-
697997
Tan
Vaccination with Streptococcus ...
Streptococcus suis
FEMS Microbiol. Lett.
296
78-83
2009
-
-
1
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1
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5
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1
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1
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1
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1
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-
-
700013
Wang
Overexpression and simple puri ...
Thermotoga maritima
Microb. Cell Fact.
8
30
2009
-
-
1
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-
3
-
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1
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1
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2
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1
1
1
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1
1
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2
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1
2
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3
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1
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2
-
1
1
1
-
1
1
-
-
-
-
-
-
-
-
685049
Chograni
-
Genetic diversity and populati ...
Lavandula multifida, Lavandula stoechas
Biochem. Syst. Ecol.
36
349-359
2008
-
-
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2
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-
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-
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-
685541
Shin
Catechin gallates are NADP+-co ...
Mus musculus
Bioorg. Med. Chem.
16
3580-3586
2008
-
-
-
-
-
-
6
-
-
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-
1
-
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-
2
-
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1
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1
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4
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1
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4
6
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2
-
-
1
-
-
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-
-
-
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-
-
-
-
-
-
-
-
685821
Maruyama
Origins of a cyanobacterial 6- ...
Cyanophora paradoxa, Cyanoptyche gloeocystis, Diplonema papillatum, Euglena gracilis, Gloeochaete wittrockiana, Peranema trichophorum
BMC Evol. Biol.
8
151
2008
-
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6
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-
688042
Ciftci
Effects of nicotine and vitami ...
Rattus norvegicus
J. Enzyme Inhib. Med. Chem.
23
261-265
2008
-
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2
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5
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5
-
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-
-
-
-
688050
Bulbul
Investigation of the effects o ...
Homo sapiens
J. Enzyme Inhib. Med. Chem.
23
418-423
2008
2
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4
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1
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1
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1
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3
-
3
2
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3
4
3
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1
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-
1
-
-
-
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-
690185
Tan
Cloning, expression and charac ...
Streptococcus suis
Vet. Microbiol.
130
363-370
2008
-
-
1
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1
-
1
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6
-
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1
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1
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1
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1
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1
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-
696246
Cervellati
Proper orientation of the nico ...
Ovis aries
Biochemistry
47
1862-1870
2008
-
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1
-
4
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1
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1
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1
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2
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1
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1
1
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4
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1
-
1
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2
-
-
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-
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-
-
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-
696574
Porco
Gluconate as suitable potentia ...
Corynebacterium glutamicum
Biol. Res.
41
349-358
2008
1
-
1
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1
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1
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1
4
-
1
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1
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1
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1
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1
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1
4
-
1
-
1
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-
-
-
-
-
-
-
1
1
-
-
-
700784
Leyva
Activity of two catabolic enzy ...
Azospirillum brasilense
Plant Physiol. Biochem.
46
898-904
2008
1
-
-
-
-
-
-
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1
-
2
-
7
-
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-
1
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4
-
1
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1
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1
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1
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1
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1
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2
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-
1
-
4
-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
701432
Yin
Expression of glucose-6-phosph ...
Arabidopsis thaliana
Z. Naturforsch. C
63
713-720
2008
-
-
-
-
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1
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2
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1
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1
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1
-
-
-
-
-
-
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-
-
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-
-
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-
-
-
-
-
685841
He
Crystal structure of Saccharom ...
Saccharomyces cerevisiae
BMC Struct. Biol.
7
38
2007
-
-
-
1
1
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2
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4
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1
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1
1
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2
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-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
686094
Ruda
Synthesis and biological evalu ...
Trypanosoma brucei
ChemMedChem
2
1169-1180
2007
-
-
-
-
-
-
1
-
-
-
-
-
-
1
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-
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-
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1
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-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
686656
Sundaramoorthy
Crystal structures of a bacter ...
Lactococcus lactis, Trypanosoma brucei
FEBS J.
274
275-286
2007
-
1
-
2
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3
1
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6
-
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1
-
-
-
-
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1
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-
-
-
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2
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-
1
-
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2
-
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3
2
1
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-
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1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688036
Adem
Effects of some drugs on human ...
Homo sapiens
J. Enzyme Inhib. Med. Chem.
22
751-754
2007
-
-
-
-
-
-
7
-
-
-
-
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1
-
-
1
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
7
-
7
-
-
-
-
-
-
-
7
7
7
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688199
Hou
-
The 6-phosphogluconate dehydro ...
Oryza sativa
J. Integr. Plant Biol.
49
655-663
2007
-
-
-
-
-
-
-
-
-
-
-
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1
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-
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1
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1
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-
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-
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-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
689032
Domagala
Application of proteomic metho ...
Homo sapiens
Mol. Hum. Reprod.
13
437-444
2007
-
-
-
-
-
-
-
-
-
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1
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1
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1
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-
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-
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-
-
-
-
-
-
-
-
-
-
-
-
667432
Goulielmos
Cloning and structural charact ...
Bactrocera oleae, Ceratitis capitata
Biochem. Biophys. Res. Commun.
341
721-727
2006
-
-
2
-
-
-
-
-
-
-
-
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8
-
-
-
-
-
-
-
-
2
2
-
-
-
-
-
-
-
2
-
-
-
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-
2
2
-
-
-
-
-
-
-
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-
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-
-
-
-
-
-
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667707
Li
Role of the S128, H186, and N1 ...
Ovis aries
Biochemistry
45
12680-12686
2006
-
-
1
-
3
-
1
8
-
-
-
-
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1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
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1
4
-
-
-
-
1
1
-
3
-
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1
4
8
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
668301
Daniely
Pneumococcal 6-phosphogluconat ...
Streptococcus pneumoniae, Streptococcus pneumoniae WU2
Clin. Exp. Immunol.
144
254-263
2006
-
-
1
-
-
-
-
-
2
-
1
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6
-
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1
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
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1
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-
-
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2
-
1
-
-
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
668323
Sledzinski
-
Gender- and age-related change ...
Rattus norvegicus
Comp. Biochem. Physiol. B
144B
70-76
2006
-
-
-
-
-
-
-
-
-
-
-
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1
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-
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2
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1
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1
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1
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-
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-
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2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
669487
Li
Importance in catalysis of the ...
Ovis aries
J. Biol. Chem.
281
25568-25576
2006
-
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1
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5
-
-
12
-
-
-
-
-
1
-
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1
-
-
1
-
1
1
-
-
-
-
-
-
-
1
1
-
-
-
-
-
1
1
-
5
-
-
-
-
12
-
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-
-
-
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1
-
1
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
670006
Wang
Catalytic mechanism of 6-phosp ...
Ovis aries
J. Phys. Chem. B
110
7029-7035
2006
-
-
-
-
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1
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1
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1
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1
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1
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-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667411
Rho
Transcriptional regulation of ...
Mus musculus
Biochem. Biophys. Res. Commun.
332
288-296
2005
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
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1
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1
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1
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-
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1
-
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-
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-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667652
Cervellati
Role of methionine-13 in the c ...
Ovis aries
Biochemistry
44
2432-2440
2005
-
-
-
-
5
-
1
5
-
-
-
-
-
1
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
6
-
-
-
-
-
1
-
5
-
-
1
6
5
-
-
-
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
670650
Erat
Purification of 6-phosphogluco ...
Gallus gallus
Prep. Biochem. Biotechnol.
35
53-69
2005
-
-
-
-
-
-
-
2
-
-
2
-
-
2
-
-
1
-
-
2
2
-
1
1
1
-
-
-
1
1
1
1
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
2
-
-
-
-
1
-
2
2
-
1
1
1
-
-
-
1
1
1
-
-
-
-
-
-
-
670806
Ceyhan
Purification and kinetic prope ...
Rattus norvegicus
Protein J.
24
293-301
2005
-
-
-
-
-
-
1
2
-
-
2
-
-
2
-
-
1
-
-
1
2
-
1
1
1
1
-
-
1
-
-
1
1
-
-
-
-
-
1
-
-
-
-
1
1
2
-
-
2
-
-
-
-
1
-
1
2
-
1
1
1
1
-
-
1
-
-
-
-
-
-
-
-
-
655880
Zamboni
The Bacillus subtilis yqjI gen ...
Bacillus subtilis
J. Bacteriol.
186
4528-4534
2004
-
-
-
-
1
-
-
-
-
-
-
1
-
3
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
656386
Akyuez
Effects of some antibiotics on ...
Homo sapiens, Rattus norvegicus
J. Enzyme Inhib. Med. Chem.
19
361-365
2004
-
-
-
-
-
-
17
-
-
-
-
2
-
2
-
-
1
-
-
2
1
-
2
-
2
-
-
-
2
-
-
2
2
-
-
-
-
-
2
-
-
-
-
17
2
-
-
-
-
2
-
-
-
1
-
2
1
-
2
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
656470
Dardonville
Selective inhibition of Trypan ...
Leishmania donovani, Ovis aries, Plasmodium falciparum, Trypanosoma brucei, Trypanosoma cruzi
J. Med. Chem.
47
3427-3437
2004
-
-
-
-
-
-
111
2
-
-
-
-
-
5
-
-
-
-
-
1
-
-
15
-
2
-
-
-
2
-
-
5
20
-
-
-
-
-
5
-
-
-
-
111
20
2
-
-
-
-
-
-
-
-
-
1
-
-
15
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
656751
Esteve
The 6-phosphogluconate dehydro ...
Trypanosoma cruzi
Mol. Biochem. Parasitol.
133
197-207
2004
-
1
1
-
1
2
-
4
-
-
3
-
-
1
-
-
1
-
-
1
1
-
1
2
1
-
-
2
1
-
1
1
-
1
-
-
1
1
1
-
1
2
-
-
-
4
-
-
3
-
-
-
-
1
-
1
1
-
1
2
1
-
-
2
1
-
1
1
-
-
-
-
-
-
654952
Pasti
Sugar derivatives as new 6-pho ...
Ovis aries, Trypanosoma brucei
Bioorg. Med. Chem.
11
1207-1214
2003
-
-
1
-
-
-
34
4
-
-
-
-
-
2
-
-
1
-
-
1
-
-
8
-
2
-
-
4
2
-
-
2
34
-
-
-
-
1
2
-
-
-
-
34
34
4
-
-
-
-
-
-
-
1
-
1
-
-
8
-
2
-
-
4
2
-
-
-
-
-
-
-
-
-
655737
Pankiewicz
Tissue specific, sex and age-r ...
Rattus norvegicus
Int. J. Biochem. Cell Biol.
35
235-245
2003
1
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
-
8
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
8
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
656766
Huang
Molecular cloning and characte ...
Oryza sativa
Mol. Biol. Rep.
30
223-227
2003
1
-
1
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
6
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
1
-
1
1
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
6
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
654929
Sindelar
-
Glucose-6-phosphate dehydrogen ...
Nicotiana tabacum
Biol. Plant.
45
575-580
2002
-
-
-
-
-
-
1
-
3
-
-
1
-
1
-
-
1
-
-
1
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
3
-
-
1
-
-
-
1
-
1
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
657143
Ciftci
Effects of some drugs on rat e ...
Rattus norvegicus
Pol. J. Pharmacol.
54
275-280
2002
1
-
-
-
-
-
3
-
-
-
-
1
-
1
-
-
1
-
-
1
-
-
2
-
1
-
-
-
1
-
-
1
-
-
-
1
-
-
1
-
-
-
-
3
-
-
-
-
-
1
-
-
-
1
-
1
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
286904
Moritz
Kinetic properties of the gluc ...
Acer pseudoplatanus, Brevibacterium flavum, Candida boidinii, Corynebacterium glutamicum, Corynebacterium glutamicum ssp. flavum, Escherichia coli, Gluconobacter oxydans, Ovis aries, Pseudomonas sp., Pseudomonas sp. C, Saccharomyces cerevisiae
Eur. J. Biochem.
267
3442-3452
2000
-
-
-
-
-
-
25
2
-
-
-
11
-
12
-
-
3
-
-
1
2
-
18
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
25
-
2
-
-
-
11
-
-
-
3
-
1
2
-
18
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286899
Phillips
A 2.8 A resolution structure o ...
Ovis aries, Trypanosoma brucei
J. Mol. Biol.
25
667-681
1998
-
-
-
1
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286900
Tetaud
Crystallization and preliminar ...
Lactococcus lactis
Acta Crystallogr. Sect. D
54
1422-1424
1998
-
-
-
1
-
-
-
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286901
Tsai
Purification and kinetic chara ...
Cyberlindnera jadinii, Dicentrarchus labrax, Gluconobacter oxydans, Leuconostoc mesenteroides, Neurospora crassa, Ovis aries, Pseudomonas sp., Salmonella enterica subsp. enterica serovar Typhimurium, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Schizosaccharomyces pombe
Biochem. Cell Biol.
76
637-644
1998
-
-
1
1
-
-
5
-
-
2
2
10
-
34
-
-
1
-
-
2
1
-
14
1
-
-
-
-
2
-
-
4
-
-
-
-
-
1
4
1
-
-
-
5
-
-
-
2
2
10
-
-
-
1
-
2
1
-
14
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
286902
Chooback
Cloning, expression, purificat ...
Cyberlindnera jadinii, Escherichia coli, Escherichia coli JM109 M15, Ovis aries
Protein Expr. Purif.
13
251-258
1998
-
-
1
-
-
-
-
-
-
-
1
4
-
4
-
-
1
-
-
1
1
-
4
3
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
4
-
-
-
1
-
1
1
-
4
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286903
Rippa
6-Phosphogluconate dehydrogena ...
Cyberlindnera jadinii, Homo sapiens, Ovis aries, Trypanosoma brucei
Biochim. Biophys. Acta
1429
83-92
1998
1
2
1
2
-
-
3
6
-
-
-
4
-
4
-
-
3
-
-
5
-
-
9
4
-
-
-
-
10
-
-
-
-
-
-
1
2
1
-
2
-
-
-
3
-
6
-
-
-
4
-
-
-
3
-
5
-
-
9
4
-
-
-
-
10
-
-
-
-
-
-
-
-
-
660941
Corpas
-
A dehydrogenase-mediated recyc ...
Pisum sativum
Biochem. J.
330
777-784
1998
-
-
-
-
-
-
-
1
1
-
-
1
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
1
-
-
-
-
-
-
1
1
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
286897
Ganea
Inhibition of 6-phosphoglucona ...
Homo sapiens
Biochem. Biophys. Res. Commun.
222
626-631
1996
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286898
Price
Kinetic and chemical mechanism ...
Ovis aries
Arch. Biochem. Biophys.
336
215-223
1996
-
-
1
-
-
-
-
1
-
-
2
1
-
1
-
-
-
-
-
1
-
-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
2
1
-
-
-
-
-
1
-
-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286895
Corpas
Kinetic properties of hexose-m ...
Cyberlindnera jadinii, Gallus sp., Homo sapiens, Rattus norvegicus, Rattus norvegicus Wistar
Mol. Cell. Biochem.
144
97-104
1995
-
-
-
-
-
-
2
2
1
-
-
5
-
170
-
-
1
-
-
5
2
-
8
3
1
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
2
1
-
-
5
-
-
-
1
-
5
2
-
8
3
1
-
-
-
3
-
-
-
-
-
-
-
-
-
286896
Signorini
Purification and properties of ...
Beta vulgaris
Biochem. Mol. Biol. Int.
35
669-675
1995
-
-
-
-
-
-
3
2
3
-
2
1
-
1
-
-
1
-
-
1
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
2
3
-
2
1
-
-
-
1
-
1
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286891
Ishida
-
Isoenzymes of phosphogluconate ...
Acer pseudoplatanus, Catharanthus roseus, Catharanthus roseus B/S, Daucus carota, Glycine max, Pisum sativum, Ricinus communis, Spinacia oleracea, Vigna radiata
Phytochemistry
33
1307-1311
1993
-
-
-
-
-
-
2
10
10
-
-
9
-
9
-
-
-
-
-
8
1
-
13
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
10
10
-
-
9
-
-
-
-
-
8
1
-
13
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286892
Berdis
Overall kinetic mechanism of 6 ...
Cyberlindnera jadinii, Haemophilus influenzae, Homo sapiens, Leuconostoc mesenteroides, Ovis aries, Rattus norvegicus
Biochemistry
32
2036-2040
1993
-
-
-
-
-
-
4
5
3
-
-
6
-
6
-
-
-
-
-
5
1
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
5
3
-
-
6
-
-
-
-
-
5
1
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286893
Berdis
Chemical mechanism of 6-phosph ...
Cyberlindnera jadinii
Biochemistry
32
2041-2046
1993
1
-
-
-
-
-
5
1
-
-
-
1
-
1
-
-
-
-
-
-
-
-
4
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
5
-
1
-
-
-
1
-
-
-
-
-
-
-
-
4
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
286894
Berdis
The 2'-phosphate of NADP is cr ...
Cyberlindnera jadinii, Ovis aries
Arch. Biochem. Biophys.
305
551-558
1993
-
-
-
-
-
-
1
10
-
-
-
2
-
2
-
-
-
-
-
1
-
-
7
-
-
-
-
-
-
-
-
7
-
-
-
-
-
-
7
-
-
-
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10
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2
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1
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7
-
-
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-
-
-
286890
Hanau
NADPH activates a decarboxylat ...
Cyberlindnera jadinii, Homo sapiens, Ovis aries
Biochim. Biophys. Acta
1122
273-277
1992
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-
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2
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3
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3
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4
1
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5
3
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4
1
-
5
3
-
-
-
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-
-
-
-
-
-
-
-
-
-
286888
Kletsova
-
Glucose-6-phosphate dehydrogen ...
Methylobacillus flagellatus
Methods Enzymol.
188
335-339
1990
-
-
-
-
-
-
2
-
-
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1
-
1
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1
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1
1
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2
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1
1
-
-
-
-
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-
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-
-
-
-
286889
Sokolov
-
Glucose-6-phosphate dehydrogen ...
Arthrobacter globiformis, Arthrobacter globiformis VKM B-175
Methods Enzymol.
188
339-345
1990
-
-
-
-
-
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7
2
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3
2
2
-
2
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1
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1
1
2
1
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1
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1
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7
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2
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3
2
2
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1
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1
1
2
1
-
-
-
-
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-
-
-
-
-
-
-
-
286887
del mar Medina-Puerta
Kinetic analysis of 6-phosphog ...
Carassius carassius, Dicentrarchus labrax
Arch. Biochem. Biophys.
262
130-141
1988
-
-
-
-
-
-
2
3
-
1
-
2
-
2
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1
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1
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3
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3
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1
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3
-
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-
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-
-
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286885
Sugimoto
-
Regulation of 6-phosphoglucona ...
Brevibacterium flavum, Enterococcus faecalis
Agric. Biol. Chem.
51
1257-1263
1987
7
-
-
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1
10
2
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-
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2
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2
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1
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2
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3
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2
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7
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3
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1
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10
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2
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1
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2
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3
-
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2
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-
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286886
Hansen
Sex differences in the control ...
Rattus norvegicus, Rattus norvegicus Wistar
Biol. Chem. Hoppe-Seyler
368
955-962
1987
-
-
-
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2
-
167
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1
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2
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1
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2
-
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-
-
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-
286883
Topham
Chemical modification of sheep ...
Cyberlindnera jadinii, Ovis aries
Eur. J. Biochem.
155
87-94
1986
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-
-
-
-
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5
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2
-
2
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1
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1
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3
2
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5
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2
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1
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1
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-
3
2
-
-
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-
-
-
-
-
-
-
286884
Topham
Kinetic studies of 6-phosphogl ...
Cyberlindnera jadinii, Ovis aries
Eur. J. Biochem.
156
555-567
1986
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-
-
-
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2
4
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2
-
2
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-
1
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1
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2
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1
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2
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4
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2
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1
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1
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-
2
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
286881
Dallocchio
Half-site reactivity in 6-phos ...
Cyberlindnera jadinii, Homo sapiens, Ovis aries
Biochem. J.
227
305-310
1985
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-
-
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3
1
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2
3
-
3
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1
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4
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3
3
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3
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1
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2
3
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1
-
4
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-
3
3
-
-
-
-
-
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-
-
-
-
-
-
-
-
286882
Sawa
-
Purification and characterizat ...
Cyberlindnera jadinii, Enterococcus faecalis, Escherichia coli, Geobacillus stearothermophilus, Neurospora crassa, Phormidium sp., Rattus norvegicus, Synechococcus sp., Synechococcus sp. PCC 6307, Synechococcus sp. PCC 6716
Agric. Biol. Chem.
49
2543-2549
1985
1
-
-
-
-
1
38
6
-
4
8
10
-
12
-
-
1
-
-
1
1
-
18
7
1
-
3
-
6
1
1
7
-
-
-
1
-
-
7
-
-
1
-
38
-
6
-
4
8
10
-
-
-
1
-
1
1
-
18
7
1
-
3
-
6
1
1
-
-
-
-
-
-
-
286877
Miernyk
In vitro inhibition of the pla ...
Nicotiana tabacum, Rattus norvegicus, Ricinus communis, Saccharomyces cerevisiae
Plant Physiol.
76
1093-1094
1984
-
-
-
-
-
-
4
-
3
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4
-
4
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4
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4
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4
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3
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4
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4
-
-
4
-
-
-
-
-
-
-
-
-
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-
-
-
-
286878
Rendina
Use of multiple isotope effect ...
Saccharomyces cerevisiae
Biochemistry
23
6257-6262
1984
-
-
-
-
-
-
-
6
-
-
-
1
-
1
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-
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1
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6
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1
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1
-
-
-
-
-
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-
-
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-
-
-
-
286879
Lubberding
-
The influence of temperature o ...
Geobacillus stearothermophilus, Synechococcus sp., Synechococcus sp. PCC 6307, Synechococcus sp. PCC 6716, Synechocystis sp. PCC 6714
Arch. Microbiol.
137
115-120
1984
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-
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4
2
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5
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7
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9
-
3
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1
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2
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4
2
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5
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-
9
-
3
-
1
-
2
-
-
-
-
-
-
-
-
-
286880
Veronese
General stability of thermophi ...
Geobacillus stearothermophilus, Geobacillus stearothermophilus NCA 1503, Saccharomyces cerevisiae
J. Appl. Biochem.
6
39-47
1984
-
-
-
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-
1
-
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1
3
3
16
-
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3
1
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2
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-
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-
-
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1
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1
3
3
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-
3
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
286875
Adams
The three dimensional structur ...
Cyberlindnera jadinii, Ovis aries
EMBO J.
6
1009-1014
1983
-
-
-
1
-
-
-
-
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1
2
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2
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-
1
-
-
1
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3
2
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1
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1
2
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1
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1
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-
3
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286876
Adams
Structure-function relationshi ...
Saccharomyces cerevisiae
Biochem. Soc. Trans.
11
429-435
1983
-
-
-
-
-
-
-
-
-
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-
1
-
1
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1
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1
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286871
Wong
-
Synthesis of ribulose 1,5-bisp ...
Cyberlindnera jadinii, Ovis aries
Methods Enzymol.
89
108-121
1982
-
-
-
-
-
-
-
-
-
-
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2
-
2
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-
1
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2
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2
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1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286872
Carne
Purification by dye-ligand chr ...
Geobacillus stearothermophilus, Ovis aries
Anal. Biochem.
121
227-229
1982
-
-
-
-
-
-
-
-
-
-
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2
-
2
-
-
2
-
-
1
1
-
4
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-
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-
-
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-
-
-
-
-
-
-
-
-
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2
-
-
-
2
-
1
1
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286873
Dallocchio
Non-enzymic protein phosphoryl ...
Cyberlindnera jadinii
Biochem. J.
203
401-404
1982
-
-
-
1
-
-
4
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
4
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286874
Veronese
6-Phosphogluconate dehydrogena ...
Cyberlindnera jadinii, Escherichia coli, Geobacillus stearothermophilus, Geobacillus stearothermophilus NCA 1503
Methods Enzymol.
89
282-291
1982
-
-
-
1
-
1
6
-
-
2
4
4
-
15
-
-
1
-
-
-
1
1
7
1
2
2
1
-
2
1
-
-
-
-
-
-
-
-
-
1
-
1
-
6
-
-
-
2
4
4
-
-
-
1
-
-
1
1
7
1
2
2
1
-
2
1
-
-
-
-
-
-
-
-
286866
Al-Quadan
-
The effect of some phenolic co ...
Nicotiana tabacum, Nicotiana tabacum W-38
Phytochemistry
20
961-964
1981
1
-
-
-
-
-
9
-
-
-
1
2
-
3
-
-
1
-
-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
9
-
-
-
-
1
2
-
-
-
1
-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286867
Al-Quadan
-
Comparison of tryptic peptide ...
Nicotiana tabacum, Nicotiana tabacum W-38
Phytochemistry
20
1201-1203
1981
-
-
-
-
-
-
-
-
-
-
1
2
-
3
-
-
1
-
-
-
-
-
4
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
2
-
-
-
1
-
-
-
-
4
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
286868
Bublitz
Physical separation of cytopla ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
98
588-594
1981
-
-
-
-
-
-
-
-
2
-
-
1
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286869
Dallocchio
Effect of the substrate on the ...
Cyberlindnera jadinii
J. Biol. Chem.
256
10778-10780
1981
-
-
-
1
-
-
1
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
1
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286870
Jessup
-
Purification of 6-phosphogluco ...
Acer pseudoplatanus, Geobacillus stearothermophilus
J. Chromatogr.
219
419-426
1981
-
-
-
-
-
-
-
-
2
-
2
2
-
2
-
-
1
-
-
2
2
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
2
2
-
-
-
1
-
2
2
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286864
Adkins
-
Glucose-6-phosphate dehydrogen ...
Avena fatua
Phytochemistry
19
2523-2525
1980
-
-
-
-
-
-
-
4
1
-
-
1
-
1
-
-
1
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
1
-
-
1
-
-
-
1
-
4
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286865
Graefe
Control by phospho-adenosinedi ...
Saccharomyces cerevisiae, Streptomyces griseus
Z. Allg. Mikrobiol.
20
607-611
1980
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286859
Gosling
-
Characterization of glucose-6- ...
Corylus avellana, Neurospora crassa, Rattus norvegicus, Sus scrofa, Vigna radiata var. radiata
Phytochemistry
18
1441-1445
1979
-
-
-
-
-
-
-
2
2
-
-
5
-
5
-
-
-
-
-
4
-
-
8
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
3
-
-
-
-
-
-
2
2
-
-
5
-
-
-
-
-
4
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286860
Rippa
The stabilization by a coenzym ...
Cyberlindnera jadinii
Arch. Biochem. Biophys.
196
619-623
1979
-
-
-
1
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
2
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286861
Orozco de Silva
The 6-phosphogluconate dehydro ...
Escherichia coli, Escherichia coli RW226/pLC33-5
J. Biol. Chem.
254
10237-10242
1979
-
-
-
-
-
-
2
-
-
-
-
2
-
2
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286862
Abdallah
Binding of coenzyme and substr ...
Ovis aries
Eur. J. Biochem.
98
121-130
1979
-
-
-
1
-
-
1
-
-
-
1
1
-
1
-
-
1
-
-
1
-
-
2
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
1
-
-
-
1
-
-
-
-
1
1
-
-
-
1
-
1
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286863
Beitner
Inhibition of 6-phosphoglucona ...
Rattus norvegicus, Saccharomyces cerevisiae
Biochim. Biophys. Acta
583
266-269
1979
-
-
-
-
-
-
1
-
-
-
-
2
-
4
-
-
1
-
-
5
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
-
1
-
5
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286987
Kato
Purification and properties of ...
Candida boidinii, Ovis aries, Saccharomyces cerevisiae
Biochim. Biophys. Acta
566
1-11
1979
-
-
-
-
-
-
8
2
-
-
2
3
-
4
-
-
1
-
-
1
1
-
3
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
8
-
2
-
-
2
3
-
-
-
1
-
1
1
-
3
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286853
Dallocchio
Evidence for the proximity of ...
Cyberlindnera jadinii
Arch. Biochem. Biophys.
185
57-60
1978
-
-
-
1
-
-
1
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286854
Rippa
Evidence for the proximity of ...
Cyberlindnera jadinii
Arch. Biochem. Biophys.
186
406-410
1978
-
-
-
1
-
-
11
-
-
-
1
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
11
-
-
-
-
1
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286855
Rippa
The active site of 6-phosphogl ...
Ovis aries
Arch. Biochem. Biophys.
189
516-523
1978
-
-
-
1
-
-
-
-
-
-
1
1
-
1
-
-
-
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286856
Adams
The crystal structure of 6-pho ...
Cyberlindnera jadinii
Biochem. Soc. Trans.
6
1112-1115
1978
-
-
-
-
-
-
1
-
-
-
1
1
-
1
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286857
Simcox
6-Phosphogluconate dehydrogena ...
Daucus carota, Ricinus communis, Spinacia oleracea, Vigna radiata var. radiata
Plant Physiol.
62
287-290
1978
-
-
-
-
-
1
-
6
3
1
2
5
-
4
-
-
1
-
-
6
2
-
7
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
6
3
1
2
5
-
-
-
1
-
6
2
-
7
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
286852
Adams
Structure of 6-phosphogluconat ...
Cyberlindnera jadinii, Ovis aries
J. Mol. Biol.
112
183-197
1977
-
-
-
1
-
-
-
-
-
-
1
2
-
2
-
-
1
-
-
1
-
-
3
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
2
-
-
-
1
-
1
-
-
3
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286850
Toews
6-Phosphogluconate dehydrogena ...
Cyberlindnera jadinii, Homo sapiens, Ovis aries, Rattus norvegicus, Sus scrofa
J. Biol. Chem.
251
7127-7131
1976
-
-
-
-
-
1
5
1
4
2
1
5
-
5
-
-
4
-
-
6
2
-
5
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
1
-
5
-
1
4
2
1
5
-
-
-
4
-
6
2
-
5
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
286851
Veronese
Isolation and properties of 6- ...
Cyberlindnera jadinii, Enterococcus faecalis, Escherichia coli, Escherichia coli MRE 600, Geobacillus stearothermophilus, Neurospora crassa
Biochemistry
15
4026-4033
1976
-
-
-
-
-
2
16
2
-
-
5
6
-
15
-
-
1
-
-
-
1
1
10
5
2
-
4
-
-
-
-
5
-
-
-
-
-
-
5
-
-
2
-
16
-
2
-
-
5
6
-
-
-
1
-
-
1
1
10
5
2
-
4
-
-
-
-
-
-
-
-
-
-
-
286840
Silverberg
6-Phospho-D-gluconate dehydrog ...
Ovis aries, Rattus norvegicus
Methods Enzymol.
41
214-220
1975
-
-
-
1
-
-
26
7
-
-
2
2
-
3
-
-
2
-
-
3
3
-
3
2
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
1
-
-
-
26
-
7
-
-
2
2
-
-
-
2
-
3
3
-
3
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286841
Pearse
6-Phosphogluconate from human ...
Homo sapiens
Methods Enzymol.
41
220-226
1975
-
-
-
-
-
-
-
2
-
-
2
1
-
1
-
-
1
-
-
1
2
-
1
1
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
2
1
-
-
-
1
-
1
2
-
1
1
-
-
-
1
1
-
-
-
-
-
-
-
-
-
286842
Rippa
6-Phosphogluconate dehydrogena ...
Cyberlindnera jadinii
Methods Enzymol.
41
237-240
1975
-
-
-
1
-
-
-
2
-
-
-
1
-
1
-
-
1
-
-
-
1
1
5
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
-
1
-
-
-
1
-
-
1
1
5
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
286843
Scott
6-Phosphogluconate dehydrogena ...
Neurospora crassa, Saccharomyces cerevisiae
Methods Enzymol.
41
227-231
1975
-
-
-
-
-
-
3
2
-
-
2
2
-
2
-
-
1
-
-
1
1
1
3
1
-
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
3
-
2
-
-
2
2
-
-
-
1
-
1
1
1
3
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
286844
Silverberg
Fluorescence studies of coenzy ...
Ovis aries
Arch. Biochem. Biophys.
168
646-651
1975
-
-
-
1
-
-
1
-
-
-
1
1
-
1
-
-
1
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
1
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286845
Bridges
6-Phosphogluconate dehydrogena ...
Enterococcus faecalis
Methods Enzymol.
41
232-237
1975
-
-
-
-
-
-
5
2
-
-
1
1
-
1
-
-
1
-
-
-
1
1
1
1
-
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
5
-
2
-
-
1
1
-
-
-
1
-
-
1
1
1
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
286846
Bridges
Purification and properties of ...
Cyberlindnera jadinii, Enterococcus faecalis, Homo sapiens, Neurospora crassa, Rattus norvegicus
J. Biol. Chem.
250
6093-6100
1975
-
-
-
-
-
-
5
12
-
-
12
5
-
7
-
-
5
-
-
2
1
1
6
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
12
-
-
12
5
-
-
-
5
-
2
1
1
6
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286847
Fontana
Comparative thermostability of ...
Escherichia coli, Geobacillus stearothermophilus, Geobacillus stearothermophilus NCA 1503
Hoppe-Seyler's Z. Physiol. Chem.
356
1191-1193
1975
-
-
-
-
-
-
-
-
-
-
-
3
-
14
-
-
2
-
-
-
-
-
3
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
2
-
-
-
-
3
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
286848
Veronese
Denaturation of thermophilic a ...
Escherichia coli, Geobacillus stearothermophilus, Geobacillus stearothermophilus NCA 1503
Int. J. Pept. Protein Res.
7
341-343
1975
-
-
-
-
-
1
-
-
-
-
-
3
-
15
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286849
Betts
Purification and properties of ...
Cyberlindnera jadinii, Escherichia coli, Homo sapiens, Oryctolagus cuniculus, Ovis aries, Rattus norvegicus
Biochem. J.
151
263-270
1975
-
-
-
-
-
-
4
2
-
-
5
6
-
6
-
-
1
-
-
7
2
-
7
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
2
-
-
5
6
-
-
-
1
-
7
2
-
7
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286836
Veronese
-
Isolation and some properties ...
Cyberlindnera jadinii, Geobacillus stearothermophilus, Geobacillus stearothermophilus NCA 1503, Homo sapiens, Neurospora crassa, Rattus norvegicus
Biochim. Biophys. Acta
334
31-44
1974
-
1
-
-
-
-
4
12
-
4
3
6
-
17
-
-
1
-
-
3
1
1
7
5
-
-
3
-
4
-
-
7
-
-
-
-
1
-
7
-
-
-
-
4
-
12
-
4
3
6
-
-
-
1
-
3
1
1
7
5
-
-
3
-
4
-
-
-
-
-
-
-
-
-
286837
Pearse
Human 6-phosphogluconate dehyd ...
Homo sapiens, Ovis aries
Eur. J. Biochem.
42
213-223
1974
-
1
-
-
-
-
4
2
-
-
-
2
-
2
-
-
1
-
-
4
1
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
4
-
2
-
-
-
2
-
-
-
1
-
4
1
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
286838
Pearse
The molecular weight and subun ...
Cyberlindnera jadinii, Drosophila sp., Homo sapiens, Ovis aries, Rattus norvegicus
Eur. J. Biochem.
42
225-235
1974
-
-
-
-
-
-
-
-
-
-
13
5
-
5
-
-
1
-
-
5
-
-
5
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
13
5
-
-
-
1
-
5
-
-
5
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286839
King
-
6-Phosphogluconat-dehydrogenas ...
Homo sapiens, Saccharomyces cerevisiae
Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. )
1
668-672
1974
-
1
-
-
-
-
-
-
1
-
-
2
-
2
-
-
-
-
-
6
-
1
4
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
6
-
1
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286828
Schnarrenberger
Two isozymes each of glucose-6 ...
Spinacia oleracea
Arch. Biochem. Biophys.
154
438-448
1973
-
-
-
-
-
-
-
4
2
-
1
1
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
2
-
1
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
286829
Dyson
Sheep liver 6-phosphogluconate ...
Cyberlindnera jadinii, Ovis aries, Rattus norvegicus
Arch. Biochem. Biophys.
154
623-635
1973
-
-
-
-
-
-
-
12
-
-
-
3
-
3
-
-
-
-
-
2
1
-
5
-
-
-
-
-
2
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
12
-
-
-
3
-
-
-
-
-
2
1
-
5
-
-
-
-
-
2
1
1
-
-
-
-
-
-
-
286830
Dyson
Sheep liver 6-phosphogluconate ...
Ovis aries
J. Biol. Chem.
248
5428-5435
1973
-
-
-
-
-
-
31
2
-
-
-
1
-
1
-
-
1
-
-
1
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
31
-
2
-
-
-
1
-
-
-
1
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286831
Scott
Neurospora 6-phosphogluconate ...
Cyberlindnera jadinii, Neurospora crassa, Ovis aries
J. Biol. Chem.
248
3535-3544
1973
-
-
-
-
-
-
7
4
-
-
2
3
-
3
-
-
1
-
-
1
1
-
5
3
-
-
1
-
1
-
-
2
-
-
-
-
-
-
2
-
-
-
-
7
-
4
-
-
2
3
-
-
-
1
-
1
1
-
5
3
-
-
1
-
1
-
-
-
-
-
-
-
-
-
286832
Scott
Neurospora 6-phosphogluconate ...
Neurospora crassa
J. Biol. Chem.
248
3542-3545
1973
-
-
-
-
-
-
-
10
-
-
-
1
-
1
-
-
1
-
-
-
1
-
2
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
10
-
-
-
1
-
-
-
1
-
-
1
-
2
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
286833
Silverberg
Crystalline 6-phosphogluconate ...
Cyberlindnera jadinii, Ovis aries, Rattus norvegicus
Eur. J. Biochem.
38
229-238
1973
-
-
-
2
-
-
3
-
-
-
9
3
-
3
-
-
2
-
-
2
1
-
3
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
3
-
-
-
-
9
3
-
-
-
2
-
2
1
-
3
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286834
Pearse
6-Phosphogluconate dehydrogena ...
Cyberlindnera jadinii, Geobacillus stearothermophilus, Geobacillus stearothermophilus NCA 1503, Homo sapiens
FEBS Lett.
38
49-52
1973
-
-
-
1
-
-
2
-
-
-
3
4
-
15
-
-
1
-
-
1
-
-
4
3
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
2
-
-
-
-
3
4
-
-
-
1
-
1
-
-
4
3
1
1
1
-
-
-
-
-
-
-
-
-
-
-
286835
Rippa
A multiple role for the coenzy ...
Cyberlindnera jadinii, Saccharomyces cerevisiae, Sus scrofa
J. Biol. Chem.
248
4920-4925
1973
-
-
-
1
-
-
1
2
-
-
-
3
-
3
-
-
1
-
-
1
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
2
-
-
-
3
-
-
-
1
-
1
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286825
Emundson
6-phosphogluconate dehydrogena ...
Dictyostelium discoideum
Biochem. J.
126
593-600
1972
1
-
-
-
-
-
-
2
-
-
-
1
-
1
-
-
-
-
-
-
-
1
1
-
-
-
-
-
1
-
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
2
-
-
-
1
-
-
-
-
-
-
-
1
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
286826
Beitner
The effect of adenine nucleoti ...
Rattus norvegicus
Biochim. Biophys. Acta
286
437-440
1972
-
-
-
-
-
-
2
-
-
-
-
1
-
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286827
Procsal
Purification and properties of ...
Mus musculus, Ovis aries, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Biochemistry
11
1310-1314
1972
-
-
-
-
-
-
2
2
1
-
4
4
-
163
-
-
2
-
-
3
1
1
4
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
2
1
-
4
4
-
-
-
2
-
3
1
1
4
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
286824
Rippa
Evidence for a tyrosine residu ...
Cyberlindnera jadinii
Arch. Biochem. Biophys.
147
487-492
1971
-
-
-
1
-
-
1
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-