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Literature summary for 1.1.1.44 extracted from

  • Pankiewicz, A.; Sledzinski, T.; Nogalska, A.; Swierczynski, J.
    Tissue specific, sex and age-related differences in the 6-phosphogluconate dehydrogenase gene expression (2003), Int. J. Biochem. Cell Biol., 35, 235-245.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
17beta-estradiol administration causes an increase in liver enzyme, but not in white adipose tissue enzyme, activity and mRNA level in female and male rats Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information ovariectomized rats show a decrease in mRNA level and enzyme activity in the liver, but not in white adipose tissue, which can be restored by 17beta-estradiol administration Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6-phosphono-D-gluconate + NADP+ Rattus norvegicus the enzyme expression and activity is independently regulated in different tissues D-ribulose 5-phosphate + CO2 + NADPH
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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male and femal Wistar rats, age 1-20 months
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Source Tissue

Source Tissue Comment Organism Textmining
brain low activity in female and male rats, constant at age 2 months to age 9 months Rattus norvegicus
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brown adipose tissue high activity in female and male rats, decreasing from age 2 months to age 9 months Rattus norvegicus
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heart low activity in female and male rats, constant at age 2 months to age 9 months Rattus norvegicus
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kidney cortex, low activity in female and male rats, decreasing from age 2 months to age 9 months Rattus norvegicus
-
liver moderate activity in female and male rats, decreasing from age 2 months to age 9 months Rattus norvegicus
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additional information enzyme mRNA concentration show age- and sex-related differences, especially in the liver, overview Rattus norvegicus
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skeletal muscle low activity in female and male rats, constant at age 2 months to age 9 months Rattus norvegicus
-
white adipose tissue moderate activity in female and male rats, decreasing from age 2 months to age 9 months Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-phosphono-D-gluconate + NADP+
-
Rattus norvegicus D-ribulose 5-phosphate + CO2 + NADPH
-
?
6-phosphono-D-gluconate + NADP+ the enzyme expression and activity is independently regulated in different tissues Rattus norvegicus D-ribulose 5-phosphate + CO2 + NADPH
-
?

Synonyms

Synonyms Comment Organism
6-phosphonogluconate dehydrogenase
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Rattus norvegicus