Activating Compound | Comment | Organism | Structure |
---|---|---|---|
17beta-estradiol | administration causes an increase in liver enzyme, but not in white adipose tissue enzyme, activity and mRNA level in female and male rats | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | ovariectomized rats show a decrease in mRNA level and enzyme activity in the liver, but not in white adipose tissue, which can be restored by 17beta-estradiol administration | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
6-phosphono-D-gluconate + NADP+ | Rattus norvegicus | the enzyme expression and activity is independently regulated in different tissues | D-ribulose 5-phosphate + CO2 + NADPH | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male and femal Wistar rats, age 1-20 months | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | low activity in female and male rats, constant at age 2 months to age 9 months | Rattus norvegicus | - |
brown adipose tissue | high activity in female and male rats, decreasing from age 2 months to age 9 months | Rattus norvegicus | - |
heart | low activity in female and male rats, constant at age 2 months to age 9 months | Rattus norvegicus | - |
kidney | cortex, low activity in female and male rats, decreasing from age 2 months to age 9 months | Rattus norvegicus | - |
liver | moderate activity in female and male rats, decreasing from age 2 months to age 9 months | Rattus norvegicus | - |
additional information | enzyme mRNA concentration show age- and sex-related differences, especially in the liver, overview | Rattus norvegicus | - |
skeletal muscle | low activity in female and male rats, constant at age 2 months to age 9 months | Rattus norvegicus | - |
white adipose tissue | moderate activity in female and male rats, decreasing from age 2 months to age 9 months | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
6-phosphono-D-gluconate + NADP+ | - |
Rattus norvegicus | D-ribulose 5-phosphate + CO2 + NADPH | - |
? | |
6-phosphono-D-gluconate + NADP+ | the enzyme expression and activity is independently regulated in different tissues | Rattus norvegicus | D-ribulose 5-phosphate + CO2 + NADPH | - |
? |
Synonyms | Comment | Organism |
---|---|---|
6-phosphonogluconate dehydrogenase | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Rattus norvegicus |