Literature summary for 1.1.1.44 extracted from

Budak, H.; Ceylan, H.; Kocpinar, E.F.; Gonul, N.; Erdogan, O.
Expression of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase in oxidative stress induced by long-term iron toxicity in rat liver (2014), J. Biochem. Mol. Toxicol., 28, 217-223.

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Inhibitors

Inhibitors	Comment	Organism	Structure
Fe3+	-	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
6-phospho-D-gluconate + NADP+	Rattus norvegicus	-	D-ribulose 5-phosphate + CO2 + NADPH + H+	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
6-phospho-D-gluconate + NADP+	-	Rattus norvegicus	D-ribulose 5-phosphate + CO2 + NADPH + H+	-	?

Synonyms

Synonyms	Comment	Organism
6-phosphogluconate dehydrogenase	-	Rattus norvegicus
6PGD	-	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
NADP+	dependent on	Rattus norvegicus

Expression

Organism	Comment	Expression
Rattus norvegicus	the nontoxic (0.87 ppm) level of Fe3+ treatment leads to transcriptional activation for the enzyme	up

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Release 2023.1 (January 2023)