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Literature summary for 1.1.1.44 extracted from

  • Veronese, F.M.; Boccu, E.; Schiavon, O.; Grandi, C.; Fontana, A.
    General stability of thermophilic enzymes: Studies on 6-phosphogluconate dehydrogenase from Bacillus stearothermophilus and yeast (1984), J. Appl. Biochem., 6, 39-47.
    View publication on PubMed

General Stability

General Stability Organism
remarkably stable to the action of trypsin, chymotrypsin and elastase Geobacillus stearothermophilus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
100000
-
-
Geobacillus stearothermophilus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6-phospho-D-gluconate + NADP+ Saccharomyces cerevisiae
-
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r
6-phospho-D-gluconate + NADP+ Geobacillus stearothermophilus
-
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r
6-phospho-D-gluconate + NADP+ Geobacillus stearothermophilus NCA 1503
-
D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r

Organic Solvent Stability

Organic Solvent Comment Organism
Acetone enzyme shows 15-20% enhanced activity Geobacillus stearothermophilus
dimethylformamide enzyme shows 15-20% enhanced activity Geobacillus stearothermophilus
dioxane enzyme shows 15-20% enhanced activity Geobacillus stearothermophilus

Organism

Organism UniProt Comment Textmining
Geobacillus stearothermophilus
-
NCA 1503
-
Geobacillus stearothermophilus NCA 1503
-
NCA 1503
-
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-phospho-D-gluconate + NADP+
-
Saccharomyces cerevisiae D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r
6-phospho-D-gluconate + NADP+
-
Geobacillus stearothermophilus D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r
6-phospho-D-gluconate + NADP+
-
Geobacillus stearothermophilus NCA 1503 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
r

Subunits

Subunits Comment Organism
dimer
-
Geobacillus stearothermophilus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
48
-
-
Saccharomyces cerevisiae
67
-
-
Geobacillus stearothermophilus