Literature summary for 1.1.1.44 extracted from

Betts, S.A.; Mayer, R.J.
Purification and properties of 6-phosphogluconate dehydrogenase from rabbit mammary gland (1975), Biochem. J., 151, 263-270.

Search for more literature for 1.1.1.44

Inhibitors

Inhibitors	Comment	Organism	Structure
citrate	-	Oryctolagus cuniculus
citrate	-	Ovis aries
diphosphate	-	Oryctolagus cuniculus
diphosphate	-	Ovis aries

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.023	-	NADP+	-	Oryctolagus cuniculus
0.054	-	6-phosphogluconate	-	Oryctolagus cuniculus

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
52000	-	2 * 52000, SDS-PAGE	Oryctolagus cuniculus
102000	-	-	Rattus norvegicus
104000	-	-	Ovis aries
104000	-	gel filtration	Homo sapiens
104000	-	gel filtration	Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
6-phospho-D-gluconate + NADP+	Cyberlindnera jadinii	-	D-ribulose 5-phosphate + CO2 + NADPH + H+	-	r
6-phospho-D-gluconate + NADP+	Escherichia coli	-	D-ribulose 5-phosphate + CO2 + NADPH + H+	-	r
6-phospho-D-gluconate + NADP+	Homo sapiens	-	D-ribulose 5-phosphate + CO2 + NADPH + H+	-	r
6-phospho-D-gluconate + NADP+	Rattus norvegicus	-	D-ribulose 5-phosphate + CO2 + NADPH + H+	-	r
6-phospho-D-gluconate + NADP+	Ovis aries	-	D-ribulose 5-phosphate + CO2 + NADPH + H+	-	r
6-phospho-D-gluconate + NADP+	Oryctolagus cuniculus	mammary gland enzyme involved in NADPH production which is essential for lipogenesis	D-ribulose 5-phosphate + CO2 + NADPH + H+	-	r

Organism

Organism	UniProt	Comment	Textmining
Cyberlindnera jadinii	-	-	-
Escherichia coli	-	-	-
Homo sapiens	-	human	-
Oryctolagus cuniculus	-	rabbit, Primiparous New Zealand white	-
Ovis aries	-	sheep	-
Rattus norvegicus	-	rat	-

Purification (Commentary)

Purification (Comment)	Organism
-	Oryctolagus cuniculus

Source Tissue

Source Tissue	Comment	Organism	Textmining
erythrocyte	-	Homo sapiens	-
erythrocyte	-	Ovis aries	-
liver	-	Homo sapiens	-
liver	-	Rattus norvegicus	-
liver	-	Ovis aries	-
mammary gland	-	Rattus norvegicus	-
mammary gland	-	Oryctolagus cuniculus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
20	-	-	Oryctolagus cuniculus
22	-	150fold purification	Oryctolagus cuniculus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
6-phospho-D-gluconate + NADP+	-	Cyberlindnera jadinii	D-ribulose 5-phosphate + CO2 + NADPH + H+	-	r
6-phospho-D-gluconate + NADP+	-	Escherichia coli	D-ribulose 5-phosphate + CO2 + NADPH + H+	-	r
6-phospho-D-gluconate + NADP+	-	Homo sapiens	D-ribulose 5-phosphate + CO2 + NADPH + H+	-	r
6-phospho-D-gluconate + NADP+	-	Rattus norvegicus	D-ribulose 5-phosphate + CO2 + NADPH + H+	-	r
6-phospho-D-gluconate + NADP+	-	Oryctolagus cuniculus	D-ribulose 5-phosphate + CO2 + NADPH + H+	-	r
6-phospho-D-gluconate + NADP+	-	Ovis aries	D-ribulose 5-phosphate + CO2 + NADPH + H+	-	r
6-phospho-D-gluconate + NADP+	mammary gland enzyme involved in NADPH production which is essential for lipogenesis	Oryctolagus cuniculus	D-ribulose 5-phosphate + CO2 + NADPH + H+	-	r

Subunits

Subunits	Comment	Organism
dimer	-	Cyberlindnera jadinii
dimer	-	Escherichia coli
dimer	-	Homo sapiens
dimer	-	Rattus norvegicus
dimer	-	Ovis aries
dimer	2 * 52000, SDS-PAGE	Oryctolagus cuniculus

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Release 2023.1 (January 2023)