Information on EC 2.7.2.3 - phosphoglycerate kinase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

EC NUMBER
COMMENTARY hide
2.7.2.3
-
RECOMMENDED NAME
GeneOntology No.
phosphoglycerate kinase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
1-butanol autotrophic biosynthesis (engineered)
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Bifidobacterium shunt
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Biosynthesis of antibiotics
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Biosynthesis of secondary metabolites
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Calvin-Benson-Bassham cycle
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Carbon fixation in photosynthetic organisms
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formaldehyde assimilation III (dihydroxyacetone cycle)
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gluconeogenesis I
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gluconeogenesis III
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glycerol degradation to butanol
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Glycolysis / Gluconeogenesis
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glycolysis I (from glucose 6-phosphate)
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glycolysis II (from fructose 6-phosphate)
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glycolysis III (from glucose)
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glycolysis IV (plant cytosol)
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heterolactic fermentation
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Metabolic pathways
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Microbial metabolism in diverse environments
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sucrose biosynthesis I (from photosynthesis)
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superpathway of glucose and xylose degradation
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glycolysis
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photosynthesis
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SYSTEMATIC NAME
IUBMB Comments
ATP:3-phospho-D-glycerate 1-phosphotransferase
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CAS REGISTRY NUMBER
COMMENTARY hide
9001-83-6
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
bream
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Manually annotated by BRENDA team
Bufo vulgaris
toad
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-
Manually annotated by BRENDA team
gene PGK1; strain 3153A
SwissProt
Manually annotated by BRENDA team
strain 3153A
SwissProt
Manually annotated by BRENDA team
Chrysophrys guttulatus
red snapper
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-
Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
gene cg1790 or pgk
UniProt
Manually annotated by BRENDA team
gene cg1790 or pgk
UniProt
Manually annotated by BRENDA team
carp
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Manually annotated by BRENDA team
nubian mutant
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Manually annotated by BRENDA team
HM1:IMSS
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Manually annotated by BRENDA team
strain K12
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Manually annotated by BRENDA team
Esox sp.
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
Frog
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
Pacific halibut
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Manually annotated by BRENDA team
2 isozymes, cytosolic and chloroplastic; cv. Golden Promise
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Manually annotated by BRENDA team
Western grey kangaroo
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Manually annotated by BRENDA team
Eastern grey kangaroo
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Manually annotated by BRENDA team
2 isoforms PGK1 and PGK2, probably cytosolic and chloroplastic form
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Manually annotated by BRENDA team
DBA/2J
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Manually annotated by BRENDA team
IFO 14297
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Manually annotated by BRENDA team
ATCC 25978T
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Manually annotated by BRENDA team
salt tolerant landrace cv. Pokkali and salt-sensitive cv. IR64, gene OsPgk2a or Os02g07260, isozyme OsPGK2a
UniProt
Manually annotated by BRENDA team
ringtail possum
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Manually annotated by BRENDA team
TACII18
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Manually annotated by BRENDA team
strain Vul 4, DSM 3773
SwissProt
Manually annotated by BRENDA team
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Uniprot
Manually annotated by BRENDA team
strain JCM2524
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Manually annotated by BRENDA team
strain JCM2524
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Manually annotated by BRENDA team
strain BY4741
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
Spirulina geitleri
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
formerly Thermoanaerobium brockii strain Rt8.G4; strain Rt8.G4
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Manually annotated by BRENDA team
strain Rt8.G4
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Manually annotated by BRENDA team
strain HB8
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Manually annotated by BRENDA team
trout
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Manually annotated by BRENDA team
Vombatus sp.
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Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
malfunction
metabolism
PGK1 is a potentially light-modulated Calvin-Benson cycle enzyme
physiological function
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2',3'-didehydro-2',3'-dideoxythymidine triphosphate + 3-phospho-D-glycerate
2',3'-didehydro-2',3'-dideoxythymidine diphosphate + 3-phospho-D-glyceroyl phosphate
show the reaction diagram
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-
-
-
?
2',3'-dideoxy-2',3'-didehydro-beta-L(-)-5-fluorodeoxycytidine 5'-triphosphate + 3-phospho-D-glycerate
2',3'-dideoxy-2',3'-didehydro-beta-L(-)-5-fluorodeoxycytidine 5'-diphosphate + 1,3-diphosphoglycerate
show the reaction diagram
2',3'-dideoxy-GTP + 3-phospho-D-glycerate
2',3'-dideoxy-GDP + 3-phospho-D-glyceroyl phosphate
show the reaction diagram
-
-
-
-
?
2'-dATP + 3-phospho-D-glycerate
2'-dADP + 3-phospho-D-glyceroyl phosphate
show the reaction diagram
-
-
-
-
?
2'-deoxycytidine 5'-triphosphate + 3-phospho-D-glycerate
2'-deoxycytidine 5'-diphosphate + 1,3-diphosphoglycerate
show the reaction diagram
2'-dGTP + 3-phospho-D-glycerate
2'-dGDP + 3-phospho-D-glyceroyl phosphate
show the reaction diagram
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-
-
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?
2'-dTTP + 3-phospho-D-glycerate
2'-dTDP + 3-phospho-D-glyceroyl phosphate
show the reaction diagram
-
-
-
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?
3'-deoxy-3'-azidothymidine triphosphate + 3-phospho-D-glycerate
3'-deoxy-3'-azidothymidine diphosphate + 3-phospho-D-glyceroyl phosphate
show the reaction diagram
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-
-
-
?
3-phospho-D-glycerate
ADP + 3-phospho-D-glyceroyl 1-phosphate
show the reaction diagram
acyclovir triphosphate + 3-phospho-D-glycerate
acyclovir diphosphate + 3-phospho-D-glyceroyl phosphate
show the reaction diagram
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-
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-
?
ADP + 1,3-bisphosphoglycerate
ATP + 3-phosphoglycerate
show the reaction diagram
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using the stopped-flow method it is shown that substrate binding kinetics that lead to the formation of the catalytic PGK-1,3-bisphosphoglycerate-ADP complexes are mutually antagonistic with D-ADP, but much less so with L-ADP. A situation that is similar to that for the formation of the abortive PGK-3-phosphoglycerate-ADP complexes
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?
ADP + 3-phospho-D-glyceroyl 1-phosphate
3-phospho-D-glycerate
show the reaction diagram
ADP + 3-phospho-D-glyceroyl 1-phosphate
ATP + 3-phospho-D-glycerate
show the reaction diagram
ADP + 3-phospho-D-glyceroyl phosphate
ATP + 3-phospho-D-glycerate
show the reaction diagram
ATP + 3-phospho-D-glycerate
ADP + 1,3-diphosphoglycerate
show the reaction diagram
ATP + 3-phospho-D-glycerate
ADP + 3-phospho-D-glyceroyl 1-phosphate
show the reaction diagram
ATP + 3-phospho-D-glycerate
ADP + 3-phospho-D-glyceroyl phosphate
show the reaction diagram
ATP + 3-phospho-D-glycerate
ADP + 3-phospho-D-glyceroyl phosphate.
show the reaction diagram
beta-L(-)-dioxolanecytidine 5'-triphosphate + 3-phospho-D-glycerate
beta-L(-)-dioxolanecytidine 5'-diphosphate + 1,3-diphosphoglycerate
show the reaction diagram
beta-L-2',3'-dideoxy-3'-thiacytidine 5'-triphosphate + 3-phospho-D-glycerate
beta-L-2',3'-dideoxy-3'-thiacytidine 5'-diphosphate + 1,3-diphosphoglycerate
show the reaction diagram
CTP + 3-phospho-D-glycerate
CDP + 1,3-diphosphoglycerate
show the reaction diagram
D-ADP + 1,3-bisphosphoglycerate
?
show the reaction diagram
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?
D-ATP + 1,3-bisphospho-D-glycerate
?
show the reaction diagram
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?
D-ATP + 3-phospho-D-glycerate
D-ADP + 3-phospho-D-glyceroyl phosphate
show the reaction diagram
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?
D-CDP + 1,3-bisphospho-D-glycerate
?
show the reaction diagram
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?
D-CTP + 3-phospho-D-glycerate
D-CDP + 3-phospho-D-glyceroyl phosphate
show the reaction diagram
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?
D-GTP + 3-phospho-D-glycerate
D-GDP + 3-phospho-D-glyceroyl phosphate
show the reaction diagram
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?
dATP + 3-phospho-D-glycerate
dADP + 1,3-diphosphoglycerate
show the reaction diagram
dGTP + 3-phospho-D-glycerate
dGDP + 1,3-diphosphoglycerate
show the reaction diagram
dITP + 3-phospho-D-glycerate
dIDP + 1,3-diphosphoglycerate
show the reaction diagram
GTP + 3-phospho-D-glycerate
GDP + 1,3-diphosphoglycerate
show the reaction diagram
ITP + 3-phospho-D-glycerate
IDP + 1,3-diphosphoglycerate
show the reaction diagram
L-2'-dATP + 3-phospho-D-glycerate
L-2'-dADP + 3-phospho-D-glyceroyl phosphate
show the reaction diagram
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?
L-2'-dGTP + 3-phospho-D-glycerate
L-2'-dGDP + 3-phospho-D-glyceroyl phosphate
show the reaction diagram
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?
L-2'-dTTP + 3-phospho-D-glycerate
L-2'-dTDP + 3-phospho-D-glyceroyl phosphate
show the reaction diagram
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?
L-ADP + 1,3-bisphosphoglycerate
?
show the reaction diagram
-
with L-ADP, the transient burst phase of ATP is more clear-cut than with D-ADP, suggesting that the product release steps are slower with L-ADP than with D-ADP. This is in accordance with the lower kcat measured with L-ADP compared to D-ADP
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?
L-ADP + 3-phospho-D-glyceroyl phosphate
ATP + 3-phospho-D-glycerate
show the reaction diagram
-
L-MgADP is almost as a good substrate for hPGK as the natural D-MgADP
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?
L-ATP + 1,3-bisphospho-D-glycerate
?
show the reaction diagram
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?
L-ATP + 3-phospho-D-glycerate
L-ADP + 3-phospho-D-glyceroyl phosphate
show the reaction diagram
-
-
-
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?
L-CDP + 1,3-bisphospho-D-glycerate
?
show the reaction diagram
-
-
-
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?
L-CTP + 3-phospho-D-glycerate
L-CDP + 3-phospho-D-glyceroyl phosphate
show the reaction diagram
-
-
-
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?
L-GTP + 3-phospho-D-glycerate
L-GDP + 3-phospho-D-glyceroyl phosphate
show the reaction diagram
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-
-
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?
L-UTP + 3-phospho-D-glycerate
L-UDP + 3-phospho-D-glyceroyl phosphate
show the reaction diagram
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-
-
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?
UTP + 3-phospho-D-glycerate
UDP + 1,3-diphosphoglycerate
show the reaction diagram
UTP + 3-phospho-D-glycerate
UDP + 3-phospho-D-glyceroyl phosphate
show the reaction diagram
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?
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ADP + 3-phospho-D-glyceroyl phosphate
ATP + 3-phospho-D-glycerate
show the reaction diagram
ATP + 3-phospho-D-glycerate
ADP + 3-phospho-D-glyceroyl phosphate
show the reaction diagram
additional information
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
-
in the presence of either beta,gamma-imido-adenosine 5'-triphosphate or ADP binding of 3-phospho-D-glycerate is weakened and the contribution of the entropy-factor to its binding is increased relative to the enthalpy factor
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