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Literature summary for 2.7.2.3 extracted from
- Characteristics of testis-specific phosphoglycerate kinase 2 and its association with human sperm quality (2016), Hum. Reprod., 31, 273-279.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene pgk1, quantitative RT-PCR enzyme expression analysis | Homo sapiens |
| gene pgk2, quantitative RT-PCR enzyme expression analysis | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 3-phospho-D-glycerate | Homo sapiens | - |
ADP + 3-phospho-D-glyceroyl phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P00558 | gene PGK1 | - |
| Homo sapiens | P07205 | gene pgk2 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| germ cell | - |
Homo sapiens | - |
| additional information | immunohistochemic enzyme analysis, overview | Homo sapiens | - |
| Sertoli cell | - |
Homo sapiens | - |
| spermatozoon | PGK1 is mainly expressed in spermatogonia and Sertoli cells | Homo sapiens | - |
| spermatozoon | PGK2 is mainly expressed in round spermatids and spermatocytes | Homo sapiens | - |
| testis | PGK1 and PGK2 had distinct cellular localizations in testicular germ cells. PGK1 is significantly decreased in the testes of elderly men | Homo sapiens | - |
| testis | testis-specific phosphoglycerate kinase 2. PGK1 and PGK2 have distinct cellular localizations in testicular germ cells. PGK2 is significantly decreased in the testes of elderly men | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 3-phospho-D-glycerate | - |
Homo sapiens | ADP + 3-phospho-D-glyceroyl phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PGK1 | - |
Homo sapiens |
| PGK2 | - |
Homo sapiens |
| phosphoglycerate kinase 1 | - |
Homo sapiens |
| phosphoglycerate kinase 2 | - |
Homo sapiens |
| testis-specific phosphoglycerate kinase 2 | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | PGK1 is involved in spermatogenesis and is related to sperm motility | Homo sapiens |
| physiological function | PGK2 is involved in spermatogenesis and is related to sperm motility | Homo sapiens |
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Release 2023.1 (January 2023)
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