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Literature summary for 2.7.2.3 extracted from

  • Danshina, P.V.; Geyer, C.B.; Dai, Q.; Goulding, E.H.; Willis, W.D.; Kitto, G.B.; McCarrey, J.R.; Eddy, E.M.; OBrien, D.A.
    Phosphoglycerate kinase 2 (PGK2) is essential for sperm function and male fertility in mice (2010), Biol. Reprod., 82, 136-145.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
129S6/SvEvTac genomic DNA fragments inserted into vector pUCBM21 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
sperm
-
 Mus musculus
-
testis
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-phospho-D-glycerate
-
 Mus musculus ADP + 3-phospho-D-glyceroyl 1-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PGK2
-
 Mus musculus
phosphoglycerate kinase 2
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus

General Information

General Information Comment Organism
malfunction targeted disruption of Pgk2 by homologous recombination eliminates PGK activity in sperm and testis, and severely impairs male fertility, but does not block spermatogenesis. Mating behavior, reproductive organ weights (testis, excurrent ducts, and seminal vesicles), testis histology, sperm counts, and sperm ultrastructure are indistinguishable between Pgk2(-/-) and wild-type mice. Sperm motility and ATP levels are markedly reduced in males lacking PGK2. Pgk2(-/-) males sire occasional pups. Alternative pathways that bypass the PGK step of glycolysis exist. One of these bypass enzymes, acylphosphatase, is active in mouse sperm, perhaps contributing to phenotypic differences between mice lacking GAPDHS or PGK2 Mus musculus
physiological function PGK2 is not required for completion of spermatogenesis, but is essential for sperm motility and male fertility Mus musculus