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Literature summary for 2.7.2.3 extracted from

  • Azevedo, A.; Toledo, J.S.; Defina, T.; Pedrosa, A.L.; Cruz, A.K.
    Leishmania major phosphoglycerate kinase transcript and protein stability contributes to differences in isoform expression levels (2015), Exp. Parasitol., 159, 222-226.
    View publication on PubMed
Search for more literature for 2.7.2.3

Cloned(Commentary)

Cloned (Comment) Organism
gene PGKB, investigation of the stability of PGKB transcript using reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) in combination with transcription and trans-splicing inhibitors, sinefungin and actinomycin D Leishmania major
gene PGKC, investigation of the stability of PGKB transcript using reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) in combination with transcription and trans-splicing inhibitors, sinefungin and actinomycin D Leishmania major

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Leishmania major 5829
-
glycosome
-
 Leishmania major 20015
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Leishmania major

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 3-phospho-D-glycerate Leishmania major
-
 ADP + 3-phospho-D-glyceroyl phosphate
-
 ?
ATP + 3-phospho-D-glycerate Leishmania major LT252
-
 ADP + 3-phospho-D-glyceroyl phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Leishmania major P50312 isozyme PGKC; gene PGKC codes for the glycosomal isoform of the enzyme
-
Leishmania major Q27683 isozyme PGKB; gene PGKB codes for the cytosolic isoform of the enzyme
-
Leishmania major LT252 P50312 isozyme PGKC; gene PGKC codes for the glycosomal isoform of the enzyme
-
Leishmania major LT252 Q27683 isozyme PGKB; gene PGKB codes for the cytosolic isoform of the enzyme
-

Source Tissue

Source Tissue Comment Organism Textmining
promastigote
-
 Leishmania major
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 3-phospho-D-glycerate
-
 Leishmania major ADP + 3-phospho-D-glyceroyl phosphate
-
 ?
ATP + 3-phospho-D-glycerate
-
 Leishmania major LT252 ADP + 3-phospho-D-glyceroyl phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PGKB
-
 Leishmania major
PGKC
-
 Leishmania major

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Leishmania major

General Information

General Information Comment Organism
evolution the PGKB transcript is approximately three-fold more abundant than the PGKC transcript in promastigotes Leishmania major